-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, FhSA4hQJrTXPOL/g5aA1HAmRMVa3s7DRHlbXRwa6Ljcc46o6Byo3V5c3nknnQ0GG jVR7z23xMGNAhpQNBW1l/A== 0000890566-97-000683.txt : 19970401 0000890566-97-000683.hdr.sgml : 19970401 ACCESSION NUMBER: 0000890566-97-000683 CONFORMED SUBMISSION TYPE: 10-K PUBLIC DOCUMENT COUNT: 11 CONFORMED PERIOD OF REPORT: 19961231 FILED AS OF DATE: 19970331 SROS: NASD FILER: COMPANY DATA: COMPANY CONFORMED NAME: LIFECELL CORP CENTRAL INDEX KEY: 0000849448 STANDARD INDUSTRIAL CLASSIFICATION: SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731] IRS NUMBER: 760172936 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 10-K SEC ACT: 1934 Act SEC FILE NUMBER: 000-19890 FILM NUMBER: 97571858 BUSINESS ADDRESS: STREET 1: 3606 RESEARCH FOREST DR STREET 2: LIFECELL CORPORATION CITY: WOODLANDS STATE: TX ZIP: 77381 BUSINESS PHONE: 7133675368 MAIL ADDRESS: STREET 1: 3606 RESEARCH FOREST DR CITY: THE WOODLANDS STATE: TX ZIP: 77381 10-K 1 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED DECEMBER 31, 1996 COMMISSION FILE NUMBER 0-19890 LIFECELL CORPORATION A DELAWARE IRS EMPLOYER IDENTIFICATION CORPORATION NO. 76-0172936 3606 RESEARCH FOREST DRIVE THE WOODLANDS, TEXAS 77381 Telephone Number (281) 367-5368 SECURITIES REGISTERED PURSUANT TO SECTION 12(B) OF THE ACT: NONE SECURITIES REGISTERED PURSUANT TO SECTION 12(G) OF THE ACT: Common Stock, $.001 Par Value Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes [X] No [ ] Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of registrant's knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K. [ ] Aggregate market value of the voting stock (Common Stock and Series B Preferred Stock, assuming conversion of such Preferred Stock into Common Stock at the current conversion rate) held by non-affiliates of registrant as of March 26, 1997 $40,933,000 Number of shares of registrant's Common Stock 6,754,761 outstanding as of March 26, 1997 DOCUMENTS INCORPORATED BY REFERENCE: Portions of registrant's proxy statement relating to the 1997 annual meeting of stockholders have been incorporated by reference into Part III hereof. TABLE OF CONTENTS DESCRIPTION ITEM PAGE - ---- ---- PART I ................................................................... 1 1. BUSINESS....................................................... 1 2. PROPERTIES..................................................... 21 3. LEGAL PROCEEDINGS.............................................. 21 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS............ 22 PART II ................................................................... 22 5. MARKET FOR THE REGISTRANT'S COMMON EQUITY AND RELATED STOCKHOLDER MATTERS............................... 22 6. SELECTED FINANCIAL DATA........................................ 24 7. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS....................... 25 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA.................... 27 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE....................... 27 PART III ................................................................... 27 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT............ 27 11. EXECUTIVE COMPENSATION........................................ 28 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT................................................ 28 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS................ 28 PART IV ................................................................... 28 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON FORM 8-K............................................... 28 GLOSSARY .......................................................... 31 PART I THIS ANNUAL REPORT ON FORM 10-K CONTAINS, IN ADDITION TO HISTORICAL INFORMATION, FORWARD-LOOKING STATEMENTS THAT INVOLVE RISKS AND UNCERTAINTIES. THE COMPANY'S ACTUAL RESULTS COULD DIFFER MATERIALLY. FACTORS THAT COULD CAUSE OR CONTRIBUTE TO SUCH DIFFERENCES INCLUDE, BUT ARE NOT LIMITED TO, THOSE DISCUSSED IN "BUSINESS", "BUSINESS--RISK FACTORS", "MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS" AND ELSEWHERE IN THIS ANNUAL REPORT ON FORM 10-K. ITEM 1. BUSINESS CERTAIN TECHNICAL TERMS USED IN THIS ITEM ARE DESCRIBED OR DEFINED IN THE GLOSSARY COMMENCING ON PAGE 33 OF THIS ANNUAL REPORT ON FORM 10-K. GENERAL LifeCell Corporation ("LifeCell" or the "Company") develops and commercializes universal tissue grafts and blood cell preservation products. The Company's universal tissue grafts are derived from a patented platform technology for processing and preserving human (allograft) and animal (xenograft) tissues to preclude rejection of transplanted foreign tissues by the human body. LifeCell removes cells that cause tissue rejection while preserving the extracellular tissue matrix and its essential biochemical and structural composition. This matrix does not cause an immune rejection response and has been clinically proven to function as a natural template or scaffold into which a patient's own cells will migrate following transplantation for effective tissue engraftment. The clinical use of a preserved tissue matrix as a natural template for tissue regeneration has been established by others through the use of processed, freeze-dried allograft bone for orthopedic and periodontal procedures. LifeCell's expertise is the ability to preserve the more delicate and sophisticated tissue matrix of soft tissues, which would otherwise be destroyed by the allograft bone process. AlloDerm(R) processed universal dermal tissue graft ("AlloDerm") is LifeCell's first commercial application of its technology. Additional universal tissue products under development include composite skin graft, XenoDermTM processed porcine dermis, heart valves for replacement surgeries and vascular conduits for bypass procedures. Using its core preservation technology, LifeCell is also developing products and patented formulations to facilitate storage, transportation and delivery of transfusable blood cells. The Company is developing ThromboSolTM platelet storage solution to permit refrigerated storage of transfusable blood platelets and intends to develop other potential preservation technologies for red blood cells and other mammalian cells. LifeCell was organized in 1986 to commercialize its core preservation technology, a process developed by The University of Texas Health Science Center in Houston and exclusively licensed from The Board of Regents of the University of Texas System involving ultra-rapid cooling and ultra-low temperature freeze-drying of biological cells and tissues. PRODUCTS ALLODERM AlloDerm is human donor (allograft) dermis that has been processed using LifeCell's patented technology. The AlloDerm process removes the cells from donated human (allograft) skin and preserves the critical structural and biochemical components of the dermal matrix which are key to the eventual engraftment of the dermal matrix. The AlloDerm process preserves an immunologically inert human dermal matrix which is freeze-dried and packaged for distribution to end-users. AlloDerm grafts are rehydrated in the operating room in a ten-minute 3 procedure prior to grafting. The intact human dermal matrix functions as a graft or implant, permanently integrating and guiding the reconstitution of dermal tissue. AlloDerm grafts consist entirely of and are intended to perform the same function as human dermis. As a result, the Company believes AlloDerm tissue products are not subject to the lengthy United States Food and Drug Administration ("FDA") approval or clearance process associated with medical devices or drugs. See "--Government Regulation" and "--Risk Factors--FDA Regulatory Status of AlloDerm". LifeCell procures human skin through sources that screen donors to meet all FDA requirements for banked human tissue and conduct blood testing recommended by the Centers for Disease Control and Prevention. Additionally, the AlloDerm process includes de-cellularization (extraction of living cells from human tissue matrix) and viral inactivation (the treatment of the tissue with a documented anti-viral agent). The AlloDerm process has been independently validated to inactivate concentrated suspensions of HIV, the virus that causes AIDS. LifeCell procures allograft skin from unaffiliated tissue banks. To date, the Company has not experienced any material difficulty in procuring adequate supplies of cadaveric skin. Additionally, LifeCell believes it has established what it believes to be adequate sources of cadaveric skin at acceptable costs to satisfy the foreseeable demand for AlloDerm tissue products. AlloDerm products address multiple clinical markets including the treatment of third-degree burns, periodontal surgery and plastic and reconstructive surgery. Since its commercial introduction, AlloDerm has been used as a dermal graft or transplant to treat over 5,000 patients. THIRD-DEGREE BURNS. AlloDerm grafts may be used in the treatment of any and all burns that require skin grafts. The Company estimates that approximately 55,000 people are hospitalized each year in the United States due to burns and that approximately 20,000 patients are admitted with major burns. LifeCell began marketing AlloDerm for use in the treatment of third-degree burns in December 1993. To date, AlloDerm grafts have been used to treat third-degree burn patients at approximately 60 of the 140 burn centers in the United States. Skin is the body's largest organ and is the first line of defense against invasion of foreign substances. It contains two functional layers, the upper surface consisting primarily of cells (epidermis) and an underlying foundational layer of extracellular matrix proteins and collagen (dermis). The epidermis functions as a water barrier and maintains hydration. The dermis provides other important skin properties including tensile strength, durability and elasticity. Third-degree burns and other acute full-thickness skin wounds destroy both the epidermis and the dermis. Destruction of dermis is of particular concern because the body has lost the framework, I.E., the extracellular matrix, to guide and support the regrowth of new cells and blood vessels. Like most organs of the body, the skin can perform some repairs but it cannot regenerate its basic structure. Instead, damaged or missing dermis is replaced with scar tissue, which lacks the important elastic and tensile properties of skin. Scar tissue also is disfiguring and can cause restricted mobility of limbs and body areas near joints. For this reason, full-thickness burns are treated with split-thickness skin grafts of the patient's own skin (autograft) taken from an uninjured area of the body. This procedure is painful and causes an additional wound at the autograft donor site. Autografts that include the dermal layer generate relatively deep donor sites which can cause medical complications including infection and hypertrophic scarring. Autografts that are too thin (containing minimal dermis) typically result in poor wound healing quality, with scarring and contracture at the wound site. AlloDerm grafts are used in conjunction with thin autografts to supply an adequate dermal layer for optimum healing of the wound. The use of AlloDerm reduces the thickness of split-thickness grafts required from the patient in treating such wounds, thereby minimizing the substantial donor site trauma associated with taking such grafts. PERIODONTAL SURGERY. LifeCell began marketing AlloDerm to periodontists in September 1995. LifeCell estimates that there are in excess of 4,000 periodontal surgeons in the United States. Periodontal surgeons use AlloDerm tissue in free-gingival grafting, a procedure used to increase the amount of attached gum tissue supporting tooth roots. This procedure previously required the use of autograft tissue, which was excised from the roof of the patient's mouth and then transplanted to the gum. In several clinical case studies, AlloDerm grafts functioned as well or better than the patient's own (autologous) graft, spared the patient the pain and discomfort associated with 4 the excision of the autograft, reduced surgical time and eliminated the cost of the dressing that was needed for the autograft donor site. AlloDerm tissue products are also used as barrier membranes in guided tissue regeneration. In this function, the AlloDerm tissue serves as a barrier membrane over allograft bone grafts, which are used to restore a degenerated jaw bone and surrounding gingival tissue. The AlloDerm tissue barrier engrafts over the bone, preventing the cells of the surrounding soft tissue from extruding the bone graft during the normal healing process. Jaw bones restored by this procedure were suitable for supporting artificial tooth implants. PLASTIC AND RECONSTRUCTIVE SURGERY. In November 1995, LifeCell began marketing AlloDerm to plastic and reconstructive surgeons. The Company estimates that there are approximately 8,000 physicians practicing plastic surgery in the United States. Plastic surgeons use AlloDerm tissue as a graft to release contractures and revise scarring resulting from previously grafted burn wounds, and as an implant to correct soft tissue (dermal) defects and to revise scars resulting from trauma or surgical excisions. TEMPORARY WOUND COVERAGE--CRYOPRESERVED ALLOGRAFT SKIN In April 1995, LifeCell began processing and distributing cryopreserved allograft skin for use as a temporary or transitional covering for severe burn wounds. For patients with extensive burns, allograft skin assists in stabilizing the patient and preparing the wound bed for a permanent graft. PRODUCT DEVELOPMENT In addition to AlloDerm tissue products, the Company is developing composite skin grafts, XenoDerm porcine dermis, universal cardiovascular products (heart valves and vascular conduits) and blood cell preservation products. COMPOSITE SKIN GRAFTS. LifeCell intends to develop a composite, full-thickness skin replacement tissue product containing an AlloDerm dermal layer and an epidermis consisting of keratinocytes (epidermal cells) isolated from the patient and expanded under cell culture conditions. Successfully developed, a composite skin graft product would effectively eliminate the requirement of taking an autologous skin graft from burn patients. In 1994, LifeCell received and completed a Phase I, Small Business Innovative Research (SBIR) grant from the National Science Foundation ("NSF") to assess the feasibility of a co-cultured composite skin product. In 1996, LifeCell received a Phase II SBIR grant from the NSF to continue the development of and initiate animal studies with this composite skin graft product. Also in 1996, LifeCell received a two-year Cooperation Agreement award from the U.S. Army Medical Research and Material Command to support the development of a composite skin graft product using AlloDerm and biopsy-sized microskin grafts from the burn patient. XENODERM TISSUE PRODUCTS. LifeCell is developing XenoDermTM processed porcine dermis, which is processed in a manner similar to the AlloDerm process to remove the targets for immune rejection and preserve the dermal matrix. Animal studies by LifeCell indicate that XenoDerm tissue does not cause a significant immune response when transplanted cross-species. Animal studies conducted by unaffiliated laboratories have shown that XenoDerm tissue is potentially as effective as AlloDerm tissue in treating full-thickness skin loss. LifeCell believes that, if successfully developed, the XenoDerm tissue products would have the advantage of a potentially increased raw material supply base and could facilitate distribution to certain international markets. See "--Sources of Materials". The Company currently plans to begin clinical testing of XenoDerm tissue products in 1997. HEART VALVES. LifeCell is applying its universal tissue processing and preservation technology to porcine heart valves intended for replacement procedures. In 1994, LifeCell and Medtronic, Inc. ("Medtronic") entered into a license and development agreement for the potential development and commercialization of heart valves processed with LifeCell's technology. Since that time, pursuant to the agreement, LifeCell and Medtronic have been engaged in a development program for heart valves that is funded fully by Medtronic. See "--Corporate Alliance". 5 LifeCell's heart valves are based on its patented universal tissue processing and preservation technology that the Company uses to process AlloDerm tissue products. The Company processes heart valves harvested from pigs to remove the cells that would be recognized by the body as foreign. By making the transplanted heart valves non-immunogenic, LifeCell believes that the new valve will last longer, become part of the body and perhaps last the patient's lifetime. Tissue heart valves on the market today have limited life spans of 10 to 18 years after transplantation as a result of progressive calcification. Mechanical heart valves last longer but lack the blood flow dynamics of tissue valves and require the patient to remain on anticoagulants for life to prevent strokes. Human donor (allogeneic) valves are used in a limited number of the procedures, but there is limited donor availability and, therefore, a limited market. Preliminary animal studies conducted by LifeCell have shown that the LifeCell heart valves transplanted in the thoracic descending aorta become populated with the recipient's own cells; I.E., they have not been rejected by the recipient. Other animal studies conducted by LifeCell have shown that the valves do not undergo significant calcification. Extensive FDA regulatory involvement in both human and xenograft heart valves may significantly delay product entry into this market. See "--Government Regulation". VASCULAR CONDUITS. LifeCell is developing vascular conduit products for arterial bypass as a treatment for atherosclerosis, a progressive, degenerative disease characterized by a build-up of fats, cholesterol and other material within the lining of arterial blood vessels located throughout the body. This build-up is called plaque, and leads to reduced blood flow through the arteries, and eventually, may result in serious arterial blockage that can cause tissue damage and death. Minimally invasive surgical devices are currently available for opening blocked or occluded arteries, including balloon angioplasty to dilate mechanically and thereby open the vessel, and atherectomy devices and lasers that physically remove plaque from the vessel wall. These procedures, however, are not recommended when the patient displays extensive deposits of atherosclerotic plaque throughout the length of one or more vessels, which makes it impractical to attempt the opening of the occluded arteries due to the procedural time involved. In these cases, a more extreme and invasive surgical procedure called arterial bypass is indicated, in which one or more of the patient's own veins (usually the saphenous veins from the legs) are transplanted to an arterial position to divert blood flow around the blockage. Arterial bypass is also used when the blockage is in a critical location or when the surgeon is unable to access the blockage safely. Coronary bypass procedures, which involve replacement of vessels supplying blood to the heart, typically use the patient's own veins or arteries. The trauma endured from the vessel removal is often more extensive than that of the bypass procedure itself. Even though immune response is not an issue with these self-derived (autologous) vessels, long-term patency (greater than five years) is limited due to eventual blockage from progressive wall thickening and thrombosis. Repeat arterial bypass procedures may be difficult due to depletion of the available supply of autologous vessels. The use of synthetic arterial substitutes has been attempted, but these devices occlude even more rapidly in the coronary and below-knee positions, which require a small diameter (6 millimeter) graft. The synthetic conduit has been used more successfully in above-the-knee peripheral procedures, but is still associated with infections, leaking and blockage. LifeCell currently is developing vascular conduit products using allograft blood vessels and plans to extend the technology to xenografts. These potential products utilize LifeCell's ability to process vascular tissue and remove cells that would be recognized by the host as foreign and trigger an immune response. Early preclinical studies conducted by LifeCell with its vascular conduits show that they become re-populated with new host cells after grafting and show no sign of rejection. As part of the Company's agreements with Medtronic for the development of heart valves, LifeCell granted Medtronic certain rights of first refusal to evaluate technology and negotiate license and development agreements for vascular conduit products utilizing LifeCell's technology. In December 1996, LifeCell received a two-year 6 Cooperative Agreement award from the U.S. Army Medical Research and Material Command to support the development of vascular graft products. BLOOD CELL PRESERVATION PRODUCTS LifeCell is developing proprietary technology to extend the shelf life of transfusable platelets, red blood cells and other mammalian cells. This technology differs from the universal tissue graft applications in that cell viability is crucial to successful processing. THROMBOSOL PLATELET STORAGE SOLUTION. LifeCell is developing a proprietary biochemical formulation called ThromboSol platelet storage solution to protect transfusable platelets from damage at low temperatures. Platelets are blood cells that control clotting. Untreated platelets are sensitive to low temperatures and cannot be effectively refrigerated. Presently, platelets are stored at room temperature and, due to the risk of microbial contamination, have a limited shelf life of three to five days. LifeCell has shown in laboratory tests that the addition of ThromboSol solution preserves the functional aspects of refrigerated platelets for up to ten days and frozen platelets for more than six months. LifeCell initiated toxicity studies for ThromboSol platelet storage solution in late 1994 and began preclinical animal studies in 1995. LifeCell intends to license this product to major pharmaceutical and other appropriate companies. The ThromboSol development program has been funded through a Phase I and II SBIR contract with the United States Army. In April 1996, the Company received additional contract funding of $613,000 for this program from the United States Navy. FREEZE-DRIED RED BLOOD CELLS. LifeCell previously has been funded by the United States Navy to develop directly transfusable freeze-dried red blood cells. The need for immediately available, screened blood units is of particular importance to the United States Armed Services because a substantial number of combat deaths have resulted from hemorrhaging due to the lack of availability of on-site transfusable blood. In addition, freeze-dried red blood cells potentially will allow for widespread autologous transfusion, thereby preventing transfusion related complications, including disease transmission. The fear of acquiring transmittable diseases such as AIDS and hepatitis from donated blood units has created a growing market for blood recycling units, preservation of autologous blood, blood cell growth stimulating factors, and blood substitutes. Freeze-dried blood can eliminate the concern of disease transmission by the patient donating his or her own blood to be freeze-dried prior to the anticipated need for transfusable blood. The Company is seeking additional funds from various government granting agencies and potential corporate partners to continue this program and intends to license this technology to third-parties at a later stage of development. CORPORATE ALLIANCE In 1994, LifeCell entered into a license and development agreement with Medtronic to develop jointly the Company's heart valve products. Pursuant to the agreement, Medtronic paid LifeCell an initial $1.5 million license fee. The agreement also provides that Medtronic will fund all costs of research and development, including clinical trials, receive the exclusive right to market any resulting commercial products and pay LifeCell royalties of up to $25 million on sales of products covered by the agreement. Medtronic may terminate the agreement at any time if in its sole business judgment it deems the development and commercialization of products thereunder not to be in its best interests or otherwise to be imprudent. In such event, and if the agreement is terminated under certain other circumstances, Medtronic has the option to convert the $1.5 million license fee into shares of Common Stock, subject to certain limitations, at the then current market price. In 1994, Medtronic also made a $500,000 equity investment in LifeCell by purchasing approximately 64,000 shares of Common Stock at $7.77 per share in exchange for rights of first refusal to negotiate licenses to LifeCell universal vascular conduit products. 7 MARKETING LifeCell currently markets AlloDerm grafts and cryopreserved allograft skin to United States burn treatment centers and other potential customers through its direct sales force. LifeCell has a sales and marketing staff consisting of a vice president of sales and marketing, a director of international sales and marketing, a national manager, a product manager, nine field technical representatives, a clinical specialist, a customer service representative, two marketing coordinators, and an international customer service assistant. The field technical representatives and clinical specialists are responsible for interacting with treatment physicians, primarily burn surgeons and plastic surgeons at burn treatment centers, and educating them regarding the use and anticipated benefit of AlloDerm tissue grafts. LifeCell also participates in national and international conferences and trade shows for burns and wound healing. The Company has engaged specialty distributors to market and sell AlloDerm tissue for plastic surgery indications. The Company has reached agreement with 11 such companies and plans to add additional distributors to cover the entire United States. The Company has nine field technical representatives, who are responsible for promoting the use of AlloDerm tissue products in plastic and reconstructive surgery and supporting regional distributors of the product. In June 1996, LifeCell engaged DENTSPLY International, Inc. (DENTSPLY) to distribute AlloDerm grafts for periodontal surgery on a worldwide basis. In March 1997, however, DENTSPLY advised LifeCell that it intends to discontinue operations of the division with responsibility for distributing AlloDerm. Accordingly, LifeCell expects that it will terminate the agreement with DENTSPLY and in the near future will resume marketing AlloDerm for periodontal applications through its direct sales force. PROCESSING LifeCell procures human skin and other tissues from unaffiliated tissue banks. See "--Sources of Materials". LifeCell provides tissue banks and their procurement agents with specific procurement protocols, which are required for the optimum removal and transportation of tissues. Tissues are transported to LifeCell in accordance with standard industry practices and are identified on delivery to LifeCell with a unique identification number that allows tracing to a specific donor. This unique identification number accompanies each processed tissue to its destination. It then becomes the responsibility of the recipient treatment center, hospital or surgeon to return a self-addressed patient tracking card (included with all LifeCell tissues) to LifeCell for donor and recipient tracking. LifeCell begins aseptic processing of donor tissue within 12 days post-mortem. Processing includes any required sizing and trimming, treatment to remove cells from the dermal matrix, which is then preserved by proprietary cryoprotection, packaging and freeze-drying. Microbiological and other quality assurance testing is conducted before AlloDerm tissue products are released for shipment to customers. Customers typically order the AlloDerm product on a just-in-time basis. The product is shipped at ambient temperature by overnight delivery services. Cryopreserved allograft skin is processed by a standard industry protocol and stored at LifeCell's premises until requisitioned by a customer. Cryopreserved allograft skin is transported to the customer on dry ice by overnight delivery. SOURCES OF MATERIALS LifeCell procures allograft skin from unaffiliated tissue banks. LifeCell is expanding its current procurement of skin and other tissues to include any of approximately 100 major national tissue banks, including approximately 35 skin banks. Procurement of certain human organs and tissue for transplantation is subject to the restrictions of the National Organ Transplant Act ("NOTA"), which prohibits purchase and sale of human organs and related tissue for "valuable consideration". See "--Government Regulation". LifeCell pays a procurement fee to the tissue bank, which covers the cost of recovering the tissue, conducting donor testing for communicable diseases, including AIDS and hepatitis tests recommended by the Centers for Disease Control and Prevention. 8 Pursuant to contractual arrangements, LifeCell reimburses tissue banks for recovering and delivering to LifeCell cadaveric skin suitable for transplantation. In procuring such tissues, LifeCell competes with treatment centers that use cadaveric skin for temporary wound dressings. LifeCell has entered into allograft skin procurement service agreements with certain tissue banks that, prior to these agreements, did not recover skin from consented tissue donors. Pursuant to these agreements, LifeCell accepts from these tissue banks all skin tissue that meets LifeCell's allograft skin procurement specifications, the requirements of the FDA and the procedural guidelines outlined by the American Association of Tissue Banks. Allograft skin tissue that is procured in excess of that required to meet the demand for AlloDerm tissue products is processed by conventional cryopreservation and distributed to burn treatment centers and hospitals for use as a temporary or transitional wound dressing. See "--Products--Temporary Wound Coverage - --Cryopreserved Allograft Skin". The Company has established what it believes to be adequate sources of cadaveric skin at acceptable costs to satisfy the foreseeable demand for AlloDerm tissue products. Although to date the Company has not experienced any material difficulty in procuring adequate supplies of cadaveric skin, there can be no assurance that the future availability of human skin will be sufficient to meet LifeCell's demand for such materials. Any supply shortage of available tissues in the future would have a material adverse effect on LifeCell's business. Different grades or thicknesses of material are required for different surgical uses. There can be no assurances that imbalances in demand will not result in shortages of desired materials and simultaneous increases in inventoried materials. GOVERNMENT REGULATION Government regulation, both domestic and foreign, is a significant factor in the manufacture and marketing of LifeCell's current and developing products. In the United States, the Company's currently marketed human skin allograft and AlloDerm products are subject to regulation by the FDA. The United States Food, Drug and Cosmetics Act (the "FDC Act"), the Public Health Service Act (the "PHS Act") and other federal statutes and regulations govern or influence the testing, manufacture, labeling, storage, record keeping, approval, advertising and promotion of such products. Noncompliance with applicable requirements can result in fines, injunctions, civil penalties, recall or seizure of products, total or partial suspension of production, refusal of the government to authorize the marketing of new products or to allow the Company to enter into supply contracts and criminal prosecution. In December 1993, the FDA published an interim rule regulating "banked human tissue". The rule defines banked human tissue as any tissue derived from a human body which is (i) intended for administration to another human for the diagnosis, cure, mitigation, treatment or prevention of any condition or disease and (ii) recovered, processed, stored or distributed by methods not intended to change tissue function or characteristics. The FDA definition excludes, among other things, tissue that currently is regulated as a human drug, biological product or medical device and kidney, liver, heart, lung, pancreas or any other vascularized human organ. Banked human tissue is regulated by the FDA in a manner the agency has deemed necessary to protect the public health from the transmission of HIV infection and hepatitis infection through transplantation of tissue from donors with or at risk of these diseases. Under the FDA regulations, all facilities engaged in the procurement, processing, storage or distribution of human tissue intended for transplant are required to assure that certain infectious disease testing and donor screening is performed and that records documenting such testing for each tissue are available for inspection by the FDA. The regulations also provide authority for the FDA to conduct inspections of banked human tissue facilities and to detain, recall or destroy tissue for which appropriate documentation is not available. Banked human tissue, however, is not subject to premarket notification or approval by the FDA as are certain drugs, biologicals and medical devices. In December 1991, the Company first contacted the FDA regarding the regulatory status of AlloDerm and was advised in May 1992 that the FDA had not made a final determination on the status of intact processed human cadaver skin, that the agency currently was studying the issue and that these products may at some future time be subject to FDA regulation. The FDA sent the Company a copy of the December 1993 publication of the FDA's banked human tissue regulations shortly after its release of such regulations and inspected the Company for compliance with those regulations in July 1994. For these reasons, the Company believed that AlloDerm was covered by the FDA's definition of banked human tissue and that the product would not be regulated as a medical device. 9 In November 1995, following LifeCell's commercial introduction of AlloDerm for periodontal applications, the Company received a letter from the FDA, stating that it considered AlloDerm to be a "device" as defined by the FDC Act, and that a 510(k) premarket notification was required to be submitted and cleared by the FDA in order to market the product. Following several months of correspondence and discussions with the FDA, the Company received a letter from the agency dated September 17, 1996, to the effect that, after considering the information and views that the Company submitted at a May 1996 meeting with agency officials and in subsequent correspondence, the FDA agrees with the Company's position that AlloDerm intended for use for replacement or repair of damaged or inadequate integumental tissue, including gingival dermis, is banked human tissue within the meaning of the interim final rule. Consequently, AlloDerm is not subject to premarket notification or approval by the FDA and the Company may continue to promote and sell AlloDerm for use in the treatment of wounds, such as third-degree burns, in periodontal surgical procedures, such as free-gingival grafting and guided tissue regeneration, and in plastic and reconstructive surgery procedures, such as contracture release grafting and scar revision. The agency also informed the Company that this decision applies only to AlloDerm when it is intended for use in transplantation, and the regulatory status of the product when it is promoted for other uses, such as a void filler for soft tissue, for cosmetic augmentation or as a wound healing agent (the "Additional Indications"), would need to be determined by the FDA on a case by case basis. While the Company's marketing efforts had not previously focused on the Additional Indications, as a follow-up to its September 17 letter, the FDA, by letter dated September 23, 1996, informed the Company that indications for Additional Indications would have to be formally presented to the FDA to determine if, with these indications, AlloDerm would continue to fall within the scope of the interim rule for banked human tissue and thus not require premarket clearance. The Company was asked to indicate what changes in advertisement and promotion it would make for AlloDerm in response to the September 23, 1996 letter. The Company responded to the FDA letter in October 1996, and informed the agency that the Company believes that the distinctions drawn regarding the definition of transplantation and banked human tissue and between integumental tissue and all other tissue in the September 17 opinion were fairly novel and ones for which the Company would require clarification from the FDA as it goes forward. The Company believes that AlloDerm, when used for augmentation and as a void filler, still qualifies as banked human tissue. Similarly, the Company advised the FDA that since almost every replacement or repair of damaged or inadequate tissue involves a cosmetic aspect, the Company believes that many cosmetic uses of AlloDerm are within the purview of banked human tissue. Nevertheless, the Company informed the FDA that it intends to follow the agency's decision and, until this matter is clarified on a case by case basis, will not promote AlloDerm for the Additional Indications. The Company also advised the FDA that it would present its arguments to the agency as to why it believes that these uses fall within the definition of banked human tissue. There can be no assurance that the FDA will not finally conclude that use of AlloDerm for the Additional Indications should be regulated as a medical device and require a 510(k) premarket notification or premarket approval ("PMA") for AlloDerm for such indications. If the FDA were to conclude definitively that the Company is required to obtain agency clearance of a 510(k) notification or approval of a PMA for AlloDerm for the Additional Indications, the FDA may require the Company to conduct laboratory testing and preclinical and clinical studies of AlloDerm to support a marketing application. Testing, preparation of necessary applications and processing of those applications by the FDA is expensive and any required laboratory testing or preclinical or clinical studies that the Company were required to conduct could take several years to complete. There can be no assurance that any required testing could be completed successfully, or that if successfully completed, would provide sufficient data and information to enable the FDA to determine, on a timely basis, if at all, that when AlloDerm is used for the Additional Indications, it is substantially equivalent to a legally marketed predicate device or is safe and effective for the Additional Indications and permit the product to be marketed for such uses. Failure of the Company to receive any required FDA clearance or approval of AlloDerm for the Additional Indications on a timely basis would preclude promotion of AlloDerm for the Additional Indications and could have a material adverse effect on the Company's business, financial condition and results of operation. See "--Risk Factors--Regulatory Status of AlloDerm". The FDA's banked human tissue regulation requires establishments engaged in the procurement, processing, and distribution of human tissue to conduct and maintain records of tissue donor screening procedures and blood testing. In addition, tissue processing establishments are periodically inspected by the FDA to ensure compliance with these requirements. If at any time the FDA determines that a banked human tissue product is not 10 procured, processed or distributed in accordance with these requirements (E.G., there is a question about the source of the tissue, the adequacy of the testing or the adequacy of donor selection), the agency may order the recall and destruction of the product. The failure of a tissue processing establishment to adhere to the FDA's requirements could subject the establishment and its principals to civil and criminal prosecution. LifeCell believes that the Company's operations substantially comply with the requirements of the FDA's interim rule. LifeCell requires that the tissue banks supplying the Company with tissue comply with the FDA's banked human tissue regulation. In addition, the Company requires supplying tissue banks to comply with procedural guidelines outlined by the American Association of Tissue Banks (the "AATB"). Since 1976, the AATB has administered a voluntary accreditation system for skin and orthopedic tissue banks. The AATB evaluates tissue banks for compliance with a rigorous set of standards through site inspections and document review. The AATB's standards apply to the procurement, processing, preservation, storage and labeling of tissue and include requirements for disease screening through donor testing and review of donor medical histories. Although the Company requires its supplying tissue banks to comply with the FDA's requirements and the AATB's standards, there can be no assurance that these tissue banks are in full compliance with these requirements. The failure of a tissue bank to comply with regulatory requirements with respect to tissue provided to the Company could have a material adverse effect on the Company. In its interim rule on banked human tissue, the FDA stated that it would propose additional requirements for such products. Additional requirements may include registration of tissue banking establishments with the FDA, donor-recipient tracking and clinical evaluation of tissues that are determined to have undergone other than "minimal processing". To date, the FDA has not proposed additional requirements; however, if significant additional regulatory requirements were to be established, the Company could incur significant additional costs in order to comply with such requirements. LifeCell's proposed human and xenograft heart valve products and its proposed xenograft tissue transplantation products including XenoDerm tissue and xenograft vascular conduits will be subject to regulation by the FDA as medical devices, although the FDA has proposed classifying human heart valves as banked human tissue. LifeCell's proposed blood cell additives, including ThromboSol platelet storage solution, will be subject to regulation as biologics. Accordingly, such products will require FDA premarket approval or clearance prior to commercialization. To obtain FDA approval or clearance for these products, the Company must submit proof of the safety and efficacy of these products. In most cases, this entails extensive pre-clinical and clinical testing. Such testing must be performed in accordance with the FDA's regulations. The testing, preparation of necessary applications and processing of those applications by the FDA is expensive and time consuming and will take several years to complete. There is no assurance that the FDA will act favorably or quickly in making such reviews, and significant difficulties or costs may be encountered by the Company in its efforts to obtain the FDA approvals or clearances that could delay or preclude the Company from marketing any product it may develop. The FDA may also require post-market testing and surveillance to monitor the effects of approved products, and may place conditions on approvals that could restrict commercial applications of such products. Product marketing approvals or clearances may be withdrawn if compliance with regulatory standards is not maintained or if problems occur following initial marketing. In addition, delays imposed by the governmental approval process may materially reduce the period during which the Company may have the exclusive right to commercialize patented products. The FDA reviews medical devices for marketing approval or clearance through two different procedures, the 510(k) premarket notification process and the PMA process. LifeCell will need to pursue one of these routes with respect to each of its proposed medical device products. The determination of which process will be required for any particular product will depend in part upon how the FDA has regulated similar products by the time LifeCell is ready to pursue its own approvals or clearances. Under the 510(k) premarket notification procedure, the applicant or "sponsor" submits an application containing data that demonstrate the "substantial equivalence" of the product to a device marketed prior to the enactment of the Medical Device Amendments of 1976 or to a device legally marketed thereafter pursuant to a 510(k). The FDA may require a 510(k) applicant to submit additional, and possibly extensive, clinical data establishing the safety and effectiveness of the product for each proposed medical use. Prior to conducting the necessary clinical trials, an applicant may be required to submit an investigational device ("IDE") protocol to the FDA for approval. An IDE application typically contains data from laboratory and animal testing demonstrating 11 that the product is sufficiently safe for study in humans as well as a description of the proposed study methods and protocol. Clinical studies must be conducted according to a written protocol and pursuant to the approval and oversight of one or more Institutional Review Boards. In addition, clinical investigators must adhere to good clinical practices. The FDA may order the temporary or permanent discontinuation of a clinical trial at any time for non-compliance with its regulations, because of safety issues or for other reasons. The collection of data and preparation of a 510(k) application can be costly and time consuming, and a 510(k) applicant may not market the product until a favorable decision is received from the FDA. The FDA review of a 510(k) premarket notification can take anywhere from a few months to several years. There can be no assurance that marketing clearance ultimately will be obtained for any of LifeCell's products that are the subject of 510(k) premarket notifications. The PMA process is significantly more complex, costly and time consuming than the 510(k) clearance procedure. To obtain premarket approval, the applicant is required to submit extensive preclinical and clinical data to the FDA. An IDE may be required to conduct the clinical trials. Upon completion and analysis of clinical studies, the applicant assembles and submits a PMA application setting forth the preclinical, clinical, manufacturing and other data. Typically, the FDA will also inspect the manufacturing facility for compliance with Good Manufacturing Practice ("GMP") regulations. The FDA review and approval of a PMA can take several years. There can be no assurance that PMA approvals will be obtained for any of LifeCell's proposed products. With respect to LifeCell's proposed biological products, the Company or its contracted designee must obtain both a product license and an establishment license from the FDA prior to marketing. A product and license application ("PLA") and establishment license application ("ELA") must be submitted and supported by extensive data, including preclinical and clinical data that demonstrate that the manufactured product meets prescribed standards of safety and efficacy. Before conducting the required clinical testing of a biological product, an applicant must submit an investigational new drug ("IND") application to the FDA. Similar to the IDE for testing of devices, the IND application must contain preclinical data demonstrating the safety of the product for human investigational use, information about the manufacturing processes and procedures, and the proposed clinical protocol. Clinical trials of biological products are typically conducted in three sequential phases, but may overlap. Phase I trials test the product in a small number of healthy subjects, primarily to determine its safety and tolerance at one or more doses. In Phase II, in addition to safety, the efficacy, optimal dose and side effects of the product are evaluated in a patient population somewhat larger than the Phase I trial. Phase III involves further safety and efficacy testing on an expanded patient population at geographically dispersed test sites. All clinical studies must be conducted in accordance with FDA approved protocol and are subject to the approval and monitoring of one or more Institutional Review Boards. In addition, clinical investigators must adhere to good clinical practices. Completion of all three phases of clinical studies may take several years, and the FDA may temporarily or permanently suspend a clinical study at any time. Upon completion and analysis of clinical trials, the applicant assembles and submits a PLA and an ELA. The ELA contains a complete description of the manufacturing process. Before the licenses can be granted, the Company or its designee must undergo a successful establishment inspection. The FDA review and approval of a biological product can take several years. There can be no assurance that LifeCell will obtain the required approvals for any of its proposed biological products. All products marketed by LifeCell pursuant to the above-described approvals and clearances will be subject to pervasive and continuing regulation by the FDA. Products must be manufactured in registered establishments and must be produced in accordance with GMP regulations. There are post-marketing surveillance and reporting requirements. Manufacturing facilities and processes are subject to periodic FDA inspection. Labeling and promotional activities are also subject to FDA scrutiny and, in certain instances, by the Federal Trade Commission. The export of devices and biologics is also subject to regulation and may require prior FDA clearance. From time to time, the FDA may modify such regulations and impose additional or different requirements. It is impossible to predict how such revisions would affect the Company's operations. Failure to comply with any applicable FDA requirements could result in civil and criminal enforcement actions and penalties. Sales of medical device and biological products outside the United States are subject to foreign regulatory requirements that vary widely from country to country. Approval of a product by comparable regulatory authorities of foreign countries must be obtained prior to commercialization of the product in those countries. The time required to obtain such foreign approval may be longer or shorter than that required for FDA approval and there can be no assurance that approvals would be obtained for any of the Company's products. 