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Liability Related to Sale of Future Royalties (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 24 Months Ended
Apr. 30, 2015
Mar. 31, 2017
Mar. 31, 2016
Mar. 31, 2017
Roll forward        
Non-cash Kadcyla royalty revenue   $ (7,613) $ (7,380)  
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes   3,575 $ 4,972  
Kadcyla        
Liability Related to Sale of Future Royalties        
Percentage of royalty payments if applicable threshold is met 85.00%      
Kadcyla | IRH        
Liability Related to Sale of Future Royalties        
Percentage of royalty payments 100.00%      
Royalty revenue $ 235,000      
Royalties on net sales of Kadcyla when royalties to the purchaser reach a specified milestone $ 260,000      
Percentage of royalty payments if applicable threshold is met 15.00%      
Proceeds from sale of future royalties - net $ 200,000      
Transaction costs for royalty agreements $ 5,900      
Roll forward        
Liability related to sale of future royalties, net — beginning balance   184,328    
Non-cash Kadcyla royalty revenue   (7,613)    
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes   3,409    
Liability related to sale of future royalties, net — ending balance   $ 180,124   $ 180,124
Effective annual interest rate       7.70%