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Agreements - Biotest (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Sep. 30, 2008
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2014
Dec. 31, 2006
Collaborative Agreements disclosures                          
Costs related to the research and development services   $ 38,652,000 $ 36,094,000 $ 38,199,000 $ 35,132,000 $ 30,437,000 $ 25,666,000 $ 27,647,000 $ 28,018,000 $ 148,077,000 $ 111,768,000 $ 106,958,000  
Development and Commercialization License | Development milestones                          
Collaborative Agreements disclosures                          
Potential milestone payments                         $ 4,500,000
Biotest                          
Collaborative Agreements disclosures                          
Costs related to the research and development services                   160,000 309,000 305,000  
Costs related to clinical materials sold                   1,800,000 $ 3,000,000 $ 670,000  
Biotest | Development and Commercialization License                          
Collaborative Agreements disclosures                          
Payments received under collaboration agreement                         1,000,000
Potential milestone payments                         35,500,000
Opt-in-fee payable on exercise of right                         15,000,000
Biotest | Development and Commercialization License | Development milestones                          
Collaborative Agreements disclosures                          
Payments received under collaboration agreement $ 500,000                        
Biotest | Development and Commercialization License | Phase IIb Clinical Trial                          
Collaborative Agreements disclosures                          
Potential milestone payments   $ 2,000,000               $ 2,000,000      
Biotest | Development and Commercialization License | Regulatory milestones                          
Collaborative Agreements disclosures                          
Potential milestone payments                         $ 31,000,000