12 In addition, NOTA prohibits the acquisition, receipt or transfer of certain human organs, including skin and heart valves and vascular conduits for "valuable consideration", but permits the payment of reasonable expenses associated with the removal, transportation, processing, preservation, quality control and storage of human tissue and skin. Assuming that NOTA applies to LifeCell's products, it may be interpreted to limit the prices that LifeCell may charge for processing and transporting such human tissue products. LifeCell includes in its AlloDerm pricing structure certain of its educational costs associated with the processing and transportation of human tissue. Although LifeCell believes that recovery of educational costs is permitted under NOTA, a future inability of LifeCell to pass these costs on to purchasers of its products could adversely affect LifeCell's business and prospects. Assuming that NOTA applies to LifeCell's products, LifeCell intends to comply with NOTA, but there can be no assurance that the government will not adopt interpretations of NOTA that would adversely affect LifeCell's pricing structure or otherwise call into question one or more aspects of LifeCell's method of operation. LifeCell is also subject to various federal, state and local laws, regulations and recommendations relating to such matters as safe working conditions, laboratory and manufacturing practices, and the use, handling and disposal of hazardous or potentially hazardous substances used and produced in connection with LifeCell's research and development work. See "--Environmental Matters". Although LifeCell believes it is in compliance in all material respects with these laws and regulations, there can be no assurance that the Company will not incur significant additional costs to comply with environmental laws or regulations in the future. RESEARCH AND DEVELOPMENT LifeCell currently uses funds received primarily through external sources, including corporate alliances and government grants and contracts, to fund the development of additional universal tissue products and products for blood cell preservation. LifeCell plans to continue to develop its non-AlloDerm technology through an ongoing research and product development program. To date, its research has been funded primarily through government SBIR grants, Department of Defense (DOD) contracts and the proceeds from various offerings of its equity securities. LifeCell's research and development costs in 1994, 1995 and 1996 for all programs, including those programs funded through corporate and government support, were approximately $2.1 million, $2.2 million and $1.6 million, respectively. The development of LifeCell heart valves is currently being funded by Medtronic. The 1996 funding of this program was approximately $546,000. See "--Corporate Alliance". The SBIR grant program provides funding for two phases of awards. Phase I is to evaluate the scientific and technical merit and feasibility of an idea. Awards are up to $100,000 with a period of performance normally not to exceed six months. Phase II is to expand on the results of and pursue the development of Phase I. Awards are up to $750,000, with a period of performance normally not to exceed two years. To date, LifeCell has been awarded approximately $4.6 million through 14 approved SBIR program awards and Department of Defense contracts. In 1996, LifeCell received a two-year Phase II SBIR grant award from the NSF in the amount of $300,000 to support the composite skin graft program, a one-year U.S. Navy contract in the amount of approximately $613,000 to support the ThromboSol program and a two-year Collaborative Agreement with the U.S. Army in the amount of approximately $1,069,000 to support investigation of AlloDerm grafts to repair dura mater, the membrane lining of the brain, the use of AlloDerm grafts in conjunction with microskin grafting in burn wounds and the development of vascular graft products. LifeCell intends to continue to seek funding through the SBIR programs, as well as to pursue additional government grant and contract programs. Generally, LifeCell has the right to patent any technologies developed from government grants and contract funding, subject to the United States government's right to receive a royalty-free license for federal government use and to require licensing to others in certain circumstances. PATENTS, PROPRIETARY INFORMATION AND TRADEMARKS LifeCell's ability to compete effectively with other companies is materially dependent upon the proprietary nature of its technologies. LifeCell relies primarily on patents and trade secrets to protect its technologies. LifeCell currently has the exclusive right to eight patents through a license agreement with the Board of Regents of the 13 University of Texas System. In addition, LifeCell has been issued three patents and has five pending United States patent applications. LifeCell has also applied for patent protection in several foreign countries. Because of the differences in patent laws and laws concerning proprietary rights, the extent of protection provided by United States patents or proprietary rights owned by or licensed to LifeCell may differ from that of their foreign counterparts. LifeCell believes that it owns or has the right to use all knowledge necessary to manufacture and market its current products and planned products without infringing any existing patent or proprietary rights of others such that it would be liable for damages or prevented from manufacturing or marketing its products. No assurances may be given, however, that the Company's patents or other proprietary rights may not be the subject of an infringement or other claim that could invalidate to some extent its patents or other rights. Any successful patent infringement claim relating to any patent could have a material adverse effect on the Company. See "-- Risk Factors--Patents and Proprietary Rights". LifeCell may decide for business reasons to retain certain knowledge that it considers proprietary as trade secrets. In that event, or if patent protection is unattainable, LifeCell must rely upon trade secrets, know-how and continuing technological innovation to maintain its competitive position. Employees and consultants of LifeCell who have access to proprietary information have signed confidentiality agreements. It is LifeCell's policy to require any new employee to sign similar confidentiality agreements. LifeCell has federal trademark or service mark registrations that it currently uses for LifeCell(R) and LifeCell Process(R), which cover processing and preserving tissue samples, and AlloDerm(R), which covers LifeCell's commercial dermal skin graft product. COMPETITION UNIVERSAL TISSUE GRAFTS LifeCell anticipates direct competition for AlloDerm tissue products and all of its proposed transplantable tissue products, as well as indirect competition from advances in therapeutic agents, such as growth factors now used to enhance wound healing. LifeCell believes that therapeutic growth factors may be used in conjunction with its proposed products and may potentially enhance the products' efficacy. LifeCell is not aware of any person or entity currently marketing transplantable tissue products with features similar to AlloDerm and LifeCell's other proposed transplantable products. There can be no assurance, however, that LifeCell will be able to compete effectively with other commercially available products or that development of other technologies will not detrimentally affect LifeCell's commercial opportunities or competitive advantage. ALLODERM TISSUE PRODUCTS--BURNS. LifeCell believes that the AlloDerm process is the only technology that consistently and effectively eliminates the targets of rejection and permits permanent transplantation of human dermal tissue. Competitive commercial products are currently in clinical trials that claim to provide permanent full-thickness wound coverage. In most cases, these products contain a "dermal equivalent", which is usually a processed animal collagen gel or a bioabsorbable synthetic material in which human cells that produce collagen (fibroblasts) are usually seeded. The fibroblasts secrete dermal-like proteins and are intended to support a split-skin graft. In comparison to these products, LifeCell has focused its product development on the extracellular matrix, and not the cell population of dermis. Advanced Tissue Sciences, Inc. and Organogenesis, Inc. each has developed or is developing such dermal equivalent products. In early 1997, Advanced Tissue Sciences received a PMA from the FDA to market a temporary wound covering. LifeCell does not believe that this product will directly compete with AlloDerm, which is a permanent graft. LifeCell believes that these "dermal equivalent products" lack important dermal components and will encounter difficulty in adequately anchoring the vital surface epithelial cells. LifeCell's primary objectives in processing AlloDerm tissue include the preservation of important dermal components, including a basement membrane complex. The Company believes this structure not only is essential for sufficient anchoring of epidermal 14 cells, but also determines the degree of differentiation of these cells, an aspect that has direct bearing on the skin's vital water barrier function. LifeCell has demonstrated by electron microscopy that its processing technology has produced preserved dermis with an intact basement membrane complex. LifeCell has further demonstrated that a human epidermal cell population (keratinocytes) will attach and differentiate into the stratified layers typical of normal skin, on both human and porcine processed dermis. The AlloDerm process also preserves the basement membrane of the vascular channels and capillaries within the dermal matrix. LifeCell has demonstrated in animal studies that these vascular channels become repopulated with host cells that normally line blood vessels and ultimately restore a normal blood supply to the tissue graft. LifeCell believes this aspect of its technology is fundamental to the ability of the transplanted tissue to engraft permanently (integrate) into host tissue and that it is its principal competitive advantage. Integra LifeSciences Corporation received a PMA in 1996 from the FDA to market two-layer wound dressings that include a biosynthetic dermal equivalent and a silicone membrane. Integra's product is currently restricted to treatment of life-threatening burns in cases where autologous tissue is not available. This treatment requires that the patient's autograft be applied in a subsequent surgery approximately two weeks later. LifeCell believes that AlloDerm grafts will effectively compete with Integra's product in the treatment of burns based on superior product performance and because AlloDerm grafts can be applied simultaneously with the patient's autograft in a single procedure as opposed to an additional subsequent procedure, thereby reducing surgical costs. COMPOSITE SKIN GRAFT. Genzyme Tissue Repair has developed technology for culturing autologous keratinocytes (epidermal) cells for commercial distribution. LifeCell believes that these cultured epidermal cell sheets alone are not optimum as a permanent skin replacement for full-thickness skin injury. This product does not contain a dermal layer, and in some clinical cases this type of treatment for a full-thickness wound has resulted in fragility with severe blistering and loss of grafts. The fragile nature of the product usually requires that it be hand-carried to the hospital. In some cases, this product has been used by burn surgeons in conjunction with AlloDerm grafts in an attempt to improve the quality of healing with these cultured cell sheets. LifeCell believes that its composite skin product will compete effectively with currently available cultured cell sheets because it will contain a dermal layer, which should improve the take rate and reduce the fragility currently associated with these products. ALLODERM TISSUE PRODUCTS--PERIODONTAL SURGERY. AlloDerm grafts used in free-gingival graft procedures compete with procedures using the patient's own tissue, removed from the roof of the mouth or from another area of the patient's skin, such as the leg, and freeze-dried allograft skin, procured from tissue banks. LifeCell believes it competes with procedures using the patient's own tissue by eliminating the need for a donor site and the resulting trauma. The Company believes it competes with freeze-dried allograft skin because of AlloDerm's higher biocompatability and reduced immune response. AlloDerm grafts used as barrier membranes for guided tissue regeneration compete with several commercial products, including "Gore-Tex", manufactured by W.L. Gore & Associates, Inc. Gore-Tex is nonabsorbable and must be removed by the periodontist several months following the initial surgery. LifeCell believes that AlloDerm grafts compete with Gore-Tex by eliminating the need for a second surgical procedure for removal of the membrane. The Company is aware of other barrier membrane products that are absorbed by the body and, therefore, do not have to be removed, including products manufactured by Guidor and Integra LifeSciences Corporation. LifeCell believes that AlloDerm grafts will compete with absorbable membrane products through more effective performance and versatility of use. ALLODERM TISSUE PRODUCTS--PLASTIC AND RECONSTRUCTIVE SURGERY. When used during reconstructive surgery as a graft to release burn wound contractures, AlloDerm competes with the patient's own tissue and potentially with the products described above intended for burn wound grafting. For the repair and replacement of damaged or inadequate integumental tissue, AlloDerm competes with injectable collagen products, such as those manufactured by Collagen Corporation, and bovine synthetic products such as Gore-Tex. LifeCell believes that AlloDerm will compete with these products because of AlloDerm's high biocompatibility and reduced immune response. 15 CRYOPRESERVED ALLOGRAFT SKIN (TEMPORARY WOUND COVERAGE). LifeCell competes with regional tissue banks for the distribution of cryopreserved allograft skin for temporary wound coverage. The Company believes that it can compete successfully with these tissue banks by offering customized products and services, such as pre- meshing of the grafts, which save time in the operating room reducing surgery costs. Advanced Tissue Sciences, Inc. has received a PMA from the FDA for a biosynthetic wound dressing consisting of a commercially available wound dressing in which human neonatal fibroblasts are cultured and then covered with a thin synthetic covering to prevent fluid loss. LifeCell believes that its cryopreserved allograft skin product will compete successfully with this product primarily because the application of cryopreserved allograft skin is considered the clinically preferred procedure for temporary wound coverage. HEART VALVES. Three current types of replacement heart valves are commercially available, mechanical valves, chemically processed animal valves and human allograft valves. Mechanical valves require the patient to be maintained on lifelong anticoagulant therapy to prevent blood clotting and subsequent complications of stroke. There also are published reports of sudden catastrophic failure of these valves, resulting in patient death. Animal valves calcify or harden over time and usually require replacement within ten to 18 years. Human allograft valves are in short supply. Major manufacturers and suppliers of mechanical and animal heart valve products include Medtronic, St. Jude Medical, Inc. and the Edwards Division of Baxter Healthcare Corporation. Human tissue valves are procured and processed and distributed by Cryolife, Inc. and non-profit tissue banks, including the American Red Cross. LifeCell's preclinical data has indicated that its processed porcine valve tissue undergoes reduced calcification compared to chemically processed porcine valves and reduced immune response compared to fresh or cryopreserved heart valve tissue. LifeCell believes that its processed heart valve, currently under development with Medtronic, will minimize complications associated with commercially available valves. VASCULAR CONDUITS. Medical treatment for cardiovascular disease, including atherosclerosis, is a highly competitive industry. Significant technological progress has been made with respect to the development of minimally invasive devices for dilation of blocked vessels and devices for physically removing the plaque from the vessel wall. Additionally, drugs are being developed to prevent or reverse atherosclerosis. Bypass surgery, however, is generally performed when the patient displays extensive deposits of plaque throughout the length of one or more vessels, when the blockage is in a critical position or when the blockage site cannot be safely accessed. The two current clinically preferred methods for coronary arterial bypass procedure are transposing available arteries and using an autologous vein from another area in the patient's body. The second procedure induces trauma to the area of vein harvest and has shown evidence of failure or occlusion after five to ten years. There are commercially available synthetic vascular conduit substitutes, but these products also show evidence of occlusion and the increased potential for leaking and infection. LifeCell believes that its processing technology will reduce the causes and, accordingly, the potential for vessel occlusion, leakage and infection. BLOOD CELL PRESERVATION PRODUCTS LifeCell currently is not aware of any product or developing product that it anticipates will compete with the products it is developing for blood cell preservation; however, technological competition in the blood banking field is intense. Several companies with significantly greater financial resources than LifeCell are developing blood substitute products. Additionally, several commercially available blood recycling units are currently used in some surgical procedures, and growth factors are being developed that are intended to increase the body's capacity for producing blood cells. LifeCell believes that its planned freeze-dried blood products and mammalian cells will successfully compete with these technologies on the basis of cost and convenience. ENVIRONMENTAL MATTERS LifeCell's research and development and processing techniques generate waste that is classified as hazardous by the United States Environmental Protection Agency and the Texas Natural Resources Commission. LifeCell segregates such waste and disposes of it through a licensed hazardous waste transporter. Although LifeCell believes it is currently in compliance in all material respects with applicable environmental regulations, 16 its failure to comply fully with any such regulations could result in the imposition of penalties, fines or sanctions that could have an adverse effect on LifeCell's business. EMPLOYEES At March 26, 1997, the Company had 73 full-time and two part-time employees of which 23 were employed in processing and support, 18 in sales and marketing, 17 in research and development and 17 in administration and accounting. As of March 26, 1997, the Company employed, full time, two persons with M.D. degrees and six persons with Ph.D. degrees. RISK FACTORS THE COMPANY'S EXPECTATIONS WITH RESPECT TO FUTURE RESULTS OF OPERATIONS THAT MAY BE EMBODIED IN ORAL AND WRITTEN FORWARD-LOOKING STATEMENTS, INCLUDING ANY FORWARD-LOOKING STATEMENTS THAT MAY BE CONTAINED IN THIS ANNUAL REPORT ON FORM 10-K, ARE SUBJECT TO RISKS AND UNCERTAINTIES THAT MUST BE CONSIDERED WHEN EVALUATING THE LIKELIHOOD OF THE COMPANY'S REALIZATION OF SUCH EXPECTATIONS. THE COMPANY'S ACTUAL RESULTS COULD DIFFER MATERIALLY. FACTORS THAT COULD CAUSE OR CONTRIBUTE TO SUCH DIFFERENCES INCLUDE, BUT ARE NOT LIMITED TO, THOSE DISCUSSED BELOW. NO ASSURANCE OF ADDITIONAL NECESSARY CAPITAL LifeCell expects to incur substantial expenses for AlloDerm marketing and the Company's product development programs (including costs of clinical studies), production, sales and marketing, product introduction, technical seminars, support of ongoing administrative activities and research and development activities, such as regulatory and quality assurance programs and continuing applications for patent protection for the proprietary aspects of its technology. The Company currently intends to fund these activities from its existing cash resources, sales of products, and research and development funding received from others. There can be no assurance that such sources of funds will be sufficient to meet these future expenses. The Company's need for additional financing will be principally dependent on the degree of market acceptance achieved by the Company's products and the extent to which the Company can achieve substantial growth in product sales during 1997 and 1998 as well as the extent to which the Company may decide or may be required to use its own resources, in addition to external funding, to expand its product development efforts. There can be no assurance that the Company will be able to obtain any such additional financing on acceptable terms. HISTORY OF OPERATING LOSSES The Company has incurred substantial losses since inception in January 1986, including losses of approximately $3.7 million, $3.9 million and $ 4.1 million for the years ended December 31, 1994, 1995, and 1996, respectively, and had an accumulated deficit of approximately $29.3 million at December 31, 1996. There can be no assurance that the Company will ever become profitable. FDA REGULATORY STATUS OF ALLODERM In December 1993, the FDA published an interim rule regulating "banked human tissue". The rule defines banked human tissue as any tissue derived from a human body which is (i) intended for administration to another human for the diagnosis, cure, mitigation, treatment or prevention of any condition or disease and (ii) recovered, processed, stored or distributed by methods not intended to change tissue function or characteristics. The FDA definition excludes, among other things, tissue that currently is regulated as a human drug, biological product or medical device and kidney, liver, heart, lung, pancreas or any other vascularized human organ. Banked human tissue is regulated by the FDA in a manner the agency has deemed necessary to protect the public health from the transmission of HIV infection and hepatitis infection through transplantation of tissue from donors with or at risk of these diseases. Under the FDA regulations, all facilities engaged in the procurement, processing, storage or distribution of human tissue intended for transplant are required to assure that certain infectious disease testing and donor screening is performed and that records documenting such testing for each tissue are available for inspection by the FDA. The regulations also provide authority for the FDA to conduct inspections of banked human tissue facilities and to detain, recall or destroy tissue for which appropriate documentation is not available. Banked human 17 tissue, however, is not subject to premarket notification or approval by the FDA as are certain drugs, biologicals and medical devices. In December 1991, the Company first contacted the FDA regarding the regulatory status of AlloDerm and was advised in May 1992 that the FDA had not made a final determination on the status of intact processed human cadaver skin, that the agency currently was studying the issue and that these products may at some future time be subject to FDA regulation. The FDA sent the Company a copy of the December 1993 publication of the FDA's banked human tissue regulations shortly after its release of such regulations and inspected the Company for compliance with those regulations in July 1994. For these reasons, the Company believed that AlloDerm was covered by the FDA's definition of banked human tissue and that the product would not be regulated as a medical device. In November 1995, following LifeCell's commercial introduction of AlloDerm for periodontal applications, the Company received a letter from the FDA, stating that it considered AlloDerm to be a "device" as defined by the FDC Act, and that a 510(k) premarket notification was required to be submitted and cleared by the FDA in order to market the product. Following several months of correspondence and discussions with the FDA, the Company received a letter from the agency dated September 17, 1996, to the effect that, after considering the information and views that the Company submitted at a May 1996 meeting with agency officials and in subsequent correspondence, the FDA agrees with the Company's position that AlloDerm intended for use for replacement or repair of damaged or inadequate integumental tissue, including gingival dermis, is banked human tissue within the meaning of the interim final rule. Consequently, AlloDerm is not subject to premarket notification or approval by the FDA and the Company may continue to promote and sell AlloDerm for use in the treatment of wounds, such as third-degree burns, in periodontal surgical procedures, such as free-gingival grafting and guided tissue regeneration, and in plastic and reconstructive surgery procedures, such as contracture release grafting and scar revision. The agency also informed the Company that this decision applies only to AlloDerm when it is intended for use in transplantation, and the regulatory status of the product when it is promoted for other uses, such as the Additional Indications, would need to be determined by the FDA on a case by case basis. To date, a minimal amount of LifeCell's aggregate product sales are attributable to the Additional Indications. While the Company's marketing efforts had not previously focused on the Additional Indications, as a follow-up to its September 17 letter, the FDA, by letter dated September 23, 1996, informed the Company that indications for Additional Indications would have to be formally presented to the FDA to determine if, with these indications, AlloDerm would continue to fall within the scope of the interim rule for banked human tissue and thus not require premarket clearance. The Company was asked to indicate what changes in advertisement and promotion it would make for AlloDerm in response to the September 23, 1996 letter. The Company responded to the FDA letter in October 1996, and informed the agency that the Company believes that the distinctions drawn regarding the definition of transplantation and banked human tissue and between integumental tissue and all other tissue in the September 17 opinion were fairly novel and ones for which the Company would require clarification from the FDA as it goes forward. The Company believes that AlloDerm, when used for augmentation and as a void filler, still qualifies as banked human tissue. Similarly, the Company advised the FDA that since almost every replacement or repair of damaged or inadequate tissue involves a cosmetic aspect, the Company believes that many cosmetic uses of AlloDerm are within the purview of banked human tissue. Nevertheless, the Company informed the FDA that it intends to follow the agency's decision and, until this matter is clarified on a case-by-case basis, will not promote AlloDerm for the Additional Indications. The Company also advised the FDA that it would present its arguments to the agency as to why it believes that these uses fall within the definition of banked human tissue. There can be no assurance that the FDA will not finally conclude that use of AlloDerm for the Additional Indications should be regulated as a medical device and require a 510(k) premarket notification or PMA for AlloDerm for such indications. If the FDA were to conclude definitively that the Company is required to obtain agency clearance of a 510(k) notification or approval of a PMA for AlloDerm for the Additional Indications, the FDA may require the Company to conduct laboratory testing and preclinical and clinical studies of AlloDerm to support a marketing application. Testing, preparation of necessary applications and processing of those applications by the FDA is expensive and any required laboratory testing or preclinical or clinical studies that the Company were required to conduct could take several years to complete. There can be no assurance that any required testing could be completed successfully, or that if successfully completed, would provide sufficient data and information to enable the FDA to determine, on a timely basis, if at all, that when AlloDerm is used for the 18 Additional Indications, it is substantially equivalent to a legally marketed predicate device or is safe and effective for the Additional Indications and permit the product to be marketed for such uses. Failure of the Company to receive any required FDA clearance or approval of AlloDerm for the Additional Indications on a timely basis would preclude promotion of AlloDerm for the Additional Indications and could have a material adverse effect on the Company's business, financial condition and results of operation. See "--Government Regulation--Proposed Products". GOVERNMENT REGULATION--PROPOSED PRODUCTS Many if not all of LifeCell's products under development will require regulatory approval or clearance prior to commercialization. Human therapeutic products are subject to rigorous preclinical and clinical testing as a condition of approval by the FDA and by similar regulatory authorities in foreign countries. The lengthy process of obtaining these approvals and clearances and the ongoing process of compliance with applicable federal statutes and regulations will require the expenditure of substantial resources, and there can be no assurance that the FDA or foreign approvals will be obtained for any of the Company's proposed products. LifeCell's proposed human and xenograft heart valve products and its proposed xenograft tissue transplantation products will be subject to regulation as medical devices. The Company's proposed blood cell additives will be subject to regulation as biologics. Such products require FDA premarket clearance prior to commercialization in the United States. To obtain FDA approval for these products, the Company must submit proof of their safety and efficacy. Testing, preparation of necessary applications and processing of those applications by the FDA is expensive and time consuming. There can be no assurance that the FDA will act favorably or quickly in making such reviews, and significant difficulties or costs may be encountered by the Company in its efforts to obtain FDA clearances that could delay or preclude the Company from marketing any product it may develop. The FDA may also place conditions on clearances that could restrict commercial applications of such products. Product marketing approvals or clearances may be withdrawn if compliance with regulatory standards is not maintained or if problems occur following initial marketing. Delays imposed by the governmental clearance process may materially reduce the period during which the Company has the exclusive right to commercialize patented products. Products marketed by LifeCell pursuant to FDA or foreign approval will be subject to pervasive and continuing regulation. In the United States, devices and biologics must be manufactured in registered establishments and must be produced in accordance with GMP regulations. Manufacturing facilities and processes are subject to periodic FDA inspection. Labeling and promotional activities are also subject to scrutiny by the FDA and, in certain instances, by the Federal Trade Commission. The export of devices and biologics is also subject to regulation and may require FDA approval. From time to time, the FDA may modify such requirements, imposing additional or different requirements. Failure to comply with any applicable FDA requirements could result in civil and criminal enforcement actions and other penalties. In addition, there can be no assurance that the various states and foreign countries in which LifeCell's products are sold will not impose additional regulatory requirements or marketing impediments. NOTA prohibits the acquisition, receipt or transfer of certain human organs, including skin, heart valves and vascular conduits, for "valuable consideration". NOTA permits the payment of reasonable expenses associated with the removal, transportation, processing, preservation, quality control and storage of human tissue and skin. NOTA may be interpreted to limit the prices that LifeCell may charge for processing and transporting its human tissue products. This could result in limited revenues which could adversely affect LifeCell's business and prospects. DEPENDENCE ON KEY MANAGEMENT AND PERSONNEL The success of LifeCell will be dependent largely on the efforts of Paul M. Frison, Chairman of the Board, President and Chief Executive Officer of the Company, and Stephen A. Livesey, M.D., Ph.D., Executive Vice President, Chief Scientific Officer and a director of the Company. The loss of either person's services would have a material adverse effect on LifeCell's business and prospects. Dr. Livesey, a citizen of Australia, has received an extension of an "H-1B" visa to work in the United States that currently expires in June 1997, and he is in the process of applying for permanent residence status in the United States. There can be no assurance that he will be able to 19 obtain such status. Further, the success of LifeCell is also dependent upon its ability to hire and retain suitable operating, marketing and technical personnel. The competition for qualified personnel in the biomedical industry is intense and, accordingly, there can be no assurance that LifeCell will be able to hire or retain necessary personnel. TECHNOLOGICAL CHANGE AND COMPETITION The biomedical field is undergoing rapid and significant technological change. LifeCell's success depends upon its ability to develop and commercialize its technology. There are many companies and academic institutions that are capable of developing products based on similar technology, and that have developed and are capable of developing products based on other technologies, which are or may be competitive with LifeCell's products. Many of those companies and academic institutions are well-established, have substantially greater financial and other resources than LifeCell and have established reputations for success in the development, sale and service of products. These companies and academic institutions may succeed in developing competing products that are more effective than LifeCell's products or that receive government approvals more quickly than LifeCell's products. AVAILABILITY OF MATERIALS The Company's business will be dependent on the availability of human cadaveric skin and cardiovascular tissue to the extent that LifeCell is unable successfully to develop products using animal tissue. A limited supply of donated skin is available. Although the Company has established what it believes to be an adequate source of cadaveric skin to satisfy the expected demand for AlloDerm, there can be no assurance that the availability of human skin and cardiovascular tissue will be sufficient to meet LifeCell's demand for such materials. UNCERTAINTY OF MARKET ACCEPTANCE Achieving broad market acceptance for AlloDerm and LifeCell's proposed products will require substantial additional marketing efforts. There can be no assurance that AlloDerm or any of LifeCell's proposed products ultimately will achieve widespread commercial acceptance. PATENTS AND PROPRIETARY RIGHTS LifeCell's ability to compete effectively with other companies is materially dependent upon the proprietary nature of its technologies. LifeCell relies primarily on patents and trade secrets to protect its technologies. LifeCell currently has the exclusive right to eight patents through a license agreement with the Board of Regents of the University of Texas System. In addition, LifeCell has been issued three patents and has five pending United States patent applications. There can be no assurance that LifeCell will obtain any additional key patents or other protection, that the patents currently applied for will be granted, that existing patents or proprietary rights owned by or licensed to LifeCell will not be invalidated or that patents will provide significant commercial benefits. The invalidation of key patents or proprietary rights owned by or licensed to LifeCell could have a material adverse effect on LifeCell and on its business prospects. LifeCell believes that it owns or has the right to use all knowledge necessary to manufacture and market its current products and planned products without infringing any existing patent or proprietary rights of others such that it would be liable for damages or prevented from manufacturing or marketing its products. No assurances may be given, however, that the Company's patents or other proprietary rights may not be the subject of an infringement or other claim that could invalidate to some extent its patents or other rights. Any successful patent infringement claim relating to any patent could have a material adverse effect on the Company. There can be no assurance that LifeCell will not be required to resort to litigation to protect its patents or other proprietary rights or that the Company may be the subject of patent litigation to defend its patents or other rights against claims of infringement or other intellectual property claims. Such litigation could result in substantial costs and diversion of resources and could have a material adverse effect on the Company's financial condition and results of operations. 20 LifeCell has also applied for patent protection in several foreign countries. Because of the differences in patent laws and laws concerning proprietary rights, the extent of protection provided by United States patents or proprietary rights owned by or licensed to LifeCell may differ from that of their foreign counterparts. LIMITED THIRD-PARTY REIMBURSEMENT Generally, hospitals, physicians and other health care providers purchase products, such as the products being sold or developed by LifeCell, for use in providing care to their patients. These parties typically rely on third-party payors, including Medicare, Medicaid, private health insurance and managed care plans, to reimburse all or part of the costs of acquiring those products and costs associated with the medical procedures performed with those products. Cost control measures adopted by third-party payors in recent years have had and may continue to have a significant effect on the purchasing practices of many health care providers, generally causing them to be more selective in the purchase of medical products. These and future changes in third-party payor reimbursement practices regarding the procedures performed with LifeCell's products may adversely affect LifeCell's business. PRODUCT LIABILITY AND INSURANCE The Company's business will expose it to potential product liability risks which are inherent in the testing, manufacturing and marketing of medical products. Although the Company has product liability insurance coverage with an aggregate limit of $5 million, there can be no assurance that such insurance will provide adequate coverage against potential liabilities or that adequate product liability insurance will continue to be available in the future or that it can be maintained on acceptable terms. LIMITATION ON THE USE OF NET OPERATING LOSSES AND RESEARCH AND DEVELOPMENT TAX CREDITS As of December 31, 1996, LifeCell had accumulated net operating loss ("NOL") carryforwards for federal income tax purposes of approximately $26 million and research and development tax credits of approximately $385,000 since its inception, and may continue to incur NOL carryforwards. United States tax laws provide for an annual limitation on the use of NOL carryforwards following certain ownership changes and also limit the time during which NOL and tax credit carryforwards may be applied against future taxable income and tax liabilities. Accordingly, LifeCell may not be able to take full advantage of its NOL carryforwards and tax credits for federal income tax purposes. DISPOSAL OF HAZARDOUS MATERIALS LifeCell's research and development and processing techniques generate waste that is classified as hazardous by the United States Environmental Protection Agency and the Texas Natural Resources Commission. LifeCell segregates such waste and disposes of it through a licensed hazardous waste transporter. Although LifeCell believes it is currently in compliance in all material respects with applicable environmental regulations, its failure to comply fully with any such regulations could result in the imposition of penalties, fines or sanctions that could have an adverse effect on LifeCell's business. ITEM 2. PROPERTIES LifeCell leases approximately 20,000 square feet of laboratory, office and warehouse space at its facilities in The Woodlands, Texas, under lease agreements that expire in January 2001. The Company's monthly rental obligation for its facilities is approximately $18,000. ITEM 3. LEGAL PROCEEDINGS None. 21 ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS None. PART II ITEM 5. MARKET FOR THE REGISTRANT'S COMMON EQUITY AND RELATED STOCKHOLDER MATTERS MARKET FOR THE COMMON STOCK The Company's Common Stock is listed on the Nasdaq SmallCap Market under the symbol "LIFC". The table below sets forth the high and low sales prices of the Common Stock for each quarter of 1995 and 1996, as reported by The Nasdaq Stock Market. The quotations reflect inter-dealer prices, without retail mark-down or commission, and may not represent actual transactions. 1995 1996 Price Range Price Range ----------------- ------------------ High Low High Low ----------------- ------------------ First Quarter $4 $1 5/8 $6 $2 1/4 Second Quarter 5 1/2 2 1/8 5 3 3/4 Third Quarter 4 3/4 3 3/8 5 7/8 3 5/8 Fourth Quarter 4 2 4 1/4 2 7/8 As of March 26, 1997, the last sales price per share of LifeCell's Common Stock, as reported by The Nasdaq Stock Market, was $7.00. At March 26, 1997, the Company's 6,754,761 shares of Common Stock outstanding were held by approximately 250 stockholders of record and the Company estimates that there are in excess of 1,500 beneficial owners. At March 26, 1977, the Company's 125,583 shares of Series B Preferred Stock outstanding were held by 52 stockholders of record. DIVIDEND POLICY LifeCell has not paid a cash dividend to its holders of Common Stock and does not anticipate paying cash dividends to the holders of its Common Stock in the foreseeable future. Pursuant to the terms of the Company's Series A Preferred Stock, on December 6, 1996, the Company paid a per share dividend of $1.60 in shares of Common Stock to the holders of the Series A Preferred Stock, on March 26, 1997, the Company paid a per share dividend of $.50 in shares of its Common Stock to such security holders, and on March 26, 1997, the Company paid a per share dividend of $.25 in cash to such security holders. Also on March 26, 1997, in accordance with the terms of the Series A Preferred Stock, the Company redeemed all of the outstanding shares of the Series A Preferred Stock through the conversion of such shares into shares of Common Stock. Accordingly, no further dividends are payable in respect of the Series A Preferred Stock. On February 15, 1997, the Company paid a per share dividend of $1.17 in shares of Series B Preferred Stock to the holders of Series B Preferred Stock. The Series B Preferred Stock bears dividends at the annual rate of (i) $6.00 (subject to adjustment in certain events) and (ii) the per annum rate of dividends per share paid, if applicable, by the Company, on the Common Stock. The dividends may be paid, at the Company's option, in cash or shares of Series B Preferred Stock or in a combination of cash and shares of Series B Preferred Stock. 22 The dividends will accrue and be paid quarterly. Under the General Corporation Law of the State of Delaware, a corporation's board of directors may declare and pay dividends only out of surplus or current net profits. RECENT SALES OF UNREGISTERED SECURITIES During November 1996, the Company completed a private placement of 124,157 shares of its Series B Preferred Stock and stock purchase warrants to purchase an aggregate of 2,803,530 shares of Common Stock for a total purchase price of $12,415,700. The Series B Preferred Stock and warrants were sold to accredited investors. Each share of Series B Preferred Stock is convertible at any time into approximately 32.26 shares of Common Stock, subject to adjustment in certain events. The placement agent for the private placement received a stock purchase warrant to purchase an aggregate of 354,734 shares of Common Stock. From January 1, 1996 through September 13, 1996, the Company issued a total of 5,000 shares of Common Stock for an aggregate consideration of $14,375 to a director of the Company pursuant to the exercise of options granted under the Company's non-employee director stock option plan. Also in 1996, the Company issued a total of 247,000 shares of Common Stock for an aggregate consideration of $765,700 to certain holders of the Company's Series A Preferred Stock pursuant to the exercise of certain stock purchase warrants. The Company considers the above-described securities to have been offered and sold in transactions not involving a public offering and, therefore, to be exempted from registration under Section 4(2) or Regulation D of the Securities Act of 1933, as amended. 23 ITEM 6. SELECTED FINANCIAL DATA The following table sets forth certain selected financial data of LifeCell for each of the years in the five-year period ended December 31, 1996, derived from the Company's audited financial statements. This information should be read in conjunction with "Management's Discussion and Analysis of Financial Condition and Results of Operations" and the Financial Statements and notes thereto included elsewhere in this Annual Report on Form 10-K.
