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Collaborative Agreements - Sanofi (Details)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended 150 Months Ended
Dec. 31, 2013
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2015
USD ($)
item
Dec. 31, 2014
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2006
USD ($)
Jul. 31, 2003
USD ($)
Collaborative Agreements disclosures                
License and milestone fees   $ 10,692 $ 41,417 $ 16,762 $ 47,651      
Sanofi | Development and Commercialization License                
Collaborative Agreements disclosures                
Number of undisclosed targets with exclusive licenses | item       1        
Potential milestone payments               $ 21,500
Payments received under collaboration agreement           $ 20,500    
License exercise fee, per license             $ 2,000  
Fee received per license $ 2,000              
License and milestone fees         1,700      
Sanofi | Development and Commercialization License | Maximum                
Collaborative Agreements disclosures                
Potential milestone payments             30,000  
Sanofi | Development and Commercialization License | Phase IIb clinical trial                
Collaborative Agreements disclosures                
Potential milestone payments   $ 4,000   $ 4,000   4,000    
Sanofi | Development and Commercialization License | Development milestones                
Collaborative Agreements disclosures                
Potential milestone payments             10,000 7,500
Sanofi | Development and Commercialization License | Regulatory milestones                
Collaborative Agreements disclosures                
Potential milestone payments             $ 20,000 14,000
Sanofi | Development and Commercialization License | Undisclosed Target | Development milestones | Phase I clinical trial                
Collaborative Agreements disclosures                
Potential milestone payments               1,000
Sanofi | Development and Commercialization License | SAR566658 | Development milestones | Phase IIb clinical trial                
Collaborative Agreements disclosures                
Potential milestone payments               3,000
Sanofi | Development and Commercialization License | Isatuximab | Phase IIb clinical trial                
Collaborative Agreements disclosures                
Payments received under collaboration agreement           $ 3,000    
Sanofi | Development and Commercialization License | Isatuximab | Development milestones | Phase III clinical trial                
Collaborative Agreements disclosures                
Potential milestone payments               $ 3,000
Sanofi | Development and Commercialization License | SAR408701 | Phase I clinical trial                
Collaborative Agreements disclosures                
Payments received under collaboration agreement         1,000      
Sanofi | Development and Commercialization License | SAR408701 | Development milestones | Phase IIb clinical trial                
Collaborative Agreements disclosures                
Potential milestone payments     $ 3,000   $ 3,000      
Sanofi | Development and Commercialization License | SAR428926 | Phase I clinical trial                
Collaborative Agreements disclosures                
License and milestone fees       $ 2,000