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Significant Agreements and Contracts - Short-Term Loans - Additional Information (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Research and Development Arrangement, Contract to Perform for Others [Line Items]      
Short-term working capital funding arrangements, net of issuance costs $ 49,743 $ 18,587 $ 8,000