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Liability Related to Sale of Future Royalties (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Apr. 30, 2015
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2015
Dec. 31, 2014
Liability Related to Sale of Future Royalties          
Royalties on net sales of Kadcyla   $ 195 $ 4,625 $ 195 $ 8,791
Percentage of royalty payments if applicable threshold is met 85.00%        
Immunity Royalty Holdings, L.P          
Liability Related to Sale of Future Royalties          
Percentage of royalty payments 100.00%        
Royalties on net sales of Kadcyla $ 235,000        
Royalties on net sales of Kadcyla when royalties to the purchaser reach a specified milestone $ 260,000        
Percentage of royalty payments if applicable threshold is met 15.00%        
Proceeds from sale of future royalties $ 200,000        
Transaction costs incurred during royalty purchase agreement $ 5,900        
Movement in Deferred Revenue [Roll Forward]          
Liability related to sale of future royalties - beginning balance       199,662  
Non cash Kadcyla royalty revenue       (11,975)  
Non cash interest expense recognized       9,621  
Liability related to sale of future royalties - ending balance   $ 197,308   $ 197,308  
Effective annual interest rate       9.70%