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Liability Related to Sale of Future Royalties (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Apr. 30, 2015
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Roll forward          
Non-cash Kadcyla royalty revenue   $ (6,503) $ (6,184) $ (20,555) $ (19,508)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes   3,385 $ 5,018 10,461 $ 14,946
Kadcyla          
Liability Related to Sale of Future Royalties          
Percentage of royalty payments if applicable threshold is met 85.00%        
Kadcyla | IRH          
Liability Related to Sale of Future Royalties          
Percentage of royalty payments 100.00%        
Royalty revenue $ 235,000        
Royalties on net sales of Kadcyla when royalties to the purchaser reach a specified milestone $ 260,000        
Percentage of royalty payments if applicable threshold is met 15.00%        
Proceeds from sale of future royalties - net $ 200,000        
Transaction costs for royalty agreements $ 5,900        
Roll forward          
Liability related to sale of future royalties, net — beginning balance       184,328  
Non-cash Kadcyla royalty revenue       (20,555)  
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes       10,010  
Liability related to sale of future royalties, net — ending balance   $ 173,783   $ 173,783  
Effective annual interest rate       7.70%