Year Ended December 31, 1992 1993 1994 1995 1996 --------- --------- -------- --------- ----------- OPERATIONS STATEMENT DATA: Revenues: Product sales ............................. -- 20,737 93,940 742,238 2,012,205 Corporate alliance ........................ $ -- $ -- $ 358,331 $ 825,221 $ 546,461 Grants and contracts ...................... 239,102 377,057 364,334 239,116 386,904 --------- --------- -------- --------- ----------- Total revenues ......................... 239,102 397,794 816,615 1,806,575 2,945,570 --------- --------- -------- --------- ----------- Costs and expenses: Cost of goods sold ........................ -- 207,398 515,500 925,174 1,281,353 Funded research and development ............................... 239,102 377,057 722,675 1,064,337 933,365 Proprietary research and development ............................... 1,354,941 1,718,799 1,363,176 1,105,427 654,821 General and administrative ................ 1,165,662 1,479,327 1,381,470 1,422,588 1,911,254 Selling and marketing ..................... 205,108 268,618 727,615 1,475,296 2,389,573 --------- --------- --------- --------- ----------- Total costs and expenses ............... 2,964,813 4,051,199 4,710,436 5,992,822 7,170,366 --------- --------- --------- --------- ----------- Loss from operations ......................... (2,725,711) (3,653,405) (3,893,821) (4,186,247) (4,224,796) --------- --------- --------- --------- ----------- Interest income and other ................. 161,443 223,973 167,300 280,843 135,082 --------- --------- --------- --------- ----------- Net loss ..................................... $(2,564,268) (3,429,472) (3,726,521) (3,905,404) (4,089,714) --------- --------- --------- --------- ----------- Loss per share(1) ............................ (0.70) (0.80) (0.90) (1.10) (1.14) --------- --------- --------- --------- ----------- Shares used in computing loss per share ........................................ 3,643,333 4,277,171 4,294,179 4,313,366 4,542,519 --------- --------- --------- --------- -----------
At December 31, 1992 1993 1994 1995 1996 --------- --------- -------- --------- ----------- BALANCE SHEET DATA: Cash and cash equivalents ........... $ 3,938,598 $ 426,104 $ 1,877,295 $ 3,015,332 $ 10,748,250 Short-term investments .............. 2,589,493 3,016,511 5,154,824 -- -- Working capital (deficit) ........... 6,770,195 3,433,008 6,613,304 2,888,048 10,884,779 Total assets ........................ 7,413,401 4,260,079 7,997,404 4,376,039 12,890,015 Long-term obligations ............... -- -- 1,500,000 1,500,000 1,500,000 Accumulated deficit ................. (13,189,203) (16,618,635) (20,678,402) (24,774,753) (29,310,934) Total stockholders' equity .......... 7,152,253 4,045,661 5,743,127 2,093,906 10,197,104
(1) Includes effect of accounting treatment of preferred stock of $0.03, $0.19 and $0.24 in 1994, 1995 and 1996, respectively. 24 ITEM 7. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS THE FOLLOWING DISCUSSION AND ANALYSIS SHOULD BE READ IN CONJUNCTION WITH THE FINANCIAL STATEMENTS AND RELATED NOTES CONTAINED ELSEWHERE IN THIS ANNUAL REPORT ON FORM 10-K. GENERAL AND BACKGROUND LifeCell was organized in 1986 and since inception has been financed through the public and private sale of equity securities to individuals, venture capital firms and corporations, product sales, its corporate alliance with Medtronic and the receipt of government grants and contracts. In December 1993, LifeCell began commercial distribution of AlloDerm human dermal grafts. The initial AlloDerm product was used as a dermal replacement in the grafting of third-degree burns. LifeCell commenced commercial sales of AlloDerm for periodontal surgery in September 1995 and for plastic and reconstructive surgery uses in June 1995. The Company reported total product sales of approximately $94,000, $742,000 and $2,012,000 in 1994, 1995 and 1996, respectively. In 1994, LifeCell entered into an agreement with Medtronic pursuant to which Medtronic agreed (subject to certain rights to terminate at Medtronic's discretion) to fund the development of LifeCell's proprietary tissue processing technology in the field of heart valves. Additionally, LifeCell's research and development of blood cell products has been substantially funded through government grants and contracts. RESULTS OF OPERATIONS YEARS ENDED DECEMBER 31, 1996 AND 1995 Total revenues for 1996 were approximately $2.9 million compared to approximately $1.8 million for 1995. As a result of increased marketing activities, expansion of distribution channels and expanded uses of the Company's AlloDerm product, product sales for the year increased $1.3 million from 1995. Corporate alliance revenue decreased from $825,000 in 1995 to $546,000 in 1996 as a result of certain non-recurring revenue received by LifeCell in the first quarter of 1995 under the Medtronic agreement and the timing of planned activities performed by LifeCell related to the progress of the project. The corporate alliance revenue is recorded based on the costs of the work performed under the agreement. During 1996, the Company recognized $387,000 in revenue from its government grants and contracts, or an increase of $148,000 over 1995, as a result of additional governmental awards received during 1996 for the Company's ThromboSol and keratinocyte development programs. Total costs and expenses for 1996 were $7.2 million, an increase of $1.2 million compared to the same period of the prior year principally as a result of expanded sales and marketing activities for the Company's products and costs related to such expanded activities. Cost of goods sold for 1996 were $1.3 million compared to $925,000 in the same period of 1995. This increase was due to an increase in product sales and the shift from the development of AlloDerm to processing, consistent with taking a product to market. The cost of funded research and development declined from $1.1 million in 1995 to $933,000 in 1996 as a result of the timing of planned activities as well as the funding available, as such costs are reimbursed by others. Proprietary research and development expense decreased to $655,000 for the 1996 from $1.1 million in 1995 primarily due to the shift in the Company's focus from the development of AlloDerm to processing. General and administrative expense increased to $1.9 million for the year ended December 31, 1996 from $1.4 million in the same period of 1995 principally as a result of expanded administrative activities as the Company increased its product sales and marketing activities as well as certain administrative expenses recognized in conjunction with its 1996 financing activities and non-cash charges related to the reissuance of certain stock options. Selling and marketing expenses increased to $2.4 million for 1996 from $1.5 million in 1995 primarily due to the addition of sales personnel and promotional activities related to AlloDerm marketing and expanded distribution activities. Interest income and other decreased by $146,000 from 1995 to 1996 as a result of the decrease in funds available for investment prior to the receipt of funds from an equity financing in late 1996, as well as lower interest rates in 1996. 25 YEARS ENDED DECEMBER 31, 1995 AND 1994 Total revenues for 1995 were $1.8 million compared to approximately $817,000 for 1994. This increase was primarily due to increased product sales and increased activities in the corporate alliance with Medtronic. Product sales increased to $742,000 in 1995 from $94,000 in 1994, due to greater market acceptance and additional sales efforts. The corporate alliance revenues increased to $825,000 in 1995 from $358,000 in 1994 due to a full year of activity in 1995 and increased heart valve development activities. In 1995, revenues included amounts recorded from one Small Business Innovative Research ("SBIR") contract of approximately $239,000, compared to $364,000 from two SBIR contracts in 1994. During 1995, research and development contracts and grants revenue consisted of $239,000 pursuant to the second year of a 1993 award of a Phase II $740,000 SBIR contract from the United States Army for the prolonged storage of platelets. Interest income increased to $281,000 in 1995 from $167,000 in 1994 due to an increase in average funds available for investment in 1995 as compared to 1994. Cost of goods sold for product sales increased $409,000 while revenues increased $648,000 during 1995 as compared to 1994. During 1994, the "start up" phase of manufacturing was still underway and the Company had excess capacity. This resulted in higher amounts of unabsorbed overhead costs in 1994 than in 1995. Proprietary research and development expense decreased to $1.1 million in 1995 from $1.4 million in 1994 primarily as a result of the transfer of AlloDerm related activities from proprietary research and development to processing (cost of goods sold). These costs previously were recorded in research and development expense. General and administrative expenses remained relatively consistent with the prior year. Selling and marketing expenses increased to $1.5 million in 1995 from $728,000 in 1994 primarily due to the addition of sales personnel, increased promotional activities related to AlloDerm marketing activities and commercial introduction of the AlloDerm graft in the periodontal surgery market. LIQUIDITY AND CAPITAL RESOURCES Since its inception, LifeCell's principal sources of funds have been equity offerings, product sales, the Medtronic corporate alliance, government grants and contracts and interest on investments. LifeCell primarily funds research and development activities for products other than AlloDerm with external funds from its corporate alliance and government grants. In April 1996, LifeCell was awarded a one-year $613,000 contract from the U.S. Navy related to the development of ThromboSol. In August 1996, LifeCell was awarded a two-year $300,000 National Science Foundation Phase II grant related to its keratinocytes program. In December 1996, LifeCell was awarded a two-year contract from the U.S. Army to support the development of vascular graft products. In 1994, LifeCell entered into agreements with Medtronic pursuant to which Medtronic paid LifeCell a license fee of $1.5 million and agreed, subject to certain rights to terminate at Medtronic's discretion, to fund the development of LifeCell's proprietary tissue processing technology in the field of heart valves. Through December 31, 1996, LifeCell has recognized approximately $1.7 million in revenues for development funding, excluding the initial license fee, for this program. In January 1996, LifeCell borrowed $120,000 from a bank for working capital purposes. The loan was secured by cash, required monthly payments of $2,000, plus interest, matured December 31, 1996, and bore interest at a rate equal to 6.05% per annum. In August 1996, LifeCell borrowed $250,000 from the same bank for working capital purposes. This loan was secured by accounts and other receivables, matured in December 1996, and bore interest at a rate equal to prime plus .25% per annum. The notes were paid in full November 1996. In November 1996, LifeCell received net proceeds of approximately $10.9 million pursuant to the private sale of shares of Series B Preferred Stock and warrants exercisable for the purchase of Common Stock. In June 1996, LifeCell engaged DENTSPLY to distribute AlloDerm grafts for periodontal surgery on a worldwide basis. In March 1997, however, DENTSPLY advised LifeCell that it intends to discontinue operations of the division with responsibility for distributing AlloDerm. Accordingly, LifeCell expects that it will terminate the 26 agreement with DENTSPLY and in the near future will resume marketing AlloDerm for periodontal applications through its direct sales force. While the Company anticipates that the termination of the DENTSPLY agreement may have some impact on revenues attributable to sales of AlloDerm for periodontal applications during this transition, LifeCell believes that it will not materially affect the Company's overall revenues attributable to AlloDerm sales. LifeCell expects to incur substantial expenses for AlloDerm marketing and the Company's product development programs (including costs of clinical studies), production, sales and marketing, product introduction, technical seminars, support of ongoing administrative activities and research and development activities, such as regulatory and quality assurance programs and continuing applications for patent protection for the proprietary aspects of its technology. The Company currently intends to fund these activities from its existing cash resources, sales of products, and research and development funding received from others. There can be no assurance that such sources of funds will be sufficient to meet these future expenses. The Company's need for additional financing will be principally dependent on the degree of market acceptance achieved by the Company's products and the extent to which the Company can achieve substantial growth in product sales during 1997 and 1998 as well as the extent to which the Company may decide or may be required to use its own resources, in addition to external funding, to expand its product development efforts. There can be no assurance that the Company will be able to obtain any such additional financing on acceptable terms. LifeCell has had losses since inception and therefore has not been subject to federal income taxes. As of December 31, 1996, LifeCell had NOL and research and development tax credit carryforwards for income tax purposes of approximately $26 million and $385,000, respectively, available to reduce future income tax and tax liabilities. Federal tax laws provide for a limitation on the use of NOL and tax credit carryforwards following certain ownership changes that could limit LifeCell's ability to use its NOL and tax credit carryforwards. A recapitalization effected by LifeCell in 1992, the issuance of additional capital stock pursuant to its initial public offering in 1992 and its sales of equity securities in 1994 and 1996 may cause a "more than 50 percent change in ownership" as defined in the applicable tax laws. Accordingly, LifeCell's ability to use its NOL and tax credit carryforwards to reduce future taxable income may be restricted. ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA The financial statements and supplementary financial information required to be filed under this Item are presented commencing on page F-1 of this Annual Report on Form 10-K, and are incorporated herein by reference. ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE None. PART III ITEM 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT The information required by this Item will be set forth in the Registrant's Proxy Statement relating to the annual meeting of the Registrant's stockholders scheduled to be held June 19, 1997, under the captions "Election of Directors" and "Executive Compensation", and such information is incorporated herein by reference. 27 ITEM 11. EXECUTIVE COMPENSATION The information required by this Item will be set forth in the Registrant's Proxy Statement relating to the annual meeting of the Registrant's stockholders scheduled to be held June 19, 1997, under the caption "Executive Compensation", and such information is incorporated herein by reference. ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT The information required by this Item will be set forth in the Registrant's Proxy Statement relating to the annual meeting of the Registrant's stockholders scheduled to be held June 19, 1997, under the caption "Security Ownership of Certain Beneficial Owners and Management", and such information is incorporated herein by reference. ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS The information required by this Item will be set forth in the Registrant's Proxy Statement relating to the annual meeting of the Registrant's stockholders scheduled to be held June 19, 1997, under the caption "Executive Compensation", and such information is incorporated herein by reference. PART IV ITEM 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON FORM 8-K (A) DOCUMENTS INCLUDED IN THIS REPORT: 1. FINANCIAL STATEMENTS PAGE ---- Report of Independent Public Accountants........................... F-2 Balance Sheets as of December 31, 1995 and 1996.................... F-3 Statements of Operations for the years ended December 31, 1994, 1995 and 1996................................... F-4 Statements of Stockholders' Equity for the years ended December 31, 1995 and 1996............................. F-5 Statements of Cash Flows for the years ended December 31, 1994, 1995 and 1996................................... F-6 Notes to Financial Statements...................................... F-7 (B) REPORTS ON FORM 8-K: During the quarter ended December 31, 1996, the Company filed (i) on November 27, 1996, a Current Report on Form 8-K dated as of November 18, 1996, to report the private placement of equity securities of the Company; and (ii) on December 31, 1996, a Current Report on Form 8-K dated as of December 27, 1996, at the request of The Nasdaq Stock Market. The latter report included the Company's balance sheet as of November 30, 1996, and was filed to evidence the Company's compliance with The Nasdaq Stock Market's continuing listing requirements for SmallCap issuers (C) EXHIBITS: Exhibits designated by the symbol * are filed with this Annual Report on Form 10-K. All exhibits not so designated are incorporated by reference to a prior filing as indicated. Exhibits designated by the symbol + are management contracts or compensatory plans or arrangements that are required to be filed with this report pursuant to this Item 14. 28 EXHIBIT NO. DESCRIPTION - ---------- ----------- LifeCell undertakes to furnish to any stockholder so requesting a copy of any of the following exhibits upon payment to the Company of the reasonable costs incurred by Company in furnishing any such exhibit. 3.1 Restated Certificate of Incorporation, as amended (incorporated by reference to Exhibit 4.1 to the Registrant's Current Report on Form 8-K dated November 18, 1996). 3.2 Amended and Restated By-laws (incorporated by reference to Exhibit 3.2 to the Registrant's Quarterly Report on Form 10-Q for the period ended June 30, 1996). 4.1* Form of Series B Preferred Stock Certificate. 4.2* See Exhibit 10.21 -- Voting Agreement dated November 18, 1996, among LifeCell Corporation and certain stockholders named therein. 10.1+ Employment Agreement and accompanying Confidentiality, Inventions and Discoveries and Non- Competition Agreement dated January 28, 1992, by and between the Registrant and Paul M. Frison (incorporated by reference to Exhibit 10.19 to Amendment No. 2 to the Registrant's Registration Statement on Form S-1, Registration No. 33-44969, filed with the Commission on February 10, 1992). 10.2+ Employment Agreement and accompanying Confidentiality, Inventions and Discoveries and Non- Competition Agreement dated January 28, 1992, by and between the Registrant and Stephen A. Livesey (incorporated by reference to Exhibit 10.20 to Amendment No. 2 to the Registrant's Registration Statement on Form S-1, Registration No. 33-44969, filed with the Commission on February 10, 1992). 10.3*+ LifeCell Corporation Second Amended and Restated 1992 Stock Option Plan, as amended. 10.4*+ LifeCell Corporation Second Amended and Restated 1993 Non-Employee Director Stock Option Plan, as amended. 10.5 Form of Confidentiality/Non-Compete Agreement (incorporated by reference to Exhibit 10.28 to the Registrant's Registration Statement on Form S-1, Registration No. 33-44969, filed with the Commission on January 9, 1992). 10.6 Exclusive License Agreement dated June 6, 1986, between the Registrant and The Board of Regents of The University of Texas System (incorporated by reference to Exhibit 10.29 to the Registrant's Registration Statement on Form S-1, Registration No. 33-44969, filed with the Commission on January 9, 1992). 10.7+ Amended and Restated Registration Rights Agreement dated February 26, 1992, by and between the Registration and the stockholders named therein (incorporated by reference to Exhibit 10.40 to Amendment No. 3 to the Registrant's Registration Statement on Form S-1, Registration No. 33- 44969, filed with the Commission on February 27, 1992). 10.8 Underwriter's Warrant Agreement dated March 6, 1992, between the Registrant and Robert Todd Financial Corporation, and First Amendment to Underwriter's Warrant Agreement dated January 26, 1993, between the Registrant and Robert Todd Financial Corporation (incorporated by reference to Exhibit 10.18 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1992). 29 EXHIBIT NO. DESCRIPTION - ---------- ----------- 10.9 Lease Agreement dated December 10, 1986, between the Registrant and The Woodlands Corporation, Modification and Ratification of Lease Agreement dated April 11, 1988, between the Registration and The Woodlands Corporation Modification and Ratification of Lease dated August 1, 1992, between the Company and The Woodlands Corporation and Modification, Extension and Ratification of Lease dated March 5, 1993, between the Registrant and The Woodlands Corporation, and Modification and Ratification of Lease Agreement dated December 21, 1995, between the Company and The Woodlands Office Equities--'95 Limited (incorporated by reference to Exhibit 10.1 to the Registrant's Quarterly Report on Form 10-Q for the period ended March 31, 1996). 10.10 Lease Agreement dated September 1, 1988, between the Registrant and The Woodlands Corporation, and Modification of Lease Agreement dated March 5, 1993, between the Registrant and The Woodlands Corporation (incorporated by reference to Exhibit 10.22 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1992). 10.11 Stock Purchase Warrant dated January 26, 1993, issued to Strategem of Alabama, Inc. (incorporated by reference to Exhibit 10.25 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 1992). 10.12 License and Development Agreement dated March 3, 1994, between the Registrant and Medtronic, Inc. (incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K dated March 3, 1994). 10.13 Investment Agreement dated March 3, 1994, between the Registrant and Medtronic, Inc. (incorporated by reference to Exhibit 10.2 to Registrant's Current Report on Form 8-K dated March 3, 1994). 10.14 Lease Agreement between LifeCell Corporation and Unichem, dated August 1, 1994 (incorporated by reference to Exhibit 10.3 to the Registrant's Quarterly Report on Form 10-Q for the period ended September 30, 1994). 10.15* Securities Purchase Agreement dated November 18, 1996, between LifeCell Corporation and the Investors named therein. 10.16* Voting Agreement dated November 18, 1996, among LifeCell Corporation and certain stockholders named therein. 10.17* Registration Rights Agreement dated November 18, 1996, between LifeCell Corporation and certain stockholders named therein. 10.18* Form of Stock Purchase Warrant dated November 18, 1996, issued to each of the warrant holders named on Schedule 10.19 attached thereto. 10.19* Stock Purchase Warrant dated November 18, 1996, issued to Gruntal & Co., Incorporated. 11.1* Statement Regarding Computation of Per Share Earnings. 23.1* Consent of Arthur Andersen LLP. 27.1* Financial Data Schedule. 30 GLOSSARY THE FOLLOWING GLOSSARY IS INTENDED TO PROVIDE THE READER WITH AN EXPLANATION OF CERTAIN TECHNICAL TERMS USED IN CERTAIN SECTIONS OF THIS ANNUAL REPORT ON FORM 10-K: ALLOGRAFT......................... Graft derived from one individual and transplanted to another of the same species (E.G., human to human). ANCHORING FIBRIL.................. A specialized collagen thread that attaches to both epidermal cells of skin and to the dermal basement membrane complex, bonding them together. ASEPTIC PROCESSING................ Processing in a sterile work environment using special procedures to keep the tissue free from exposure to infectious material. AUTOGRAFT......................... Graft derived from one part of an individual's body and transplanted to another location in the same individual. BASEMENT MEMBRANE COMPLEX.......................... A highly specialized surface structure of dermis that separates and anchors a layer of epithelial cells to the underlying dermis. CALCIFICATION..................... Abnormal deposition of calcium salts within a tissue, leading to hardening. CELL CULTURE...................... The maintenance and growth of living cells outside of the body, typically in glass or plastic containers containing nutrients and other supportive substances. CHEILOPLASTY...................... Surgical lip augmentation. CLINICAL TRIAL.................... An evaluation or experiment to test safety and therapeutic value of a device or substance in humans. COLLAGEN.......................... A specialized group of proteins which form fibers and comprise the structural support for numerous tissues of the body (including dermis, blood vessels, heart valves, ligaments, and tendons). CONTRACTURE RELEASE............... A surgical procedure to remove scar tissue that is preventing free movement of muscles, tendons or joints. CORONARY BYPASS................... A surgically established shunt of blood flow from the aorta (main artery) to the blood vessels of the heart (coronary arteries), bypassing an obstruction in the coronary artery. CRYOPRESERVATION.................. The preservation of a biological cell or tissue by the use of freezing and low temperature storage. CRYOPROTECTION.................... The use of chemical substances that reduce ice crystal damage associated with freezing. DERMIS............................ The inner layer of skin, composed of extracellular protein matrix, collagen and fibroblasts, which provides strength and durability. DIFFERENTIATION................... The developmental process whereby an immature primary cell divides and acquires properties required for its specialized function. ELA............................... Establishment License Application; filed with the FDA Center for Biologic Evaluation and Research to obtain approval to manufacture a biological product at a facility. ENDOTHELIAL CELLS................. Thin flattened cells that line body cavities, including the inside surface of blood vessels. 31 EPIDERMIS......................... The outermost superficial layer of skin composed of epithelial cells (keratinocytes) and pigment cells, which overlies the dermis and is responsible for water barrier function and pigmentation. EPITHELIAL CELLS.................. Sheets of cells that cover exposed surfaces of the body (including skin) and serve especially to close and protect other parts of the body. EXTRACELLULAR MATRIX.............. A proteinaceous substance of lattice, secreted by cells, which forms connective tissue and serves as structural support for certain tissues or organs of the body. (See Dermis). FIBROBLAST........................ A cell that secretes collagen and other proteins involved in the formation of connective tissue. FREEZE-DRY........................ To dry a sample in a frozen state under high vacuum especially for preservation. FULL-THICKNESS WOUND.............. A skin injury that results in the loss of all skin components, including epidermis and dermis (E.G., third-degree burn). GLABELLAR CONTOURING.............. A surgical procedure to restore the smooth appearance of the forehead between the eyebrows by filling in the depression created by frown lines. GRAFT............................. To surgically bond tissues that are normally separate, or the tissue used in a grafting procedure. HEMORRHAGE........................ To undergo heavy or uncontrolled bleeding. HOMOLOGOUS CELLS.................. Cells from another person which, when transplanted, can be recognized by the body as foreign and thus provoke an immune response. IDE APPLICATION................... Investigational Device Exemption allows a company to conduct clinical studies with an investigational medical device. IMMUNE RESPONSE................... An inflammatory reaction of the body's immune cells to a transplanted tissue or organ, leading to its destruction. IMMUNOSUPPRESSIVE................. That which suppresses the body's natural immune response, preventing the destruction or rejection of a transplanted tissue or organ. IND............................... An Investigational New Drug application (IND) is usually the first step in the process of obtaining FDA approval to commercially distribute a new drug. Under an IND, a sponsor can use the drug with human subjects during and in connection with clinical investigations. The clinical trials generally consist of three Phases. Phase I, involves the study of a drug's safety in a small number of normal healthy volunteers. Phase II, involves the assessment of a drug's effectiveness (efficacy) in a larger group of volunteer patients with the condition for which the drug is directed. Phase III, involves close monitoring of a larger number of patients with the condition for which the drug is directed in order to ascertain the drug's effectiveness and to identify any adverse reactions. IN-VITRO.......................... A biological process conducted outside of the body, as in a laboratory flask. KERATINOCYTE...................... Primary epithelial cells of the skin which have the ability to differentiate to full-thickness when associated with a dermal basement membrane complex. 32 MOLECULAR DISTILLATION DRY......... To dry a sample containing unstable frozen water under conditions of vacuum and temperature such that ice crystallization and subsequent damage to the sample does not occur. NASAL SEPTAL DEFECT............... An imperfection of the membrane inside the nose that separates the nostrils. NDA............................... A New Drug Approval application is an application to the FDA for approval to market a drug. ORTHOPEDIC........................ Pertaining to the restoration of function following injury to, and the correction of deformities of, the skeletal system, its joints and associated structures. PERIPHERAL BYPASS................. An arterial bypass procedure in an area away from the heart, usually in a limb. PLA............................... A Product License Application (PLA) is an application to the FDA for approval to market a biological product. PMA............................... A Pre-market Approval Application (PMA) is an application to the FDA for approval to market a medical device for human therapeutic use. PORCINE........................... Derived from pigs. PRECLINICAL TRIALS................ Trials related to experimentation to test safety and therapeutic value of a device or product in living animals, prior to testing in humans. PREMARKET APPROVAL................ An approved premarket approval application (PMA) is required for new types of Class III medical devices prior to commercialization. REJECTION......................... Destruction of a transplanted tissue or organ by the host's immune cells. RHINOPLASTY....................... Plastic surgical operation on the nose. RHYTIDECTOMY...................... Removal of skin to eliminate wrinkles. SAPHENOUS VEIN.................... Either of the two chief superficial veins of the legs, commonly used for coronary bypass procedures. SPLIT-SKIN GRAFT.................. Skin containing both epidermis and dermis which is excised from healthy sites and transplanted to a full-thickness wound on some other area of the body. TAKE RATE......................... The percentage of the total graft area in which the graft has adhered and vascularized. THIRD-DEGREE BURN................. Full-thickness injury of the skin, with loss of both the epidermal and dermal components. VASCULAR CONDUIT.................. A tubular structure through which blood flows (i.e., blood vessel, artery or vein). VENOUS STASIS ULCERS.............. Skin ulcers resulting from the slowing or stoppage of normal blood flow because of deteriorating valves in the veins. XENOGRAFT......................... A tissue graft derived from one species and transplanted to a different species (e.g., animal to human). 510(K) (REVIEW)................... A process which enables a manufacturer to demonstrate to the FDA that a proposed product is "substantially equivalent" to another product that was in commercial distribution in the United States before May 28, 1976, or has subsequently been cleared 33 INDEX TO FINANCIAL STATEMENTS Page ---- AUDITED FINANCIAL STATEMENTS Report of Independent Public Accountants ................................. F-2 Balance Sheets as of December 31, 1995 and 1996 .......................... F-3 Statements of Operations for the years ended December 31, 1994, 1995 and 1996 ................................... F-4 Statements of Stockholders' Equity for the years ended December 31, 1994, 1995 and 1996 ............................. F-5 Statements of Cash Flows for the years ended December 31, 1994, 1995 and 1996 ................................... F-6 Notes to Financial Statements ............................................ F-7 F-1 REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS To LifeCell Corporation: We have audited the accompanying balance sheets of LifeCell Corporation (a Delaware corporation) as of December 31, 1995 and 1996, and the related statements of operations, stockholders' equity and cash flows for each of the three years in the period ended December 31, 1996. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits in accordance with generally accepted auditing standards. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion. In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of LifeCell Corporation as of December 31, 1995 and 1996, and the results of its operations and its cash flows for each of the three years in the period ended December 31, 1996, in conformity with generally accepted accounting principles. ARTHUR ANDERSEN LLP Houston, Texas March 26, 1997 F-2 LIFECELL CORPORATION BALANCE SHEETS
December 31, ------------------------------------ 1995 1996 ------------ ------------ A S S E T S CURRENT ASSETS Cash and cash equivalents .......................................... $ 3,015,332 $ 10,748,250 Accounts and other receivables ..................................... 251,509 436,839 Inventories ........................................................ 351,502 839,821 Prepayments and other .............................................. 51,838 52,780 ------------ ------------ Total current assets .......................................... 3,670,181 12,077,690 FURNITURE AND EQUIPMENT, net ........................................... 415,563 478,098 INTANGIBLE ASSETS, net ................................................. 290,295 334,227 ------------ ------------ Total assets .................................................. $ 4,376,039 $ 12,890,015 ============ ============ LIABILITIES AND STOCKHOLDERS' EQUITY CURRENT LIABILITIES Accounts payable ................................................... $ 384,780 $ 514,848 Accrued liabilities ................................................ 218,351 539,271 Deferred revenues .................................................. 179,002 138,792 ------------ ------------ Total current liabilities ..................................... 782,133 1,192,911 DEFERRED CREDIT ......................................................... 1,500,000 1,500,000 COMMITMENTS AND CONTINGENCIES STOCKHOLDERS' EQUITY Series A preferred stock, $.001 par value, 300,000 shares authorized, 264,500 and 260,000 issued and outstanding including accrued dividends of $70,533 and $86,667 .................... 5,496,793 5,291,473 Series B preferred stock, $.001 par value, 182,205 shares authorized, none and 124,157 issued and outstanding and accrued dividends of none and 1,426 shares......................... -- 126 Undesignated preferred stock, $.001 par value, 1,517,795 shares authorized, none issued and outstanding .......................... -- -- Common stock, $.001 par value, 12,500,000 and 25,000,000 shares authorized, respectively, 4,403,658 and 4,899,944 shares issued and outstanding, respectively ................. 4,404 4,900 Warrants outstanding to purchase 574,066 and 3,378,264 shares of Common Stock, respectively .................................. 226,560 423,218 Additional paid in capital .............................................. 21,160,808 33,788,321 Unearned portion of restricted stock compensation & warrants ............ (19,906) -- Accumulated deficit ..................................................... (24,774,753) (29,310,934) ------------ ------------ Total stockholders' equity ......................................... 2,093,906 10,197,104 ------------ ------------ Total liabilities and stockholders' equity ......................... $ 4,376,039 $ 12,890,015 ============ ============
The accompanying notes are an integral part of these financial statements. F-3 LIFECELL CORPORATION STATEMENTS OF OPERATIONS
For the Year Ended December 31, ------------------------------------------------------- 1994 1995 1996 ----------- ----------- ----------- REVENUES Product sales ............................... $ 93,940 $ 742,238 $ 2,012,205 Corporate alliance .......................... 358,331 825,221 546,461 Grants and contracts ........................ 364,344 239,116 386,904 ----------- ----------- ----------- Total revenues ......................... 816,615 1,806,575 2,945,570 ----------- ----------- ----------- COSTS AND EXPENSES Cost of goods sold .......................... 515,500 925,174 1,281,353 Funded research and development ............. 722,675 1,064,337 933,365 Proprietary research and development ........ 1,363,176 1,105,427 654,821 General and administrative .................. 1,381,470 1,422,588 1,911,254 Selling and marketing ....................... 727,615 1,475,296 2,389,573 ----------- ----------- ----------- Total costs and expenses ............... 4,710,436 5,992,822 7,170,366 ----------- ----------- ----------- LOSS FROM OPERATIONS ............................. (3,893,821) (4,186,247) (4,224,796) ----------- ----------- ----------- Interest income ............................. 167,300 280,843 135,082 ----------- ----------- ----------- NET LOSS ......................................... $(3,726,521) $(3,905,404) $(4,089,714) =========== =========== =========== Loss per share before effect of preferred dividends, accretion of preferred stock and warrant exercises ....................... $ (0.87) $ (0.91) $ (0.90) Effect of preferred dividends, accretion of preferred stock and warrant exercises ....... $ (0.03) $ (0.19) $ (0.24) ----------- ----------- ----------- LOSS PER SHARE ................................... $ (0.90) $ (1.10) $ (1.14) =========== =========== =========== SHARES USED IN COMPUTING LOSS PER SHARE .......... 4,294,179 4,313,366 4,542,519 =========== =========== ===========
The accompanying notes are an integral part of these financial statements. F-4 LIFECELL CORPORATION STATEMENTS OF STOCKHOLDERS' EQUITY
Series A Series B Class I Preferred Stock Preferred Stock Common Stock Common Stock ----------------------- -------------- ------------------ -------------------- Shares Amount Shares Amount Shares Amount Shares Amount -------- ----------- ------- ---- --------- ------ ---------- ------- Balance at December 31, 1993 .................. -- $ -- -- $-- 1,473,359 $1,473 2,803,812 $ 2,804 Class I common converted to common ............ -- -- -- -- 2,803,812 2,804 (2,803,812) (2,804) Purchase of common stock ...................... -- -- -- -- -- -- -- -- Issuance for cash ($7.77 per share) ........... -- -- -- -- 20,421 21 -- -- Issuance of Series A preferred stock and warrants for cash ........................ 264,500 4,877,995 -- -- -- -- -- -- Warrant issued to purchase common stock ....... -- -- -- -- -- -- -- -- Earned portion of restricted stock compensation -- -- -- -- -- -- -- -- Earned portion of warrants .................... -- -- -- -- -- -- -- -- Dividends accrued on preferred stock .......... -- 333,246 -- -- -- -- -- -- Accretion of preferred stock .................. -- 68,668 -- -- -- -- -- -- Expiration of warrants ........................ -- -- -- -- -- -- -- -- Net Loss ...................................... -- -- -- -- -- -- -- -- -------- ----------- ------- ---- --------- ------ ---------- ------- Balance at December 31, 1994 .................. 264,500 $ 5,279,909 -- $-- 4,297,592 $4,298 -- $ -- Warrant issued to purchase common stock ....... -- -- -- -- -- -- -- -- Stock options exercised ....................... -- -- -- -- 1,000 1 -- -- Warrants exercised ............................ -- -- -- -- 1,250 1 -- -- Issuance of common stock as dividends on Series A Preferred stock ................. -- (317,400) -- -- 103,816 104 -- -- Earned portion of restricted stock compensation -- -- -- -- -- -- -- -- Earned portion of warrants .................... -- -- -- -- -- -- -- -- Dividends accrued on preferred stock .......... -- 190,947 -- -- -- -- -- -- Accretion of preferred stock .................. -- 343,337 -- -- -- -- -- -- Net Loss ...................................... -- -- -- -- -- -- -- -- -------- ----------- ------- ---- --------- ------ ---------- ------- Balance at December 31, 1995 .................. 264,500 $ 5,496,793 -- $-- 4,403,658 $4,404 -- $ -- Stock options exercised ....................... -- -- -- -- 6,062 6 -- -- Warrants exercised ............................ -- -- -- -- 339,066 339 -- -- Expiration of warrants ........................ -- -- -- -- -- -- -- -- Conversion of preferred stock ................. (4,500) (90,000) -- -- 30,104 30 -- -- Issuance of common stock as dividends on Series A Preferred stock ................. -- (415,920) -- -- 121,054 121 -- -- Earned portion of restricted stock compensation -- -- -- -- -- -- -- -- Issuance of stock options for services ........ -- -- -- -- -- -- -- -- Issuance of Series B preferred stock and common stock warrants for cash .............. -- -- 124,157 124 -- -- -- -- Dividends accrued on preferred stock .......... -- 300,600 -- 2 -- -- -- -- Net Loss ...................................... -- -- -- -- -- -- -- -- -------- ----------- ------- ---- --------- ------ ---------- ------- Balance at December 31, 1996 .................. 260,000 $ 5,291,473 124,157 $126 4,899,944 $4,900 -- $ -- ======== =========== ======= ==== ========= ====== ========== =======
Warrants Unearned to Purchase Portion of Common Stock Restricted Stock Additional ------------------------- Compensation Paid In Shares Amount and Warrants Capital ---------- ----------- --------- ------------ Balance at December 31, 1993 .................. 165,933 $ 116,260 $(529,942) $ 21,073,701 Class I common converted to common ............ -- -- -- -- Purchase of common stock ...................... -- -- -- -- Issuance for cash ($7.77 per share) ........... -- -- -- 174,341 Issuance of Series A preferred stock and warrants for cash ........................ 264,500 105,800 -- -- Warrant issued to purchase common stock ....... 90,816 5,000 -- -- Earned portion of restricted stock compensation -- -- 238,872 -- Earned portion of warrants .................... -- -- 21,958 -- Dividends accrued on preferred stock .......... -- -- -- -- Accretion of preferred stock .................. -- -- -- (68,668) Expiration of warrants ........................ (5,933) -- -- -- Net Loss ...................................... -- -- -- -- ---------- ----------- --------- ------------ Balance at December 31, 1994 .................. 515,316 $ 227,060 $(269,112) $ 21,179,374 Warrant issued to purchase common stock ....... 60,000 -- -- -- Stock options exercised ....................... -- -- -- 2,999 Warrants exercised ............................ (1,250) (500) -- 4,574 Issuance of common stock as dividends on Series A Preferred stock ................. -- -- -- 317,198 Earned portion of restricted stock compensation -- -- 238,872 -- Earned portion of warrants .................... -- -- 10,334 -- Dividends accrued on preferred stock .......... -- -- -- -- Accretion of preferred stock .................. -- -- -- (343,337) Net Loss ...................................... -- -- -- -- ---------- ----------- --------- ------------ Balance at December 31, 1995 .................. 574,066 $ 226,560 $ (19,906) $ 21,160,808 Stock options exercised ....................... -- -- -- 17,274 Warrants exercised ............................ (339,066) (104,300) -- 1,155,617 Expiration of warrants ........................ (15,000) (6,000) -- 6,000 Conversion of preferred stock ................. -- -- -- 89,970 Issuance of common stock as dividends on Series A Preferred stock ................. -- -- -- 409,700 Earned portion of restricted stock compensation -- -- 19,906 -- Issuance of stock options for services......... -- -- -- 150,000 Issuance of Series B preferred stock and common stock warrants for cash .............. 3,158,264 306,958 -- 10,653,087 Dividends accrued on preferred stock .......... -- -- -- 145,865 Net Loss ...................................... -- -- -- -- ---------- ----------- --------- ------------ Balance at December 31, 1996 .................. 3,378,264 $ 423,218 $ -- $ 33,788,321 ========== =========== ========= ============
Total Treasury Accumulated Stockholders' Stock Deficit Equity --------- ------------ ------------ Balance at December 31, 1993 .................. $ -- $(16,618,635) $ 4,045,661 Class I common converted to common ............ -- -- -- Purchase of common stock ...................... (307,755) -- (307,755) Issuance for cash ($7.77 per share) ........... 307,755 -- 482,117 Issuance of Series A preferred stock and warrants for cash ........................ -- -- 4,983,795 Warrant issued to purchase common stock ....... -- -- 5,000 Earned portion of restricted stock compensation -- -- 238,872 Earned portion of warrants .................... -- -- 21,958 Dividends accrued on preferred stock .......... -- (333,246) -- Accretion of preferred stock .................. -- -- -- Expiration of warrants ........................ -- -- -- Net Loss ...................................... -- (3,726,521) (3,726,521) --------- ------------ ------------ Balance at December 31, 1994 .................. $ -- $(20,678,402) $ 5,743,127 Warrant issued to purchase common stock ....... -- -- -- Stock options exercised ....................... -- -- 3,000 Warrants exercised ............................ -- -- 4,075 Issuance of common stock as dividends on Series A Preferred stock ................. -- -- (98) Earned portion of restricted stock compensation -- -- 238,872 Earned portion of warrants .................... -- -- 10,334 Dividends accrued on preferred stock .......... -- (190,947) -- Accretion of preferred stock .................. -- -- -- Net Loss ...................................... -- (3,905,404) (3,905,404) --------- ------------ ------------ Balance at December 31, 1995 .................. $ -- $(24,774,753) $ 2,093,906 Stock options exercised ....................... -- -- 17,280 Warrants exercised ............................ -- -- 1,051,656 Expiration of warrants ........................ -- -- -- Conversion of preferred stock ................. -- -- -- Issuance of common stock as dividends on Series A Preferred stock ................. -- -- (6,099) Earned portion of restricted stock compensation -- -- 19,906 Issuance of stock options for services......... -- -- 150,000 Issuance of Series B preferred stock and common stock warrants for cash .............. -- -- 10,960,169 Dividends accrued on preferred stock .......... -- (446,467) -- Net Loss ...................................... -- (4,089,714) (4,089,714) --------- ------------ ------------ Balance at December 31, 1996 .................. $ -- $(29,310,934) $ 10,197,104 ========= ============ ============
The accompanying notes are an integral part of these financial statements. F-5 LIFECELL CORPORATION STATEMENTS OF CASH FLOWS
For the Year Ended December 31, 1994 1995 1996 ------------ ------------ ------------ CASH FLOWS FROM OPERATING ACTIVITIES Net Loss ....................................................... $ (3,726,521) $ (3,905,404) $ (4,089,714) Adjustments to reconcile net loss to net cash used in operating activities-- Depreciation and amortization ............................. 107,351 138,518 229,237 Stock and warrant compensation expense .................... 260,830 249,206 169,906 Change in assets and liabilities -- (Increase) in accounts and other receivables ................. (67,237) (87,014) (185,330) Increase in inventories ...................................... (54,834) (243,720) (488,319) (Increase) decrease in prepayment and other .................. (8,580) 11,347 (942) Increase in accounts payable and accrued liabilities ......... 270,219 118,494 450,988 Increase (decrease) in deferred revenues and credit .......... 1,769,640 (90,638) (40,210) ------------ ------------ ------------ Total adjustments .............................................. 2,277,389 96,193 135,330 ------------ ------------ ------------ Net cash used in operating activities ................ (1,449,132) (3,809,211) (3,954,384) ------------ ------------ ------------ CASH FLOWS FROM INVESTING ACTIVITIES Capital expenditures ........................................... (90,509) (190,199) (278,673) Intangible assets .............................................. (34,012) (24,354) (57,032) Short-term investments ......................................... (2,138,313) 5,154,824 -- ------------ ------------ ------------ Net cash provided by (used in) investing activities .. (2,262,834) 4,940,271 (335,705) ------------ ------------ ------------ CASH FLOWS FROM FINANCING ACTIVITIES Proceeds from issuance of stock and warrants ................... 5,163,157 6,977 12,029,105 Proceeds from issuance of notes payable ........................ -- -- 370,000 Dividends paid ................................................. -- -- (6,098) Payments of notes payable ...................................... -- -- (370,000) ------------ ------------ ------------ Net cash provided by (used in) financing activities .. 5,163,157 6,977 12,023,007 ------------ ------------ ------------ NET INCREASE IN CASH AND CASH EQUIVALENTS ........................... 1,451,191 1,138,037 7,732,918 CASH AND CASH EQUIVALENTS AT BEGINNING OF YEAR ........................................................... 426,104 1,877,295 3,015,332 ------------ ------------ ------------ CASH AND CASH EQUIVALENTS AT END OF YEAR ............................ $ 1,877,295 $ 3,015,332 $ 10,748,250 ============ ============ ============ SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION: Cash paid during the year for interest ......................... $ - $ - $ 13,766 SUPPLEMENTAL SCHEDULE OF NONCASH FINANCING ACTIVITIES: During 1995 and 1996 , the Company issued common stock as payment for dividends in the amount of $317,400 and $415,920, respectively
