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Liability Related to Sale of Future Royalties (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended 27 Months Ended
Apr. 30, 2015
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Roll forward            
Non-cash Kadcyla royalty revenue   $ (6,439) $ (5,944) $ (14,052) $ (13,324)  
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes   3,501 $ 4,956 7,076 $ 9,928  
Kadcyla            
Liability Related to Sale of Future Royalties            
Percentage of royalty payments if applicable threshold is met 85.00%          
Kadcyla | IRH            
Liability Related to Sale of Future Royalties            
Percentage of royalty payments 100.00%          
Royalty revenue $ 235,000          
Royalties on net sales of Kadcyla when royalties to the purchaser reach a specified milestone $ 260,000          
Percentage of royalty payments if applicable threshold is met 15.00%          
Proceeds from sale of future royalties - net $ 200,000          
Transaction costs for royalty agreements $ 5,900          
Roll forward            
Liability related to sale of future royalties, net — beginning balance       184,328    
Non-cash Kadcyla royalty revenue       (14,052)    
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes       6,741    
Liability related to sale of future royalties, net — ending balance   $ 177,017   $ 177,017   $ 177,017
Effective annual interest rate           7.70%