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Significant Agreements and Contracts - Acquisition of ACEA Therapeutics, Inc. - Additional Information (Details) - USD ($)
$ / shares in Units, $ in Thousands, shares in Millions
3 Months Ended 6 Months Ended
Jun. 01, 2021
Jun. 30, 2022
Jun. 30, 2022
Dec. 31, 2021
Research and Development Arrangement, Contract to Perform for Others [Line Items]        
Goodwill   $ 81,351 $ 81,351 $ 79,525
Acquired in-process research and development        
Research and Development Arrangement, Contract to Perform for Others [Line Items]        
Impairment charges   $ 90,800 $ 90,800  
ACEA Therapeutics, Inc        
Research and Development Arrangement, Contract to Perform for Others [Line Items]        
Business acquisition, effective date of acquisition     Jun. 01, 2021  
Business acquisition, name of acquired entity     ACEA  
Stock consideration shares value $ 38,100      
Stock consideration value 5.5      
Stock consideration value per share (usd per share) $ 6.8955      
Business combination additional payments $ 450,000      
Business combination current liability true up amount     $ 7,500  
Upfront consideration 44,100      
Impairment charges 90,800      
Goodwill 36,000      
Fair value of debt assumed liability 32,100      
Deferred tax liabilities assumed 31,400      
Purchase price allocation resulted in net identifiable assets, other net assets 2,900      
ACEA Therapeutics, Inc | Acquired in-process research and development        
Research and Development Arrangement, Contract to Perform for Others [Line Items]        
Purchase price allocation resulted in net identifiable assets $ 190,800      
ACEA Therapeutics, Inc | Minimum        
Research and Development Arrangement, Contract to Perform for Others [Line Items]        
Percentage of annual net sales on royalty bearing products 5.00%      
ACEA Therapeutics, Inc | Maximum        
Research and Development Arrangement, Contract to Perform for Others [Line Items]        
Percentage of annual net sales on royalty bearing products 10.00%