The accompanying notes are an integral part of these financial statements. F-6 LIFECELL CORPORATION NOTES TO FINANCIAL STATEMENTS DECEMBER 31, 1996 1. ORGANIZATION: LifeCell Corporation, a Delaware corporation (LifeCell or the Company), is engaged in the research, development and commercialization of transplantable tissue and transfusable blood products. The Company was incorporated on January 6, 1992 for the purpose of merging with its predecessor entity, which was formed in 1986. LifeCell commercially introduced its first transplantable tissue product, AlloDerm(R), during December 1993. Sales of AlloDerm to date have not been sufficient to fund the Company's operations, and the Company expects continued operating losses during 1997. The future operating results of the Company will be principally dependent on the market acceptance of its current and future products, competition from other products or technologies, protection of the Company's proprietary technology, and access to funding as required. Accordingly, there can be no assurance of the Company's future success. See "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" elsewhere herein. 2. ACCOUNTING POLICIES: CASH AND CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS The Company considers all highly liquid investments purchased with an original maturity of three months or less to be cash equivalents. Investments that the Company intends to hold to maturity are classified as either current or non-current assets based on the maturity date of the security. As of December 31, 1995 and 1996, the Company held $3,009,376 and $10,638,981, respectively, of interest bearing money market accounts and A1/P1 commercial paper which were classified as "held to maturity" securities. The carrying basis of these investments approximated fair value and amortized cost. The securities held at December 31, 1996 matured prior to March 31, 1997. INVENTORIES Inventories are stated at the lower of cost or market, cost being determined on a first-in, first-out (FIFO) basis. FURNITURE AND EQUIPMENT Furniture and equipment are stated at cost. Maintenance and repairs that do not improve or extend the life of the assets are expensed as incurred. Expenditures for renewals and betterments are capitalized. The cost of assets retired and the related accumulated depreciation are removed from the accounts and any gain or loss is included in the results of operations. Depreciation of furniture and equipment is provided on the straight-line method based on the estimated useful lives of the assets of five years. Leasehold improvements are depreciated over the life of the lease. INTANGIBLE ASSETS Intangible assets primarily consist of the costs of obtaining patents for the proprietary technology owned by or licensed to the Company. These costs are being amortized over the lesser of the legal (generally 17 years) or economic life of the patent. Accumulated amortization at December 31, 1995 and 1996, amounted to $39,933 and $53,033, respectively. F-7 REVENUE RECOGNITION Product sales are recognized as revenue when the product is shipped to fill customer orders. Revenues from corporate alliances and from government grants and contracts are recognized as the work is performed unless the Company has continuing performance obligations, in which case revenue is recognized upon the satisfaction of such obligations. Revenue received, but not yet earned, is classified as deferred revenue. RESEARCH AND DEVELOPMENT COSTS Research and development costs are expensed when incurred. The Company performs research funded by others, including research funded through the corporate alliance with Medtronic (see Note 8), as well as its own independent proprietary research, development and clinical testing of its products. Externally funded research consists of direct costs associated with specific projects as well as an allocation of overhead associated with administering these activities. LOSS PER SHARE Loss per share has been computed by dividing net loss, which has been increased for periodic accretion and imputed and stated dividends on outstanding Preferred Stock and the discount offered on warrant exercises induced during 1996, by the weighted average number of shares of Common Stock outstanding during the periods. In all applicable years, all Common Stock equivalents, including the Series A Preferred Stock and the Series B Preferred Stock, were antidilutive and, accordingly, were not included in the computation. In March 1997, the Financial Accounting Standards Board issued Statement of Financial Accounting Standards No. 128, "Earnings Per Share." Statement 128 establishes standards for computing and presenting earnings per share (EPS). This statement simplifies the standards for computing earnings per share previously found in APB Opinion No. 15, EARNINGS PER SHARE, and makes them comparable to international EPS standards. The statement also retroactively revises the presentation of earnings per share in the financial statements. The Company will adopt this Standard for the year ended December 31, 1997, and has not currently quantified the effect of applying the new Standard. STOCK-BASED COMPENSATION The Company accounts for employee stock-based compensation pursuant to the provisions of Accounting Principles Board Opinion No. 25. Compensation expense for stock options issued to employees and directors is generally recorded at the intrinsic value (the discount, if any, of the option price from the market price of the Common Stock under option) of the option at the date of grant. Subsequent changes in the market price of the underlying stock do not affect the accounting treatment of the option. Options granted to others are accounted for under the provisions of Statement of Financial Accounting Standards No. 123, which requires that the option be recorded at its estimated fair value using option-pricing formulas used in the financial markets. USE OF ESTIMATES The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates. F-8 3. INVENTORIES: Inventories consist of products in various stages produced for sale and includes the costs of raw materials, labor, and overhead. A summary of inventories is as follows: 1995 1996 -------- -------- Raw Materials ................ $ 29,171 $ 52,738 Work-In-Process .............. 107,988 437,221 Finished Goods ............... 214,343 349,862 -------- -------- $351,502 $839,821 ======== ======== 4. FURNITURE AND EQUIPMENT: A summary of furniture and equipment is as follows: 1995 1996 ---------- ---------- Office furniture and fixtures .............. $ 57,636 $ 61,130 Machinery and equipment .................... 1,097,480 1,342,243 Leasehold improvements ..................... 189,877 220,293 ---------- ---------- 1,344,993 1,623,666 Less - Accumulated depreciation and amortization 929,430 1,145,568 ---------- ---------- Net furniture and equipment .......... $ 415,563 $ 478,098 ========== ========== 5. CAPITAL STOCK: AUTHORIZED CAPITAL STOCK As of December 31, 1996, the authorized capital of the Company consisted of 25,000,000 shares of Common Stock, $.001 par value, and 2,000,000 shares of Preferred Stock, $.001 par value, of which 300,000 shares were designated as Series A Convertible Preferred Stock and 182,205 shares were designated as Series B Preferred Stock. As of December 31, 1996, there were 4,899,944 shares of Common Stock, 260,000 shares of Series A Convertible Preferred Stock and 124,157 shares of Series B Preferred Stock outstanding. During March 1997, all outstanding shares of Series A Convertible Preferred Stock and a portion of the accrued dividends were converted into 1,772,433 shares of Common Stock. SERIES A PREFERRED STOCK During November 1994, the Company issued 264,500 shares of Series A Convertible Preferred Stock (Series A Preferred Stock) and warrants to acquire 264,500 shares of Common Stock for gross proceeds of approximately $5.3 million in a private placement. Each share of Series A Preferred Stock was convertible at any time at the option of the holder into 6.69 shares of Common Stock. During 1996, 4,500 shares of Series A Preferred Stock were converted into 30,104 shares of Common Stock. The Series A Preferred Stock had a liquidation preference of $20 per share, or $5,200,000 as of December 31, 1996. The Series A Preferred Stock bore dividends at annual rates of $1.20, $1.60, and $2.00 per share for each of the first, second and third years, respectively, after the date of original issuance. Dividends were payable in cash, Common Stock, or any combination of cash and Common Stock at the Company's discretion. The Series A Preferred Stock had no ordinary voting rights. While the preferred shares were outstanding or any dividends were owed thereon, the Company could not declare or pay cash dividends on its Common Stock. During 1995 and 1996, respectively, the Company paid $317,400 and $415,920 in accrued dividends on the Series A Preferred Stock by issuing 103,816 shares and 121,054 shares of Common Stock. F-9 The preferred stock was automatically convertible into Common Stock on November 9, 1997 and could be redeemed sooner by the Company if, after November 9, 1995, the closing bid price of the Company's Common Stock averaged or exceeded $5.17 per share for 20 consecutive days. Pursuant to such provisions, during February 1997, the Company called for redemption all outstanding shares of Series A Preferred Stock. During March 1997 the Company issued 1,739,128 shares of Common Stock to redeem the Series A Preferred Stock and paid a cash dividend of $65,000 and issued an additional 33,305 shares of Common Stock for dividends accrued through the date of redemption. The carrying amount of the Series A Preferred Stock was increased for accrued and unpaid stated dividends plus periodic accretion, using the effective interest method, such that the carrying amount equaled the redemption amount on November 9, 1995. In November 1994, the Series A Preferred Stock was also increased by imputed dividends resulting from the increasing dividend rates. SERIES B PREFERRED STOCK During November 1996, the Company issued 124,157 shares of Series B Preferred Stock (Series B Preferred Stock) and warrants to acquire 2,803,530 shares of Common Stock for gross proceeds of approximately $12.4 million in a private placement. Each share of Series B Preferred Stock is initially convertible at any time at the option of the holder into approximately 32.26 shares of Common Stock (or 4,005,064 shares of Common Stock at December 31, 1996), subject to adjustment for dilutive issuances of securities. The Series B Preferred Stock has a liquidation preference of $100 per share, or $12,415,700 as of December 31, 1996, and shares ratable in any residual assets after payment of such liquidation preference. The Series B Preferred Stock bears cumulative dividends, payable quarterly, for five years at the greater of the annual rate of $6.00 per share or the rate of any dividends paid on the Series A Preferred Stock (effectively $10 per share until the Series A Preferred Stock was redeemed in March 1997). Dividends may be paid in cash, in additional shares of Series B Preferred Stock based on the stated value of $100 per share, or any combination of cash and Series B Preferred Stock at the Company's option. On all matters for which the Company's stockholders are entitled to vote, each share of Series B Preferred Stock will entitle the holder to one vote for each share of Common Stock into which the share of Series B Preferred Stock is then convertible. Additionally, the holders of Series B Preferred Stock have the right to elect up to three directors to the Board of Directors of the Company. While the preferred shares are outstanding or any dividends are owned thereon, the Company may not declare or pay cash dividends on its Common Stock. During 1996 the Company declared accrued dividends on the Series B Preferred Stock of $145,867 payable through the issuance of 1,426 additional shares of Series B Preferred Stock on February 15, 1997. The preferred stock will be automatically converted into Common Stock if (i) the closing price of the Company's Common Stock averages or exceeds $9.30 per share for 30 consecutive trading days and (ii) the Company conducts an underwritten public offering of newly issued Common Stock with gross proceeds, net of underwriting discounts and commissions, exceeding $20 million. Additionally, the preferred stock will be automatically converted into Common Stock if the Company conducts an underwritten public offering of newly issued Common Stock with gross proceeds, net of underwriting discounts and commissions, exceeding $20 million and the price per share in such offering equals or exceeds $9.30. COMMON STOCK During February 1994, all previously outstanding shares of Class I Common Stock were automatically converted into 2,803,812 shares of Common Stock and the Class I Common Stock was eliminated during June 1995. During 1995 and 1996, respectively, the Company issued 103,816 shares and 121,054 shares of Common Stock as payment of accrued dividends on Series A Preferred Stock. Additionally, during 1996, the Company induced the exercise of warrants by temporarily lowering exercise prices and issued 339,066 shares of Common Stock at a weighted average price of $3.10 upon exercise of certain warrants. F-10 During March 1997, the Company issued 1,739,128 shares of Common Stock to redeem all outstanding shares of the Series A Preferred Stock and paid a cash dividend of $65,000 and issued an additional 33,305 shares of Common Stock for dividends accrued through the date of redemption. During 1994, the Company purchased 43,965 shares of Common Stock from several employees, including officers and directors, for the purpose of satisfying their income tax liabilities for shares and options previously granted under a deferred compensation arrangement. These treasury shares were subsequently reissued during 1994. In 1992, the Company adopted a Restricted Stock Plan and issued 241,372 shares of Common Stock to employees, a director and a consultant of the Company for $.001 per share. The restricted stock vested over a four year period. Deferred compensation expense totaling $965,000 was expensed over the vesting period of the grants. The non-cash charge related to these stock grants was $239,000 for 1994 and 1995 and $20,000 for 1996. OPTIONS The Company's 1992 Stock Option Plan, as amended (1992 Plan), provides for the grant of options to purchase up to 1,000,000 shares of Common Stock. Granted options generally become exercisable over a four year period, 25 percent per year beginning on the first anniversary of the date of grant. To the extent not exercised, options generally expire on the tenth anniversary of the date of grant, except for employees who own more than 10 percent of all the voting shares of the Company, in which event the expiration date is the fifth anniversary of the date of grant. All options granted under the plan have exercise prices equal to the fair market value at the dates of grant. The 1993 Non-Employee Director Stock Option Plan (Director Plan) was adopted in 1993 and amended during 1996. A total of 750,000 shares of Common Stock are available for grant under the Director Plan. Upon amendment of the Director Plan in 1996, options to purchase 50,000 shares of Common Stock were granted to each then-current non-employee director of the Company at an exercise price equal to the fair market value of a share of Common Stock on the date of the Director Plan. Options to purchase 25,000 shares of Common Stock will be granted to newly elected directors at an exercise price equal to the fair market value of a share of Common Stock on such election date. The provisions of the Director Plan provide for an annual grant of an option to purchase 10,000 shares of Common Stock to each non-employee director. Options under the Director Plan generally vest one year after date of grant and expire after 10 years. F-11 A summary of stock option activity is as follows:
1992 Stock Option Plan Director Plan --------------------- --------------------- Weighted- Weighted Avg. exercise Avg. Exercise Options Price ($) Options Price ($) ---------- ------- ---------- ------- Balance at December 31, 1993 ............ 224,593 9.06 40,000 11.00 Granted ............................ 192,819 2.87 10,000 3.00 Exercised .......................... -- -- -- -- Forfeited .......................... (2,650) 7.68 -- -- ---------- ---------- Balance at December 31, 1994 ............ 414,762 6.19 50,000 9.40 ---------- ---------- Granted ............................ 266,350 2.46 10,000 2.75 Exercised .......................... (1,000) 3.00 -- -- Forfeited .......................... (225,917) 8.97 -- -- ---------- ---------- Balance at December 31, 1995 ............ 454,195 2.63 60,000 8.29 ---------- ---------- Granted ............................ 558,000 3.80 240,000 3.07 Exercised .......................... (1,062) 2.74 (5,000) 2.88 Forfeited .......................... (42,313) 3.18 -- -- Reissue ............................ -- -- (220,000) 4.14 ---------- ---------- Balance at December 31, 1996 ............ 968,820 3.28 75,000 4.11 ========== ========== Exercisable at December 31, 1994 ........ 57,606 9.11 40,000 11.00 Exercisable at December 31, 1995 ........ 158,330 2.61 50,000 9.40 Exercisable at December 31, 1996 ........ 255,429 2.61 15,000 8.29
At December 31, 1996, 28,718 and 670,000 options were available for future grant under the 1992 Plan and the Director Plan, respectively. The exercise prices of options outstanding under the 1992 Plan and the Director Plan at December 31, 1996 range from $0.07 to $4.375 and $2.75 to $11.00, respectively. The weighted average contractual life of options outstanding at December 31, 1996 was 9.1 years for the 1992 Plan and 7.8 years for the Director Plan. In addition to the amounts set forth in the table above, during 1996, the Company granted options to purchase 220,000 shares of Common Stock to directors who resigned upon the closing of the sale of the Series B Preferred Stock in exchange for options previously granted under the Director Plan. These options have provisions identical to the options previously granted under the Director Plan, including exercise prices and vesting periods. The weighted average exercise price of the options granted was $4.14. The weighted average remaining contractual life of the grants was 8.8 years as of December 31, 1996. The Company expensed $150,000, which was the difference between the market price and the option price on the date of the grant, during 1996 related to this reissuance. In October 1995, the Financial Accounting Standards Board issued SFAS No. 123 "Accounting for Stock-Based Compensation" which, if fully adopted, requires the Company to record stock-based compensation at fair value. The Company has adopted the disclosure requirements of SFAS No. 123 and has elected to record employee compensation expense in accordance with Accounting Principles Board Opinion (APB) No. 25. The Company accounts for its employee stock-based compensation plans under APB No. 25 and its related interpretations. Accordingly, deferred compensation expense is recorded for stock options based on the excess of the market value of the common stock on the date the options were granted over the aggregate exercise price of the options. This deferred compensation is amortized over the vesting period of each option. As the exercise price of options granted under the 1992 Plan and the Director Plan has been equal to or greater than the market price of the Company's stock on the date of grant, no compensation expense related to these plans has been recorded. Had compensation expense for its 1992 Plan and Director Plan been determined consistent with SFAS No. 123, the Company's net loss and loss per share would have been increased to the following pro forma amounts: F-12 1995 1996 ---- ---- Net Loss: As reported $3,905,404 $4,089,714 Pro forma $3,940,041 $5,372,049 Loss Per Share: As reported $1.10 $1.14 Pro forma $1.10 $1.42 Because the Statement 123 method of accounting has not been applied to options granted prior to January 1, 1995, the resulting pro forma compensation cost may not be representative of that to be expected in future years. Under the provisions of SFAS No. 123, the weighted average fair value of options granted in 1995 and 1996 was $1.88 and $3.21, respectively, under the 1992 Plan. The weighted average fair value of options granted in 1995 and 1996 was $2.21 and $2.40, respectively, under the Director Plan. The fair value of each option grant is estimated on the date of grant using the Black-Scholes option pricing model with the following weighted average assumptions used for grants in 1995 and 1996, respectively: a weighted average risk-free interest rate of 6 percent for both years; no expected dividend yields for both years; expected lives of 3 years for both years and expected volatility between 96 and 100 percent. The stock options issued to retiring directors in 1996 had a weighted average fair value of $2.57. The fair values of such options are estimated on the date of grant using Black-Scholes option price model with the following assumptions used: a weighted average risk-free interest rate of 6 percent, expected lives of 3 to 5 years, expected volatility of 99 percent and no expected dividends. During 1995, options to purchase 225,917 shares of Common Stock at exercise prices of $9.00 and $14.50 were canceled and reissued at substantially the same terms, but with an exercise price equal to the then current market price of $2.50. WARRANTS As of December 31, 1996, warrants to acquire a total of 3,378,264 shares of Common Stock were outstanding as set forth below. During 1996, the Company issued warrants to acquire 2,803,530 shares of Common Stock in conjunction with the sale of the Series B Preferred Stock (the 1996 Warrants). The 1996 Warrants are exercisable at an exercise price of $4.13 per share. The warrants expire on the fifth anniversary of the date of grant, are callable if the average closing price of the Company's Common Stock for 30 trading days equals or exceeds three times the then-exercise price, and allow cashless exercise. The warrants also have provisions for adjustment of the exercise price and number of shares for below-exercise price issuance of securities. Additionally, the Company issued a warrant to acquire 354,734 shares of Common Stock to the placement agent for the Series B Preferred Stock (Agent Warrant). The Agent Warrant is exercisable at an exercise price of $4.50 per share. The warrant expires on the fifth anniversary of the date of grant and allows cashless exercise. The warrant also has provisions for adjustment of the exercise price and number of shares for below-exercise price issuance of securities. In connection with the sale of the Series A Preferred Stock, the Company issued warrants to acquire 264,500 shares of Common Stock at exercise prices of $3.26 per share during the first year and $3.54 per share during the second year. Additionally, the placement agent was issued a warrant to purchase 90,816 shares of Common Stock at $6.00 per share. A total of 339,066 warrants were exercised during 1996 through inducement of exercise by lowering the exercise price to $3.10 per share. The difference between the market price on the date of inducement and the induced exercise price has been deducted from net income to determine loss per Common share. A total of 15,000 warrants expired unexercised. As of December 31, 1996, additional warrants to acquire 100,000 shares of Common Stock were outstanding with exercise prices ranging from $2.50 to $11.05. Such warrants expire during periods ranging from December 31, F-13 1997 to December 13, 2000. Additionally, as of December 31, 1996, warrants to acquire 120,000 shares of Common Stock were outstanding but expired unexercised on February 27, 1997. 6. EMPLOYEE BENEFIT PLANS: The Company maintains a retirement savings plan as described in Section 401(k) of the Internal Revenue Code of 1986. The Company may, at its discretion, contribute amounts not to exceed each employee's contribution. During January 1996 and January 1997, the Company made total contributions of $5,292 and $8,187 to the plan for a partial matching of employee contributions during 1995 and 1996, respectively. During 1996, the Company established an Employee Stock Purchase Plan to allow for the purchase of the Company's Common Stock on the open market using employee and any employer matching contributions. During 1996, the Company contributed $1,328 to this plan. 7. FEDERAL INCOME TAXES: The Company has not made any income tax payments since inception. As of December 31, 1996, the Company has a net operating loss (NOL) carryforward for federal income tax purposes of approximately $26 million, subject to the limitations described below, expiring as follows: YEAR EXPIRES 2001.................................. $ 500,000 2002.................................. 1,500,000 2003.................................. 2,800,000 2004.................................. 2,200,000 2005.................................. 1,700,000 2006.................................. 1,400,000 2007.................................. 2,400,000 2008.................................. 3,000,000 2009.................................. 2,500,000 2010.................................. 4,000,000 2011.................................. 4,000,000 ----------- $26,000,000 =========== Additionally, the Company has approximately $385,000 of research and development tax credit carryforwards which will expire in varying amounts commencing in 2001. The Company's ability to utilize its tax loss and credit carryforwards to reduce future taxable income may be limited by either the prior expiration of such loss or credit or by the occurrence of a "change in ownership," as such term is defined by federal income tax laws and regulations. A change in ownership may occur upon the sale of additional equity securities by the Company, conversion of existing shares of Series B Preferred Stock or by sales of stock by existing stockholders. In the event of a change in ownership, the amount of the tax loss and credit carryforwards that may be utilized to offset taxable income in any year may be limited and result in the payment of federal income taxes that otherwise would be offset by such tax losses or credits. For financial reporting purposes, a valuation allowance of $9,897,000 has been recorded as of December 31, 1996 to fully offset the deferred tax asset related to these carryforwards. The principal components of the deferred tax asset as of December 31, 1995 and 1996, assuming a 34% federal tax rate, are as follows: F-14 1995 1996 ---------- ---------- Temporary differences: Deferred revenue ........................ 582,000 510,000 Restricted stock compensation............ (196,000) 154,000 Uniform capitalization of inventory costs ...................... 160,000 37,000 Other items ............................. 66,000 (29,000) ---------- ---------- Total temporary differences ............. 612,000 672,000 Federal tax losses and credits not currently utilizable ............. 7,845,000 9,225,000 ---------- ---------- Total deferred tax assets ................... 8,457,000 9,897,000 Less valuation allowance ................ (8,457,000) (9,897,000) ---------- ---------- Net deferred tax asset ...................... -- -- ========== ========== The net increase in the deferred tax valuation allowance for 1995 and 1996 was $1,691,000, and $1,440,000, respectively. Other than the net operating loss and tax credit carryforwards, there is no significant difference between the statutory federal income tax rate and the Company's effective tax rate during 1994, 1995 and 1996. 8. COLLABORATIONS AND CORPORATE ALLIANCES MEDTRONIC CARDIOVASCULAR COLLABORATION During March 1994, the Company entered into a collaboration with Medtronic, Inc. (Medtronic) for the development and commercialization of universal tissue heart valves engineered with LifeCell's proprietary technology. Medtronic paid the Company an initial licensing fee of $1,500,000, agreed to fund development of heart valve products, and acquired $500,000 of the Company's Common Stock at a price of $7.77 per share. Medtronic is obligated to pay royalties, up to a maximum of $25,000,000, on any product sales . Medtronic was also granted a right of first refusal to evaluate technology and negotiate license and development agreements for vascular conduit products utilizing the Company's technology. In the event Medtronic terminates funding of the heart valve program, Medtronic may convert its initial $1.5 million license fee into newly issued shares of the Company's Common Stock at the then-current market price. Accordingly, the Company has deferred recognition of the initial license fee and recorded a $1.5 million deferred credit in the accompanying balance sheet. Medtronic also has the right, subject to certain restrictions, to purchase additional shares of the Company's Common Stock, to have the Company register the resale of any Common Stock acquired from it, and to appoint one member of the Board of Directors of the company through March 1999. OTHER PRODUCT SALES ARRANGEMENTS The Company has negotiated other distribution or sales collaboration arrangements with various parties with exclusive regional or international territories under each agreement. The agreements generally provide that the distributor must meet certain performance measures or the agreement may be terminated by the Company. The markets served by these arrangements include plastic and reconstructive surgery. 9. COMMITMENTS AND CONTINGENCIES: EXTERNAL FUNDING FOR RESEARCH Certain of the Company's research programs have been funded by Small Business Innovation Research (SBIR) grants and other direct federal government funding contracts. The grants and contracts generally obligate the Company to perform specified research activities in return for such funding, and the utilization of funds under the grants is subject to audit by the appropriate governmental agencies. At December 31, 1996, the Company had received $138,792 of deferred revenue, including advance payments from a corporate alliance, for research to be F-15 conducted during 1997. Additionally, as of December 31, 1996, the Company has unfunded awards totaling $1,597,000 for research that is expected to occur and be funded during 1997 and 1998. EXCLUSIVE LICENSE AGREEMENT The Company has an exclusive license agreement with the Board of Regents of the University of Texas System (Board) to technology and patents related to the analysis or preservation of certain cells or tissues. The Company is required to pay the Board royalties on net sales of products encompassing the licensed technologies. For the periods ended December 31, 1994, 1995 and 1996 no significant royalties were paid under the agreement. LEASES The Company leases approximately 20,000 square feet for office and laboratory space. The future minimum lease payments under noncancelable lease terms in excess of one year as of December 31, 1996 were as follows: 1997................................... $ 218,028 1998................................... 221,320 1999................................... 221,320 2000................................... 221,320 2001................................... 18,443 --------- Total........................ $ 900,431 ========== 10. TRANSACTIONS WITH RELATED PARTIES: The Company leases office space from an affiliate of a stockholder of the Company. The Company paid rent expense of approximately $139,000, $129,000 and $142,000 during 1994, 1995, and 1996 respectively, related to this lease. The Company paid consulting fees and expenses to an affiliate of a stockholder and a former director of the Company, totaling approximately $96,000, $91,000 and $80,000 during the years ended December 31, 1994, 1995 and 1996 respectively, pursuant to a consultant agreement. As of December 31, 1996, the Company has notes receivable totaling $95,060 from participants, two of whom are directors of the Company, in a previous deferred compensation plan. Such notes represent loans of federal income tax amounts payable by the individuals as a result of grants under the plan. F-16 11. QUARTERLY FINANCIAL DATA (UNAUDITED) The following table presents summary unaudited financial data for the years ended December 31, 1995 and 1996. The Company believes that this information reflects all adjustments, consisting of only normal recurring items, considered necessary for a fair presentation of the quarterly financial information presented. The operating results for any quarterly period are not necessarily indicative of the results that may be expected for future periods. First Second Third Fourth Quarter Quarter Quarter Quarter ------- ------- ------- ------- (In thousands except per share amounts) 1995 Product Sales ............ $ 98 $ 130 $ 251 $ 263 Total Revenues ........... $ 430 $ 399 $ 514 $ 464 Gross Margin ............. $ (5) $ (52) $ (7) $ (119) Net loss ................. $(958) $(1,016) $ (867) $(1,064) Loss per share ........... $(0.27) $ (0.29) $ (0.25) $ (0.29) 1996 Product Sales ............ $ 421 $ 429 $ 561 $ 602 Total Revenues ........... $ 576 $ 678 $ 816 $ 876 Gross Margin ............. $ 149 $ 157 $ 205 $ 220 Net loss ................. $(949) $ (909) $(1,023) $(1,209) Loss per share ........... $(0.25) $ (0.24) $ (0.33) $ (0.32) F-17 SIGNATURES In accordance with Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. LIFECELL CORPORATION (Registrant) By: /s/ PAUL M. FRISON Paul M. Frison, President and Chief Executive Officer and Chairman of the Board of Directors Dated: March 26, 1997. In accordance with the Securities Exchange Act of 1934, this report has been signed by the following persons on behalf of the registrant and in the capacities and on the dates indicated: SIGNATURE TITLE DATE /S/ PAUL M. FRISON Chairman of the Board, March 26, 1997 (Paul M. Frison) President and Chief Executive Officer (Principal Executive Officer) /S/ J. DONALD PAYNE Vice President, Secretary March 26, 1997 (J. Donald Payne) and Chief Financial Officer (Principal Financial and Accounting Officer) /S/ MICHAEL E. CAHR Director March 26, 1997 (Michael E. Cahr) /S/ JAMES G. FOSTER Director March 26, 1997 (James G. Foster) /S/ LORI KOFFMAN Director March 26, 1997 (Lori Koffman) /S/ STEPHEN A. LIVESEY Director March 26, 1997 (Stephen A. Livesey) /S/ K. FLYNN MCDONALD Director March 26, 1997 (K. Flynn McDonald)
EX-4.1 2 EXHIBIT 4.1 INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE NUMBER SHARES ______________ LIFECELL (R) ______________ | | | | | | | | |____________| |____________| THIS CERTIFICATE IS TRANSFERABLE IN CUSIP 531927-50-7 NEW YORK, NEW YORK, CLEVELAND, OHIO SEE REVERSE FOR CERTAIN DEFINITIONS OR HOUSTON, TEXAS LIFECELL CORPORATION SERIES B PREFERRED STOCK - -------------------------------------------------------------------------------- THIS CERTIFIES THAT SPECIMEN is the owner of - -------------------------------------------------------------------------------- FULLY PAID AND NON-ASSESSABLE SHARES OF SERIES B PREFFERED STOCK, PAR VALUE $.001 PER SHARE, OF LifeCell Corporate transferable on the books of the Corporation by the holder hereof in person or by duly authorized authorized attorney upon surrender of this certificate properly endorsed. This certificate is not valid until countersigned by the Transfer Agent and registered by the Registrar. Witness the facsimile seal of the Corporation and the facsimile signatures of its duly authorized Officers.
Dated: [LIFECELL CORPORATION] Countersigned and Registered: [ CORPORATE SEAL ] KEYCORP SHAREHOLDER SERVICES, INC. SPECIMEN Transfer Agent and Registrar PAUL M. FRISON JUDITH H. COLYN By SPECIMEN President Assistant Secretary Authorized Signature
- -------------------------------------------------------------------------------- LIFECELL CORPORATION THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE LAW, AND NO INTEREST THEREIN MAY BE SOLD OR OTHERWISE TRANSFERED IN THE ABSENCE OF SUCH REGISTRATION AND QUALIFICATION WITHOUT AN OPINION OF LEGAL COUNSEL FOR THE HOLDER THAT SUCH REGISTRATION AND QUALIFICATION ARE NOT REQUIRED, WHICH OPINION AND COUNSEL SHALL BE REASONABLY SATISFACTORY TO THE THE CORPORATION. THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE CERTAIN TRANFER AND VOTING REGISTRATIONS PURSUANT TO A SECURITIES PURCHASE AGREEMENT AND A VOTING AGREEMENT AMONG THE CORPORATION AND CERTAIN OF THE CORPORATION'S STOCKHOLDERS. COPIES OF SUCH SECURITIES PURCHASE AGREEMENT AND SUCH VOTING AGREEMENT WILL BE FURNISHED WITHOUT CHARGE BY THE CORPORATION TO THE HOLDER HEREOF UPON WRITTEN REQUEST. THE CORPORATION WILL FURNISH WITHOUT CHARGE TO EACH STOCKHOLDER WHO SO REQUESTS THE POWERS, DESIGNATIONS, PREFERENCES AND RELATIVES, PARTICIPATING, OPTIONAL OR OTHER SPECIAL RIGHTS OF EACH CLASS OF STOCK OR SERIES THEREOF WHICH THE CORPORTATION IS AUTHORIZED TO ISSUE AND THE QUALIFICATIONS, LIMITATIONS OR RESTRICTIONS OF SUCH PREFERENCES AND/OR RIGHTS. ANY SUCH REQUEST SHOULD BE ADDRESSED TO THE CORPORATION AT ITS PRICIPAL PLACE OF BUSINESS OR TO THE TRANSFER AGENT. The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were written out in full according to applicable laws or regulations:
TEN COM --as tenants in common UNIF GIFT MIN ACT--________Custodian_________ TEN ENT --as tenants by the entireties (CUST) (MINOR) JT TEN --as joint tenants with right of under Uniform Gifts to Minors Act survivorship and not as tenants in common _________________________________ (STATE) Additional abbreviations may also be used though not in the above list. For Value Recieved,____________________________________hereby sell, assign and transfer unto PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE [_____________________________________]__________________________________________________________________________________ _________________________________________________________________________________________________________________________ (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESSS, INCLUDING ZIP OR POSTAL CODE, OF ASSIGNEE) _________________________________________________________________________________________________________________________ ___________________________________________________________________________________________________________________Shares of the Series B Preffered Stock represented by the within certificate, and do hereby irreevocably constitute and appoint _________________________________________________________________________________________________________________Attorney to transfer the said shares on the books of the within named Corporation with full power of substitution in the premises. Dated,_______________________________ X__________________________________________________________ NOTICE: THE SIGNATURE(S) TO THIS ASSIGMENT MUST CORRESPOND WITH THE NAME(S) AS WRITTEN UPON THE FACE OF THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGMENT OR ANY CHANGE WHATEVER. X__________________________________________________________ ALL GUARANTEES MUST BE MADE BY A FINACIAL INSTITUTION (SUCH AS A BLANK OR BROKER) WHICH IS A PARTICIPANT IN THE SECURITIES TRANSFER AGENTS MEDALLION PROGRAM ("STAMP"), THE NEW YORK STOCK EXCHANGE, INC. MEDALLION SIGNATURE PROGRAM ("MSP"), OR THE STOCK EXCHANGES MEDALLION PROGRAM ("SEMP") AND MUST NOT BE DATED. GUARTANTEES BY A NOTARY PUBLIC ARE NOT ACCEPTABLE.
EX-10.3 3 EXHIBIT 10.3 LIFECELL CORPORATION SECOND AMENDED AND RESTATED 1992 STOCK OPTION PLAN SEPTEMBER 19, 1994 1. PURPOSE. This Second Amended and Restated 1992 Stock Option Plan (this "Plan") of LifeCell Corporation, a Delaware corporation (the "Company"), is adopted for the benefit of certain individuals who have substantial responsibility for the Company's management and growth, and is intended to advance the interests of the Company by providing these individuals with additional incentive by increasing their proprietary interest in the success of the Company and thereby encouraging them to remain in its employ or affiliation. 2. ADMINISTRATION. This Plan shall be administered by a committee to be appointed by the Board of Directors of the Company (the "Committee"), which Committee shall consist of not less than two members of the Board of Directors, who for a period of at least one year prior to being appointed to the Committee and at all times during service on the Committee shall not have been granted or awarded equity securities of the Company pursuant to this Plan or any other plan of the Company (other than pursuant to a plan of the Company that would not cause such Committee member to lose his status as a disinterested person as defined in Rule 16b- 3(c)(2)(i) of the Securities Exchange Act of 1934, as amended (the "Securities Exchange Act")). The Board of Directors of the Company shall have the power from time to time to add or remove members of the Committee, and to fill vacancies thereon arising by resignation, death, removal, or otherwise. Meetings shall be held at such times and places as shall be determined by the Committee. A majority of the members of the Committee shall constitute a quorum for the transaction of business, and the vote of a majority of those members present at any meeting shall decide any question brought before that meeting. No member of the Committee shall be liable for any act or omission of any other member of the Committee or for any act or omission on his own part, including but not limited to the exercise of any power or discretion given to him under this Plan, except those resulting from his own gross negligence or willful misconduct. All questions of interpretation and application of this Plan, or as to options granted hereunder (the "Options"), shall be subject to the determination, which shall be final and binding, of a majority of the whole Committee. When appropriate, this Plan shall be administered in order to qualify certain of the Options granted hereunder as "incentive stock options" described in Section 422 of the Internal Revenue Code of 1986, as amended. 3. OPTION SHARES. The stock subject to the Options and other provisions of this Plan shall be shares of the Company's Common Stock, $.001 par value (the "Common Stock"). The total amount of Common Stock with respect to which Options may be granted shall not exceed in the aggregate 530,254 shares, PROVIDED that the class and aggregate number of shares which may be subject to the Options granted hereunder shall be subject to adjustment in accordance with the provisions of Paragraph 17 hereof. Such shares may be treasury shares or authorized but unissued shares. In the event that any outstanding Option for any reason shall expire or terminate by reason of the death or severance of employment of the optionee, the surrender of any such Option, or any other cause, the shares of Common Stock allocable to the unexercised portion of such Option may again be subject to an Option under this Plan. 4. AUTHORITY TO GRANT OPTIONS. The Committee may grant the following options from time to time to such eligible individuals of the Company as it shall from time to time determine: (a) "Incentive Stock Options". The Committee may grant to an eligible employee an Option, or Options, to buy a stated number of shares of Common Stock under the terms and conditions of this Plan, so that the Option will be an "incentive stock option" within the meaning of Section 422 of the Internal Revenue Code of 1986, as amended. (b) "Non-incentive Stock Options". The Committee may grant to an eligible individual an Option, or Options, to buy a stated number of shares of Common Stock under the terms and conditions of this Plan, even though such Option or Options would not constitute an "incentive stock option" within the meaning of Section 422 of the Internal Revenue Code of 1986, as amended. Each option granted shall be approved by the Committee. Subject only to any applicable limitations set forth in this Plan, the number of shares of Common Stock to be covered by an Option shall be as determined by the Committee. 5. ELIGIBILITY. The individuals who shall be eligible to receive incentive stock options under this Plan shall be such full-time key employees, including officers and directors if they are employees, of the Company, or of any parent or subsidiary corporation, as the Committee shall determine from time to time, PROVIDED, that no such employee who owns stock possessing more than ten percent of the total combined voting power of all classes of stock of the corporation employing the employee or of its parent or subsidiary corporation shall be eligible to receive an incentive stock option unless at the time that it is granted the option price is at least 110% of the fair market value of Common Stock at the time the Option is granted and the Option by its own terms is not exercisable after the expiration of five years from the date such Option is granted. For the purposes of the preceding paragraph, an employee will be considered as owning the stock owned, directly or indirectly, by or for his brothers and sisters (whether by the whole or half blood), spouse, ancestors, and lineal descendants; and stock owned, directly or indirectly, by or for a corporation, partnership, estate or trust will be considered as being owned proportionately by or for its shareholders, partners or beneficiaries. Except as otherwise provided, for all purposes of this Plan the term "parent corporation" shall mean any corporation (other than the Company) in an unbroken chain of corporations ending with the Company if, on the date of grant of the Option in question, each of the corporations other than the Company owns stock possessing 50% or more of the total combined voting power of all classes of stock -2- in one of the other corporations in such chain; and the term "subsidiary corporation" shall mean any corporation in an unbroken chain of corporations beginning with the Company if, on the date of grant of the Option in question, each of the corporations, other than the last corporation in the chain, owns stock possessing 50% or more of the total combined voting power of all classes of stock in one of the other corporations in such chain. The individuals who shall be eligible to receive non-incentive stock options shall be such individuals as the Committee shall determine from time to time. No individual shall be eligible to receive an Option under this Plan while the individual is a member of the Committee. 6. OPTION PRICE. The price at which shares may be purchased pursuant to an Option, whether it is an incentive stock option or a non-incentive stock option, shall be not less than the fair market value of the shares of Common Stock on the date such Option is granted and the Committee in its discretion may provide that the price at which shares may be so purchased shall be more than such fair market value. In the case of any employee described in Paragraph 5 who owns stock possessing more than ten percent of the total combined voting power of all classes of stock of the corporation employing the employee or of its parent or subsidiary corporation (described in Paragraph 5), the option price at which shares may be so purchased pursuant to any Option which is an incentive stock option granted hereunder shall be not less than 110% of the fair market value of the Common Stock on the date such Option is granted. 7. DURATION OF OPTIONS. No Option which is an incentive stock option shall be exercisable after the expiration of ten years from the date such Option is granted; and the Committee in its discretion may provide that such Option shall be exercisable throughout such ten-year period or during any lesser period of time commencing on or after the date of grant of such Option and ending upon or before the expiration of such ten-year period. In the case of any employee who owns stock possessing more than ten percent of the total combined voting power of all classes of stock of the corporation employing the employee or of its parent or subsidiary corporation (described in Paragraph 5), no Option which is an incentive stock option shall be exercisable after the expiration of five years from the date such Option is granted. No Option which is a non-incentive stock option shall be exercisable after the expiration of ten years from the date such Option is granted; and the Committee in its discretion may provide that such Option shall be exercisable throughout such ten-year period or during any lesser period of time commencing on or after the date of grant of such Option and ending upon or before the expiration of such ten-year period. 8. MAXIMUM VALUE OF STOCK SUBJECT TO OPTIONS WHICH ARE INCENTIVE STOCK OPTIONS. Notwithstanding any other provisions of this Plan to the contrary, the aggregate fair market value (determined as of the date the Option is granted) of the stock with respect to which incentive stock options are exercisable for the first time by the optionee in any calendar year (under this Plan and any other incentive stock option plan(s) of the Company and any parent and subsidiary corporation(s) thereof) shall not exceed $100,000. -3- 9. AMOUNT EXERCISABLE. Each Option may be exercised, so long as it is valid and outstanding, from time to time in part or as a whole, in such manner and subject to such conditions as the Committee in its discretion may provide in the option agreement. However, the Committee in its absolute discretion may accelerate the time at which any outstanding Option may be exercised. 