X0306 4 2016-07-11 0 0000850261 Sorrento Therapeutics, Inc. SRNE 0001242112 EBERSOLE DOUGLAS O C/O SORRENTO THERAPEUTICS, INC. 9380 JUDICIAL DRIVE SAN DIEGO CA 92121 1 0 0 0 Stock Options 6.44 2016-07-11 4 A 0 35000 0.00 A 2026-07-11 Common Stock 35000 94000 D 1/12 of the original number of shares subject to this option shall vest and become exercisable following each one month of service thereafter, subject to the reporting person's continued service on the issuer's board of directors on each such date. /s/ Douglas Ebersole 2016-07-12