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    <submissionType>13F-HR</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>true</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
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      <filer>
        <credentials>
          <cik>0000854157</cik>
          <ccc>XXXXXXXX</ccc>
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      <periodOfReport>09-30-2022</periodOfReport>
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      <reportCalendarOrQuarter>09-30-2022</reportCalendarOrQuarter>
      <filingManager>
        <name>STATE OF WISCONSIN INVESTMENT BOARD</name>
        <address>
          <ns1:street1>P.O. BOX 7842</ns1:street1>
          <ns1:street2>121 EAST WILSON STREET</ns1:street2>
          <ns1:city>MADISON</ns1:city>
          <ns1:stateOrCountry>WI</ns1:stateOrCountry>
          <ns1:zipCode>53707</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F HOLDINGS REPORT</reportType>
      <form13FFileNumber>028-02519</form13FFileNumber>
      <provideInfoForInstruction5>N</provideInfoForInstruction5>
    </coverPage>
    <signatureBlock>
      <name>LISA LANGE</name>
      <title>DIRECTOR OF COMPLIANCE &amp; SENIOR LEGAL COUNSEL</title>
      <phone>608-261-2419</phone>
      <signature>LISA LANGE</signature>
      <city>MADISON</city>
      <stateOrCountry>WI</stateOrCountry>
      <signatureDate>11-11-2022</signatureDate>
    </signatureBlock>
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      <isConfidentialOmitted>false</isConfidentialOmitted>
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