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Agreements (Details 7) (USD $)
3 Months Ended 12 Months Ended 31 Months Ended 1 Months Ended 12 Months Ended 31 Months Ended
Jun. 30, 2014
Mar. 31, 2014
Dec. 31, 2013
Sep. 30, 2013
Jun. 30, 2013
Mar. 31, 2013
Dec. 31, 2012
Sep. 30, 2012
Jun. 30, 2014
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2014
Lilly
Jun. 30, 2013
Lilly
Jun. 30, 2012
Lilly
Jun. 30, 2014
Lilly
Jun. 30, 2014
Lilly
Sales milestones
Jun. 30, 2014
Lilly
Future Technological Improvements
Jun. 30, 2014
Lilly
Research Services
Dec. 31, 2011
Lilly
Right-to-test agreement
Dec. 31, 2013
Lilly
Development and Commercialization License
Dec. 31, 2011
Lilly
Development and Commercialization License
item
Jun. 30, 2014
Lilly
Development and Commercialization License
Jun. 30, 2014
Lilly
Development and Commercialization License
Dec. 31, 2011
Lilly
Development and Commercialization License
No exercise fee
Dec. 31, 2011
Lilly
Development and Commercialization License
No exercise fee
Maximum
Dec. 31, 2011
Lilly
Development and Commercialization License
Exercise fee of $2 million
Dec. 31, 2011
Lilly
Development and Commercialization License
Exercise fee of $2 million
Maximum
Dec. 31, 2011
Lilly
Development and Commercialization License
Development milestones
No exercise fee
Dec. 31, 2011
Lilly
Development and Commercialization License
Development milestones
Exercise fee of $2 million
Jun. 30, 2014
Lilly
Development and Commercialization License
Development milestones
Phase I clinical trial
Dec. 31, 2011
Lilly
Development and Commercialization License
Regulatory milestones
Dec. 31, 2011
Lilly
Development and Commercialization License
Sales milestones
Collaborative Agreements disclosures                                                                
Term of agreement                                     3 years                          
Payments received under collaboration agreement                             $ 28,200,000 $ 800,000 $ 600,000 $ 3,300,000 $ 20,000,000 $ 2,000,000     $ 23,500,000                  
Potential milestone payments for each subsequent license                                           2,000,000 2,000,000   200,500,000   199,000,000 30,500,000 29,000,000 5,000,000 70,000,000 100,000,000
Number of development and commercialization licenses taken                                         2                      
License exercise fee, per subsequent license                                         2,000,000     0   2,000,000            
Estimated utilization period after commercialization                                           10 years                    
Discount rate (as a percent)                                           16.00%                    
Amount of arrangement consideration included in license and milestone fees 305,000 305,000 25,678,000 13,167,000 855,000 22,010,000 429,000 933,000 39,455,000 24,227,000 9,161,000                     7,800,000                    
Estimated term of development and commercialization license                                           25 years                    
Remaining arrangement consideration to be recognized as license revenue                                           15,700,000 15,700,000                  
Costs related to the research and development services 25,787,000 38,280,000 20,862,000 22,029,000 20,399,000 21,318,000 21,656,000 23,700,000 106,958,000 87,073,000 69,192,000 1,200,000 310,000 94,000                                    
Costs related to clinical materials sold                       $ 26,000 $ 10,000 $ 0