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Agreements - CytomX (Details) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended 36 Months Ended
Jan. 31, 2017
Jan. 31, 2014
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2014
Sep. 30, 2014
Dec. 31, 2016
Dec. 31, 2015
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2014
Dec. 31, 2016
Collaborative Agreements disclosures                                    
Long-term deferred revenue     $ 19,086,000   $ 19,288,000       $ 40,855,000       $ 19,086,000   $ 19,288,000 $ 40,855,000   $ 19,086,000
Deferred revenue, net of current portion     19,086,000   19,288,000       40,855,000       19,086,000   19,288,000 40,855,000   19,086,000
Costs related to the research and development services     33,657,000 $ 32,909,000 $ 38,652,000 $ 36,094,000 $ 38,199,000 $ 35,132,000 $ 30,437,000 $ 25,666,000 $ 27,647,000 $ 28,018,000 66,566,000 $ 73,331,000 148,077,000 111,768,000 $ 106,958,000  
CytomX                                    
Collaborative Agreements disclosures                                    
Potential milestone payments   $ 160,000,000                                
Potential milestone payments to be paid   $ 80,000,000                                
Estimated utilization period after commercialization   10 years                                
Discount rate (as a percent)   13.00%                                
Value of collaborators licenses     13,100,000                   13,100,000         13,100,000
Fair value of consideration for services provided $ 13,000,000                                  
Estimated term of development and commercialization license   25 years                                
Fair value of consideration for services received   $ 13,100,000                                
Costs related to the research and development services                         427,000   $ 868,000 $ 130,000 0  
CytomX | Development milestones                                    
Collaborative Agreements disclosures                                    
Potential milestone payments   10,000,000                                
Potential milestone payments to be paid   7,000,000                                
Fair value of consideration for services provided                                   12,700,000
CytomX | Phase I clinical trial                                    
Collaborative Agreements disclosures                                    
Potential milestone payments     1,000,000                   1,000,000         1,000,000
Potential milestone payments to be paid     1,000,000                   1,000,000         1,000,000
CytomX | Future Technological Improvements                                    
Collaborative Agreements disclosures                                    
Value of collaborators licenses     13,000,000                   13,000,000         13,000,000
Fair value of consideration for services provided                                   350,000
CytomX | Research Services                                    
Collaborative Agreements disclosures                                    
Value of collaborators licenses     $ 140,000                   140,000         140,000
Fair value of consideration for services provided                                   $ 140,000
Fair value of consideration for services received   310,000                             $ 12,800,000  
CytomX | Right-to-test agreement                                    
Collaborative Agreements disclosures                                    
Fair value of consideration for services provided                         $ 12,700,000          
CytomX | Regulatory milestones                                    
Collaborative Agreements disclosures                                    
Potential milestone payments   50,000,000                                
Potential milestone payments to be paid   23,000,000                                
CytomX | Sales milestones                                    
Collaborative Agreements disclosures                                    
Potential milestone payments   100,000,000                                
Potential milestone payments to be paid   $ 50,000,000