10. EXERCISE OF OPTIONS. Options shall be exercised by the delivery of written notice to the Company setting forth the number of shares with respect to which the Option is to be exercised, together with: (i) cash, certified check, bank draft, or postal or express money order payable to the order of the Company for an amount equal to the option price of such shares, (ii) Common Stock at the fair market value on the date of exercise, or (iii) any other form of payment which is acceptable to the Committee, and specifying the address to which the certificates for such shares are to be mailed. As promptly as practicable after receipt of such written notification and payment, the Company shall deliver to the optionee certificates for the number of shares with respect to which such Option has been so exercised, issued in the optionee's name; provided that such delivery shall be deemed effected for all purposes when a stock transfer agent of the Company shall have deposited such certificates in the United States mail, addressed to the optionee, at the address specified pursuant to this Paragraph 10. 11. TAX WITHHOLDING. The Company shall be entitled to deduct from other compensation payable to each employee any sums required by federal, state or local tax law to be withheld with respect to the grant or exercise of an Option. In the alternative, the Company may require the employee (or other individual exercising the Option) to pay the sum directly to the Company. If the employee (or other individual exercising the Option) is required to pay the sum directly, payment in cash or by check of such sums for taxes shall be delivered within ten days after the date of exercise. The Company shall have no obligation upon exercise of any Option until payment has been received, unless withholding (or offset against a cash payment) as of or prior to the date of exercise is sufficient to cover all sums due with respect to that exercise. The Company shall not be obligated to advise an employee of the existence of the tax or the amount which the employer corporation will be required to withhold. 12. TRANSFERABILITY OF OPTIONS. Options shall not be transferable by the optionee otherwise than by will or under the laws of descent and distribution. 13. TERMINATION OF EMPLOYMENT OR AFFILIATION OR DEATH OF OPTIONEE. Except as may be otherwise expressly provided herein, Options shall terminate on the earlier of the date of the expiration of the Option or one day less than three months after the date of the severance, upon severance of the employment or affiliation relationship between the Company and the optionee for any reason, for or without cause, other than death. Whether authorized leave of absence, or absence on military or government service, shall constitute severance of the employment or affiliation relationship between the Company and the optionee shall be determined by the Committee at the time thereof. In the event of the death of the holder of an Option while in the employ or affiliation of the Company and before the date of expiration of such Option, such Option shall terminate on the earlier of such date of expiration or six months following the date of such death. After the death of the optionee, his executors, administrators -4- or any person or persons to whom his Option may be transferred by will or by the laws of descent and distribution, shall have the right, at any time prior to such termination, to exercise the Option, in whole (subject to the provisions of Paragraph 8 hereof, but without regard to any limitations set forth in or imposed pursuant to Paragraph 9 hereof) or in part. An employment or affiliation relationship between the Company and the optionee shall be deemed to exist during any period in which the optionee is employed by or affiliated with the Company, by any parent or subsidiary corporation, by a corporation issuing or assuming a common stock option in a transaction to which Section 424(a) of the Internal Revenue Code of 1986, as amended, applies, or by a parent or subsidiary corporation of such corporation issuing or assuming a stock option (and for this purpose, the phrase "corporation issuing or assuming a stock option" shall be substituted for the word "Company" in the definitions of parent and subsidiary corporations specified in Paragraph 5 of this Plan, and the parent-subsidiary relationship shall be determined at the time of the corporate action described in Section 424(a)). 14. REQUIREMENTS OF LAW. The Company shall not be required to sell or issue any shares under any Option if the issuance of such shares shall constitute a violation by the optionee or the Company of any provisions of any law or regulation of any governmental authority. Each Option granted under this Plan shall be subject to the requirements that, if at any time the Board of Directors of the Company or the Committee shall determine that the listing, registration or qualification of the shares subject thereto upon any securities exchange or under any state or federal law of the United States or of any other country or governmental subdivision thereof, or the consent or approval of any governmental regulatory body, or investment or other representations, are necessary or desirable in connection with the issue or purchase of shares subject thereto, no such Option may be exercised in whole or in part unless such listing, registration, qualification, consent, approval or representations shall have been effected or obtained free of any conditions not acceptable to the Board of Directors. Any determination in this connection by the Committee shall be final, binding and conclusive. In the event the shares issuable on exercise of an Option are not registered under the Securities Act of 1933, as amended, (the "Securities Act") the Company may imprint on the certificate for such shares the following legend or any other legend which counsel for the Company considered necessary or advisable to comply with the Securities Act: "The shares of stock represented by this certificate have not been registered under the Securities Act of 1933 or under the securities laws of any state and may not be sold or transferred except upon such registration or upon receipt by the Corporation of an opinion of counsel satisfactory to the Corporation, in form and substance satisfactory to the Corporation, that registration is not required for such sale or transfer." The Company may, but shall in no event be obligated to, register any securities covered hereby pursuant to the Securities Act (as now in effect or as hereafter amended) and, in the event any shares are so registered, the Company may remove any legend on certificates representing such shares. The Company shall not be obligated to take any other affirmative action in order to cause the exercise of an Option or the issuance of shares pursuant thereto to comply with any law or regulation or any governmental authority. -5- 15. NO RIGHTS AS STOCKHOLDER. No optionee shall have rights as a stockholder with respect to shares covered by his Option until the date of issuance of a stock certificate for such shares; and, except as otherwise provided in Paragraph 17 hereof, no adjustment for dividends, or otherwise, shall be made if the record date therefor is prior to the date of issuance of such certificate. 16. EMPLOYMENT OR AFFILIATION OBLIGATION. The granting of any Option shall not impose upon the Company any obligation to employ or affiliate with or continue to employ or affiliate with any optionee; and the right of the Company to terminate the employment or affiliation of any officer, employee or other individual shall not be diminished or affected by reason of the fact that an Option has been granted to him. 17. CHANGES IN THE COMPANY'S CAPITAL STRUCTURE. The existence of outstanding Options shall not affect in any way the right or power of the Company or its stockholders to make or authorize any or all adjustments, recapitalizations, reorganizations or other changes in the Company's capital structure or its business, or any merger or consolidation of the Company, or any issue of bonds, debentures, preferred or prior preference stock ahead of or affecting the Common Stock or the rights thereof, or the dissolution or liquidation of the Company, or any sale or transfer of all or any part of its assets or business, or any other corporate act or proceeding, whether of a similar character or otherwise. If the Company shall effect a subdivision or consolidation of shares or other capital readjustment, the payment of a stock dividend, or other increase or reduction of the number of shares of Common Stock outstanding, without receiving compensation therefor in money, services or property, then (a) the number, class and per share price of shares of stock subject to outstanding Options hereunder shall be appropriately adjusted in such a manner as to entitle an optionee to receive upon exercise of an Option, for the same aggregate cash consideration, the same total number and class or classes of shares as he would have received had he exercised his Option in full immediately prior to the event requiring the adjustment, disregarding any fractional shares; and (b) the number and class of shares then reserved for issuance under this Plan shall be adjusted by substituting for the total number and class of shares of stock then reserved for the number and class or classes of shares of stock that would have been received by the owner of an equal number of outstanding shares of Common Stock as the result of the event requiring the adjustment, disregarding any fractional shares. If the Company merges or consolidates with another corporation, whether or not the Company is a surviving corporation, or if the Company is liquidated or sells or otherwise disposes of substantially all its assets while unexercised Options remain outstanding under this Plan, or if any "person" (as that term is used in Section 13(d) and 14(d)(2) of the Securities Exchange Act) is or becomes the beneficial owner, directly or indirectly, of securities of the Company representing greater than 50% of the combined voting power of the Company's then outstanding securities, (i) subject to the provisions of clause (iii) below, after the effective date of such merger, consolidation, liquidation, sale or other disposition, or change in beneficial ownership, as the case may be, each holder of an outstanding Option shall be entitled, upon exercise of such Option, to receive, in lieu of shares of Common Stock, the number and class -6- or classes of shares of such stock or other securities or property to which such holder would have been entitled if, immediately prior to such merger, consolidation, liquidation, sale or other disposition, or change in beneficial ownership, such holder had been the holder of record of a number of shares of Common Stock equal to the number of shares as to which such Option may be exercised; (ii) the Board of Directors may waive any limitations set forth in or imposed pursuant hereto so that all Options, from and after a date prior to the effective date of such merger, consolidation, liquidation, sale or other disposition, or change in beneficial ownership, as the case may be, specified by the Board of Directors, shall be exercisable in full; and (iii) all outstanding Options may be canceled by the Board of Directors as of the effective date of any such merger, consolidation, liquidation, sale or other disposition or change in beneficial ownership. Except as hereinbefore expressly provided, the issue by the Company of shares of stock of any class, or securities convertible into shares of stock of any class, for cash or property, or for labor or services either upon direct sale or upon the exercise of rights or warrants to subscribe therefor, or upon conversion of shares or obligations of the Company convertible into such shares or other securities, shall not affect, and no adjustment by reason thereof shall be made with respect to, the number or price of shares of Common Stock then subject to outstanding Options. 18. SUBSTITUTION OPTIONS. Options may be granted under this Plan from time to time in substitution for stock options held by employees of other corporations who are about to become employees of the Company, or whose employer is about to become a parent or subsidiary corporation, conditioned in the case of an incentive stock option upon the employee becoming an employee as the result of a merger or consolidation of the Company with another corporation, or the acquisition by the Company of substantially all the assets of another corporation, or the acquisition by the Company of at least 50% of the issued and outstanding stock of another corporation as the result of which it becomes a subsidiary of the Company. The terms and conditions of the substitute Options so granted may vary from the terms and conditions set forth in this Plan to such extent as the Board of Directors of the Company at the time of grant may deem appropriate to conform, in whole or in part, to the provisions of the stock options in substitution for which they are granted, but with respect to stock options which are incentive stock options, no such variation shall be such as to affect the status of any such substitute option as an "incentive stock option" under Section 422 of the Internal Revenue Code of 1986, as amended. 19. AMENDMENT OR TERMINATION OF PLAN. The Board of Directors may modify, revise or terminate this Plan at any time and from time to time, PROVIDED that without the further approval of the holders of at least a majority of the outstanding shares of voting stock, or if the provisions of the corporate charter, by-laws or applicable state law prescribe a greater degree of stockholder approval for this action, without the degree of stockholder approval thus required, the Board of Directors may not (a) increase the aggregate number of shares which may be issued under Options granted pursuant to the provisions of this Plan; (b) materially increase the benefits accruing to participants under this Plan; (c) change the class of employees eligible to receive incentive stock options; or (d) materially modify the requirements as to eligibility for -7- participation in this Plan, PROVIDED, FURTHER, that the Board shall have the power to make such changes in this Plan and in the regulations and administrative provisions hereunder or in any outstanding Option as in the opinion of counsel for the Company may be necessary or appropriate from time to time to enable any Option granted pursuant to this Plan to qualify as incentive stock options under Section 422 of the Internal Revenue Code of 1986, as amended, and the regulations which may be issued thereunder as in existence from time to time. All Options granted under this Plan shall be subject to the terms and provisions of this Plan and any amendment, modification or revision of this Plan shall be deemed to amend, modify or revise all Options outstanding under this Plan at the time of such amendment, modification or revision. In the event this Plan is terminated by action of the Board of Directors, all Options outstanding under this Plan may be terminated. 20. WRITTEN AGREEMENT. Each Option granted hereunder shall be embodied in a written option agreement, which shall be subject to the terms and conditions prescribed above, and shall be signed by the optionee and by the appropriate officer of the Company for and in the name and on behalf of the Company. Such an option agreement shall contain such other provisions as the Committee in its discretion shall deem advisable. 21. INDEMNIFICATION OF THE COMMITTEE AND THE BOARD OF DIRECTORS. The Company will, to the fullest extent permitted by law, indemnify, defend and hold harmless any person who at any time is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding (whether civil, criminal, administrative or investigative) in any way relating to or arising out of this Plan or any Option or Options granted hereunder by reason of the fact that such person is or was at any time a director of the Company or a member of the Committee against judgments, fines, penalties, settlements and reasonable expenses (including attorneys' fees) actually incurred by such person in connection with such action, suit or proceeding. This right of indemnification will inure to the benefit of the heirs, executors and administrators of each such person and is in addition to all other rights to which such person may be entitled by virtue of the by-laws of the Company or as a matter of law, contract or otherwise. 22. EFFECTIVE DATE OF PLAN. This Plan shall become effective and shall be deemed to have been adopted on January 17, 1992, if within one year of that date it shall have been approved by the holders of at least a majority of the outstanding shares of voting stock of the Company voting in person or by proxy at a duly held stockholders' meeting, or if the provisions of the corporate charter, by-laws or applicable state law prescribe a greater degree of stockholder approval for this action, the approval by the holders of that percentage, at a duly held meeting of stockholders. No Options shall be granted pursuant to this Plan after January 16, 2002. -8- FIRST AMENDMENT TO LIFECELL CORPORATION SECOND AMENDED AND RESTATED 1992 STOCK OPTION PLAN ADOPTED BY THE BOARD OF DIRECTORS MARCH 15, 1996 AND BY THE STOCKHOLDERS MAY 20, 1996 1. Paragraph 3 of the LifeCell Corporation Second Amended and Restated 1992 Stock Option Plan is hereby deleted in its entirety and replaced by the following: 3. OPTION SHARES. The stock subject to the Options and other provisions of this Plan shall be shares of the Company's Common Stock, $.001 par value (the "Common Stock"). The total amount of Common Stock with respect to which Options may be granted shall not exceed in the aggregate 1,000,000, PROVIDED that the class and aggregate number of shares which may be subject to the Options granted hereunder shall be subject to adjustment in accordance with the provisions of Paragraph 17 hereof. Such shares may be treasury shares or authorized but unissued shares. In the event that any outstanding Option for any reason shall expire or terminate by reason of the death or severance of employment of the optionee, the surrender of any such Option, or any other cause, the shares of Common Stock allocable to the unexercised portion of such Option may again be subject to an Option under this Plan. 2. Except as expressly amended by this First Amendment, the LifeCell Corporation Second Amended and Restated 1992 Stock Option Plan shall continue in full force and effect in accordance with its terms. SECOND AMENDMENT TO LIFECELL CORPORATION SECOND AMENDED AND RESTATED 1992 STOCK OPTION PLAN ADOPTED BY THE BOARD OF DIRECTORS FEBRUARY 10, 1997 1. The first sentence of Paragraph 2 of the LifeCell Corporation Second Amended and Restated 1992 Stock Option Plan, as amended by the First Amendment to LifeCell Corporation Second Amended and Restated 1992 Stock Option Plan adopted by the Board of Directors on March 15, 1996 and the stockholders of LifeCell Corporation on June 20, 1996 (the "First Amendment"), is hereby deleted in its entirety and replaced by the following: This Plan shall be administered by a committee to be appointed by the Board of Directors of the Company (the "Committee"), which Committee shall consist of not less than two members of the Board of Directors and shall be comprised solely of members of the Board of Directors who qualify as non-employee directors as defined in Rule 16b-3(b)(3) of the Securities Exchange Act of 1934, as amended (the "Securities Exchange Act"). 2. Except as expressly amended by the First Amendment and this Second Amendment, the LifeCell Corporation Second Amended and Restated 1992 Stock Option Plan shall continue in full force and effect in accordance with its terms. EX-10.4 4 EXHIBIT 10.4 LIFECELL CORPORATION SECOND AMENDED AND RESTATED 1993 NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN MARCH 15, 1996 1. PURPOSE. This Second Amended and Restated 1993 Non-Employee Director Stock Option Plan (this "Plan") of LifeCell Corporation, a Delaware corporation (the "Company"), is adopted, subject to stockholder approval, for the benefit of the directors of the Company who at the time of their service are not employees of the Company or any of its subsidiaries ("Non-Employee Directors"), and is intended to advance the interests of the Company by providing the Non-Employee Directors with additional incentive to serve the Company by increasing their proprietary interest in the success of the Company. 2. ADMINISTRATION. This Plan shall be administered by a committee to be appointed by the Board of Directors of the Company (the "Committee"), the members of which shall consist of not less than two members of the Board of Directors. For the purposes of this Plan, a majority of the members of the Committee shall constitute a quorum for the transaction of business, and the vote of a majority of those members present at any meeting shall decide any question brought before that meeting. No member of the Committee shall be liable for any act or omission of any other member of the Committee or for any act or omission on his own part, including (without limitation) the exercise of any power or discretion given to him under this Plan, except those resulting from his own gross negligence or willful misconduct. All questions of interpretation and application of this Plan, or as to options granted hereunder (the "Options"), shall be subject to the determination, which shall be final and binding, of a majority of the whole Committee. Notwithstanding the above, the selection of Non-Employee Directors to whom Options are to be granted, the number of shares subject to any Option, the exercise price of any Option and the term of any Option shall be as hereinafter provided and the Committee shall have no discretion as to such matters. 3. OPTION SHARES. The stock subject to the Options and other provisions of this Plan shall be shares of the Company's Common Stock, $.001 par value per share (or such other par value as may be designated by act of the Company's stockholders, the "Common Stock"). The total amount of Common Stock with respect to which Options may be granted shall not exceed 750,000 shares in the aggregate; PROVIDED, that the class and aggregate number of shares which may be subject to the Options granted hereunder shall be subject to adjustment in accordance with the provisions of Section of this Plan. Such shares may be treasury shares or authorized but unissued shares. If any outstanding Option for any reason shall expire or terminate by reason of the death of the optionee or the fact that the optionee ceases to be a director, the surrender of any such Option, or any other cause, the shares of Common Stock allocable to the unexercised portion of such Option may again be subject to an Option under this Plan. 4. GRANT OF OPTIONS. (a) DIRECTORS ON THE EFFECTIVE DATE OF THIS PLAN. (i) Subject to the provisions of Section hereof, there shall be granted to each person who is a Non-Employee Director upon the effective date of this Plan an Option to purchase 50,000 shares of Common Stock at a per share Option Price equal to the fair market value (as defined in Subsection (c) below) of a share of Common Stock on such date. (ii) For so long as this Plan is in effect and shares are available for the grant of Options hereunder, on June 1 of each year beginning June 1, 1996, there shall be granted to each person who is a Non-Employee Director on the effective date of this Plan and on such June 1 an Option to purchase 10,000 shares of Common Stock at a per share Option Price equal to the fair market value of a share of the Company's Common Stock on such date (such number of shares being subject to the adjustments provided in Section of this Plan). (b) DIRECTORS ELECTED AFTER THE EFFECTIVE DATE OF THIS PLAN. (i) Subject to the provisions of Section , for so long as this Plan is in effect and shares are available for the grant of Options hereunder, each person who shall become a Non-Employee Director after the effective date of this Plan shall be granted, on the date of his election, an Option to purchase 25,000 shares of Common Stock at a per share Option Price equal to the fair market value of a share of Common Stock on such date (such number of shares being subject to the adjustments provided in Section of this Plan). (ii) For so long as this Plan is in effect and shares are available for the grant of Options hereunder, on June 1 of each year beginning June 1, 1996 there shall be granted to each person who shall become a Non-Employee Director after the effective date of this Plan and is a Non-Employee Director on such June 1 an Option to purchase 10,000 shares of Common Stock at a per share Option Price equal to the fair market value of a share of Common Stock on such date (such number of shares being subject to the adjustments provided in Section of this Plan). (c) FAIR MARKET VALUE. For purposes of this Section , the "fair market value" of a share of Common Stock as of any particular date shall mean (i) if the Common Stock is listed or admitted to trading on any securities exchange or on the National Association of Securities Dealers (the "NASD") Automated Quotation System ("Nasdaq") National Market, the closing price on such day on the principal -2- securities exchange or on the Nasdaq National Market on which the Common Stock is traded or quoted, or if such day is not a trading day for such securities exchange or the Nasdaq National Market, the closing price on the first preceding day that was a trading day, (ii) if the Common Stock is not then listed or admitted to trading on any securities exchange or on the Nasdaq National Market, the closing bid price on such day as reported by the NASD, or if no such price is reported by the NASD for such day, the closing bid price as reported by the NASD on the first preceding day for which such price is available, and (iii) if the Common Stock is not then listed or admitted to trading on any securities exchange or on the Nasdaq National Market and no such closing bid price is reported by the NASD, as determined by another reputable quotation source selected by the Committee in good faith. 5. DURATION OF OPTIONS. Each Option granted under this Plan shall be exercisable for a term of nine years from the date such Option first becomes exercisable pursuant to Section hereof, subject to earlier termination as provided in Section of this Plan. 6. AMOUNT EXERCISABLE. Each Option granted under this Plan may be exercised in whole or in part at any time commencing one year after the grant thereof. 7. EXERCISE OF OPTIONS. An optionee may exercise his Option by delivering to the Company a written notice stating (a) that such optionee wishes to exercise such Option on the date such notice is so delivered, (b) the number of shares of stock with respect to which such Option is to be exercised and (c) the address to which the certificate representing such shares of stock should be mailed. To be effective, such written notice shall be accompanied by payment of the Option Price of each of such shares of stock. Each such payment shall be made by cash, cashier's check or bank draft drawn on a national banking association or postal or express money order, payable to the order of the Company in United States dollars. As promptly as practicable after the receipt by the Company of (a) such written notice from the optionee and (b) payment, in the form required by the foregoing provisions of this Section , of the Option Price of the shares of stock with respect to which such Option is to be exercised, a certificate representing the number of shares of stock with respect to which such Option has been so exercised registered in the name of such optionee, shall be delivered to such optionee, provided that such delivery shall be considered to have been made when such certificate shall have been mailed, postage prepaid, to such optionee at the address specified for such purpose in such written notice from the optionee to the Company. -3- 8. TRANSFERABILITY OF OPTIONS. Options shall not be transferable by the optionee otherwise than by will or under the laws of descent and distribution. 9. TERMINATION. Except as may be otherwise expressly provided in this Plan, each Option, to the extent it shall not have been exercised previously, shall terminate on the earlier of the following: (a) On the last day of the three-month period commencing on the date on which the optionee ceases to be a member of the Company's Board of Directors, for any reason other than the death or permanent disability of the optionee, during which period the optionee shall be entitled to exercise all Options held by the optionee on the date on which the optionee ceased to be a member of the Company's Board of Directors which could have been exercised on such date; (b) On the last day of the six-month period commencing on the date of the optionee's death while serving as a member of the Company's Board of Directors, during which period the executor or administrator of the optionee's estate or the person or persons to whom the optionee's Option shall have been transferred by will or the laws of descent or distribution, shall be entitled to exercise all Options in respect of the number of shares that the optionee would have been entitled to purchase had the optionee exercised such Options on the date of his death; or (c) Ten years after the date of grant of such Option. 10. REQUIREMENTS OF LAW. The Company shall not be required to sell or issue any shares under any Option if the issuance of such shares shall constitute a violation by the optionee or the Company of any provisions of any law or regulation of any governmental authority. Each Option granted under this Plan shall be subject to the requirements that, if at any time the Board of Directors of the Company or the Committee shall determine that the listing, registration or qualification of the shares subject thereto upon any securities exchange or under any state or federal law of the United States or of any other country or governmental subdivision thereof, or the consent or approval of any governmental regulatory body, or investment or other representations, are necessary or desirable in connection with the issue or purchase of shares subject thereto, no such Option may be exercised in whole or in part unless such listing, registration, qualification, consent, approval or representation shall have been effected or obtained free of any conditions not acceptable to the Board of Directors. Any determination in this connection by the Committee shall be final, binding and conclusive. If the shares issuable on exercise of an Option are not registered under the Securities Act of 1933, as amended (the "Securities Act"), the Company may imprint on the certificate for such shares the following legend or any other legend which counsel for the Company considers necessary or advisable to comply with the Securities Act: -4- THE SHARES OF STOCK REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 OR UNDER THE SECURITIES LAWS OF ANY STATE AND MAY NOT BE SOLD OR TRANSFERRED EXCEPT UPON SUCH REGISTRATION OR UPON RECEIPT BY THE CORPORATION OF AN OPINION OF COUNSEL SATISFACTORY TO THE CORPORATION, IN FORM AND SUBSTANCE SATISFACTORY TO THE CORPORATION, THAT REGISTRATION IS NOT REQUIRED FOR SUCH SALE OR TRANSFER. The Company may, but shall in no event be obligated to, register any securities covered hereby pursuant to the Securities Act (as now in effect or as hereafter amended) and, if any shares are so registered, the Company may remove any legend on certificates representing such shares. The Company shall not be obligated to take any other affirmative action to cause the exercise of an Option or the issuance of shares pursuant thereto to comply with any law or regulation of any governmental authority. 11. NO RIGHTS AS STOCKHOLDER. No optionee shall have rights as a stockholder with respect to shares covered by his Option until the date of issuance of a stock certificate for such shares; and, except as otherwise provided in Section hereof, no adjustment for dividends, or otherwise, shall be made if the record date therefor is prior to the date of issuance of such certificate. 12. CHANGES IN THE COMPANY'S CAPITAL STRUCTURE. The existence of outstanding Options shall not affect in any way the right or power of the Company or its stockholders to make or authorize any or all adjustments, recapitalizations, reorganizations or other changes in the Company's capital structure or its business, or any merger or consolidation of the Company, or any issue of bonds, debentures, preferred or prior preference stock ahead of or affecting the Common Stock or the rights thereof, or the dissolution or liquidation of the Company, or any sale or transfer of all or any part of its assets or business, or any other corporate act or proceeding, whether of a similar character or otherwise. If the Company shall effect a subdivision or consolidation of shares or other capital readjustment, the payment of a stock dividend or other increase or reduction of the number of shares of Common Stock outstanding, without receiving compensation therefor in money, services or property, then (a) the number, class and per share price of shares of stock subject to outstanding Options hereunder shall be appropriately adjusted in such a manner as to entitle an optionee to receive upon exercise of an Option, for the same aggregate cash consideration, the same total number and class or classes of shares as he would have received had he exercised his Option in full immediately prior to the event requiring the adjustment; and (b) the number and class of shares then reserved for issuance under this Plan and the number of shares to be subject to the grants to be made pursuant to Subsections (a)(ii), (b)(i) and (b)(ii) shall be adjusted by substituting for the total number and class of shares of stock then reserved or subject to grant the number and class or classes of shares of stock that would have been received by the owner of an equal number of outstanding shares of Common Stock as the result of the event requiring the adjustment, disregarding any fractional shares. If the Company merges or consolidates with another corporation, whether or not the Company -5- is a surviving corporation, or if the Company is liquidated or sells or otherwise disposes of substantially all its assets while unexercised Options remain outstanding under this Plan, or if any "person" (as that term is used in Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934, as amended (the "Securities Exchange Act")) is or becomes the beneficial owner, directly or indirectly, of securities of the Company representing greater than 50% of the combined voting power of the Company's then outstanding securities, after the effective date of such merger, consolidation, liquidation, sale or other disposition, as the case may be, each holder of an outstanding Option shall be entitled, upon exercise of such Option, to receive, in lieu of shares of Common Stock, the number and class or classes of shares of such stock or other securities or property to which such holder would have been entitled if, immediately prior to such merger, consolidation, liquidation, sale or other disposition, such holder had been the holder of record of a number of shares of Common Stock equal to the number of shares as to which such Option may be exercised. Except as otherwise expressly provided in this Plan, the issue by the Company of shares of stock of any class, or securities convertible into shares of stock of any class, for cash or property, or for labor or services either upon direct sale or upon the exercise of rights or warrants to subscribe therefor, or upon conversion of shares or obligations of the Company convertible into such shares or other securities, shall not affect, and no adjustment by reason thereof shall be made with respect to, the number or price of shares of Common Stock then subject to outstanding Options. 13. AMENDMENT OR TERMINATION OF PLAN. The Board of Directors may modify, revise or terminate this Plan at any time and from time to time; PROVIDED, HOWEVER, that without the further approval of the holders of at least a majority of the outstanding shares of voting stock, or if the provisions of the corporate charter, bylaws or applicable state law prescribes a greater degree of stockholder approval for this action, without the degree of stockholder approval thus required, the Board of Directors may not (a) materially increase the benefits accruing to participants under this Plan; (b) materially increase the number of shares of Common Stock which may be issued under this Plan; or (c) materially modify the requirements as to eligibility for participation in this Plan, unless, in each such case, the Board of Directors of the Company shall have obtained an opinion of legal counsel to the effect that stockholder approval of the amendment is not required (x) by law, (y) by the rules and regulations of, or any agreement with, the National Association of Securities Dealers, Inc. or (z) to make available to the optionee with respect to any option granted under this Plan, the benefits of Rule 16b-3 of the Rules and Regulations under the Securities Exchange Act, or any similar or successor rule. In addition, this Plan may not be amended more than once every six months with respect to the plan provisions referred to in Rule 16b-3(c)(2)(ii)(A) of the Rules and Regulations under the Securities Exchange Act other than to comport with changes in the Internal Revenue Code of 1986, as amended, the Employee Retirement Income Security Act of 1974, as amended, or the rules thereunder. All Options granted under this Plan shall be subject to the terms and provisions of this Plan and any amendment, modification or revision of this Plan shall be deemed to amend, modify or revise all Options outstanding under this Plan at the time of such amendment, modification or revision. If this Plan is terminated by action of the Board of Directors, all outstanding Options may be terminated. -6- 14. WRITTEN AGREEMENT. Each Option granted hereunder shall be embodied in a written option agreement, which shall be subject to the terms and conditions prescribed above, and shall be signed by the optionee and by the appropriate officer of the Company for and in the name and on behalf of the Company. Such an option agreement shall contain such other provisions as the Committee in its discretion shall deem advisable. 15. INDEMNIFICATION OF COMMITTEE AND BOARD OF DIRECTORS. The Company shall, to the fullest extent permitted by law, indemnify, defend and hold harmless any person who at any time is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding (whether civil, criminal, administrative or investigative) in any way relating to or arising out of this Plan or any Option or Options granted hereunder by reason of the fact that such person is or was at any time a director of the Company or a member of the Committee against judgments, fines, penalties, settlements and reasonable expenses (including attorneys' fees) actually incurred by such person in connection with such action, suit or proceeding. This right of indemnification shall inure to the benefit of the heirs, executors and administrators of each such person and is in addition to all other rights to which such person may be entitled by virtue of the by-laws of the Company or as a matter of law, contract or otherwise. 16. EFFECTIVE DATE OF PLAN. This Plan restates and integrates, and also amends, the LifeCell Corporation 1993 Non-Employee Director Stock Option Plan originally adopted effective July 22, 1993, as amended. This Plan shall become effective, subject to stockholder approval, on March 15, 1996. This Plan, and all Options granted under this Plan on or after March 15, 1996, and prior to stockholder approval, shall be void and of no further force and effect unless this Plan shall have been approved by the requisite vote of the stockholders entitled to vote at a meeting of the stockholders of the Company called for such purpose prior to March 15, 1997. No Option shall be granted pursuant to this Plan on or after July 22, 2003. -7- FIRST AMENDMENT TO LIFECELL CORPORATION SECOND AMENDED AND RESTATED 1993 NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN ADOPTED BY THE BOARD OF DIRECTORS ON FEBRUARY 10, 1997 1. The first sentence of Paragraph 2 of the LifeCell Corporation 1993 Non-Employee Director Stock Option Plan, as amended, is hereby deleted in its entirety and replaced by the following: This Plan shall be administered by a committee to be appointed by the Board of Directors of the Company (the "Committee"), which Committee shall consist of not less than two members of the Board of Directors and shall be comprised solely of members of the Board of Directors who qualify as non-employee directors as defined in Rule 16b-3(d)(1) of the Securities Exchange Act of 1934, as amended (the "Securities Exchange Act"). 2. Except as expressly amended by this First Amendment, the LifeCell Corporation Second Amended and Restated 1993 Non-Employee Director Stock Option Plan, as amended, shall continue in full force and effect in accordance with its terms. EX-10.15 5 EXHIBIT 10.15 - ------------------------------------------------------------------------------ LIFECELL CORPORATION SECURITIES PURCHASE AGREEMENT SERIES B PREFERRED STOCK AND WARRANTS - ------------------------------------------------------------------------------ NOVEMBER 18, 1996 LIST OF SCHEDULES Schedule 1 Investors; Securities Purchased; Purchase Price Schedule 3.2 Capital Stock Schedule 3.4 Conflicts Schedule 3.5 Litigation Schedule 3.10 Taxes Schedule 3.11 Material Adverse Effect Schedule 3.12 Title Schedule 3.13 Proprietary Rights Schedule 3.14 Contracts Schedule 3.15 Indebtedness Schedule 3.16 Compliance with Law Schedule 3.18 Insurance Schedule 3.21 Related Party Transactions Schedule 4.9 Principal Office or Domicile Schedule 6.1 Use of Proceeds LIST OF EXHIBITS Exhibit A Form of Warrant Exhibit B Form of Certificate of Designation Exhibit C Form of Voting Agreement Exhibit D Form of Registration Rights Agreement Exhibit E Form of Opinion of Counsel SECURITIES PURCHASE AGREEMENT, dated as of November 18, 1996 (this "AGREEMENT"), by and among LIFECELL CORPORATION, a Delaware corporation (the "COMPANY"), and those persons whose names are set forth on SCHEDULE 1 annexed hereto (each, an "INVESTOR" and collectively, the "INVESTORS"). R E C I T A L S: WHEREAS, the Company wishes to issue and sell to the Investors, and the Investors wish to purchase from the Company, for an aggregate purchase price of $12,415,700 (the "PURCHASE PRICE"), (a) an aggregate of 124,157 shares of the Series B Preferred Stock, and (b) warrants, in the form of EXHIBIT A attached hereto and made a part hereof (the "WARRANTS"; together with the Series B Preferred Stock, the "SECURITIES"), to purchase 2,803,530 shares of the Company's common stock, par value $.001 per share ("COMMON STOCK"), subject to and upon the terms and conditions hereinafter set forth. Capitalized terms not otherwise defined herein are defined in Section 12. AGREEMENTS; NOW, THEREFORE, in consideration of the foregoing and of the respective covenants and undertakings hereunder and for other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the Company and the Investors agree as follows: 1. SECURITIES. 1.1 PURCHASE. The Company hereby agrees to sell to the Investors, and the Investors hereby agree to purchase from the Company, the Series B Preferred Stock and the Warrants for an aggregate purchase price equal to the Purchase Price. At the closing of the separate purchases and sales of shares of the Series B Preferred Stock and the Warrants to each Investor (the "CLOSING"), the Company shall issue, sell and deliver to each Investor, and each Investor, severally and not jointly, shall purchase from the Company, the number of shares of the Series B Preferred Stock and Warrants set forth opposite the name of such Investor listed on SCHEDULE 1, for the PRO RATA portion of the Purchase Price set forth opposite the name of such Investor on such SCHEDULE 1. The Purchase Price shall be paid by the Investors to the Company at the Closing in immediately available funds by wire transfer or by delivery of bank cashier's checks or certified checks or by such other form as approved by the Company. 1.2 CERTIFICATE OF DESIGNATION. In connection with the issuance of shares of the Series B Preferred Stock, the Company will designate, authorize and create the Series B Preferred Stock, which will have the designations, powers, preferences and rights and the qualifications, limitations or restrictions thereof set forth in the Certificate of Designation (the "CERTIFICATE OF DESIGNATION") with respect to such series in the form of EXHIBIT B attached hereto and made a part hereof. 2. CLOSING. 2.1 PLACE AND TIME. The Closing shall take place at the offices of Kirkland & Ellis, 200 East Randolph Drive, Chicago, Illinois 60601 at 11:00 a.m. (Chicago time) November 18, 1996 following the satisfaction of the conditions set forth in this Agreement or at such other place, date and time as the Company and the Investors may agree in writing. 2.2 DELIVERIES. (a) COMPANY. At the Closing, upon receipt by the Company from the Investors of the Purchase Price, the Company shall deliver to each Investor (i) a certificate representing the number of shares of the Series B Preferred Stock set forth opposite such Investor's name on SCHEDULE 1, duly registered in the name of such Investor, (ii) a Warrant duly registered in the name of such Investor, representing the right to purchase in the aggregate the number of shares of Common Stock set forth opposite such Investor's name on such SCHEDULE 1 and (iii) all other documents, instruments and writings required by this Agreement to be delivered by the Company at the Closing. (b) INVESTORS. At the Closing, each Investor shall deliver to the Company (i) by wire transfer of immediately available funds or bank cashier's or certified check payable to the order of the Company in the amount of the Purchase Price set forth opposite such Investor's name on SCHEDULE 1, and (ii) all other documents, instruments and writings required by this Agreement to be delivered by such Investor at the Closing. 3. REPRESENTATIONS AND WARRANTIES OF THE COMPANY. The Company represents and warrants to and agrees with the Investors that: 3.1 ORGANIZATION AND QUALIFICATION. The Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware and has all requisite corporate power and authority to own its assets, carry on its business and carry out the transactions contemplated by this Agreement. The Company is qualified to do business in each of the jurisdictions in which the character of its assets or the nature of its activities makes such qualification in such jurisdictions necessary, except where the failure to so qualify would not have a Material Adverse Effect (as defined in Section 3.8 hereof). The Company has no subsidiaries and does not own of record or beneficially any securities of any corporation or any instrument or investment in any partnership, association, corporation, fund or business entity. 3.2 CAPITAL STOCK. Subject to the valid filing of the Certificate of Designation with the Secretary of State of Delaware, the authorized capital stock of the Company immediately following the Closing will consist of 25,000,000 shares of Common Stock and 2,000,000 shares of preferred stock, par value $.001 per share ("PREFERRED STOCK"), of which 300,000 shares are designated as shares of the Company's Series A Preferred Stock, par value $.001 per share ("SERIES A PREFERRED STOCK"), and 182,205 shares are designated as shares of the Series B Preferred Stock. Immediately following the Closing, there will be (a) 4,778,890 fully paid and non-assessable shares of Common Stock duly issued and outstanding and additional shares of Common Stock duly authorized and reserved for issuance (including (i) 1,761,139 shares of Common Stock duly 2 authorized and reserved for issuance upon conversion of the Series A Preferred Stock, (ii) 4,005,062 shares of Common Stock duly authorized and reserved for issuance upon conversion of the Series B Preferred Stock, (iii) 3,613,264 shares of Common Stock duly authorized and reserved for issuance upon exercise of those outstanding options and warrants (excluding employee and director stock options) set forth on SCHEDULE 3.2 - CAPITAL STOCK annexed hereto, (iv) 1,750,000 shares of Common Stock duly authorized and reserved for issuance pursuant to options granted or which may be granted under the Company's Second Amended and Restated 1992 Stock Option Plan and Second Amended and Restated 1993 Non-Employee Director Option Plan, (v) such number of shares of Common Stock as may be necessary, from time to time, for issuance to Medtronic, Inc. pursuant to that certain Investment Agreement, dated March 3, 1994, between the Company and Medtronic, Inc. and (vi) such number of shares of Common Stock as may be issued, from time to time, as dividends on the Preferred Stock; (b)260,000 fully paid and non-assessable shares of the Series A Preferred Stock duly issued and outstanding, registered to those holders of the Series A Preferred Stock set forth on SCHEDULE 3.2 - CAPITAL STOCK; and (c) 124,157 fully paid and non-assessable shares of the Series B Preferred Stock duly issued and outstanding, registered to the Investors as set forth on SCHEDULE 1. Upon the Closing, except as disclosed in this Section 3.2, no other capital stock of the Company will be outstanding or authorized or reserved for issuance. Except as disclosed on SCHEDULE 3.2 - CAPITAL STOCK, or as otherwise provided for in or contemplated by this Agreement, there are no preemptive rights or rights of first refusal to purchase any shares of the Series B Preferred Stock. The Company has not violated any applicable federal or state securities laws in connection with the offer, sale or issuance of any of its capital stock, and, assuming the accuracy of the representations and warranties set forth in Section 4, the offer, sale and issuance of the Series B Preferred Stock and the Warrants hereunder do not require registration under the Securities Act of 1933, as amended (the "SECURITIES ACT"), or registration or qualification under any applicable state securities laws other than such registration or qualification which the Company has obtained as of the Closing and which is disclosed on SCHEDULE 3.2 - CAPITAL STOCK. Other than as set forth on SCHEDULE 3.2 - CAPITAL STOCK, there are no options, warrants or rights to purchase any Common Stock, the Company has not authorized the issuance of any Common Stock, and there is no instrument or security convertible into or exchangeable for, or which entitles the holder thereof to purchase, any security of the Company. 