CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Cash flows from operating activities:
Net loss	$ (17,345)	$ (31,928)
Adjustments to reconcile net loss to net cash used for operating activities:
Non-cash royalty revenue related to sale of future royalties	(7,613)	(7,380)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes	3,575	4,972
Depreciation and amortization	1,506	1,435
Loss (gain) on sale/disposal of fixed assets and impairment charges	180	(3)
Stock and deferred share unit compensation	2,665	7,283
Deferred rent	25	42
Change in operating assets and liabilities:
Accounts receivable	(1,867)	699
Unbilled revenue	4,727	(142)
Inventory	(1,033)	629
Prepaid and other current assets	(1,008)	(717)
Other assets	(173)	17
Accounts payable	(2,543)	(2,378)
Accrued compensation	(2,019)	1,134
Other accrued liabilities	775	1,490
Deferred revenue, net of non-cash upfront license payment	(12,811)	(1,232)
Net cash used for operating activities	(32,959)	(26,079)
Cash flows from investing activities:
Purchases of property and equipment	(437)	(3,479)
Net cash used for investing activities	(437)	(3,479)
Cash flows from financing activities:
Proceeds from stock options exercised		188
Net cash provided by financing activities		188
Net change in cash and cash equivalents	(33,396)	(29,370)
Cash and cash equivalents, beginning balance	159,964	212,283
Cash and cash equivalents, ending balance	$ 126,568	$ 182,913