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Commitments and Contingencies (Details)
€ in Millions
1 Months Ended 6 Months Ended 12 Months Ended
Feb. 28, 2017
EUR (€)
Apr. 30, 2013
ft²
Dec. 31, 2016
USD ($)
item
Jun. 30, 2016
USD ($)
Jun. 30, 2015
USD ($)
Jun. 30, 2014
USD ($)
Dec. 31, 2016
GBP (£)
ft²
Dec. 31, 2016
USD ($)
ft²
Feb. 29, 2016
USD ($)
ft²
Dec. 31, 2015
USD ($)
Apr. 30, 2014
USD ($)
Dec. 31, 2013
USD ($)
Operating leases                        
Construction allowance       $ 6,236,000 $ 6,301,000     $ 5,914,000        
Facilities rent expense, net of sublease income     $ 3,500,000 $ 6,500,000 $ 6,000,000 $ 5,400,000            
Minimum rental commitments under the non-cancelable operating lease agreements                        
2017               7,946,000        
2018               7,736,000        
2019               7,235,000        
2020               7,283,000        
2021               7,107,000        
Thereafter               30,794,000        
Total minimum lease payments               68,101,000        
Total minimum rental payments from sublease               (190,000)        
Total minimum lease payments, net               67,911,000        
Obligations under capital leases               0        
Collaborations and Licenses                        
Potential milestone payable               162,000,000        
Amount reimbursable by a third party               1,400,000        
Obligation to make payment to vendor for certain contractual services | £             £ 300,000          
Manufacturing Commitments                        
Collaborations and Licenses                        
Term of agreement 5 years                      
Other Commitment € 46.2             $ 7,200,000        
Noncancelable commitment | € € 4.2                      
830 Winter Street, Waltham, MA                        
Operating leases                        
Area of space leased | ft²             110,000 110,000        
Number of additional terms for which lease agreement can be extended | item     2                  
Lease term extension period     5 years                  
Construction allowance                   $ 186,000 $ 1,100,000 $ 746,000
930 Winter Street, Walham, MA                        
Operating leases                        
Area of space leased | ft²                 10,281      
Construction allowance                 $ 617,000      
333 Providence Hwy, Norwood MA                        
Operating leases                        
Area of space leased | ft²             43,850 43,850        
Lease term extension period     5 years                  
100 River Ridge Drive, Norwood, MA                        
Operating leases                        
Area of space leased | ft²   7,507                    
Lease term extension period   5 years                    
Lease term period   5 years 2 months