3.3 AUTHORIZATION. The Company has taken all action necessary to authorize the issuance of the Securities and the execution and delivery of (a) this Agreement, (b) that certain Voting Agreement, dated as of the date hereof (the "VOTING AGREEMENT"), by and among the Company and the Investors, in the form of EXHIBIT C attached hereto and made a part hereof, (c) that certain Registration Rights Agreement, dated as of the date hereof (the "REGISTRATION RIGHTS AGREEMENT"), by and among the Company and the Investors, in the form of EXHIBIT D attached hereto and made a part hereof, and (d) the Warrants (collectively, the "TRANSACTION DOCUMENTS"). The Transaction Documents, when duly and validly executed and delivered by the Company, will thereafter constitute the legal, valid and binding obligations of the Company, enforceable in accordance with their respective terms, except as such enforceability may be limited by or subject to any bankruptcy, insolvency, reorganization, moratorium or similar laws affecting the enforcement of creditors' rights generally, and subject to general principles of equity. 3 3.4. NO CONFLICT. Except as set forth in SCHEDULE 3.4 - CONFLICTS, neither the execution and delivery of the Transaction Documents nor the fulfillment of the terms thereof will (a) conflict with or constitute a breach of, or a default under or give any third party the right to modify, terminate or accelerate any obligation under, (i) the Company's Restated Certificate of Incorporation, as amended (the "CERTIFICATE OF INCORPORATION"), (ii) the Company's Amended and Restated By-Laws (the "BY-LAWS"), (iii) any material agreement to which the Company is a party or by which the Company is bound, or (iv) any provision of law or any order of any court or governmental agency or authority entered in any proceeding to which the Company was or is now a party or by which the Company is bound or (b) result in the creation of any lien, charge or encumbrance on any of the business, assets or properties of the Company. 3.5 LITIGATION, ETC. Except as disclosed on SCHEDULE 3.5 - LITIGATION annexed hereto, there are no actions, suits, proceedings or investigations pending or, to the knowledge of the Company, threatened against the Company or which relate to the Company before any court or before any administrative agency or administrative officer, nor is there any litigation pending or, to the knowledge of the Company, threatened against the Company or against the principal executive officers of the Company by reason of employment agreements, confidentiality agreements, noncompetition agreements or other agreements or arrangements. Except as set forth on SCHEDULE 3.5 - LITIGATION, neither the Company nor any of its assets is subject to any judicial or administrative order, judgment or decree. Except as set forth on SCHEDULE 3.5 - LITIGATION, the Company has no knowledge of any existing violations by the Company or the principal executive officers of the Company of federal, state or local laws, regulations or orders. 3.6 GOVERNMENTAL AUTHORIZATIONS . Except for the filing of the Certificate of Designation with the Secretary of the State of Delaware and filings pursuant to federal and state securities and blue sky laws (which securities or blue sky law filings have been made, or are not required to be made, prior to the Closing), no approval or authorization of, or registration, qualification or filing with, any state regulatory body or any federal, state or municipal governmental authority in the United States or in any foreign country is required in connection with the execution, delivery or performance by the Company of the Transaction Documents or the issuance of the Securities or the performance by the Company of its obligations under the Certificate of Designation. 3.7 FURNISHING OF DOCUMENTS. The Company has furnished to the Investors a copy of the Company's Final Confidential Private Placement Memorandum, dated October 29,1996 and a Supplement thereto dated November __, 1996 (together, the "MEMORANDUM"), together with such information and documentation as the Investors have deemed necessary or appropriate to verify and confirm the accuracy and completeness of the information set forth in the Memorandum. 3.8 FULL DISCLOSURE. Neither (x) the Memorandum nor (y) the representations and warranties of the Company contained in this Section 3 contains any untrue statement of a material fact or omits to state a material fact necessary to make the statements contained therein, in the light of the circumstances under which they were made, not misleading. There is no fact known to the Company which the Company has not disclosed to the Investors which has had or, to the knowledge of the Company, could reasonably be expected to have a Material Adverse Effect (as defined below). A "MATERIAL ADVERSE EFFECT" shall mean any fact, event or occurrence or reasonably anticipated future event or occurrence which (a) involves an aggregate of $100,000 or more or (b) could be expected 4 to materially adversely effect (i) the business, assets, prospects, profits or condition (financial or otherwise) of the Company or (ii) the Company's ability to perform its obligations under the Transaction Documents or the Certificate of Designation. 3.9 FINANCIAL STATEMENTS. The Company has delivered to the Investors (a) an audited balance sheet of the Company as of December 31, 1995, and the related income statements for the fiscal year then ended (the "ANNUAL FINANCIAL STATEMENTS"), (b) an unaudited balance sheet of the Company as of June 30, 1996 and the related income statement for the fiscal quarter then ended (the "QUARTERLY FINANCIAL STATEMENTS"); and (c) a balance sheet of the Company as of August 31, 1996 (the "AUGUST BALANCE SHEET"; together with the Annual Financial Statements and the Quarterly Financial Statements, the "FINANCIAL STATEMENTS") and the related statement of income for the month then ended. The Financial Statements (a) present fairly the financial condition of the Company as of their respective dates and, as applicable, the results of operations for their respective periods (subject to, in the case of the Quarterly Financial Statements and the August Balance Sheet, year-end adjustments), (b) were prepared in accordance with the books and records of the Company in accordance with generally accepted accounting principles ("GAAP") consistently applied and (c) are true, correct and complete in all material respects. The Company hereby specifically confirms that there have been no changes during the periods covered in the Financial Statements in the Company's accounting principles and practices except as disclosed in the Financial Statements and there have been no changes in the Company's accounting principles and practices since the August Balance Sheet. 3.10 TAXES. Except as set forth on SCHEDULE 3.10 - TAXES annexed hereto, the Company has filed or caused to be filed on a timely basis all Tax Returns (as defined below) that are or were required to be filed by or with respect to it pursuant to the laws, regulations or administrative requirements of each governmental agency or authority with taxing power over it or its assets; the Company has paid, or has made adequate provision for the payment of, all Taxes (as defined below) that have or may have become due and no Tax Returns referred to above have been audited by any governmental agency or authority; the Company has not given or been requested to give waivers or extensions (or is or would be subject to a waiver or extension given by any other entity) of any statute of limitations relating to the payment of Taxes by the Company or for which the Company may be liable; the Company has received no notice of any proposed tax assessment against the Company. All Taxes that the Company is or was required by law to withhold or collect have been duly withheld or collected and, to the extent required, have been paid to the proper governmental agency or authority or other person; there is no claim, audit, action, suit, proceeding, or investigation with respect to Taxes due or claimed to be due from the Company or any Tax Return filed or required to be filed by the Company pending or, to the Company's knowledge, threatened against or with respect to the Company; to the knowledge of the Company, no Tax Return of the Company is being examined by the Internal Revenue Service (the "IRS") or any other governmental agency or authority, and no property of the Company which serves as the basis for the imposition of Taxes has been appraised, examined or reassessed by any taxing authority since the filing of the last Tax Return relating to the payment of such Taxes; the Company is not party to a tax sharing agreement; the Company has not made an election under Section 341(f) of the Internal Revenue Code of 1986, as amended (the "CODE"); to the knowledge of the Company, the Company is not liable for the taxes of another person in any material amount under (a) Treas. Reg. Section 1.1502-6 (or any comparable provisions of state, federal, local or foreign law), (b) as a transferee or successor, (c) by contract or 5 indemnity or (d) otherwise; and the Company has disclosed on its federal income Tax Returns any position taken for which substantial authority (within the meaning of Code Sec. 6662(d)(2)(B)(i)) did not exist at the time such return was filed by the Company. For the purposes hereof, (a) "TAX RETURNS" shall mean any return, report, information return or other document (including any related or supporting information) filed or required to be filed with any governmental agency or authority in connection with the determination, assessment or collection of any Taxes or the administration of any laws, regulations or administrative requirements relating to any Taxes; and (b) "TAXES" shall mean all taxes, duties, charges, fees, levies, interest, penalties, additions to tax or other assessments, including, but not limited to, foreign, federal, state and local income, excise, employment, property, sales, use, occupation, value added and franchise taxes and customs duties, imposed by any governmental agency or authority and any payments with respect thereto required under any tax-sharing agreement. 3.11 NO MATERIAL ADVERSE CHANGE. Since the date of the Annual Financial Statements, except as set forth on SCHEDULE 3.11 - MATERIAL ADVERSE EFFECT annexed hereto, there has not been any occurrence which could have a Material Adverse Effect (including without limitation the (a) entering into of any transaction (whether or not in the Company's ordinary course of business); (b) damage to, or destruction or loss of, physical property (whether or not covered by insurance); (c) borrowing or agreement to borrow by the Company or change in the contingent obligations of the Company by way of guaranty, endorsement, indemnity, warranty, or otherwise or grant of a mortgage or security interest in any properties of the Company; (d) payment of any obligation or liability other than current liabilities paid in the ordinary course of business; or (e) sale, assignment, transfer, or encumbrance of any tangible or intangible asset of the Company (except in the ordinary course of business) or the unauthorized discourse of any proprietary or confidential information on the Company.) 3.12 TITLE TO PROPERTIES; ENCUMBRANCES. The Company owns no real property, and has good and valid title to all other properties (personal and mixed, tangible and intangible) that it purports to own and a valid leasehold interest in all properties that it has leased. The Company is in compliance with all leases to which it is a party. The properties owned or leased by the Company are sufficient for the operation of the business of the Company as now conducted and as proposed to be conducted. Except as set forth on SCHEDULE 3.12 - TITLE annexed hereto, all properties and assets owned by the Company are owned free and clear of all encumbrances, except for security interests incurred in connection with the purchase of its property or assets (such security being limited to the property or assets so acquired and securing the purchase price therefor). 3.13 PROPRIETARY RIGHTS. Except as set forth on SCHEDULE 3.13 - PROPRIETARY RIGHTS annexed hereto, to the best knowledge of the Company, the Company owns or possesses, or has adequate and enforceable licenses or other rights to use and license for all purposes, all Proprietary Rights (as defined below) necessary for its business as now conducted and as proposed to be conducted without any conflict with or infringement of the rights of others. SCHEDULE 3.13-PROPRIETARY RIGHTS sets forth a true, complete and correct list of the Company's Proprietary Rights. Except as set forth on SCHEDULE 3.13 - PROPRIETARY RIGHTS, no claim has been asserted or, to the knowledge of the Company, threatened, by any person regarding the use or licensing of any of the Company's Proprietary Rights by the Company or challenging or questioning the validity, enforceability or effectiveness of any licenses or agreements (including, without limitation, 6 assignments) relating to Proprietary Rights or asserting any rights in such Proprietary Rights. To the best knowledge of the Company, other than as set forth on SCHEDULE 3.13 - PROPRIETARY RIGHTS, the use by the Company of its Proprietary Rights does not violate or infringe, and has not in the past violated or infringed, the rights of any person. Except as set forth on SCHEDULE 3.13 - PROPRIETARY RIGHTS, no claims have been asserted by the Company against any other person claiming infringement of the Company's Proprietary Rights. Except as set forth on SCHEDULE 3.13 - PROPRIETARY RIGHTS, the Company is not aware of any third parties who are infringing or violating any of the Company's Proprietary Rights. Neither the Company nor, to the knowledge of the Company, any other person is in default under any license or other agreement relating to the Company's Proprietary Rights (including without limitation, assignments), and all such licenses and agreements are valid, enforceable and in full force and effect. All inventors of patents and patent applications of the Company are or have been employees of the Company and have executed or agreed to execute an assignment of Proprietary Rights with respect to any such Proprietary Rights, and the Company has no obligation to pay any royalties with respect to the use of any such Proprietary Rights, except as set forth on SCHEDULE 3.13 - PROPRIETARY RIGHTS. SCHEDULE 3.13 - PROPRIETARY RIGHTS annexed hereto sets forth a list of those assignments of any Proprietary Rights of the Company which have been executed. As used in this Section 3.13, "PROPRIETARY RIGHTS" means all patents, patent applications, patent disclosures and inventions (whether or not patentable and whether or not reduced to practice), patent licenses, trademarks, trade names, trade secrets, service marks, brand marks, brand names, internet domain names, copyrights, copyright applications, inventions, mask works, technologies, know-how, formulae, processes, computer software, names and likenesses owned by the Company or pursuant to which the Company has a valid and enforceable license to use. 3.14 CONTRACTS. SCHEDULE 3.13 - PROPRIETARY RIGHTS, SCHEDULE 3.14 - CONTRACTS annexed hereto and SCHEDULE 3.21 - RELATED PARTY TRANSACTIONS annexed hereto set forth a true, complete and correct list of all material contracts, agreements, commitments, obligations and licenses to which the Company is a party ("COMPANY CONTRACTS"). For purposes hereof, a Company Contract is "material" if it is a Contract (or series of related Contracts) that (a) obligates the Company to pay in excess of $50,000 per annum or pursuant to which the Company would receive in excess of $50,000 per annum or (b) is not cancelable within sixty (60) days' notice by the Company without premium or penalty. All of the Company Contracts are valid and binding and in full force and effect; other than as set forth on SCHEDULE 3.14 - CONTRACTS, there are no existing defaults (or events which, with notice or lapse of time or both, would constitute a default) by the Company, or to the Company's knowledge, by any other party, thereunder. The Company has provided the Investors' counsel with copies of all of the Company Contracts identified on SCHEDULE 3.13 - PROPRIETARY RIGHTS, SCHEDULE 3.14 - CONTRACTS and SCHEDULE 3.21 - RELATED PARTY TRANSACTIONS, as such Company Contracts are in effect as of the date of the Closing. 3.15 INDEBTEDNESS. As of the date hereof, except as set forth on SCHEDULE 3.15-INDEBTEDNESS, the Company has no indebtedness or liabilities of any nature (matured or unmatured, fixed or contingent, direct or indirect, as guarantor or in any other capacity) which are not set forth in the Financial Statements and all reserves established by the Company and set forth in the Financial Statements are adequate for the purposes for which they were established. 3.16 REQUIRED APPROVALS; COMPLIANCE WITH LAW. Other than (a) the valid adoption by the Board of Directors of resolutions (i) embodied in the Certificate of Designation, and (ii) 7 authorizing the execution and delivery by the Company of the Transaction Documents (and the consummation of the transactions contemplated hereby and thereby, and the performance by the Company of its obligations hereunder and thereunder), (b) the consent of the majority of the holders of shares of the Series A Preferred Stock to the authorization and issuance of shares of the Series B Preferred Stock, and (c) the waiver by certain stockholders of the Company of those registration rights set forth on Schedule 5.1 to the Registration Rights Agreement ("CONFLICTING REGISTRATION RIGHTS"), and (d) the required consent of the holders of Conflicting Registration Rights to certain amendments to such Conflicting Registration Rights, no approval or consent is required by law or by the Certificate of Incorporation or By-Laws or by any indenture, agreement or other instrument to which the Company is a party or is otherwise bound or to which its assets are subject, or by any indebtedness of the Company, in connection with the issuance and sale of the Securities to the Investors pursuant to this Agreement and the performance by the Company of its obligations under the Transaction Documents and the Certificate of Designation. Other than as set forth on SCHEDULE 3.16 - COMPLIANCE WITH LAW annexed hereto, the Company is in compliance in all material respects with all laws (including without limitation the United States Food, Drug and Cosmetics Act, as amended, and the United States Public Health Service Act, as amended), rules, regulations and other requirements of all governmental bodies, domestic and foreign, having jurisdiction over the Company including, without limitation, the United States Food and Drug Administration. 3.17 ENVIRONMENTAL PROTECTION. (a) COMPLIANCE. The Company is in compliance in all material respects with all limitations, restrictions, conditions, standards, prohibitions, requirements, obligations, schedules and timetables contained in any Applicable Environmental Laws (as defined below), or in any judicial and administrative orders, determinations, decrees or judgments issued, entered, promulgated or approved thereunder or in connection therewith. The Company is not aware of, and has not received notice of, any past, present or future events, conditions, circumstances, activities, practices, incidents, actions or plans which would reasonably be expected to interfere with or prevent continued compliance, or which may give rise to any common law or legal liability, or otherwise form the basis of any claim, action, suit, proceedings, hearing or investigation, based on or related to the manufacture, processing, distribution, use, treatment, storage, disposal, transport, or handling, or the emission, discharge, release or threatened release into the environment, of any Hazardous Material (as defined below). (b) HAZARDOUS MATERIAL. No Hazardous Material has been incorporated in, used on, stored on or under, released from, treated on, transported to or from, or disposed of on or from any property leased by the Company during the period of the Company's lease(s) (or, to the knowledge of the Company, any prior period), such that, under Applicable Environmental Laws, (i) any such Hazardous Material would be required to be removed, cleaned-up or remediated before the property could be altered, renovated, demolished or transferred, or (ii) the owner or lessee of the property could be subjected to liability for the removal, clean-up or remediation of such Hazardous Material; and the Company has not received any notification from any Governmental Bodies or other third parties relating to Hazardous Material on or affecting any property owned or leased by the Company or relating to any potential or known liability under Applicable Environmental Laws arising from the ownership or leasing of any property. 8 (c) DEFINITIONS. For the purposes of this Agreement, "APPLICABLE ENVIRONMENTAL LAWS" shall mean the Comprehensive Environmental Response, Compensation and Liability Act, 42 U.S.C. ss.ss. 6901 et seq. ("CERCLA"), Resource Conservation and Recovery Act, 42 U.S.C. ss.ss. 6901 et seq. ("RCRA"), the Federal Waste Pollution Control Act, 33 U.S.C. ss. ss. 1261 et seq., the Clean Air Act, 42 U.S.C. ss. ss. 7401 et seq., any similar provisions of state or local law in the countries and jurisdictions where the properties of the Company are located and where the Company conducts its business and the regulations thereunder and any other local, state and/or federal laws or regulations that govern (i) the existence, cleanup and/or remediation of contamination on property; (ii) the protection of the environment from spilled, deposited or otherwise emplaced contamination; (iii) the control of hazardous wastes; or (iv) the use, generation, transport, handling, treatment, storage, disposal, removal or recovery of Hazardous Material, including building materials. For the purposes of this Agreement, "HAZARDOUS MATERIAL" shall mean any substance which as of the date of this Agreement shall be identified as "hazardous" or "toxic" or otherwise regulated under CERCLA or RCRA or which has been determined by any agency or court to be a hazardous or toxic substance under Applicable Environmental Law. 3.18 INSURANCE. The Company has insured by reputable insurers its assets that are of an insurable character against risks of liability (including product liability), casualty, and fire in adequate and customary amounts for similarly situated companies in similar businesses. SCHEDULE 3.18 - INSURANCE annexed hereto sets forth a true, complete and correct list of the Company's insurance policies, including policy limits and deductibles. The Company's insurance coverage is customary for well insured corporations of similar size engaged in similar lines of business. Except as set forth on SCHEDULE 3.18 - INSURANCE, the Company does not have any self-insurance or co-insurance programs, and the reserves set forth on the August Balance Sheet are adequate to cover all anticipated liabilities with respect to any such self-insurance or co-insurance programs. There are no material claims, actions, suits or proceedings arising out of or based upon any of such policies of insurance and, to the knowledge of the Company, no basis for any such material claim, action, suit or proceeding exists. 3.19 ERISA. (a) COMPANY BENEFIT PLAN AND BENEFIT ARRANGEMENT DEFINITIONS. The Company has previously delivered or made available to the Investors true and complete copies of: (i) all plan texts and agreements relating to each of the Company's benefit plan and benefit arrangements ("PLANS"); (ii) annual reports (Forms 5500) and periodic reports, if any, with respect to each plan for the last five years; (iii) the most recent actuarial valuation reports and financial statements for the last five years and the most recent determination letter received from the IRS with respect to the Company's Profit Sharing Plan; and (iv) the most recent summary plan description, each summary of material modifications thereto and the most recent employee handbook of the Company. (b) COMPLIANCE, LITIGATION. With respect to each Plan: (i) the Company has timely made all payments due from it to date, and all amounts properly accrued to date as liabilities of the Company which have not been paid have been properly recorded on the books of the Company if required by GAAP; (ii) the Company has complied in all material respects with, and each such Plan conforms in all material respects to, all applicable laws and regulations, including, without limitation, the Employee Retirement Income Security Act of 1974, as amended ("ERISA"), and the 9 Code, and each such plan or arrangement that is intended to be "qualified" within the meaning of Section 401(a) or 403(a) of the Code has been determined by the IRS to be qualified; and (iii) there are no actions, suits, claims or audits pending (other than routine claims for benefits) or, to the Company's knowledge, threatened, with respect to any Plan or against the assets of any Plan. The Company has made all contributions in respect of its 1995 fiscal year on account of each Plan (including, without limitation, unfunded pension liabilities and profit sharing liabilities), whether or not such contributions have come due as of the date of this Agreement. As of the date of this Agreement, there is no unfunded past service cost in respect of any Plan. (c) PENSION PLANS. No Plan that is a "pension plan" (as defined in Section 3(2) of ERISA) that is or was subject to Title IV of ERISA has been terminated or merged; no proceeding has been initiated to terminate any such Plan; no "reportable event" within the meaning of Section 4043(b) of ERISA has occurred or is expected to occur (other than as a result of this transaction); neither the Company nor any Plan fiduciary (as defined in Section 3(21) of ERISA) with respect to any Plan, has engaged in any transaction or acted or failed to act in a manner that violates Section 404 or 406 of ERISA or engaged in any prohibited transaction (as defined in Section 4975(c)(1) of the Code) for which there exists neither a statutory or regulatory exemption or for which an exemption has not been obtained; and the Company has not incurred any liability, whether to the Pension Benefit Guaranty Corporation or otherwise, except for required premium payments, which payments have been made when due. No event has occurred, and there exists no condition or set of circumstances which presents a risk of the partial termination of any such Plan. (d) FUNDING DEFICIENCY. No such Plan has incurred an "accumulated funding deficiency" (as defined in Section 302 of ERISA and Section 412 of the Code), whether or not waived. (e) TRIGGERING EVENTS. The consummation of the transactions contemplated by this Agreement by itself and without consideration of subsequent events will not (i) entitle any current or former employee of the Company to severance pay, unemployment compensation or any similar payment, or (ii) accelerate the time of payment or vesting, or increase the amount of any compensation due to any such employee or former employee. (f) MULTIPLE EMPLOYER PLAN. No Plan is a "multiple employer plan," within the meaning of the Code or ERISA or the regulations promulgated thereunder, or a "multi-employer plan" as defined in Section 4001(a)(3) of ERISA, and the Company has not made any contributions to or participated in any "multiple employer plan" or "multi-employer plan." 3.20 NO BROKER OR FINDER. Other than Gruntal & Co., Incorporated, the Company has engaged no broker or finder in connection with this Agreement or the transactions contemplated hereby. 3.21 RELATED PARTY TRANSACTIONS. SCHEDULE 3.21 - RELATED PARTY TRANSACTIONS contains a list of all Contracts (including summaries of any oral Contracts) between the Company and any employee, officer or director of the Company, any existing holder of five percent (5%) or more of the outstanding shares of Common Stock, or any Affiliate or immediate family member of any of the foregoing (any of the foregoing, a "RELATED PARTY"). Except as disclosed in the Memorandum or 10 on SCHEDULE 3.21 - RELATED PARTY TRANSACTIONS, no Related Party is indebted to the Company, and the Company is not indebted and is not committed to make loans or extend or guarantee credit to any Related Party. Except as disclosed on SCHEDULE 3.21 - RELATED PARTY TRANSACTIONS, no Related Party is interested, directly or indirectly, in any Contract with the Company except by reason of such Related Party's ownership interest in the Company. Except as disclosed on SCHEDULE 3.21 - RELATED PARTY TRANSACTIONS, no Related Party or party to this Agreement is presently, directly or indirectly through such party's affiliation with any other person, a party to any transaction with the Company providing for the furnishing of services by, or rental of real or personal property from, or otherwise requiring cash payments to, any such person pursuant to a Contract. 3.22 SMALL BUSINESS MATTERS (a) REPRESENTATIONS. (i) The information set forth in the United States Small Business Administration ("SBA") Forms 480, 652 and Part A of Form 1031 regarding the Company and its Affiliates is accurate and complete. Copies of such forms shall have been completed and executed by the Company and delivered to each Investor that has advised the Company that it is licensed as a "small business investment company" by the SBA (each, a "SBIC INVESTOR") at the Closing. (ii) The proceeds from the sale of the Securities will be used by the Company as set forth on SCHEDULE 6.1 - USE OF PROCEEDS annexed hereto. No portion of such proceeds will be used (A) to provide capital to a corporation licensed under the Small Business Investment Act of 1958, as amended (the "SBIA"), (B) to acquire farm land, (C) to fund production of a single item or defined limited number of items, generally over a defined production period, with such production constituting the majority of the activities of the Company (examples include motion pictures and electric generating plants), or (D) for any purpose contrary to the public interest (including, but not limited to, activities which are in violation of law) or inconsistent with free competitive enterprise, in each case, within the meaning of 13 C.F.R. ss. 107.720. (iii) The Company's primary business activity does not involve, directly or indirectly, providing funds to others, the purchase or discounting of debt obligations, factoring or long-term leasing of equipment with no provision for maintenance or repair; and the Company is not classified under Major Group 65 (Real Estate) of the SIC Manual. The assets of the Company's business will not be reduced or consumed, generally without replacement, as the life of the business progresses; and the nature of the Company's business does not require that a stream of cash payments be made to the financing sources of the Company's business, on a basis associated with the continuing sale of assets (examples of such businesses would include real estate development projects and oil and gas wells). (SEE 13 C.F.R. 107.720) (iv) The proceeds from the sale of the Securities will not be used substantially for a foreign operation; and at the time of the Closing or within one year thereafter, no more than 49% of the employees or tangible assets of the Company will be located outside the United States. This clause (iv) does not prohibit such proceeds from being used to acquire foreign materials and equipment or foreign property rights for use or sale in the United States. 11 (v) If the Company breaches the representation contained in clauses (ii), (iii) or (iv) of this subsection 3.22 (a) in any material respect, then in addition to all other remedies available to each SBIC Investor, each SBIC Investor may demand that the Company immediately repurchase all Securities purchased by each SBIC Investor hereunder at original cost. (b) REGULATORY COMPLIANCE COOPERATION. (i) In the event that a SBIC Investor determines that it has a Regulatory Problem (as defined in clause (iv) below), the Company and each Investor agree to use commercially reasonable efforts to take all such actions as are reasonably requested by the SBIC Investor in order (A) to effectuate and facilitate any transfer by the SBIC Investor of any Capital Stock of the Company then held by the SBIC Investor to any person designated by the SBIC Investor (B) to permit the SBIC Investor (or any member of its Group) to exchange all or any portion of the voting Capital Stock of the Company then held by such person on a share-for-share basis for shares of a class of non-voting Capital Stock of the Company, which non-voting Capital Stock shall be identical in all respects to such voting Capital Stock, except that such new Capital Stock shall be non-voting and shall be convertible into voting Capital Stock on such reasonable (and substantially equivalent terms to the Capital Stock now held) as are requested by the SBIC Investor in light of regulatory considerations then prevailing, and (C) to continue and preserve the respective allocation of the voting interests with respect to the Company provided for in this Agreement and/or arising out of the SBIC Investor's ownership of the voting Capital Stock of the Company. Any such transferee shall agree to be bound by the terms of this Agreement. Such actions may include, but shall not necessarily be limited to: (A) entering into such additional agreements as are reasonably requested by the SBIC Investor to permit any person(s) designated by the SBIC Investor to exercise any voting power which is relinquished by the SBIC Investor upon any exchange of voting Capital Stock for non-voting Capital Stock of the Company; and (B) entering into such additional agreements, adopting such amendments to the Certificate of Incorporation and By-Laws of the Company and taking such additional actions as are reasonably requested by the SBIC Investor in order to effectuate the intent of the foregoing. If the SBIC Investor elects to transfer Capital Stock of the Company to a Regulated Holder (as defined below) in order to avoid a Regulatory Problem, the Company shall enter into such agreements with such Regulated Holder as it may reasonably request in order to assist such Regulated Holder in complying with applicable laws, rules and regulations to which it is subject. Such agreements may include restrictions on the redemption, repurchase or retirement of Capital Stock of the Company that would result or be reasonably expected to result in such Regulated Holder holding more voting securities or total securities (equity and debt) than it is permitted to hold under such regulations. (ii) In the event the SBIC Investor has the right to acquire any of the Company's Capital Stock (as the result of Section 5 hereof or otherwise), at the SBIC Investor's request the Company will offer to sell to the SBIC Investor non-voting Capital Stock (or, if the Company is not the proposed seller, will arrange for the exchange of any voting Capital Stock for 12 non-voting Capital Stock immediately prior to or simultaneous with such sale) on the same terms as would have existed had the SBIC Investor acquired the Capital Stock so offered and immediately requested its exchange for non-voting Capital Stock pursuant to clause (i) above. (iii) In the event that any subsidiary of the Company ever offers to sell any of its Capital Stock to the SBIC Investor, then the Company will cause such subsidiary to enter into agreements with the SBIC Investor substantially similar to this subsection (b) and subsection (c) below. (iv) The Company shall grant to any subsequent holder of Capital Stock originally acquired by the SBIC Investor (a "SUBSEQUENT PURCHASER"), upon such person's request, the same rights granted to the SBIC Investor pursuant to this subsection (b) and subsection (c) below. (c) INFORMATION RIGHTS AND RELATED COVENANTS. (i) Within 75 days after the Closing, upon request of a SBIC Investor and the furnishing by such SBIC Investor of an appropriate form therefor, the Company shall provide to such SBIC Investor a certificate of its chief financial officer (A) verifying (and describing in reasonable detail) the use of the proceeds of the SBIC Investor's financing hereunder and (B) certifying compliance by the Company with the provisions of this Agreement. In addition to any other rights granted hereunder, the Company shall provide each SBIC Investor, any Affiliate of each SBIC Investor and the SBA access to its books and records for the purpose of verifying the use of the proceeds of such person's financing and for all other purposes required by the SBA. (ii) Upon request of a SBIC Investor and the furnishing by such SBIC Investor of an appropriate form therefor, after the end of each fiscal year (but in any event prior to February 28 of each year), the Company shall provide such SBIC Investor with a written assessment, in form and substance satisfactory to each SBIC Investor, of the economic impact of each SBIC Investor's financing under this Agreement, specifying the full-time equivalent jobs created or retained, the impact of the financing on the Company's business in terms of expanded revenue and taxes and other appropriate economic benefits, including, but not limited to, technology development or commercialization, minority business development, urban or rural business development, expansion of exports and assistance to manufacturing firms. (iii) Upon the request of a SBIC Investor, any Affiliate of a SBIC Investor or any Subsequent Purchaser, the Company will furnish to such person all information reasonably requested by it in order for it to prepare and file SBA Form 468 and any other information requested or required by any governmental agency asserting jurisdiction over such person. (iv) For a period of one year following the date hereof, neither the Company nor any subsidiaries thereof will change its business activity such that the Company would be unable to make the representations contained in clauses (ii), (iii) or (iv) of Section 3.22(a) and accordingly be ineligible to receive financial assistance from a "small business investment company" under the SBIA and the regulations thereunder (within the meanings of 13 C.F.R. 107.720 and 107.760(b)). If the Company breaches this covenant, then, in addition to all other remedies available 13 to a SBIC Investor, a SBIC Investor may demand that the Company immediately repurchase all Securities acquired by a SBIC Investor at original cost. (v) The Company will at all times comply with the non-discrimination requirements of 13 C.F.R., Parts 112, 113 and 117. 3.23 EMPLOYEES. The Company is not aware that any executive or key employee of the Company or any group of employees of the Company has any plans to terminate employment with the Company. 4. REPRESENTATIONS AND WARRANTIES OF THE INVESTORS. The parties hereto acknowledge that each Investor (a) is making representations and warranties in this Agreement only with respect to such Investor and (b) shall be liable only for representations and warranties made with respect to such Investor and not for any representations and warranties made with respect to any other Investor. Therefore, giving effect to the provisions set forth in the immediately preceding sentence, each of the Investors, severally and not jointly, hereby represents and warrants to the Company as follows: 4.1 AUTHORITY, EXECUTION AND DELIVERY. Such Investor, if a corporation, partnership or trust, has taken all corporate and other action or taken all action under applicable partnership and other agreements and applicable laws, as the case may be, necessary to authorize the execution and delivery of the Transaction Documents to which it is a party. Such Investor, if a corporation, has all necessary corporate power and authority to execute and deliver the Transaction Documents to which it is a party and to perform all of the terms and conditions herein and therein which are required to be performed by such Investor. Such Investor, if a partnership, trust or an individual, has all necessary power and authority, to execute and deliver the Transaction Documents to which it is a party and to perform all of the terms and conditions herein and therein which are required to be performed by such Investor. The Transaction Documents to which such Investor is a party have been duly and validly executed and delivered by such Investor and constitute the legal, valid and binding obligations of such Investor, enforceable in accordance with their respective terms, except as such enforceability may be limited by or subject to any bankruptcy, insolvency, reorganization, moratorium or similar laws affecting the enforcement of creditors' rights generally, and subject to general principles of equity. 4.2 NO CONFLICT OR VIOLATION. Neither the execution and delivery of the Transaction Documents to which such Investor is a party nor the fulfillment of the terms hereof or thereof will conflict with or constitute a breach of, or a default under, the organization documents of such Investor (if the Investor is a corporation, partnership, trust or other entity) or any other material Contract to which such Investor is a party or by which such Investor is bound, or result in the creation of any lien, charge or encumbrance on any of the business, assets or property of such Investor. The execution and delivery of this Agreement and the purchase of the Securities by such Investor will not violate any laws, rules, decisions or orders to which such Investor is subject. 4.3 INVESTMENT REPRESENTATIONS. The Investor is acquiring the Securities for the Investor's own account, for investment, and not with a view to, or for sale in connection with, the distribution thereof or of any interest therein, in violation of state or federal law. The Investor is an accredited investor as such term is defined in Rule 501(a) promulgated under the Securities Act. The Investor has adequate net worth and means of providing for its current needs and contingencies and 14 is able to sustain a complete loss of the investment in the Securities and has no need for liquidity in such investment. The Investor, itself or through its officers, employees or agents, has sufficient knowledge and experience in financial and business matters to be capable of evaluating the merits and risks of an investment such as an investment in the Securities, and the Investor, either alone or through its officers, employees or agents, has evaluated the merits and risks of the investment in the Securities. 4.4 TRANSFERS. (a) GENERAL. The Investors understand that the Securities have not been registered under the Securities Act, and that the Securities may not be sold, transferred, assigned or otherwise disposed of (any of the foregoing, a "TRANSFER") except pursuant to (x) an effective registration statement under the Securities Act, or (y) an available exemption from registration under the Securities Act permitting such disposition of securities and, if requested by the Company, an opinion of counsel, which opinion of counsel shall be reasonably satisfactory to counsel for the Company, that an exemption from such registration is available. In the event any of the Investors desires to Transfer any of the Securities or any interest therein (other than pursuant to an effective registration statement under the Securities Act or a sale pursuant to Rule 144 promulgated under the Securities Act, including Rule 144(k) or any successor thereto (any of the foregoing, a "PUBLIC SALE"); such Investor must give the Company prior written notice of such proposed Transfer including the name and address of the proposed transferee. Prior to any such proposed Transfer (other than in a Public Sale), and as a condition thereto, such Investor will deliver to the Company (i) an investment covenant signed by the proposed transferee, (ii) an agreement by such transferee to the restrictive investment legend set forth in Section 4.5 hereof on the certificate or certificates representing the Securities acquired by such transferee, and (iii) an agreement by the transferee to be subject to this Section 4.4, the Voting Agreement and the Registration Rights Agreement to the same extent as if such transferee were originally a signatory to this Agreement, the Voting Agreement and the Registration Rights Agreement. Except as restricted hereby, the Securities may be transferred by any Investor in whole or in part at any time or from time to time. Any Transfer of the Securities attempted contrary to the provisions of this Agreement, or any levy of execution, attachment or other process attempted upon the Securities, shall be null and void and without effect. (b) CERTAIN PERMITTED TRANSFERS. (i) MEMBERS OF GROUP. Notwithstanding any provisions to the contrary contained in subsection (a) above, (i) in the case of a Transfer by an Investor to a member of such Investor's Group, no opinion of counsel shall be necessary, provided that the transferee agrees in writing to be subject to this Section 4.4, the Voting Agreement and the Registration Rights Agreement to the same extent as if such transferee were originally a signatory to this Agreement, the Voting Agreement and the Registration Rights Agreement, and (ii) in the case of any Investor that is a partnership, no opinion of counsel shall be necessary for a Transfer by such Investor to a partner of such Investor, or a retired partner of such Investor who retires after the date hereof or the estate of any Investor, or the estate of any such partner or retired partner if, with respect to such Transfer by a partnership, such Transfer is made in accordance with the partnership agreement of such partnership, and the transferee agrees in writing to be subject to the terms of this Section 4.4, the Voting Agreement and the Registration Rights Agreement to the same extent as if such transferee 15 were originally a signatory to this Agreement, the Voting Agreement and the Registration Rights Agreement. (ii) METHOD OF TRANSFER. Upon surrender of any certificate representing the Securities to the Company or at the office of its stock transfer agent, if any, with assignment documentation duly executed and, upon compliance with the foregoing provisions, the Company shall, without charge, execute and deliver a new certificate representing such Securities in the name of the assignee named in such instrument of assignment, and the old certificate representing such Securities shall promptly be canceled. 4.5 LEGEND. So long as the Securities received by the Investors remain subject to the restrictions set forth in this Agreement, each instrument or certificate representing any of the Securities shall bear a legend substantially as follows: THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE LAW, AND NO INTEREST THEREIN MAY BE SOLD OR OTHERWISE TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION, WITHOUT AN OPINION OF LEGAL COUNSEL FOR THE HOLDER THAT SUCH REGISTRATION IS NOT REQUIRED, WHICH OPINION OF COUNSEL SHALL BE REASONABLY SATISFACTORY TO THE ISSUER OF SUCH SECURITIES (THE "COMPANY"). THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN TRANSFER AND VOTING RESTRICTIONS PURSUANT TO A SECURITIES PURCHASE AGREEMENT AND A VOTING AGREEMENT EACH DATED AS OF NOVEMBER 18, 1996, AMONG THE COMPANY AND CERTAIN OF THE COMPANY'S STOCKHOLDERS. COPIES OF SUCH SECURITIES PURCHASE AGREEMENT AND SUCH VOTING AGREEMENT WILL BE FURNISHED WITHOUT CHARGE BY THE COMPANY TO THE HOLDER HEREOF UPON WRITTEN REQUEST. The Company and any transfer agent acting on behalf of the Company may maintain on the Company's register for the Securities appropriate "stop transfer" notations with respect to the securities. 4.6 INFORMATION REGARDING COMPANY. The Investor has received from the Company a copy of the Memorandum and is aware of the risks related to an investment in the Securities. The Investor has obtained such further information and has had the opportunity to make any further investigation and inquiry concerning the Company as it has deemed necessary in order to verify and update the information contained in the Memorandum. All such questions have been answered to the full satisfaction of the Investor. The Investor further acknowledges that there can be 16 no assurance that the Company will be successful in the implementation of its business and that a total loss of the investment in the Securities is possible. 4.7 NO BROKER OR FINDER. The Investor has engaged no broker or finder in connection with this Agreement or the transactions contemplated hereby. 4.8 PRINCIPAL OFFICE OR DOMICILE. The principal office of the Investor (if the Investor is a corporation, partnership, trust or other entity) or domicile of the Investor (if the Investor is an individual) is set forth on SCHEDULE 4.8 - DOMICILE annexed hereto. 5. RIGHT OF FIRST REFUSAL. 5.1 FIRST OFFER. (a) So long as any shares of the Series B Preferred Stock are outstanding, if the Company proposes to issue any shares of Common Stock or any security convertible into or exchangeable for shares of Common Stock, or any unit of securities which includes shares of Common Stock or any security convertible into or exchangeable or exercisable for shares of Common Stock (in the case of securities convertible into or exchangeable or exercisable for shares of Common Stock, whether or not so convertible or exchangeable or exercisable only upon payment of additional consideration), in each case in connection with a financing by the Company, subject to Section 5.5 hereof (an "OFFERING"), then the Company shall prior thereto or simultaneously therewith offer to each Investor a percentage of the securities being issued in the Offering (the "OFFERING SECURITIES") equal to such Investor's then percentage ownership of the aggregate of the Underlying Common Stock and the Common Stock (such Investor's "PERCENTAGE SHARE"). Such offer shall be made by written notice setting forth the quantity and description of the security proposed to be issued, the price to be received in exchange therefor and the proposed date, time and place of the closing of the Offering (the "OFFERING NOTICE"). The Offering Notice shall be delivered by hand or by first-class, certified or overnight mail, postage prepaid, or by telecopier, by the Company to each Investor. (b) Each such Investor shall thereupon be entitled, for a period ending thirty (30) days after the date of the Offering Notice (the "ELECTION PERIOD"), to elect to purchase, at the price and upon the terms set forth in the Offering Notice, all or a portion of such Investor's Percentage Share of the Offering Securities by notice to the Company during the Election Period. (c) Each Investor electing to purchase its Percentage Share of the Offering Securities pursuant to this Section 5.1 (a "PARTICIPATING INVESTOR") shall, concurrently with the closing of any such Offering, deliver to the Company an official bank or certified check for the appropriate amount to the Company by hand delivery or by first-class, certified or overnight mail, postage prepaid addressed to the Company's principal office (or at such other place as the Company may designate at least ten (10) days prior to the closing of such Offering); and simultaneously therewith the Company shall issue and deliver to each Participating Investor certificates representing the Offering Securities being purchased by such Participating Investor. The Company covenants and agrees that all Offering Securities will, upon issuance and payment therefor, be duly and validly issued and outstanding, fully paid and non-assessable and free from all taxes, liens, and charges with respect to the issue thereof. 