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Consolidated Statements of Cash Flows - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Cash flows from operating activities:    
Net loss $ (5,961,892) $ (2,707,535)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation expense 7,117 1,659
Amortization of discounts related to convertible notes payable 675,025 46,150
Amortization of capitalized financing costs 114,128 15,648
Gains on settlement(s) - With former management (91,710) (1,038,270)
Gains on settlement(s) - With service providers $ (75,375) (393,590)
Gains on settlement(s) - Of project advance (287,809)
Stock-based compensation expense included in – General and administrative expenses $ 2,342,895 3,131,500
Stock-based compensation expense included in – Research and development expenses 363,551 99,000
Stock-based compensation expense included in – Foreign currency transaction gain (13,328) (43,637)
(Increase) decrease in -    
Grant receivable 48,000 (48,000)
Prepaid expenses 46,145 (84,730)
Increase (decrease) in -    
Accounts payable and accrued expenses 490,380 452,099
Accrued compensation and related expenses 684,409 (118,084)
Accrued interest payable 108,888 55,397
Unearned grant revenue (34,333) 34,333
Net cash used in operating activities (1,296,100) (885,869)
Cash flows from investing activities:    
Purchases of equipment (2,497) (18,400)
Net cash used in investing activities (2,497) $ (18,400)
Cash flows from financing activities:    
Proceeds from sale of common stock units $ 1,194,710
Proceeds from sale of Series G 1.5% Convertible Preferred Stock $ 928,500
Proceeds from convertible note and warrant financing $ 210,000 369,500
Proceeds from issuance of note payable to Chairman 40,000 $ 75,000
Principal paid on other short-term notes payable (95,152)
Repayment of note payable to Chairman (40,000) $ (150,000)
Cash payments made for costs incurred in connection with the sale of common stock units (104,814)
Cash payments made for deferred costs incurred in connection with convertible note and warrant financing $ (15,700) $ (77,410)
Cash payments made for costs incurred in connection with sale of Series G 1.5% Convertible Preferred Stock (92,921)
Net cash provided by financing activities $ 1,189,044 1,052,669
Cash and cash equivalents:    
Net increase (decrease) (109,553) 148,400
Balance at beginning of period 162,752 14,352
Balance at end of period 53,199 162,752
Supplemental disclosures of cash flow information:    
Interest $ 6,873 $ 102
Income taxes
Non-cash financing activities:    
Amortization of deemed dividend on Series G 1.5% Convertible Preferred Stock $ 10,049,846
Dividends on Series G 1.5% Convertible Preferred Stock $ 6,867 10,926
Gross exercise price of Series G 1.5% Convertible Preferred Stock placement agent warrants exercised on a cashless basis 4,778 $ 18,689
Gross exercise price of 10% convertible notes payable placement agent warrants exercised on a cashless basis 35,595
Short-term note payable issued in connection with financing of insurance policy premium 36,125
Stated value of Series G 1.5% Convertible Preferred Stock converted into common stock 621,038 $ 66,689
Fair value of common stock options issued in connection with settlements with former management 26,290 179,910
Fair value of common stock options issued in connection with settlements with service providers $ 608,064 42,250
Fair value of common stock issued in connection with settlement of project advance 49,000
Fair value of common stock warrants issued to investors in connection with the convertible note and warrant financing $ 112,557 176,549
Fair value of common stock warrants issued to placement agents in connection with the convertible note and warrant financing 12,726 23,940
Fair value of beneficial conversion feature of convertible notes payable issued to investors in connection with the convertible note and warrant financing 97,443 $ 192,951
Fair value of common stock warrants issued to investors in connection with the extension of the convertible notes 97,188
Fair value of extending common stock warrants issued to investors in connection with the convertible note and warrant financing 180,730
Fair value of beneficial conversion feature of extended convertible notes payable issued to investors in connection with the convertible note and warrant financing $ 206,689
Fair value of common stock warrants issued to placement agents and selected dealers in connection with the sale of Series G 1.5% Convertible Preferred Stock $ 664,169
Fair value of common stock warrants issued to placement agents and selected dealers in connection with the sale of common stock units $ 135,116
Deferred financing costs transferred to additional paid-in capital in connection with sale of Series G 1.5% Convertible Preferred Stock $ 35,120