X0306 4 2021-09-03 0 0000850261 Sorrento Therapeutics, Inc. SRNE 0001365035 Smith Robin L C/O SORRENTO THERAPEUTICS, INC. 4955 DIRECTORS PLACE SAN DIEGO CA 92121 1 0 0 0 Common Stock 2021-09-03 4 M 0 75000 3.95 A 135000 D Common Stock 2021-09-03 4 M 0 100000 4.89 A 235000 D Stock Options 3.95 2021-09-03 4 M 0 75000 0.00 D 2029-12-16 Common Stock 75000 0 D Stock Options 4.89 2021-09-03 4 M 0 100000 0.00 D 2030-06-15 Common Stock 100000 0 D 1/12 of the original number of shares subject to this option vested and became exercisable on January 16, 2020 and 1/12 of the original number of shares subject to the option vested following each one month of service thereafter. 1/12 of the original number of shares subject to this option vested and became exercisable on July 15, 2020 and 1/12 of the original number of shares subject to the option vested following each one month of service thereafter. /s/ Henry Ji, Ph.D., as Attorney-in-Fact 2021-09-03