17 5.2 OVERSUBSCRIPTION AS TO OTHER INVESTORS. If any Investor has not elected to purchase all of such Investor's Percentage Share of the Offering Securities pursuant to Section 5.1 (such Investor, the "NONPARTICIPATING INVESTOR"), the Company shall so advise the Participating Investors by providing them with written notice, transmitted as aforesaid within five (5) days after the expiration of the Election Period. Each Participating Investor shall thereupon for a period of seven (7) days from the date of such notice be entitled to elect to purchase all or a portion of the Nonparticipating Investors' Percentage Share of the Offering Securities (the "AVAILABLE OFFERING SECURITIES"); PROVIDED, HOWEVER, that to the extent that more than one Participating Investor desires to purchase a portion of the Available Offering Securities which exceeds such Participating Investor's pro rata share of the Available Offering Securities (based on the Underlying Common Stock owned by all Participating Investors) (the "ADJUSTED PRO RATA SHARE"), the amount of such Available Offering Securities which each such Participating Investor shall be entitled to purchase shall be reduced to such Participating Investor's Adjusted Pro Rata Share. The rights granted by this Section 5.2 shall be exercisable in the manner described in Section 5.1. Any Offering Securities not so purchased may be sold at the closing of any Offering to Persons other than Investors for the price and upon the terms set forth in the Offering Notice. 5.3 OVERSUBSCRIPTION AS TO OTHER PERSONS. In addition to the rights granted under Section 5.2, if any holder of capital stock of the Company who is entitled to exercise rights comparable to those granted to the Investors under Section 5.1 does not exercise such rights in connection with any such Offering, in whole, after being notified of the availability of such rights, the Company shall so advise the Participating Investors by providing them with written notice, transmitted as aforesaid within five (5) days after the first to occur of (i) being advised of the failure of such other holders to exercise such rights or (ii) the expiration of any period in which such rights could have been exercised. Each Participating Investor shall thereupon for a period of seven (7) days from the date of such notice be entitled to elect to purchase some or all of the Offering Securities which could have been purchased by such other holders who did not exercise such rights; PROVIDED, HOWEVER, that to the extent that more than one of such Participating Investors exercising its rights granted under this Section 5.3 desires to purchase Offering Securities exceeding such Participating Investor's pro rata share (based on the aggregate number of securities held by all Participating Investors exercising their purchase rights under this Section 5.3) ("EXCESS ADDITIONAL SECURITIES"), the amount of such Excess Additional Securities which each such Participating Investor shall be entitled to purchase shall be reduced PRO RATA in accordance with that proportion as the number of securities held by such Investor then bears to the total number of securities then held by all such Investors desiring to purchase Excess Additional Securities pursuant to this Section 5.3. The rights granted by this Section 5.3 shall be exercisable in the manner described in Section 5.1. Any securities not so purchased may be sold at the closing of any Offering to Persons other than Investors who are entitled to purchase securities in the Offering for the price and upon the terms set forth in the notice first sent pursuant to said Section 5.1. 5.4 NO FRACTIONS. Notwithstanding the foregoing provisions, any purchase of securities pursuant to Sections 5.1, 5.2 or 5.3 may be made by a Participating Investor only of full shares or units and not of fractions of shares or units, any fraction to be rounded up to the nearest whole shares or unit and a Non-Participating Investor shall not be entitled to exercise any rights pursuant to such Sections from and after the date on which it becomes a Non-Participating Investor. 18 5.5 NON-APPLICABILITY. The foregoing provisions of this Section 5 shall not apply to (a) Common Stock issued in an offering registered under the Securities Act or to the public through a broker, dealer or market maker pursuant to the provisions of Rule 144 adopted under the Securities Act, (b) Common Stock issued by the Company as a dividend on Preferred Stock or upon any subdivision or split-up of the outstanding shares of any capital stock of the Company or any recapitalization thereof, or upon conversion of any shares of Preferred Stock, (c) Common Stock issued pursuant to any option or warrants or other rights that are outstanding as of the Closing identified on SCHEDULE 3.2 - CAPITAL STOCK, (d) Common Stock of the Company issued in connection with a Board-approved acquisition of a business by the Company as a result of which the Company owns in excess of 50% of the voting power of such business, (e) Common Stock issued to employees, officers, consultants, directors or vendors of the Company or pursuant to any Board-approved employee, officer, consultant or director benefit plan including, without limitation, any Board- approved stock option plan, and (f) Common Stock issued to (1) banks, savings and loan associations, equipment lessors or similar lending institutions in connection with such entities providing Board-approved credit facilities or equipment financings to the Company or (2) any party to any technology transfer agreement, distribution agreement, marketing agreement or any other agreement similar thereto, with the Company, as approved by the Board. 6. COVENANTS OF THE COMPANY. So long as at least 25% of the Underlying Common Stock remains outstanding or, if earlier, until the sixth anniversary of the date of the Closing: 6.1 USE OF PROCEEDS. The proceeds of the sale of the Series B Preferred Stock to be purchased pursuant to this Agreement shall be used solely as set forth on SCHEDULE 6.1 - USE OF PROCEEDS. 6.2 RESERVATION OF SHARES. The Company shall reserve and keep available out of its authorized but unissued Common Stock the number of shares of Common Stock required for issuance upon (a) the conversion of all of the Series B Preferred Stock and (b) the exercise of the Warrants (including in each case, any additional shares of Common Stock that may become so issuable by reason of the operation of anti-dilution provisions contained in the Certificate of Designation or the Warrants, respectively). 6.3 CORPORATE EXISTENCE; COMPLIANCE WITH LAW. The Company will maintain, preserve and renew its corporate existence and all material permits necessary to the conduct of the business of the Company as currently conducted and will comply, in all material respects, with all applicable statutes, rules, regulations and orders of all governmental bodies with respect to the conduct of its business and the ownership of its properties. 6.4 ENVIRONMENTAL MATTERS. The Company shall not discharge, place, release, spill or dispose of any Hazardous Materials or any other pollutants or effluents upon any properties leased by the Company or elsewhere (including, but not limited to, underground injection of such substances) other than in compliance with the Applicable Environmental Laws and the Company shall not discharge into the air any emission which would require a permit under the Clean Air Act or its state counterparts or any other Environmental Laws unless any and all such permit(s) are obtained prior to any discharge. 19 6.5 SMALL BUSINESS STOCK. The Company will take all actions reasonably necessary to ensure that the Underlying Common Stock shall constitute small business stock within the meaning of Section 1202(c) of the Code, and will make all filings required under Section 1202(d)(1)(C) of the Code and any related Treasury Regulations in connection therewith. 6.6 OPERATING COMPANY. The Company shall take all actions necessary to allow it to continue to constitute an Operating Company (as defined below), or otherwise not to cause any of the underlying assets of the Company or any of its subsidiaries to be deemed Plan Assets (as defined below) with respect to any qualified pension plan investor in the Company. For the purposes hereof, (a) "OPERATING COMPANY" shall mean an "operating company" within the meaning of Department of Labor Regulation ss.2510.3-101(c) or successor rule or regulation, as from time to time amended and in effect, and (b) "PLAN ASSETS" shall mean "plan assets" within the meaning of Department of Labor Regulation ss.2510.3-101(c) or successor rule or regulation, as from time to time amended and in effect. 6.7 EMPLOYMENT AND NON-COMPETITION AGREEMENTS. The Company shall not, without the prior consent of the majority of the Company's Board of Directors, amend any of (i) the Employment Agreement dated January 28, 1992 between the Company and Paul M. Frison, (ii) the Confidentiality, Inventions and Discoveries and Non-Competition Agreement dated as of January 28, 1992 between the Company and Mr. Frison, (iii) the Employment Agreement dated January 28, 1992 between the Company and Stephen A. Livesey, and (iv) the Confidentiality, Inventions and Discoveries and Non-Competition Agreement dated January 28, 1992 between the Company and Dr. Livesey, and shall enforce each of the foregoing agreements to the fullest extent permitted by law. 6.8 FINANCIAL AND OTHER INFORMATION. The Company shall provide the following information to each Investor holding at least 30% of the Underlying Common Stock as of the Closing (so long as such Investor holds any Underlying Common Stock): (a) ANNUAL STATEMENTS. As soon as practicable and in any event within 100 calendar days after the close of each fiscal year of the Company, copies of (A) the balance sheet of the Company as of the end of such fiscal year, (B) statements of operations of the Company for such fiscal year, and (C) statements of changes in cash flows of the Company for such fiscal year, setting forth in each case in comparative form the corresponding figures of the previous annual period and the most recent Budget (as defined in clause (d) below), all in reasonable detail, prepared in accordance with generally accepted accounting principles ("GAAP") consistently applied throughout the periods involved and audited and reported on (except for the comparison to the most recent Budget), by Arthur Andersen LLP or another firm of independent certified public accountants of recognized national standing. (b) QUARTERLY STATEMENTS. As soon as practicable, and in any event within 55 calendar days after the end of each of the first three fiscal quarters of the Company, copies of an unaudited balance sheet of the Company as at the end of each such fiscal quarter and unaudited statements of operations, and changes in cash flows for such fiscal quarter, setting forth in each case in comparative form corresponding figures for the preceding year's respective fiscal quarter and for the Budget, all in reasonable detail and (except for corresponding figures for the Budget) in the form 20 in which the Company currently provides such information to its stockholders, prepared in accordance with GAAP consistently applied throughout the period involved and certified as being correct and complete and fairly presenting the results of operations of the Company for the quarter indicated, subject to year-end audit adjustment, by the principal financial officer of the Company and in the form in which the Company currently provides such information to its directors. (c) MONTHLY STATEMENTS. For each calendar month, as soon as practicable and in any event within 30 calendar days after the close of each such month, copies of (A)(1) the balance sheet of the Company as of the end of such month, (2) statements of operations of the Company for such month, and (3) statements of changes in cash flows of the Company for such month setting forth in each case in comparative form the corresponding figures for the preceding month and for the Budget, for the year to date and for the comparable periods in the preceding year, all in reasonable detail and in the form in which the Company currently provides such information to its directors, prepared in accordance with generally accepted accounting principles consistently applied throughout the periods involved and certified as being correct and complete and fairly presenting the results of operations of the Company for the month indicated, subject to year-end audit adjustment, by the principal financial officer of the Company and (B) a certificate of the principal financial officer of the Company giving a narrative analysis of operations and trends in the business of the Company during such month and in the form in which the Company currently provides such information to its directors. (d) BUDGET. As soon as practicable and in any event no later than the end of each fiscal year of the Company, a proposed annual operating budget for the Company for the succeeding fiscal year, containing forecasts of profit and loss and cash flow with monthly and quarterly breakdowns and management's reasonably estimated projections of indebtedness and commitments for the succeeding fiscal year (the "BUDGET"). (e) MISCELLANEOUS DOCUMENTS. Promptly upon, and in any event within ten (10) calendar days after transmission thereof, a copy of all reports, proxy statements, financial statements, management letters and other materials (A) delivered or sent by the Company to its stockholders, (B) filed by the Company with the Securities and Exchange Commission or with any securities exchange on which any of the securities are then listed, and copies of all press releases and other statements made available generally by the Company to the public concerning material developments in the Company's and the subsidiaries' businesses; or (C) given to the Company by its independent accountants (and not otherwise contained in materials provided hereunder) to the extent such information concerns significant aspects of the Company. If for any period the Company shall have any subsidiary or subsidiaries whose accounts are consolidated with those of the Company, then the financial statements delivered for such period pursuant to the foregoing clauses (i) and (ii) shall be the consolidated and consolidating financial statements of the Company and all such consolidated subsidiaries and, if the financial statements of such subsidiary or subsidiaries are not consolidated with those of the Company, separate financial statements for such subsidiary or subsidiaries shall be provided. (f) ENVIRONMENTAL MATTERS. Written notification as to any pending or threatened claim, demand or action by any governmental agency or authority or other Person relating 21 to any Hazardous Materials affecting any properties leased by the Company of which it has knowledge promptly after the receipt of such knowledge. (g) LITIGATION. Written notification as to any material pending or threatened claim, demand or action by any governmental agency or authority or other Person promptly after the receipt of such knowledge. (h) BUSINESS RECORDS. During normal business hours, (a) all business records of the Company for inspection, and (b) the officers, employees and public accountants of the Company for discussions concerning the business, affairs and finances of the Company. 6.9 PROTECTIVE PROVISIONS. So long as the Company is required to deliver financial and other information to certain Investors pursuant to Section 6.8 hereof, the Company shall not select a lead managing underwriter for a public offering of Common Stock or other securities convertible into Common Stock without the prior approval of the Board of Directors of the Company which approval shall include the approval of a majority of the Investor Directors (as defined in the Voting Agreement). 6.10LIVESEY KEY-MAN LIFE INSURANCE. As soon as reasonably practicable after the Closing, the Company shall cause the death benefit of the Key Man Policy (as defined in Section 7.9) on the life of Dr. Livesey to be increased from $1.0 million to $3.0 million (or, alternatively the Company shall obtain an additional such policy with a death benefit of $2.0 million), naming the Company as sole beneficiary, from an insurer reasonably acceptable to the holders of a majority of the Series B Preferred Stock. 7. CONDITIONS TO OBLIGATIONS OF THE INVESTORS. The Investors' obligation to purchase the Securities shall be subject to the satisfaction of the following conditions, any of which may be waived in writing: 7.1 DELIVERY OF SECURITIES. The Company shall have delivered to each Investor the number of Securities set forth opposite such Investor's name on SCHEDULE 1. 7.2 REPRESENTATIONS AND WARRANTIES TRUE AT CLOSING: NON-OCCURRENCE OF DEFAULT. The representations and warranties contained in Section 3 hereof shall be true immediately prior to the Closing, there shall exist no condition, event or fact constituting (or which, with notice or passage of time or both would constitute) a default in the observance of any of the Company's undertakings or covenants hereunder or pursuant to the Certificate of Designation, and all conditions precedent to the Closing to be performed by the Company shall have been complied with; and the Chief Executive Officer and the Chief Financial Officer of the Company shall deliver to the Investors at the Closing a certificate to such effect, executed by them. 7.3 CORPORATE PROCEEDINGS. All corporate and other proceedings required to be taken in connection with the transactions contemplated hereby and by the Certificate of Designation (including, without limitation, the valid adoption and filing of the Certificate of Designation, the consent of the majority of the holders of the Series A Preferred Stock to the authorization and issuance of the Series B Preferred Stock and the waivers of holders of Conflicting Registration 22 Rights), and all documents incident hereto and thereto, shall be satisfactory in form and substance to the Investors, and the Investors shall have received all such counterpart originals or certified or other copies of such documents as they shall reasonably request. 7.4 CERTIFICATE OF DESIGNATION. The Board shall have adopted the resolutions embodied in the Certificate of Designation; and the Certificate of Designation shall have been filed with the Secretary of State of the State of Delaware, and its terms shall have become effective, and the Investors shall have received a copy of the Certificate of Designation, certified by the Secretary of State of the State of Delaware. The Certificate of Designation shall be in full force and effect as of the Closing and shall not have been amended or modified. 7.5 GOOD STANDING CERTIFICATES. The Investors shall have received (a) a copy of the Certificate of Incorporation certified as a recent date by the Secretary of State of Delaware, and (b) certificates of the Secretary of State of the State of Delaware with respect to the Company, and of each state in which the Company is qualified to do business as a foreign corporation as of a recent date showing the Company to be validly existing or qualified as a foreign corporation in its states of existence and qualification, as the case may be, and in good standing. 7.6 SECRETARY'S CERTIFICATE. The Investors shall have received a Certificate of the Secretary of the Company certifying that (a) no document has been filed relating to or affecting the Certificate of Incorporation of the Company after the date of the Certificate of the Secretary of the State of Delaware furnished pursuant to Section 7.4 except the Certificate of Designation, (b) attached to the Certificate is a true and complete copy of By-Laws of the Company, as in full force and effect at the Closing Date and (c) the names and true signatures of each officer of the Company who has been authorized to execute and deliver this Agreement and any other document to be delivered by the Company at the Closing. 7.7 VOTING AGREEMENT. The Company and the Investors shall have entered into the Voting Agreement, in the form of EXHIBIT C, and a copy of the signed Voting Agreement shall have been delivered to the Investors. 7.8 REGISTRATION RIGHTS AGREEMENT. The Company and the Investors shall have entered into the Registration Rights Agreement, in the form of EXHIBIT D, and a copy of the signed Registration Rights Agreement shall have been delivered to the Investors. 7.9 KEY-MAN LIFE INSURANCE. The Company shall have obtained key man life insurance policies (the "KEY-MAN POLICIES") on the lives of Mr. Frison and Dr. Livesey with death benefits of $1.0 million and $1.0 million, respectively, each naming the Company as the sole beneficiary, from an insurer of recognized responsibility; and upon completion of the Closing, the Key-Man Policies shall be effective, in full force and unencumbered, and all premiums, fees or charges which are due thereon shall have been paid. 7.10 OPINION OF COUNSEL. The Investors shall have received from Fulbright & Jaworski L.L.P., counsel to the Company, an opinion of counsel substantially in the form of EXHIBIT E attached hereto and made a part hereof. 23 7.11 SMALL BUSINESS ADMINISTRATION FORMS. Each SBIC Investor shall have received SBA Forms 480, 652 and Part A of Form 1031 properly completed and executed from the Company. 7.12 LITIGATION. No action or proceeding shall be pending or, to the knowledge of the Company, threatened, by or before any person, court or other governmental body to restrain or prohibit or to recover damages in respect of the consummation of any or all of the transactions contemplated by the Transaction Documents, nor shall there be any other action or proceeding pending or threatened which action, or other proceeding in the reasonable opinion of the Investors, may result in a decision, ruling, or finding that individually or in the aggregate has or may reasonably be expected to have a Material Adverse Effect or a material adverse effect on (a) the validity or enforceability of this Agreement, or (b) the Company's ability to perform its obligations under this Agreement. 7.13 APPROVALS AND CONSENTS. All licenses, authorizations, consents, orders and regulatory approvals of governmental bodies necessary in the good faith judgment of the Investors for the consummation of any or all of the transactions contemplated hereby shall have been obtained on terms satisfactory to the Investors and shall be in full force and effect; and consents or waivers from parties other than governmental bodies that are required in connection with the consummation of any or all of the transactions contemplated hereby shall have been obtained on terms satisfactory to the Investors and shall be in full force and effect and signed copies thereof shall have been delivered to the Investors. 7.14 COMPLIANCE EVIDENCE. The Investors shall have received such certificates, opinions, documents and information as they may reasonably request in order to establish satisfaction of the conditions set forth in this Section 7. 7.15 PROCEEDINGS SATISFACTORY. All certificates, opinions and other documents to be delivered by the Company and all other matters to be accomplished prior to or at the Closing shall be satisfactory in the reasonable judgment of the Investors and their counsel. 7.16 DUE DILIGENCE SATISFACTORY. The Investors shall have completed due diligence satisfactory to them with respect to the Company including, without limitation, due diligence relating to regulatory compliance and the Company's Proprietary Rights. 8. CONDITIONS TO OBLIGATIONS OF COMPANY. The Company's obligation to issue the Securities shall be subject to the satisfaction of the following conditions, any of which may be waived in writing: 8.1 DELIVERY OF PURCHASE PRICE. Each Investor shall have delivered to the Company that portion of the Purchase Price set forth opposite such Investor's name on SCHEDULE 1 annexed hereto. 8.2 REPRESENTATIONS AND WARRANTIES TRUE AT CLOSING; NON-OCCURRENCE OF DEFAULT. The representations and warranties contained in Section 4 hereof shall be true upon completion of the Closing, there shall exist no condition, event or fact constituting, or which, with notice or passage of time or both would constitute, a default in the observance of any of such Investor's undertakings 24 hereunder, and all conditions precedent to the Closing to be performed by the Investors shall have been complied with. 8.3 PROCEEDINGS AND DOCUMENTS. All legal and corporate proceedings in connection with the transactions contemplated by this Agreement shall be in form and substance reasonably satisfactory to the Company and its counsel, and the Company shall have received all such counterpart originals or certified or other copies of such documents and proceedings in connection with such transactions as the Company reasonably requests. 9. INDEMNIFICATION. The Company shall indemnify and hold harmless each Investor, its directors, partners, any member of its Group and each other person which controls (within the meaning of the Securities Act) such Investor or any of its directors or partners (any of the foregoing, a "COVERED PERSON") of, against and from any losses, claims, damages, liabilities or expenses ("LOSSES") insofar as such Losses (or actions in respect thereof) arise out of or are based upon (a) the falsity or incorrectness as of the Closing of any representation or warranty of the Company contained in or made pursuant to Section 3 hereof, (b) a default in the observance of any of the Company's undertakings or covenants under any Transaction Document or pursuant to the Certificate of Designation, (c) any action, claim or proceeding, asserted or unasserted, by any stockholder or creditor of the Company, or (d) the use, generation, storage, release, threatened release, discharge, disposal, transport, handling, treatment, removal, recovery or presence of Hazardous Materials on, under or about any properties leased by the Company by any person during the period that the Company was the tenant of any properties leased by the Company or which occurred prior to such time and was otherwise actually known by, or should have been known by, the Company. The obligation of the Company to indemnify each Covered Person shall specifically cover and include, without limitation, all fines and penalties imposed by federal, state or local authorities, costs of removing or neutralizing the Hazardous Materials, injury to the property adjoining any properties leased by the Company, injury to persons living or working on or about any properties leased by the Company or adjoining or otherwise affecting any such property, and all other indirect or consequential damages incurred by each Covered Person. The Company shall also pay all attorney's and accountant's fees and costs and court costs incurred by any Covered Person in enforcing the indemnification provided for herein. Notwithstanding the foregoing, the Company expressly agrees and acknowledges that the right of indemnification granted to each Covered Person herein shall not be deemed to be the exclusive remedy available to such Covered Person for any of the matters described herein. 10. EXPENSES. The Company agrees, in the event the transactions contemplated hereby are consummated, to pay, and save the Investors harmless against liability for the payment of, (a) their reasonable out-of-pocket costs, accounting fees, and legal fees arising in connection with the negotiation, execution and Closing of the transactions contemplated hereby, including without limitation (i) expenses relating to the Investors' due diligence investigation with respect to the transactions contemplated hereby and (ii) expenses of counsel for the Investors, (b) stamp and other transfer taxes which may be payable in respect of the execution and delivery of this Agreement or the issuance of the Securities and the Common Stock issuable on conversion or exercise thereof, and (c) fees and expenses (including, without limitation, reasonable attorneys' fees) incurred in respect of the enforcement by the Investors or the holders of the Securities of the rights granted to the Investors or the holders of the Securities under the Transaction Documents or the Certificate of Designation. 25 11. CONFIDENTIALITY. No Investor shall disclose any Confidential Information (as defined below); provided that, notwithstanding the foregoing, no Investor shall be prohibited from disclosing to any Person information that (i) is obtainable from a third party who is not obligated to maintain such information's confidentiality, (ii) is or becomes generally available to the public other than as a result of a breach by an Investor of its obligations under this Section 11 or has been published in a form generally available to the public, (iii) is lawfully in such Investor's possession prior to it being disclosed to such Investor through the Memorandum or otherwise by the Company, or (iv) an Investor is legally compelled to disclose. For purposes of this Section 11, the term "CONFIDENTIAL INFORMATION" means information that is not generally known to the public and that is developed or obtained by the Company in connection with its business which is contained in the Memorandum or provided to any Investor pursuant to the provisions of Sections 4.6 and 6.8 of this Agreement. 12. CERTAIN DEFINITIONS. "AFFILIATE" has the meaning set forth in Section 405 of the Securities Act. "CAPITAL STOCK" means, with respect to any person, such person's capital stock or any options, warrants or other securities which are directly or indirectly convertible into, or exercisable or exchangeable for, such person's capital stock (whether or not such derivative securities are issued by the Company). Whenever a reference herein to "CAPITAL STOCK" refers to any derivative securities, the rights of the SBIC Investor shall apply to such derivative securities and all underlying securities directly or indirectly issuable upon conversion, exchange or exercise of such derivative securities. "CIBC-WG" means CIBC Wood Gundy Ventures, Inc. "GROUP" shall mean as to (i) an Investor that is a limited partnership, such Investor with any and all of the limited partnerships now existing or hereafter arising that are Affiliates, in whole or in part, of one or more general partners or of one or more general partners of a general partner of such Investor and any predecessor or successor partnership and any limited and general partners of any such partnership; (ii) an Investor that is a trust, such Investor together with any of the beneficiaries, settlors or grantors now existing or hereafter arising of, or any person under common control with, such Investor and (iii) as to any other type of Investor, such Investor, together with the Affiliates of such Investor. "PERSON" means an individual, a partnership, a corporation, limited liability company, an association, a joint stock company, a trust, a joint venture, an unincorporated organization and a governmental entity or any department, agency or political subdivision thereof. "REGULATED HOLDER" means any holder of the Company's Capital Stock that is (or that is a subsidiary of a bank holding company that is) subject to the various provisions of Regulation Y of the Board of Governors of the Federal Reserve Systems, 12 C.F.R., Part 225 (or any successor to Regulation Y); "REGULATORY PROBLEM" means (A) any set of facts or circumstances wherein it has been asserted by any governmental regulatory agency (or the SBIC Investor or any Subsequent 26 Purchaser reasonably believes that there is a significant risk of such assertion) that such person (or any bank holding company that controls such person) is not entitled to hold, or exercise any material right with respect to, all or any portion of the Capital Stock of the Company which such person holds or (B) when such person and its Affiliates would own, control or have power (including voting rights) over a greater quantity of Capital Stock of the Company than is permitted under any law or regulation or any requirement of any governmental authority applicable to such person or to which such person is subject. "SALE" means a sale of all or substantially all of the Company's assets or a sale of all or substantially all of the Company's outstanding capital stock (whether by merger, recapitalization, consolidation, reorganization, combination or otherwise). "UNDERLYING COMMON STOCK" means (i) the Common Stock issued or issuable upon conversion of the Series B Preferred Stock or upon exercise of the Warrants and (ii) any Common Stock issued or issuable with respect to the securities referred to in clause (i) above by way of stock dividend or stock split or in connection with a combination of shares, recapitalization, merger, consolidation or other reorganization. For purposes of this Agreement, any Person who holds Series B Preferred Stock or any Warrants shall be deemed to the holder of the Underlying Common Stock obtainable upon conversion of the Series B Preferred or exercise of the Warrants in connection with the transfer thereof or otherwise regardless of any restriction or limitation on the conversion of the Series B Preferred to exercise of the Warrants, such Underlying Common Stock shall be deemed to be in existence and such person shall be entitled to exercise the rights of a holder of Underlying Common Stock hereunder. As to any particular shares of Underlying Common Stock, such shares shall cease to be Underlying Common Stock when they have been (a) effectively registered under the Securities Act and disposed of in accordance with the registration statement covering them, (b) distributed to the public through a broker, dealer or market maker pursuant to Rule 144 under the Securities Act (or any similar provision the in force) or (c) repurchased by the Company. "VECTOR" means Vector Later-Stage Equity Fund, L.P. 13. MISCELLANEOUS. 13.1 GOVERNING LAW; JURISDICTION. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE DOMESTIC LAWS OF THE STATE OF NEW YORK APPLICABLE TO CONTRACTS MADE AND TO BE PERFORMED IN THAT STATE WITHOUT GIVING EFFECT TO ANY CHOICE OR CONFLICT OF LAW PROVISION OR RULE (WHETHER IN THE STATE OF NEW YORK OR ANY OTHER JURISDICTION) THAT WOULD CAUSE THE APPLICATION OF THE LAWS OF ANY JURISDICTION OTHER THE STATE OF NEW YORK. THE PARTIES HERETO CONSENT TO THE JURISDICTION OF THE STATE OF NEW YORK OR STATE OR FEDERAL COURTS LOCATED THEREIN FOR ALL DISPUTES ARISING UNDER THIS AGREEMENT. 13.2 SURVIVAL. All representations, warranties and covenants contained in this Agreement or in any Exhibit or Schedule annexed hereto or certificate delivered in connection herewith shall survive the execution and delivery of this Agreement and the Closing and any investigation at any time made by the Investors or on their behalf and shall continue for a period of four (4) years following the Closing; PROVIDED, HOWEVER, that all representations, warranties and 27 covenants relating to Taxes and environmental matters shall survive until the expiration of the applicable statute of limitations relating thereto. 13.3 NOTICES. All notices, certificates or other communications hereunder shall be in writing, addressed as follows, and shall be effective (a) upon receipt if delivered personally or by telecopy (followed by telephonic confirmation of receipt), (b) three (3) business days after the date of postmark by the U.S. Postal Service when mailed, by registered or certified mail, return receipt requested, postage prepaid, or (c) the next business day following delivery to a reputable overnight courier service: If to the Company, to: LifeCell Corporation 3606 Research Forest Drive The Woodlands, Texas 77381 Attention: President Tel. No.: (713) 367-5368 Fax No.: (713) 363-3360 with a copy to: Fulbright & Jaworski L.L.P. 1301 McKinney, Suite 5100 Houston, Texas 77010-3095 Attention: Robert E. Wilson, Esq. Tel. No.: (713) 651-5151 Fax No.: (713) 651-5246 If to any Investor, to the address set forth opposite the name of such Investor on SCHEDULE 4.9 annexed hereto with a copy to Kirkland & Ellis, 200 East Randolph Drive, Chicago, Illinois 60601, Attention: Wendy L. Chronister, Esq.. Any party hereto may, by notice given hereunder, designate any further or different addresses to which subsequent notice, certificates or other communications shall be sent, which notice shall be deemed given when received. 13.4UNDERSTANDING AMONG THE INVESTORS. The determination of each Investor to purchase the Securities pursuant to this Agreement has been made by such Investor independent of any other Investor and independent of any statements or opinions as to the advisability of such purchase or as to the business, assets, prospects, profits or condition (financial or otherwise) of the Company which may have been made or given by any other Investor or by any agent or employee of any other Investor. In addition, it is acknowledged by each Investor that no other Investor has acted as an agent of such Investor in connection with making its investment hereunder and that no other Investor shall be acting as an agent of such Investor in connection with monitoring its investment hereunder. 28 13.5 BINDING EFFECT. The provisions of this Agreement shall bind and inure to the benefit of the parties hereto and their respective heirs, successors and permitted assigns. 13.6 NO WAIVER. No failure on the part of the Company or the Investors in exercising any right, power or privilege granted hereunder shall operate as a waiver thereof or of any other right, power or privilege, nor shall any single or partial exercise of such right, power or privilege preclude any other or further exercise thereof or of any other right, power or privilege. 13.7 ENTIRE AGREEMENT. This Agreement, together with the other Transaction Documents and the Certificate of Designation, sets forth the entire agreement among the parties hereto with respect to the subject matter hereof, and supersedes any prior oral or written agreement among the parties. 13.8 HEADINGS. The headings of this Agreement are solely for the convenience of the parties and shall not serve to limit or otherwise affect the interpretation or effect of any terms or provisions hereof. 13.9 COUNTERPARTS. This Agreement may be executed in two or more counterparts, each of which shall be deemed to be an original, but all of which together shall constitute one and the same document. 13.10 SEVERABILITY. In the event that any court or any governmental authority or agency declares all or any part of any Section of this Agreement to be unlawful or invalid, such unlawfulness or invalidity shall not serve to invalidate any other Section of this Agreement, and in the event that only a portion of any Section is so declared to be unlawful or invalid, such unlawfulness or invalidity shall not serve to invalidate the balance of such Section. 13.11 FURTHER ASSURANCES. Each party shall cooperate and take such action as may be reasonably requested by another party in order to carry out the provisions and purposes of this Agreement and the transactions contemplated hereby. 13.12 AMENDMENTS AND WAIVERS. This Agreement may be amended, modified and supplemented, and compliance with any term, covenant, agreement or condition contained herein may be waived either generally or in particular instances, and either retroactively or prospectively, only by a written instrument executed by (a) the Company and (b) holders of at least a majority of the Underlying Common Stock. No course of dealing between or among any persons having any interest in this Agreement will be deemed effective to modify, amend or discharge any part of this Agreement or any rights or obligations of any person under or by reason of this Agreement. * * * * * 29 IN WITNESS WHEREOF, the parties hereto have executed this Agreement on the date first above written, in the case of corporations by their respective officers thereunto duly authorized. LIFECELL CORPORATION By: PAUL M. FRISON Name Paul M. Frison Title Chairman of the Board, President and Chief Executive Officer VECTOR LATER-STAGE EQUITY FUND, L.P. By: [SIGNATURE ILLEGIBLE] Name: Title: PRESIDENT CIBC WOOD GUNDY VENTURES, INC. By: LORI KOFFMAN Name: Lori Koffman Title: Managing Director 30 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 6th day of November, 1996. /s/ STEPHEN LIVESEY (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Stephen Livesey 3606 Research Forest Dr. The Woodlands, TX 77381 ###-##-#### 250 5,645 $ 25,000 ==================================== ================ ============== ============ =============
31 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /s/ CHRISTOPHER C. KRAFT, JR. (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Christopher C. Kraft, Jr. Smith Barney Inc. KEO P/S Cust. 14919 Village Elm St. Houston, TX 77062 ###-##-#### 250 175 $ 25,000 ==================================== ================ ============== ============ =============
32 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /s/ P. WILLIAM CURRERI, M.D. (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= P. William Curreri, M.D. 217 Berwyn Dr. W. #222 Mobile, AL 36608 ###-##-#### 400 280 $ 40,000 ==================================== ================ ============== ============ =============
33 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ DAVID SAKS (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= David Saks 2 Knollwood Road Woodcliff Lake, NJ 07675 ###-##-#### 500 11,290 $ 50,000 ==================================== ================ ============== ============ =============
34 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ WILLIAM J. MCCLUSKEY (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= William J. McCluskey 25 Wisconsin St. Long Beach, NY 11561 ###-##-#### 186 4,200 $ 18,600 ==================================== ================ ============== ============ =============
35 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. The Woodlands Venture Capital Company By: /s/ DON E. ROOSE, JR. (Signature) Don E. Roose, Jr. Vice President and Controller
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================= ============= ============ ============= The Woodlands Venture Capital Company 74-2177794 2,500 $ 250,000 ==================================== ================= ============= ============ =============
36 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ JOHN S. BAI (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= John S. Bai 30 W. 61st - 27A New York, NY 10023 ###-##-#### 70 49 $ 21,700 ==================================== ================ ============== ============ =============
37 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ ROBERT WEINSTEIN (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Robert Weinstein 155 W. 68th St., 24C New York, NY 10023 ###-##-#### 155 3,500 $ 15,500 ==================================== ================ ============== ============ =============
38 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/JAMES C. GALE /s/ JUDITH S. HASELTON (Signature)
NUMBER OF SHARES OF FEDERAL SERIES B NUMBER OF EMPLOYER I.D. OR PREFERRED WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY STOCK SHARES INVESTMENT NUMBER PURCHASED ==================================== ================ ============== ============ ============= James C. Gale & Judith S. Haselton 315 W. 106 St., Apt. 4A ###-##-#### New York, New York 10025 ###-##-#### 1,550 35,000 $ 155,000 ================================== ================ =============== =========== ==============
39 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/JAMES C. GALE, TRUSTEE (Signature)
NUMBER OF SHARES OF FEDERAL SERIES B NUMBER OF EMPLOYER I.D. OR PREFERRED WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY STOCK SHARES INVESTMENT NUMBER PURCHASED ==================================== ================ ============== ============ ============= James C. Gale, Trustee F/B/O Ariana J. Gale 315 W. 106 St., Apt. 4A New York, New York 10025 13-6882735 620 14,000 $ 62,000 ================================== ================ =============== =========== ==============
[SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /s/ JOHN CIRRITO (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= John Cirrito 29 Rambling Drive Scotch Plains, NJ 07076 ###-##-#### 250 5645 $ 25,000 ==================================== ================ ============== ============ =============
40 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ B. MICHAEL PISANI (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= B. Michael Pisani 44 Lake Rd. Short Hills, NJ 07078 ###-##-#### 775 17,500 $ 77,500 ==================================== ================ ============== ============ =============
41 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /s/ JOHN LATSHAW (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= John Latshaw 5049 Wornall #2C Kansas City, MO 64112 ###-##-#### 930 21,000 $ 93,000 ==================================== ================ ============== ============ =============
42 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ EVAN KLEINBERG (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Evan Kleinberg, IRA Gruntal & Co. Custodian 3 Centennial Rd. Livingston, NJ 07039 ###-##-#### 155 3,500 $ 15,500 ==================================== ================ ============== ============ =============
43 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ DOUGLAS KLEINBERG (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Douglas Kleinberg 200 E. 94th St., Apt. 126 New York, NY 10128 ###-##-#### 248 5,600 $ 24,800 ==================================== ================ ============== ============ =============
44 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ DANIEL KLEINBERG /s/ ELAINE KLEINBERG (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Daniel & Elaine Kleinberg 3 Centennial Rd. Livingston, NJ 07039 ###-##-#### 263.50 5,950 $ 26,350 ==================================== ================ ============== ============ =============
45 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ ALLAN BOORSTEIN (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Chinook Equities 147 E. 48th St. New York, NY 10017 13-3226477 500 11,290 $ 50,000 ==================================== ================ ============== ============ =============
46 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /s/ BARRY RICHTER (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Barry Richter Tideway Sandspoint, NY 11050 ###-##-#### 250 5,645 $ 25,000 ==================================== ================ ============== ============ =============
47 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ STEPHEN G. WEISS (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Stephen G. Weiss 115 Ravinoaks Ln. Highland Park, IL 60035 ###-##-#### 330 7,451 $ 33,000 ==================================== ================ ============== ============ =============
48 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ JOSEPH BATTIPAGLIA (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Joseph Battipaglia 77 Water Street (10th Fl.) New York, NY 10005 ###-##-#### 150 3,387 $ 15,000 ==================================== ================ ============== ============ =============
49 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ WILLIAM J. STRAZZULLO (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= William J. Strazzullo 750 Columbus Ave., 4C New York, NY 10025 ###-##-#### 800 1,806 $ 8,000 ==================================== ================ ============== ============ =============
50 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ ROBERT SABLOWSKY (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Robert Sablowsky 150 East 69th Street, 16th Fl. New York, NY 10021 ###-##-#### 465 10,500 $ 46,500 ==================================== ================ ============== ============ =============
51 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /s/ JOHN D. GOLDBERG (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= John D. Goldberg 2500 E. Hallandale Beach Blvd. Suite 500 Hallandale, FL 33009 ###-##-#### 310 7,000 $ 31,000 ==================================== ================ ============== ============ =============
52 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ JOSEPH A. RUSSO (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Joseph A. Russo 3 Midwood Ave. Verona, NJ 07044 ###-##-#### 50 35 $ 15,500 ==================================== ================ ============== ============ =============
53 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 31st day of October, 1996. /s/ MICHAEL GIRONTA (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Michael Gironta 89 Rigewood Ave. Glen Ridge, NJ 07028 ###-##-#### 1,000 22,581 $ 100,000 ==================================== ================ ============== ============ =============
54 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ DONNA GREENBERG /s/ CHARLES C. GREENBERG (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Charles & Donna Greenberg JTWROS 503 Pinehurst Court Roslyn, NY 11576 ###-##-#### 1,500 33,870 $ 150,000 ==================================== ================ ============== ============ =============
