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Agreements - Sanofi (Details)
$ in Thousands
1 Months Ended 3 Months Ended 168 Months Ended
Mar. 31, 2017
USD ($)
Jan. 31, 2017
USD ($)
Mar. 31, 2017
USD ($)
item
Mar. 31, 2016
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2008
USD ($)
Dec. 31, 2003
USD ($)
Collaborative Agreements disclosures              
License and milestone fees     $ 18,730 $ 10,077      
Development milestones              
Collaborative Agreements disclosures              
Potential milestone payments           $ 16,000  
Sanofi              
Collaborative Agreements disclosures              
Potential milestone payments             $ 21,500
Payments received under collaboration agreement     $ 26,500   $ 26,500    
Number of single-target licenses | item     1        
Sanofi | Development milestones              
Collaborative Agreements disclosures              
Potential milestone payments             7,500
Sanofi | Phase I clinical trial              
Collaborative Agreements disclosures              
Potential milestone payments $ 1,000   $ 1,000        
Sanofi | Phase IIb Clinical Trial              
Collaborative Agreements disclosures              
Potential milestone payments 3,000   3,000        
License and milestone fees 3,000            
Sanofi | Phase III Clinical Trial              
Collaborative Agreements disclosures              
Potential milestone payments 3,000   3,000        
License and milestone fees   $ 3,000          
Sanofi | Regulatory milestones              
Collaborative Agreements disclosures              
Potential milestone payments $ 3,000   $ 3,000       $ 14,000