Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	IgDraSol, Inc. [Member]	Sherrington Pharmaceuticals, Inc. [Member]	Concortis Biosystems, Corp. [Member]	Common Stock [Member]	Common Stock [Member] IgDraSol, Inc. [Member]	Common Stock [Member] Sherrington Pharmaceuticals, Inc. [Member]	Common Stock [Member] Concortis Biosystems, Corp. [Member]	Additional Paid-in Capital [Member]	Additional Paid-in Capital [Member] IgDraSol, Inc. [Member]	Additional Paid-in Capital [Member] Sherrington Pharmaceuticals, Inc. [Member]	Additional Paid-in Capital [Member] Concortis Biosystems, Corp. [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Other Comprehensive Income (Loss) [Member] IgDraSol, Inc. [Member]	Accumulated Other Comprehensive Income (Loss) [Member] Sherrington Pharmaceuticals, Inc. [Member]	Accumulated Other Comprehensive Income (Loss) [Member] Concortis Biosystems, Corp. [Member]	Accumulated deficit [Member]	Accumulated deficit [Member] IgDraSol, Inc. [Member]	Accumulated deficit [Member] Sherrington Pharmaceuticals, Inc. [Member]	Accumulated deficit [Member] Concortis Biosystems, Corp. [Member]	Noncontrolling Interest [Member]	Noncontrolling Interest [Member] IgDraSol, Inc. [Member]	Noncontrolling Interest [Member] Sherrington Pharmaceuticals, Inc. [Member]	Noncontrolling Interest [Member] Concortis Biosystems, Corp. [Member]
Balance at Dec. 31, 2012	$ 6,197				$ 1				$ 17,146				$ 0				$ (10,950)				$ 0
Balance, shares at Dec. 31, 2012					12,004,687
Issuance of common stock in connection with the exercise of stock options	17				$ 0				17				0				0				0
Issuance of common stock in connection with the exercise of stock options, shares					7,300
Issuance of common stock for cash | October 2013 [Member]	31,347				$ 1				31,346				0				0				0
Issuance of common stock for cash	6,354				$ 0				6,354				0				0				0
Issuance of common stock for cash, shares | March 2013 [Member]					1,426,406
Issuance of common stock for cash, shares | October 2013 [Member]					4,772,500
Issuance of common stock with assignment agreement	40				$ 0				40				0				0				0
Issuance of common stock with assignment agreement, shares					10,000
Issuance of common stock in connection with merger and acquisition		$ 27,811	$ 1,698	$ 11,295		$ 0	$ 0	$ 0		$ 27,811	$ 1,698	$ 11,295		$ 0	$ 0	$ 0		$ 0	$ 0	$ 0		$ 0	$ 0	$ 0
Issuance of common stock in connection with merger and acquisition, shares						3,006,641	200,000	1,331,978
Issuance of common stock warrants in connection loan and security agreement	215				$ 0				215				0				0				0
Issuance of common stock for convertible note holders	1,857				$ 0				1,857				0				0				0
Issuance of common stock for convertible note holders, shares					256,119
Issuance of common stock in lieu of cash legal fees	100				$ 0				100				0				0				0
Issuance of common stock in lieu of cash legal fees, shares					12,469
Stock-based compensation	1,789				$ 0				1,789				0				0				0
Change in unrealized gain on marketable securities	0
Net loss	(21,911)				0				0				0				(21,911)				0
Balance at Dec. 31, 2013	66,809				$ 2				99,668				0				(32,861)				0
Balance, shares at Dec. 31, 2013					23,028,100
Issuance of common stock in connection with the exercise of stock options	304				$ 0				304				0				0				0
Issuance of common stock in connection with the exercise of stock options, shares					64,000
Issuance of common stock for cash | May 2014 [Member]	26,643				$ 1				26,642				0				0				0
Issuance of common stock for cash | October 2014 [Member]	3,420				$ 0				3,420				0				0				0
Issuance of common stock for cash, shares | May 2014 [Member]					5,479,750
Issuance of common stock for cash, shares | October 2014 [Member]					400,000
Issuance of common stock with assignment agreement	209				$ 0				209				$ 0				$ 0				0
Issuance of common stock with assignment agreement, shares					25,000								0				0
Issuance of common stock warrants in connection with amended loan and security agreement	322				$ 0				322				$ 0				$ 0				0
Issuance of common stock and warrants for cash	41,723				$ 1				41,722				0				0				0
Issuance of common stock and warrants for cash, shares					7,188,062
Stock-based compensation	3,940				$ 0				3,940				0				0				0
Change in unrealized gain on marketable securities	0
Net loss	(34,657)				0				0				0				(34,657)				0
Balance at Dec. 31, 2014	$ 108,713				$ 4				176,227				0				(67,518)				0
Balance, shares at Dec. 31, 2014	36,184,912				36,184,912
Issuance of common stock with exercise of warrants	$ 0				$ 0				0				0				0				0
Issuance of common stock with exercise of warrants, shares					3,563
Issuance of common stock in connection with the exercise of stock options	1,699				$ 0				1,699				0				0				0
Issuance of common stock in connection with the exercise of stock options, shares					276,712
Issuance of common stock upon achievement of milestone	0				$ 0				0				0				0				0
Issuance of Common Stock Upon Achievement of Milestone, shares					1,306,272
Stock-based compensation	6,972				$ 0				6,972				0				0				0
Change in unrealized gain on marketable securities	73,579				0				0				73,579				0				0
Sale of a noncontrolling interest	49				0								0				0				49
Net loss	(50,074)				0				0				0				(45,811)				(4,263)
Balance at Dec. 31, 2015	$ 140,938				$ 4				184,898				73,579				(113,329)				(4,214)
Balance, shares at Dec. 31, 2015	37,771,459				37,771,459
Net loss	$ (26,599)
Balance at Dec. 31, 2015	$ 140,938				$ 4				$ 184,898				$ 73,579				$ (113,329)				$ (4,214)
Balance, shares at Dec. 31, 2015	37,771,459				37,771,459