CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016
Cash flows from operating activities:
Net loss	$ (26,212)	$ (77,850)
Adjustments to reconcile net loss to net cash used for operating activities:
Non-cash royalty revenue related to sale of future royalties	(14,052)	(13,324)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes	7,076	9,928
Depreciation and amortization	2,934	2,940
Loss on sale/disposal of fixed assets and impairment charges	180	5
Stock and deferred share unit compensation	5,801	11,862
Deferred rent	49	105
Change in operating assets and liabilities:
Accounts receivable	1,002	(80)
Unbilled revenue	4,971	(524)
Inventory	(1,290)	630
Prepaid and other current assets	628	1,737
Other assets	(128)	(487)
Accounts payable	(2,394)	(525)
Accrued compensation	266	5,269
Other accrued liabilities	802	1,900
Deferred revenue	11,487	(716)
Proceeds from landlord for tenant improvements		144
Net cash used for operating activities	(8,880)	(58,986)
Cash flows from investing activities:
Purchases of property and equipment	(779)	(5,249)
Net cash used for investing activities	(779)	(5,249)
Cash flows from financing activities:
Proceeds from stock options exercised	32	370
Proceeds from issuance of convertible 4.5% notes, net of $3,392 of transaction costs		96,608
Net cash provided by financing activities	32	96,978
Net change in cash and cash equivalents	(9,627)	32,743
Cash and cash equivalents, beginning balance	159,964	212,283
Cash and cash equivalents, ending balance	$ 150,337	$ 245,026