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Agreements (Details 2) - Products and Services [Domain] - Range [Domain]
1 Months Ended 3 Months Ended 12 Months Ended 40 Months Ended
Oct. 31, 2013
USD ($)
May. 31, 2013
USD ($)
item
Dec. 31, 2012
USD ($)
Nov. 30, 2011
USD ($)
item
Nov. 30, 2009
USD ($)
Sep. 30, 2009
USD ($)
Jun. 30, 2015
USD ($)
Mar. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Sep. 30, 2014
USD ($)
Jun. 30, 2014
USD ($)
Mar. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Sep. 30, 2013
USD ($)
Jun. 30, 2015
USD ($)
item
Jun. 30, 2014
USD ($)
Jun. 30, 2013
USD ($)
Dec. 31, 2012
item
Collaborative Agreements disclosures                                    
Amount of arrangement consideration included in license and milestone fees             $ 5,086,000 $ 5,078,000 $ 41,417,000 $ 6,234,000 $ 305,000 $ 305,000 $ 25,678,000 $ 13,167,000 $ 57,815,000 $ 39,455,000 $ 24,227,000  
Costs related to the research and development services             30,437,000 $ 25,666,000 $ 27,647,000 $ 28,018,000 $ 25,787,000 $ 38,280,000 $ 20,862,000 $ 22,029,000 111,768,000 106,958,000 87,073,000  
Amgen                                    
Collaborative Agreements disclosures                                    
Costs related to the research and development services                             62,000 179,000 174,000  
Costs related to clinical materials sold                             0 664,000 $ 670,000  
Amgen | Development milestones | Phase II clinical trial                                    
Collaborative Agreements disclosures                                    
Potential milestone payments             3,000,000               3,000,000      
Amgen | Future Technological Improvements                                    
Collaborative Agreements disclosures                                    
Remaining arrangement consideration to be recognized as license revenue             430,000               $ 430,000      
Amgen | Development and Commercialization License                                    
Collaborative Agreements disclosures                                    
Potential milestone payments $ 34,000,000                                  
Estimated utilization period after commercialization                             10 years      
Discount rate (as a percent)                             13.00%      
Estimated term of development and commercialization license                             25 years      
Amgen | Development and Commercialization License | IND application effective                                    
Collaborative Agreements disclosures                                    
Fee received per license       $ 1,000,000                            
Number of compounds under development and commercialization licenses | item       2                            
Number of milestone payments received | item       2                            
Amgen | Development and Commercialization License | Development milestones                                    
Collaborative Agreements disclosures                                    
Potential milestone payments 9,000,000                                  
Amgen | Development and Commercialization License | Development milestones | IND application effective                                    
Collaborative Agreements disclosures                                    
Potential milestone payments             $ 1,000,000               $ 1,000,000      
Amgen | Development and Commercialization License | Regulatory milestones                                    
Collaborative Agreements disclosures                                    
Potential milestone payments 20,000,000                                  
Amgen | Development and Commercialization License | Sales milestones                                    
Collaborative Agreements disclosures                                    
Potential milestone payments 5,000,000                                  
Amgen | Development and Commercialization License | Exclusive license                                    
Collaborative Agreements disclosures                                    
Amount of arrangement consideration included in license and milestone fees                               $ 2,200,000    
Number of single-target licenses | item                             4     3
Fee received per license     $ 1,000,000   $ 1,000,000 $ 1,000,000                        
Fee received on conversion of non-exclusive license agreement to an exclusive license $ 500,000                                  
Amgen | Development and Commercialization License | Non-exclusive license                                    
Collaborative Agreements disclosures                                    
Number of single-target licenses | item   1                                
Fee received per license   $ 500,000