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Income Taxes (Details) - USD ($)
$ in Thousands
12 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Jun. 30, 2013
Reconciliation of the Company's expected tax benefit, as computed by applying the U.S. federal corporate tax rate to loss before the benefit for income taxes, and actual tax      
U.S. federal corporate tax rate (as a percent) 34.00% 34.00% 34.00%
Loss before income tax expense $ (60,739) $ (71,364) $ (72,811)
Expected tax benefit at 34% (20,651) (24,264) (24,756)
Permanent differences 2,766 1,953 1,540
State tax benefit net of federal benefit (3,252) (4,062) (3,921)
Increase in valuation allowance, net 27,940 26,011 25,624
Federal research credit (1,407) (1,002) (2,260)
Federal orphan drug credit (5,471)    
Expired loss and credit carryforwards 75 $ 1,364 $ 3,773
Federal      
Net operating loss carryforwards      
Operating loss carryforward 249,300    
Operating loss carryforward related to deductions from the exercise of stock options 25,600    
State      
Net operating loss carryforwards      
Operating loss carryforward 87,100    
Operating loss carryforward related to deductions from the exercise of stock options $ 22,200