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Collaborative Agreements - Lilly (Details)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended 37 Months Ended
Sep. 30, 2015
USD ($)
Dec. 31, 2011
USD ($)
item
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2015
USD ($)
item
Dec. 31, 2014
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Collaborative Agreements disclosures                
Amount of arrangement consideration included in license and milestone fees     $ 10,692 $ 41,417 $ 16,762 $ 47,651    
Lilly | Right-to-test agreement                
Collaborative Agreements disclosures                
Number of development and commercialization licenses taken | item   3            
Payments received under collaboration agreement   $ 20,000            
Lilly | Right-to-test agreement | No exercise fee                
Collaborative Agreements disclosures                
License exercise fee, per subsequent license   0            
Lilly | Right-to-test agreement | Exercise fee of $2 million                
Collaborative Agreements disclosures                
License exercise fee, per subsequent license   $ 2,000           $ 2,000
Lilly | Development and Commercialization License                
Collaborative Agreements disclosures                
Payments received under collaboration agreement             $ 23,500  
Amount of arrangement consideration included in license and milestone fees       15,600   15,600    
Lilly | Development and Commercialization License | Exclusive license                
Collaborative Agreements disclosures                
Number of development and commercialization licenses taken | item         3      
Lilly | Development and Commercialization License | No exercise fee                
Collaborative Agreements disclosures                
Number of development and commercialization licenses taken | item         1      
Lilly | Development and Commercialization License | No exercise fee | Maximum                
Collaborative Agreements disclosures                
Potential milestone payments for each subsequent license       200,500   200,500 200,500  
Lilly | Development and Commercialization License | Exercise fee of $2 million                
Collaborative Agreements disclosures                
Number of development and commercialization licenses taken | item   2     2      
License exercise fee, per subsequent license       2,000   2,000 2,000  
Lilly | Development and Commercialization License | Exercise fee of $2 million | Maximum                
Collaborative Agreements disclosures                
Potential milestone payments for each subsequent license       199,000   199,000 199,000  
Lilly | Development and Commercialization License | Phase I clinical trial                
Collaborative Agreements disclosures                
Number of development and commercialization licenses taken | item         2      
Lilly | Development and Commercialization License | Development milestones | No exercise fee                
Collaborative Agreements disclosures                
Potential milestone payments for each subsequent license       30,500   30,500 30,500  
Lilly | Development and Commercialization License | Development milestones | Exercise fee of $2 million                
Collaborative Agreements disclosures                
Potential milestone payments for each subsequent license       29,000   29,000 29,000  
Lilly | Development and Commercialization License | Development milestones | Phase I clinical trial                
Collaborative Agreements disclosures                
Payments received under collaboration agreement $ 5,000              
Potential milestone payments for each subsequent license     $ 5,000   $ 5,000      
Lilly | Development and Commercialization License | Development milestones | Phase II clinical trial                
Collaborative Agreements disclosures                
Potential milestone payments for each subsequent license $ 9,000              
Lilly | Development and Commercialization License | Regulatory milestones                
Collaborative Agreements disclosures                
Potential milestone payments for each subsequent license       70,000   70,000 70,000  
Lilly | Development and Commercialization License | Sales milestones                
Collaborative Agreements disclosures                
Potential milestone payments for each subsequent license       $ 100,000   $ 100,000 $ 100,000