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Collaborative Agreements (Details)
$ in Thousands
1 Months Ended 3 Months Ended
Sep. 30, 2015
USD ($)
Dec. 31, 2011
USD ($)
item
Sep. 30, 2015
USD ($)
item
Sep. 30, 2014
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Collaborative Agreements disclosures            
Amount of arrangement consideration included in license and milestone fees     $ 6,070 $ 6,234    
Costs related to the research and development services     $ 35,132 $ 28,018    
Lilly | Right-to-test agreement            
Collaborative Agreements disclosures            
Payments received under collaboration agreement   $ 20,000        
Number of development and commercialization licenses taken | item   3        
Lilly | Right-to-test agreement | No exercise fee            
Collaborative Agreements disclosures            
License exercise fee, per subsequent license   $ 0        
Lilly | Right-to-test agreement | Exercise fee of $2 million            
Collaborative Agreements disclosures            
License exercise fee, per subsequent license   $ 2,000       $ 2,000
Lilly | Development and Commercialization License | Exclusive license            
Collaborative Agreements disclosures            
Number of development and commercialization licenses taken | item     3      
Lilly | Development and Commercialization License | No exercise fee            
Collaborative Agreements disclosures            
Number of development and commercialization licenses taken | item     1      
Lilly | Development and Commercialization License | No exercise fee | Maximum            
Collaborative Agreements disclosures            
Potential milestone payments for each subsequent license         $ 200,500  
Lilly | Development and Commercialization License | Exercise fee of $2 million            
Collaborative Agreements disclosures            
Number of development and commercialization licenses taken | item   2 2      
License exercise fee, per subsequent license         2,000  
Lilly | Development and Commercialization License | Exercise fee of $2 million | Maximum            
Collaborative Agreements disclosures            
Potential milestone payments for each subsequent license         199,000  
Lilly | Development and Commercialization License | Phase I clinical trial            
Collaborative Agreements disclosures            
Number of development and commercialization licenses taken | item     2      
Lilly | Development and Commercialization License | Development milestones | No exercise fee            
Collaborative Agreements disclosures            
Potential milestone payments for each subsequent license         30,500  
Lilly | Development and Commercialization License | Development milestones | Exercise fee of $2 million            
Collaborative Agreements disclosures            
Potential milestone payments for each subsequent license         29,000  
Lilly | Development and Commercialization License | Development milestones | Phase I clinical trial            
Collaborative Agreements disclosures            
Payments received under collaboration agreement $ 5,000          
Potential milestone payments for each subsequent license 5,000   $ 5,000      
Lilly | Development and Commercialization License | Development milestones | Phase II clinical trial            
Collaborative Agreements disclosures            
Potential milestone payments for each subsequent license $ 9,000   $ 9,000      
Lilly | Development and Commercialization License | Regulatory milestones            
Collaborative Agreements disclosures            
Potential milestone payments for each subsequent license         70,000  
Lilly | Development and Commercialization License | Sales milestones            
Collaborative Agreements disclosures            
Potential milestone payments for each subsequent license         $ 100,000