X0306 4 2021-08-30 0 0000850261 Sorrento Therapeutics, Inc. SRNE 0001717972 Lemus David C/O SORRENTO THERAPEUTICS, INC. 4955 DIRECTORS PLACE SAN DIEGO CA 92121 1 0 0 0 Stock option (right to buy) 8.86 2021-08-30 4 A 0 250000 0.00 A 2031-08-30 Common Stock 250000 250000 D 1/48th of the original number of shares subject to this option shall vest and become exercisable on September 30, 2021, and 1/48th of the original number of shares subject to the option shall vest following each one month of service thereafter, subject to the Reporting Person's continued service to the Issuer through each such vesting date. /s/ Henry Ji, Ph.D., as attorney-in-fact 2021-08-30