55 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ RICHARD L. SERRANO (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Richard L. Serrano 64 Brighton Ave. Bloomfield, NJ 07003 ###-##-#### 46.5 1,050 $ 4,650 ==================================== ================ ============== ============ =============
56 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ DAVID HARRIS /s/ MARY JANE HARRIS (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= David and Mary Jane Harris JTWROS 174 Pacific St., Apt. 2A Brooklyn, NY 11201 ###-##-#### 200 4,516 $ 20,000 ==================================== ================ ============== ============ =============
57 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ PAUL B. ANKIN /s/ LOIS F. ANKIN (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Paul B. Ankin and Lois F. Ankin as joint tenants w/r/o/s 4233 W. Grove Skokie, IL 60076 ###-##-#### $ 25,000 ==================================== ================ ============== ============ =============
58 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ JEROME SCHACHTER (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Jerome Schachter 2926 Leanne Ct. Northbrook, IL 60062 ###-##-#### 500 11,290 $ 50,000 ==================================== ================ ============== ============ =============
59 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ LISA B. TUCKERMAN (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= S.B.S.F. Biotechnology Partners, L.P. c/o Lisa Tuckerman Spears Benick Salomon & Farrell 45 Rockefeller Plaza New York, NY 10111 13-386-8438 1,000 22,580 $ 100,000 ==================================== ================ ============== ============ =============
60 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /s/ MARK RICE (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Namax Corp. (Attn: Mark Rice) 666 Dundee Rd., Suite 1801 Northbrook, IL 60062 36-393-4918 2,100 45,161 $ 200,000 ==================================== ================ ============== ============ =============
61 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 11th day of November, 1996. /s/ DON A. SANDERS (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Don A. Sanders 3100 Texas Commerce Tower Houston, TX 77002 ###-##-#### 620 14,000 $ 62,000 ==================================== ================ ============== ============ =============
62 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 2nd day of November, 1996. /s/ RONALD KOENIG (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Ronald Koenig 114 No. Village Way Jupiter, FL 33458 ###-##-#### 310 7,000 $ 31,000 ==================================== ================ ============== ============ =============
63 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ ROBERT M. ADAMS (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Robert M. Adams P. O. Box 998 Plandome, NJ 11030 ###-##-#### 1,550 35,000 $ 155,000 ==================================== ================ ============== ============ =============
64 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /s/ EDWARD A. KERBS (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Edward A. Kerbs 8 South Cherry Ln. Rumson, NJ 07760 ###-##-#### 310 7,000 $ 31,000 ==================================== ================ ============== ============ =============
65 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ BERNARD B. SALZMAN (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Bernard B. Salzman IRA Gruntal & Co., Inc., Custodian 20 S. Charles Street Baltimore, MD 21201 ###-##-#### 55.8 1,260 $ 5,580 ==================================== ================ ============== ============ =============
66 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /s/ MICHAEL H. RICHMOND (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Michael H. Richmond 20 E. Wedgewood Glen The Woodlands, TX 77381 ###-##-#### 400 9,032 $ 40,000 ==================================== ================ ============== ============ =============
67 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 2nd day of November, 1996. /s/ MICHAEL E. CAHR (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Michael E. Cahr 1051 Saxony Dr. Highland Park, IL 60035 ###-##-#### 500 11,290 $ 50,000 ==================================== ================ ============== ============ =============
68 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. By: Technology Funding, Inc. Managing General Partner BY: /s/ THOMAS J. TOY (Signature) Thomas J. Toy, Vice President
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Technology Funding Medical Partners I, L.P. 2000 Alameda de Las Pulgas San Mateo, CA 94403 94-3166762 2,500 56,451 $ 250,000 ==================================== ================ ============== ============ =============
69 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 6th day of November, 1996. /s/ MICHAEL J. KOBLITZ (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Michael J. Koblitz 12 Downey Dr. Tenafly, NJ 07670 ###-##-#### 50 1,129 $ 5,000 ==================================== ================ ============== ============ =============
70 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 6th day of November, 1996. /s/ FRED GREENBERG (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Pharmaceutical & Medical Technology Fund 300 Park Ave. 13-3603142 3,000 67,741 $ 300,000 New York, NY 10022 Stragegic Healthcare Fund 300 Park Ave. New York, NH 10022 N/A 1,000 22,580 $ 100,000 ==================================== ================ ============== ============ =============
71 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ LISA B. TUCKERMAN (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= S.B.S.F. Biotechnology Fund, L.P. c/o Lisa Tuckerman Spears Benzak Salomon & Farrell 45 Rockefeller Plaza New York, NY 10111 13-3523468 9,000 203,225 $ 900,000 ==================================== ================ ============== ============ =============
72 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /s/ JEFFREY KEELER (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Jeffrey Keeler 577 W. 50th Street Miami Beach, FL 33140 ###-##-#### 86.8 1,960 $ 8,680 ==================================== ================ ============== ============ =============
73 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /s/ JONATHAN GREENWALD, GENERAL PARTNER (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Harbour Court L.P. II 13-391-5074 250 5,645 $ 25,000 ==================================== ================ ============== ============ =============
74 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /s/ MICHAEL J. KOBLITZ (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Marcus J. Koblitz Lauren J. Koblitz 12 Downey Dr. ###-##-#### 25 $ 2,500 Tenafly, NJ 07670 ###-##-#### 25 $ 2,500 ==================================== ================ ============== ============ =============
75 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /s/ SHELDON DROBNY (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Sheldon Drobny 95 Revere Drive, Suite A Northbrook, IL 60062 ###-##-#### 500 11,290 $ 50,000 ==================================== ================ ============== ============ =============
76 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /s/ PERRY H. BACON (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Perry H. Bacon 5300 Mission Woods Rd. Shawnee Mission, KS 66205 ###-##-#### 620 14,000 $ 62,000 ==================================== ================ ============== ============ =============
77 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /s/ JAMES J. PELTS (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= James J. Pelts 29 E. Madison St., Suite 1505 Chicago, IL 60602 ###-##-#### 500 11,290 $ 50,000 ==================================== ================ ============== ============ =============
78 [SECURITIES PURCHASE AGREEMENT] SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /s/ ROBERT WEINSTEIN (Signature)
NUMBER OF SHARES OF SERIES B FEDERAL PREFERRED NUMBER OF EMPLOYER I.D. OR STOCK WARRANT TOTAL NAME AND ADDRESS SOCIAL SECURITY PURCHASED SHARES INVESTMENT NUMBER ==================================== ================ ============== ============ ============= Robert Weinstein 155 W. 68th St., 24C New York, NY 10023 ###-##-#### 20 1,400 $ 6,200 ==================================== ================ ============== ============ =============
79 SCHEDULE 1 INVESTORS; SECURITIES PURCHASED; PURCHASE PRICE Shares Warrant Purchase Purchased Shares Price - -------------------------------------------------------------------------------- CIBC Wood Gundy Ventures, Inc. ............ 44,800 1,011,612 $4,480,000 The Woodlands Venture Capital Company ..... 2,500 56,451 250,000 P. William Curreri, M.D ................... 400 9,032 40,000 Christopher C. Kraft, Jr., Smith .......... 250 5,645 25,000 Barney Inc. KEO P/S Custodian Acct: 721-66059-10-022 Michael H. Richmond ....................... 400 9,032 40,000 Stephen Livesey ........................... 250 5,645 25,000 Michael E. Cahr ........................... 500 11,290 50,000 Technology Funding Medical ................ 2,500 56,451 250,000 Partners I, L.P. .......................... Vector Later-Stage Equity Fund, L.P. ...... 40,000 903,225 4,000,000 William J. McCluskey ...................... 186 4,200 18,600 David Saks ................................ 500 11,290 50,000 Joseph Battipaglia ........................ 150 3,387 15,000 S.B.S.F. Biotechnology Partners, L.P. ..... 1,000 22,580 100,000 S.B.S.F. Biotechnology Fund, L.P. ......... 9,000 203,225 900,000 Jerome Schachter .......................... 500 11,290 50,000 Paul B. Ankin and Lois F. Ankin, .......... 250 5,645 25,000 JTWROS David and Mary Jane Harris, ............... 200 4,516 20,000 JTWROS Richard L. Serrano ........................ 50 1,129 5,000 80 Shares Warrant Purchase Purchased Shares Price - -------------------------------------------------------------------------------- Charles and Donna Greenberg, ............... 1,500 33,870 150,000 JTWROS Michael Gironta ............................ 1,000 22,580 100,000 Joseph A. Russo ............................ 155 3,500 15,500 John D. Goldberg ........................... 310 7,000 31,000 Robert Sablowsky ........................... 465 10,500 46,500 William J. Strazzullo ...................... 80 1,806 8,000 Stephen G. Weiss ........................... 330 7,451 33,000 Barry Richter .............................. 250 5,645 25,000 Chinook Equities, Inc. ..................... 500 11,290 50,000 Daniel and Elaine Kleinberg, JTWROS ........ 267 6,029 26,700 Douglas Kleinberg .......................... 248 5,600 24,800 Evan Kleinberg IRA, Gruntal & Co., ......... 155 3,500 15,500 Inc., Custodian Dated July 19, 1996 John Latshaw ............................... 930 21,000 93,000 B. Michael Pisani .......................... 775 17,500 77,500 John Cirrito ............................... 250 5,645 25,000 James C. Gale, Trustee F/B/O Ariana ........ 620 14,000 62,000 J. Gale The James C. Gale Trust, dated November 21, 1986 James C. Gale and Judith S. Haselton ....... 1,550 35,000 155,000 JTWROS John S. Bai ................................ 217 4,900 21,700 Ronald Koenig .............................. 310 7,000 31,000 Robert M. Adams ............................ 1,550 35,000 155,000 Edward A. Kerbs ............................ 310 7,000 31,000 81 Shares Warrant Purchase Purchased Shares Price - -------------------------------------------------------------------------------- Bernard B. Salzman IRA, Gruntal & ........... 55 1,241 5,500 Co., Inc., Custodian Dated May 14, 1982 Acct: 215-67321-1-3-231 Don A. Sanders .............................. 620 14,000 62,000 Jeffrey Keeler .............................. 87 1,964 8,700 Harbour Court L.P., II ...................... 250 5,645 25,000 Namax Corp. ................................. 2,000 45,161 200,000 Sheldon Drobny .............................. 500 11,290 50,000 Perry H. Bacon .............................. 620 14,000 62,000 James J. Pelts .............................. 500 11,290 50,000 Robert Weinstein ............................ 217 4,900 21,700 The Marcus L. Koblitz Trust, Michael ........ 25 564 2,500 J. Koblitz, Trustee Est. April 14, 1992 The Lauren J. Koblitz Trust, Michael ........ 25 564 2,500 J. Koblitz, Trustee Est. April 14, 1992 Pharmaceutical & Medical Technology ......... 3,000 67,741 300,000 Fund Strategic Healthcare Fund ................... 1,000 22,580 100,000 Michael J. Koblitz .......................... 50 1,129 5,000 ------- --------- ---------- TOTAL .................. 124,157 2,803,530 12,415,700 ======= ========= ========== 82 SCHEDULE 3.2 CAPITAL STOCK OUTSTANDING OPTIONS Pursuant to certain Non-Statutory Stock Options granted on November 4, 1996, P. William Curreri, Christopher C. Kraft, Jr. and Martin P. Sutter have the right to purchase an aggregate of 225,000 shares of common stock, par value $.001 per share (the "Common Stock"), of LifeCell Corporation (the "Company"). 1,000,000 shares of Common Stock are reserved for issuance under the Company's Second Amended and Restated 1992 Stock Option Plan, as amended. As of November 18, 1996, options to purchase 998,945 shares have been granted pursuant to such plan and are outstanding. 750,000 shares of Common Stock are reserved for issuance under the Company's Second Amended and Restated 1993 Non-Employee Director Stock Option Plan. As of November 18, 1996, options to purchase 90,000 shares have been granted pursuant to such plan and are outstanding. OUTSTANDING WARRANTS As of November 18, 1996, the persons or entities listed below hold warrants to purchase the number of shares of Common Stock set forth opposite their name. Robert Todd Financial Corporation 120,000 Strategem of Alabama, Inc. 5,000 Thomas James Associates 20,000 The Renaissance Group Limited 75,000 Donald P. Callan, D.D.S. 10,000 Gruntal & Co. Incorporated 354,734 As of November 18, 1996, the holders of the Company's Series B Preferred Stock, par value $.001 per share (the "Series B Preferred Stock"), hold warrants to purchase an aggregate of 2,803,530 shares of Common Stock. HOLDERS OF SERIES A PREFERRED STOCK Allstate Insurance Company Medtronic, Inc. The Woodlands Venture Capital Company Technology Funding Partners III, L.P. P. William Curreri, M.D. Gil Fuqua, Jr. 83 Smith Barney, Inc., Custodian of the Christopher C. Kraft, Jr. Keogh Profit Sharing Plan Robert E. Garrison II Martin P. Sutter David R. Sincox CONVERTIBLE INSTRUMENTS AND RIGHTS The Series A Preferred Stock, of which 260,000 shares are outstanding as of November 18, 1996, is convertible into an aggregate of 1,761,139 shares of Common Stock, subject to adjustment upon certain events, including the issuance of Common Stock as a dividend with respect to the outstanding Common Stock, subdivisions, splits or combinations of Common Stock, or the issuance of any shares of capital stock by reclassification of Common Stock. The Series B Preferred Stock, of which 124,157 shares are outstanding as of November 18, 1996, is convertible into an aggregate of 4,005,052 shares of Common Stock, subject to adjustment as described in the Certificate of Designation of the Series B Preferred Stock. Additionally, any dividends on the Series B Preferred Stock paid in shares of Series B Preferred Stock will be convertible into shares of Common Stock. Pursuant to the License and Development Agreement dated March 3, 1994, between the Company and Medtronic, Inc. ("Medtronic"), Medtronic paid the Company a $1.5 million licensing fee. If such agreement is terminated under certain circumstances, including Medtronic's right to terminate at any time if in its sole business judgment it deems the development and commercialization of products thereunder not to be in its best interests or otherwise imprudent, Medtronic has the option the convert the $1.5 million licensing fee into shares of Common Stock, at the then current market price, unless immediately following such conversion the number of shares received upon such conversion together with all other shares of Common Stock held by Medtronic would exceed 19% of the then issued and outstanding shares of Common Stock, in which case LifeCell shall pay cash or issue a promissory note or deliver a combination of the two to Medtronic in an amount equal to the difference between the $1.5 million and the value of the number of shares of Common Stock actually issued to Medtronic pursuant to such conversion. In addition, if immediately following such conversion the number of shares of Common Stock issued in connection with such conversion together with the number of shares of Common Stock then held by Medtronic equal less than 5% of the then issued and outstanding shares of Common Stock, Medtronic shall have the option to purchase from LifeCell in cash on the date on such conversion a number of shares of Common Stock such that the aggregate number of shares of Common Stock held by Medtronic shall equal up to but no more than 5% of the then issued and outstanding shares of Common Stock. The price at which Medtronic may purchase such additional shares would be equal to the arithmetic average of the market price for the Common Stock for the 20 trading days immediately preceding such date. 84 DIVIDEND SHARES Holders of the Series A Preferred Stock are entitled to receive, when, as and if declared by the Board of Directors, out of the funds of the Company legally available therefor, an annual dividend of $1.60 per share for the year ended November 9, 1996, and $2.00 per share for the year ended November 9, 1997, which may be paid in shares of Common Stock. The number of shares to be issued will be based upon the then current market price of the Common Stock. BLUE SKY REGISTRATIONS/QUALIFICATIONS The filing of a Form M-11 with the Department of Law of the State of New York. 85 SCHEDULE 3.4 CONFLICTS The consent of the holders of the Series A Preferred Stock is required to authorize, create and issue the Series B Preferred Stock. The waiver of certain holders of capital stock of the Company of certain registration rights of such holders under an Amended and Restated Registration Rights Agreement, dated February 26, 1992, by and among the Company and such holders (the "Prior Registration Rights Agreement") and certain amendments to the Prior Registration Rights Agreement are required to avoid a conflict resulting from the Company's execution and delivery of the Registration Rights Agreement. The waiver of Medtronic, Inc. of certain registration rights it has under an Investment Agreement dated March 3, 1994, between the Company and Medtronic, Inc. and certain amendments to such Investment Agreement are required to avoid a conflict resulting from the Company's execution and delivery of the Registration Rights Agreement. Section 10.2(c) of the Distribution Agreement dated June 1, 1996, between the Company and DENTSPLY International, Inc. ("DENTSPLY"), allows DENTSPLY to terminate such Distribution Agreement if the Company comes under the ownership or control, directly or indirectly, of any person other than persons having ownership or control of the Company at the date such Distribution Agreement was executed. The Company has been advised by the Nasdaq Stock Market that the issuance of the Series B Preferred Stock may violate Rule 4310(c)(21) of the Rules of The Nasdaq Stock Market. The Company disagrees with this interpretation and currently is discussing this issue with the Nasdaq Stock Market. 86 SCHEDULE 3.5 Litigation None. 87 SCHEDULE 3.10 TAXES None. 88 SCHEDULE 3.11 MATERIAL ADVERSE EFFECT None other than as disclosed under "Risk Factors", "Management's Discussion and Analysis of Financial Condition and Results of Operation" and otherwise in the Confidential Private Placement Memorandum dated October 29, 1996 of the Company (the "Memorandum"). 89 SCHEDULE 3.12 TITLE Pursuant to a Security Agreement - Pledge of Certificate of Deposit and Assignment of Deposit Account dated January 3, 1996, between the Company and Texas Commerce Bank National Association ("TCB"), Certificate of Deposit No. 0039001256 is pledged to secure the obligations of the Company under the Term Installment Note dated January 3, 1996, in the original principal amount of $120,000, payable by the Company to TCB (the "Installment Note"). The Company granted TCB a security interest in its tangible personal property, accounts and other receivables to secure the Company's obligations under the Term Promissory Note dated October 8, 1996, in the original principal amount of $250,000, payable by the Company to TCB (the "Term Note"). Liens for taxes or assessments or other governmental charges or levies to the extent not yet due and payable. Mechanics and materialmen liens or encumbrances for construction in progress to the extent not perfected by filing, recording, giving of notice or other appropriate action in the relevant jurisdiction. Workmen, repairmen, warehousemen, carriers, lessors and operators liens or encumbrances arising in the ordinary course of business to the extent not perfected by filing, recording, giving of notice or other appropriate action in the relevant jurisdiction. 90 SCHEDULE 3.13 PROPRIETARY RIGHTS See ANNEX 3.13 attached hereto. The Company has federal trademark and service mark registrations for LifeCell, LifeCell Process and AlloDerm. Pursuant to a Non-Exclusive License Agreement dated September 1, 1996, between Competitive Technologies, Inc. ("CTI") and the Company, the Company was granted a non-exclusive license to (i) U.S. Patent No. 4,810,299, issued January 31, 1989 and entitled "Body Implants of Extracellular Matrix and Means and Methods of Making and Using Such Implants, invented by Klaus Brendel and Raymond C. Duhamel, and (ii) Japan Patent No. 1842777, the foreign counterpart to the patent referred to in clause (i) above. The Company is obligated to pay royalties pursuant to such agreement. The Company is obligated to pay royalties pursuant to the terms of the Exclusive License Agreement dated June 6, 1986, by and between the Board of Regents of the University of Texas System and the Company. Pursuant to a License and Development Agreement with Medtronic, Inc., the Company granted an irrevocable, worldwide, exclusive license to Medtronic, Inc. for certain patents and know-how relating to homograft and heterograft heart valve bioprostheses. Pursuant to such License Agreement, Medtronic paid the Company a $1.5 million licensing fee, agreed to fund the development of heart valve products using the Company's technology, and agreed to pay total cumulative royalties of up to $25 million in respect of any sales of any products developed and sold using the Company's patented technologies. On the same date, the Company also entered into an Investment Agreement with Medtronic pursuant to which the Company granted Medtronic certain rights of first refusal to evaluate technology and negotiate a license and development agreement for vascular conduit products using the Company's technology. The distribution agreements set forth in Schedule 3.14 are incorporated herein by reference thereto. Page 1 of Schedule 3.13 ANNEX 3.13 THE LIFECELL PATENT PORTFOLIO March 25, 1997
DOCKET NUMBER SERIAL FILING DATE PATENT NUMBER ISSUE DATE OFFICIAL TITLE/ (AWD/UT) COUNTRY NUMBER [DESCRIP. TITLE] - --------- ------------- -------- ----------- ------------ ----------- ----------------------------------- UTSH:022 United States 525,626 08-23-83 4,510,169 04-09-85 Method and Apparatus for UTHSC/HOU:0 Cryopreparing Biological Tissue for 22 Australia 31666/84 08-07-84 583477 08-25-89 Ultrastructural Analysis. [ABANDONED Canada 460,541 08-08-84 1,239,289 07-19-88 ALL CASES ABANDONED BY NON- PAYMENT OF MAINTENANCE FEES Canada-1 547,938 09-25-87 *European 84305391.9 08-08-84 Patent Convention *France *Great Britain *West Germany *Sweden *Switzerland/ Liechtenstein 175807/84 08-23-84 Japan United States ABANDONED UTSH:032 8/9/88 038,038 04/13/87 Quick Release Flange
Page 2 of Schedule 3.13 UTSH:040 Apparatus and Method for UTHSC/HOU:0 United States 777,083 09-17-85 Cryopreparing Biological Tissue 40 [continuation ABANDONED of 041 which 1/31/87 777,083 09-17-85 [Sample Chamber] is a CIP of 022] United States 767,855 11-30-84 4,567,847 02-04-86 Apparatus and Method for UTSH:041 Cryopreparing Biological Tissue for UTHSC/HOU:0 Australia 49963/85 11-15-85 Ultrastructural Analysis 41 [CIP of 022] Canada 495,267 11-13-85 1,239,290 07-12-88 [Generic Apparatus] [ABANDONED Canada-1 547,937 09-25-87 1,301,465 05-26-92 ALL CASES ABANDONED BY NON- PAYMENT OF MAINTENANCE FEES *European 85308760.9 12-02-85 Patent Convention *Austria *Belgium *France *Great Britain *West Germany *Italy *Luxembourg *Netherlands *Sweden *Switzerland/ Liechtenstein Japan 275080/85 11-30-85
Page 3 of Schedule 3.13 UTSH:044 United States 676,856 11-30-84 4,619,257 10-28-86 Apparatus and Method for UTHSC/HOU:044 Cryopreparing Corneal Tissue for [CIP of 022] Surgical Procedures [Corneal Tissue Method] UTSH:051 United States 770,772 08-29-85 4,676,070 06-30-87 UTHSC/HOU:051 Apparatus and Method for [continuation of Cryopreparing Biological Tissue 041 which is a for Ultrastructural Analysis CIP of 022] [Generic Tissue Method] Preparation of Biological Tissue for UTSH:052 Ultrastructural Analysis UTHSC/HOU:052 [INACTIVE] [Omnibus application] UTSH:065 UTHSC/HOU:065 [INACTIVE] UTSH:082 United 939,701 12-03-86 4,707,998 11-24-87 Apparatus and Method for Ultrarapid UTHSC/HOU:0 States Cooling of Biological Sample [Cryo 82 Slammer] [ABANDONED
Page 4 of Schedule 3.13 UTSH:089 United 926,985 11-04-86 4,799,361 1-24-89 Apparatus and Method for UTHSC/HOU:0 States Cryopreparing Biological Tissue for 89 80664/87 11-04-87 ABANDONED Ultrastructural Analysis [CIP OF 051] Australia [Second Generic Sample] 551010 11-04-87 1,239,291 7-19-88 Canada 87309774.5 11-04-87 ABANDONED *European Patent Convention *Austria *Belgium *France *Germany *Greece *Italy *Luxembourg *Netherlands *Spain *Sweden *Switzerland/ Liechtenstein *Great Britain Japan 278994/87 11-04-87 ABANDONED
Page 5 of Schedule 3.13 UTSH:091 United 942,172 12-16-86 4,742,690 5-10-88 Apparatus and Method for UTHSC/HOU:0 States Cryopreparing Biological Tissue for 91 87118696.1 12-16-87 ABANDONED Ultrastructural Analysis [CIP of 040 *European [Sample Holder] which is a Patent continuation Convention ALL CASES ABANDONED BY NON- of 041 which PAYMENT OF MAINTENANCE FEES is a CIP of *Austria 022] *Belgium *France [ABANDONED] *Germany *Greece *Italy *Luxembourg *Netherlands *Spain *Sweden *Switzerland/ Liechtenstein *United Kingdom UTSH:095 [INACTIVE] UTHSC/HOU:0 95 UTSH:096 Apparatus and Method for [CIP of Cryopreparing Biological tissue for UTSH:091 et United Ultrastructural Analysis seq.] States 038,840 04-13-87 4,745,771 5-24-88 [Sample Holder] [ABANDONED]
Page 6 of Schedule 3.13 UTSH:097 United States 102,395 09-29-87 4,807,442 02-28-89 Cryo-Slamming Apparatus and Method for for Ultrarapid Cooling of Biological Samples [ABANDONED] Australia 23559/88 10-07-88 616,687 03-03-92 [Cryo-Slammer] Canada 579683 10-07-88 1,311,620 12-22-92 *European 88309764.4 10-18-88 364,633 ALL CASES ABANDONED BY NON- Patent PAYMENT OF MAINTENANCE FEES Convention *Austria *Belgium *France *W. Germany *Greece *Italy *Luxembourg *Netherlands *Spain *Sweden *Switzerland/ Liechtenstein *United 272883/88 10-28-88 Kingdom Japan
Page 7 of Schedule 3.13 UTSH:113 United 284,989 12-15-88 5,044,165 09-03-91 Improved Cryo-Slammer [CIP of States UTSH:097] Australia 31516 3-20-89 627,718 01-12-93 Canada 284,989 12-15-88 1,320,646 07-27-93 *European 284,989 12-15-88 373,738 Patent Convention *Austria *Belgium *France *West Germany *Italy *Luxembourg *Netherlands *Sweden *Switzerland/ Liechtenstein 098624/89 4-8-89 *United UTSH:113 Kingdom [CIP of UTSH:097] Japan UTSH:116 United 217,561 7-11-88 4,865,871 9-12-89 Method for Cryopreparing Biological States Tissue [Cryoprotectant] UTSH:117 United 230,768 8-9-88 5,024,830 06-18-91 Apparatus and Method for [Divisional States Cryopreparing Biological Tissue for of UTSH:089] Ultrastructural Analysis [Generic Method] UTSH:120 United 343,882 4-13-89 D323,895 02-11-92 Design Patent for CF-100 Cryo States Slammer
Page 8 of Schedule 3.13 United Molecular Distillation Dryer UTSH:129 States 395,028 8-17-89 4,964,280 10-23-90 (Apparatus for distillation drying) UTSH:141 United 492,724 3-13-90 5,154,007 10-13-92 Molecular Distillation Dryer [Divisional States of UTSH:129] LIFD:027 United 581,584 9-12-90 ABANDONED Method for Cryopreparation and Dry States (CIP LIFD:031) Stabilization of Vaccines and Viruses LIFD:028 United INACTIVE Cryopreparation of Collagen Based States Transplantable Tissue LIFD:029 United INACTIVE Cryopreparation of Biological Tissue States Using Mid-Range Drying United Preservation of Biological Heart Valves LIFD:030 States INACTIVE in the Dry State LIFD:031 United 709,504 06-03-91 ABANDONED [CIP of States (FWC LIFD:027] LIFD:045)
Page 9 of Schedule 3.13 Australia 83797/91 09-10-91 Method for Cryopreparation & Dry 650045 09/27/94 Stabilization of Vaccines and Viruses Australia 67405/94 07-13-94 [Nebulizing] Canada 2,051,092 09-10-91 *European 91115480.5 09-12-91 Patent 047549 Convention *Austria *Belgium *Denmark *France *Germany *Greece *Italy *Luxembourg *Netherlands *Spain *Sweden *Switzerland *United Kingdom 91/233340 09-12-91 Japan LIFD:037 ABANDONED (CIP of United (CIP is Method for Processing Collagen-Based LIFD:031) States 835,138 2-12-92 LIFD:038) Tissues for Transplantation
Page 10 of Schedule 3.13 LIFD:038 United (CIP of States 08/004,752 02-02-93 5,336,616 08/09/94 Method for Processing and Preserving LIFD:037) Collagen-Based Tissues for Australia 32934/93 02-10-93 668703 09/09/96 Transplantation [Generic Method] Canada 93102264.4 2/12/93 *European 0564786 Patent Convention *Austria *Belgium *Denmark *France *Germany *Greece *Ireland *Italy *Luxembourg *Monaco *Netherlands *Portugal *Spain *Sweden *Switzerland/ Liechtenstein *United Kingdom Japan LIFD:045 United 08/018,357 02-16-93 5,364,756 11-15-94 Method for Cryopreparation & Dry (FWC of States Stabilization of Vaccines and Viruses LIFD:031) [Nebulizing]
Page 11 of Schedule 3.13 LIFD:050 United 08/227,264 04-13-94 Method for Processing and Preserving (Con. of States Collagen-Based Tissue for LIFD:038) Transplantation LIFD:051 United To be prepared Method for Processing and Preserving C-I-P of States Collagen-Based Tissue for LIFD:050 Transplantation LIFD:052 United 08/326,036 10-19-94 Prolonged Preservation of Blood States Platelets (Thrombosol) PCT US95/1332 10/19/95 WO96/13158 40 LIFD:054 United 08/291,340 08-17-94 Apparatus for Cryopreserving a DIV of States Suspension of Biological Material LIFD:045 LIFD:061PZ1 United 60/002,882 08/25/95 Reconstituted Skin States LIFD:064 United 08/600343 02/13/96 Prolonged Preservation of Blood CIP of States Platelets (Cytokines) LIFD:052 LIFD065 CIP of United Prolonged Preservation of Blood LIFD:052 States 08/600,816 02/13/96 Platelets (Taxol)
Page 13 of Schedule 3.13 SCHEDULE 3.14 CONTRACTS The contracts, agreements, commitments, obligations and licenses referred to in Schedules 3.2, 3.12, 3.13, 3.18 and 3.21 are incorporated herein by reference thereto. Agreement dated September 1, 1996, between the Company and Medidas. Distribution Agreement dated October 1, 1996, by and between the Company and Boracchia & Associates. Distribution Agreement dated October 1, 1996, by and between the Company and Cosmetic Surgery Suppliers, Inc. Distribution Agreement dated June 1, 1996, by and between DENTSPLY International, Inc. and the Company. Distribution Agreement dated April 1, 1996, by and between the Company and Implant Specialties Ltd., Inc. Distribution Agreement dated May 1, 1996, by and between the Company and Life Lines Medical, Inc. Distribution Agreement dated October 1, 1996, by and between the Company and Martell Medical Products, Inc. Distribution Agreement dated July 1, 1996, by and between the Company and OR Specialties, Inc. Distribution Agreement dated August 1, 1996, by and between the Company and Quantum Medical. Distribution Agreement dated February 7, 1996, by and between the Company and Sun Medical Inc. Page 1 of Schedule 3.14 Distribution Agreement dated April 1, 1996, by and between the Company and Tech Medical Services, Inc. Distribution Agreement dated April 1, 1996, by and between the Company and Vista Medical Systems, Inc. Agreement dated effective April 4, 1996, between the Company and Medlink Europe B.V. Employment Agreement and accompanying Confidentiality, Inventions and Discoveries and Non-Competition Agreement dated January 28, 1992, by and between the Company and Paul M. Frison. Employment Agreement and accompanying Confidentiality, Inventions and Discoveries and Non-Competition Agreement dated January 28, 1992, by and between the Company and Stephen A. Livesey. Sub-lease Agreement dated August 1, 1994, by and between the Company and The Western Company of North America (predecessor to B.J. Services). Small Business Innovative Research Contract dated August 15, 1996, between the Company and National Science Foundation. Small Business Innovative Research Contract dated April 16, 1996, between the Company and the Department of Defense U.S. Navy. Amended and Restated Registration Rights Agreement, dated February 26, 1992, by and among the Company and the holders of capital stock of the Company identified therein. Underwriter's Warrant Agreement, dated March 6, 1992, between the Company and Robert Todd Financial Corporation, as amended by First Amendment to Underwriter's Warrant Agreement, dated January 26, 1993, between the Company and Robert Todd Financial Corporation (the "Underwriter's Warrant Agreement"). Subscription Agreement, dated November 1994, executed by each of the Subscriber's named therein (the "Series A Subscription Agreement"). Page 2 of Schedule 3.14 DEFAULTS The Company has not provided notice to Robert Todd Financial Corporation of certain price and share adjustments under the terms of the Underwriter's Warrant Agreement. Page 3 of Schedule 3.14 SCHEDULE 3.15 INDEBTEDNESS $100,000.00, plus accrued interest, under the Installment Note. $250,000.00, plus accrued interest, under the Term Note. $698,422.15 in trade payables. $416,000.00 in accrued and unpaid dividends on the Series A Preferred Stock as of November 9, 1996. $120,793.66 in other payables. SCHEDULE 3.16 COMPLIANCE WITH LAW None. SCHEDULE 3.18 INSURANCE See ANNEX 3.18 attached hereto. LifeCell Corporation 3606 Research Forest Drive The Woodlands, Texas 77381 ANNEX 3.18 SCHEDULE OF INSURANCE [GRAPHIC OMMITTED] [GRAPHIC DEPICTING COVERAGE, LIMITS, EXPIRATION, COMPANY, POLICY NO., COMMENTS, AND PREMIUM. THE COVERAGES ARE PRETAINING TO PROPERTY INSURANCE, GENERAL LIABILITY, BUSINESS AUTOMOBILE, DIRECTORS AND OFFICERS, KEYMEN, CARGO, WORKERS' COMPENSATION, BONDED EMPLOYEES AND HEALTH.] Page 2 of Schedule 3.18 SCHEDULE 3.21 RELATED PARTY TRANSACTIONS The Contracts between the Company and any Related Party referred to in Schedules 3.2, 3.13, 3.14 and 3.18 are incorporated herein by reference thereto. See "Certain Transactions" on page 50 of the Memorandum. Pursuant to a Letter of Agreement dated September 15, 1996, the Company engaged NRS Communications Inc. ("NRS"), of which Leslie Summers-Schwartz, wife of Randy Schwartz, Vice President Sales and Marketing of the Company, is a principal. NRS is engaged through December 15, 1996 for a fee of $3,800 to complete a one-time public relations project. SCHEDULE 4.8 PRINCIPAL OFFICE OR DOMICILE Vector Later-Stage Equity Fund, L.P. Charles and Donna Greenberg 1751 Lake Cook Road, Suite 350 503 Pinehurst Court Deerfield, Illinois 60015 Roslyn, NY 11576 CIBC Wood Gundy Ventures, Inc. Michael Gironta 425 Lexington Avenue 89 Ridgewood Avenue New York, New York 10017 Glen Ridge, NJ 07028 The Woodlands Venture Capital Company Joseph A. Russo 2201 Timberloch Place 3 Midwood Avenue The Woodlands, TX 77380 Verona, NJ 07044 SBSF Biotechnology Fund, L.P. John D. Goldberg c/o Lisa Tuckerman 2500 East Hallandale Beach Blvd. Spears Benzak Salomon & Farrell Suite 500 45 Rockefeller Plaza -- 33rd Floor Hallandale, FL 33009-4838 New York, NY 10111 Robert Sablowsky SBSF Biotechnology Partners, L.P. 150 East 69th Street, 16A c/o Lisa Tuckerman New York, NY 10021 Spears Benzak Salomon & Farrell 45 Rockefeller Plaza -- 33rd Floor William J. Strazzullo New York, NY 10111 750 Columbus Avenue, 4C New York, NY 10025 Jerome Schachter 2926 Leanne Court Joseph Battipaglia Northbrook, IL 60062 77 Water Street (10th Floor) New York, NY 10005 Paul B. Ankin and Lois F. Ankin, as joint tenants Stephen G. Weiss 4233 W. Grove 115 Ravin Oaks Lane Skokie, IL 60076 Highland Park, IL 60035 David and Mary Jane Harris Barry Richter 174 Pacific Street, Apt. 2A Tideway Brooklyn, NY 11201 Sandspoint, NY 11050 Richard L. Serrano 64 Brighton Avenue Bloomfield, NJ 07003 35 Chinook Equities, Inc. William J. McCluskey 147 East 48th Street 25 Wisconsin Street New York, NY 10017 Long Beach, NY 11561 Daniel and Elaine Kleinberg 3 Centennial Road Livingston, NJ 07039 Douglas Kleinberg 200 East 95th Street, Apt. 126 New York, NY 10128 Evan Kleinberg IRA Gruntal & Co. Custodian 3 Centennial Road Livingston, NJ 07039 John Latshaw 5049 Wornall #2C Kansas City, MO 64112 B. Michael Pisani 44 Lake Road Short Hills, NJ 07078 John Cirrito 29 Rambling Drive Scotch Plains, NJ 07076 James C. Gale, Trustee F/B/O Ariana J. Gale 315 W. 106th Street, Apt. 4A New York, NY 10025 James C. Gale and Judith S. Haselton 315 West 106th Street, Apt. 4A New York, NY 10025 Robert Weinstein 155 West 68th Street, 24C New York, NY 10023 John S. Bai 30 West 61st, 27A New York, NY 10023 36 David F. Saks Bernard B. Salzman IRA, 2 Knollcliff Road Gruntal & Co., Inc., Custodian Woodcliff Lake, NJ 07675 20 S. Charles Street Baltimore, MD 21201 P. William Curreri, M.D. 217 Berwyn Drive, W. #222 Don A. Sanders Mobile, Alabama 36608 3100 Texas Commerce Tower Houston, TX 77002 Christopher C. Kraft, Jr. Smith Barney Inc. KEO P/S Custodian Jeffrey Keeler 14919 Village Elm Street 577 W. 50th Street Houston, TX 77062 Miami Beach, FL 33140 Michael H. Richmond Harbour Court L.P., II 20 E. Wedgewood Glen 253 W. 73rd St., Apt. 6D The Woodlands, TX 77381 New York, NY 10023 Attention: Jonathan Greenwald Stephen Livesey 3606 Research Forest Drive Namax Corp. The Woodlands, TX 77381 666 Dundee Road, Suite 1801 Northbrook, IL 60062 Michael E. Cahr Attention: Mark Rice, President 1051 Saxony Drive Highland Park, IL 60035 Sheldon Drobny 95 Revere Drive, Suite A Technology Funding Medical Partners I, L.P. Northbrook, IL 60062 2000 Alameda de las Pulgas San Mateo, CA 94403 Perry H. Bacon 5300 Mission Woods Road Ronald Koenig Shawnee Mission, KS 66205 114 No. Village Way Jupiter, Florida 33458 James J. Pelts 29 East Madison Street, Suite 1505 Robert M. Adams Chicago, IL 60602 P.O. Box 998 Plandome, NY 11030 The Marcus L. Koblitz Trust Michael J. Koblitz, Trustee Edward A. Kerbs 12 Downey Drive 8 South Cherry Lane Tenafly, NJ 07670 Rumson, NJ 07760 The Lauren J. Koblitz Trust, Michael J. Koblitz, Trustee 12 Downey Drive Tenafly, NJ 07670 37 Pharmaceutical & Medical Technology Fund 300 Park Avenue New York, NY 10022 Strategic Healthcare Fund 300 Park Avenue New York, NY 10022 Michael J. Koblitz 12 Downey Drive Tenafly, NJ 07670 38 SCHEDULE 6.1 USE OF PROCEEDS See "Use of Proceeds" on page 12 of the Memorandum. EXHIBIT A This Warrant was originally issued on November 18, 1996, and such issuance was not registered under the Securities Act of 1933, as amended. The transfer of this Warrant and the securities obtainable upon exercise thereof is subject to the conditions on transfer specified in the Securities Purchase Agreement, dated as of November 18, 1996 (as amended and modified from time to time), between the issuer hereof (the "COMPANY") and the initial holder hereof, and the Company reserves the right to refuse the transfer of such security until such conditions have been fulfilled with respect to such transfer. Upon written request, a copy of such conditions shall be furnished by the Company to the holder hereof without charge. LIFECELL CORPORATION STOCK PURCHASE WARRANT Date of Issuance: November 18, 1996 Certificate No. BW-___ FOR VALUE RECEIVED, LIFECELL Corporation, a Delaware corporation (the "COMPANY"), hereby grants to _________________________________________ or its registered assigns (the "REGISTERED HOLDER") the right to purchase from the Company __________ shares of the Company's Common Stock, par value $.001 per share ("COMMON STOCK"), at a price per share of $4.13 (as adjusted from time to time hereunder, the "EXERCISE PRICE"). This Warrant is one of several warrants (collectively, the "WARRANTS") issued by the Company to certain investors pursuant to the Securities Purchase Agreement, dated as of November 18, 1996 (the "PURCHASE AGREEMENT"). Certain capitalized terms used herein are defined in Section 5 hereof. The amount and kind of securities obtainable pursuant to the rights granted hereunder and the purchase price for such securities are subject to adjustment pursuant to the provisions contained in this Warrant. This Warrant is subject to the following provisions: Section 1. EXERCISE OF WARRANT. 1A. EXERCISE PERIOD. Subject to the provisions of Paragraph 1B, the Registered Holder may exercise, in whole or in part (but not as to a fractional share of Common Stock), the purchase rights represented by this Warrant at any time and from time to time after the Date of Issuance to and including the fifth anniversary thereof (the "EXERCISE PERIOD"). The Company shall give the Registered Holder written notice of the expiration of the rights hereunder at least 30 days but not more than 90 days prior to the end of the Exercise Period. In the event the Company fails to give the Registered Holder such notice, the Exercise Period shall continue until and terminate on the thirtieth calendar day following the day the Company gives such notice. 1B. MANDATORY EXERCISE. Notwithstanding the provisions of Paragraph 1A, during the period commencing with the second anniversary of the Date of Issuance through the Exercise Period (the "MANDATORY EXERCISE PERIOD"), upon written notice from the Company evidencing that the Current Market Price equals or exceeds an amount equal to three times the then Exercise Price (the "MANDATORY EXERCISE NOTICE"), the Registered Holder shall exercise all (but not as to any fractional share of Common Stock) of the purchase rights represented by this Warrant; provided that, notwithstanding the foregoing, the Registered Holder shall have no obligation pursuant to this Paragraph 1B to exercise any portion of the purchase rights represented by this Warrant on any date if on such date or at any time during the 30 consecutive trading day period ending immediately prior to such date the Common Stock is not listed or admitted to trading on any national securities exchange and is not traded over the counter and reported by Nasdaq or any comparable system. for purposes of this paragraph, "CURRENT MARKET PRICE" means, at any date during the Mandatory Exercise Period, the average of the daily closing price per share of Common Stock for the 30 consecutive trading day period during the Mandatory Exercise Period ending on the trading day immediately before such date ( as adjusted for any stock dividend, split, combination or reclassification that took effect during such 30 trading day period). The closing price for each day shall be the last reported sale price on the principal national securities exchange on which Common Stock is listed or admitted to trading or if not listed or admitted to trading on any national securities exchange, as reported by Nasdaq, if such security is traded over the counter and quoted in the Nasdaq National Market or Nasdaq Small Cap Market, or if such equity security is so traded, but not so quoted, the closing bid price of Common Stock as reported by Nasdaq or any comparable system. The Registered Holder shall be required to exercise pursuant to Paragraph 1C all of the then unexercised purchase rights represented by this Warrant no earlier than the 30th day following the Registered Holder's receipt of the Mandatory Exercise Notice. 1C. EXERCISE PROCEDURE. (i) This Warrant shall be deemed to have been exercised at such time when the Company has received all of the following items (the "EXERCISE TIME"): (a) a completed Exercise Agreement, as described in Paragraph 1D, executed by the Person exercising all or part of the purchase rights represented by this Warrant (the "PURCHASER"); (b) this Warrant; 3 (c) if this Warrant is not registered in the name of the Purchaser, an Assignment or Assignments in the form set forth in EXHIBIT I hereto evidencing the assignment of this Warrant to the Purchaser, in which case the Registered Holder shall have complied with the provisions set forth in Section 7 hereof; and (d) either (1) a check payable to the Company in an amount equal to the product of the Exercise Price multiplied by the number of shares of Common Stock being purchased upon such exercise (the "AGGREGATE EXERCISE PRICE"), (2) the surrender to the Company of debt or equity securities of the Company or any of its wholly-owned Subsidiaries having a Market Price equal to the Aggregate Exercise Price of the shares of Common Stock being purchased upon such exercise (provided that for purposes of this subparagraph 1C(i)(d), the Market Price of any note or other debt security or any preferred stock shall be deemed to be equal to the aggregate outstanding principal amount or liquidation value thereof plus all accrued and unpaid interest thereon or accrued or declared and unpaid dividends thereon) or (3) a written notice to the Company that the Purchaser is exercising this Warrant (or a portion thereof) by authorizing the Company to withhold from issuance a number of shares of Common Stock issuable upon such exercise of this Warrant which when multiplied by the Market Price of the Common Stock is equal to the Aggregate Exercise Price (and such withheld shares shall no longer be issuable under this Warrant). (ii) Certificates for shares of Common Stock purchased upon exercise of this Warrant shall be delivered by the Company to the Purchaser as soon as practicable but in any event within ten business days after the date of the Exercise Time. Unless this Warrant has expired or all of the purchase rights represented hereby have been exercised, the Company shall prepare a new Warrant, substantially identical hereto, representing the rights formerly represented by this Warrant which have not expired or been exercised and shall within such ten-day period, deliver such new Warrant to the Person designated for delivery in the Exercise Agreement. (iii) The shares of Common Stock issuable upon the exercise of this Warrant shall be deemed to have been issued to the Purchaser at the Exercise Time, and the Purchaser shall be deemed for all purposes to have become record holder of such shares of Common Stock at the Exercise Time. (iv) The issuance of certificates for shares of Common Stock issued upon exercise of this Warrant shall be made without charge to the Registered Holder for any issuance tax in respect thereof or other cost incurred by the Company in connection with such exercise and the related issuance of shares of Common Stock. Each share of Common Stock issuable upon exercise of this Warrant shall, upon payment of the Exercise Price therefor, be fully paid and nonassessable and free from all liens and 4 charges with respect to the issuance thereof. (v) The Company shall not close its books against the transfer of this Warrant or of any share of Common Stock issued or issuable upon the exercise of this Warrant in any manner which interferes with the timely exercise of this Warrant. The Company shall from time to time take all such action as may be necessary to assure that the part value per share of the unissued Common Stock acquirable upon exercise of this Warrant is at all times equal to or less than the Exercise Price then in effect. (vi) The Company shall assist and cooperate with the Registered Holder or the Purchaser, as the case may be, in connection with any governmental filings or any governmental approvals required to be made or obtained by the Registered Holder or the Purchaser, as the case may be, prior to or in connection with any exercise of this Warrant (including, without limitation, making any filings required to be made by the Company). (vii) Notwithstanding any other provision hereof, if an exercise of any portion of this Warrant is to be made in connection with a registered public offering or the sale of the Company, such exercise may, at the election of the holder hereof, be conditioned upon the consummation of the public offering or sale of the Company in which case such exercise shall not be deemed to be effective until the consummation of such transaction. (viii) The Company shall at all times reserve and keep available out of its authorized but unissued shares of Common Stock solely for the purpose of issuance upon the exercise of the Warrants, such number of shares of Common Stock issuable upon the exercise of all outstanding Warrants. All shares of Common Stock which are so issuable shall, when issued, be duly and validly issued, fully paid and nonassessable and free from all taxes, liens and charges. The Company shall take all such actions as may be necessary to assure that all such shares of Common Stock may be so issued without violation of any applicable law or governmental regulation or any requirements of any domestic or foreign securities exchange upon which shares of Common Stock may be listed (except for official notice of issuance which shall be immediately delivered by the Company upon each such issuance) including without limitation, the Nasdaq National Market or the Nasdaq Small Cap Market (as the case may be). The Company shall not take any action which would cause the number of authorized but unissued shares of Common Stock to be less than the number of such shares required to be reserved hereunder for issuance upon exercise of the Warrants. 1D. EXERCISE AGREEMENT. Upon any exercise of this Warrant, the Exercise Agreement shall be substantially in the form set forth in EXHIBIT II hereto, except that if the shares of Common Stock are not to be issued in the name of 5 the Person in whose name this Warrant is registered, the Exercise Agreement shall also state the name of the Person to whom the certificates for the shares of Common Stock are to be issued, and if the number of shares of Common Stock to be issued does not include all shares of Common Stock purchasable hereunder, it shall also state the name of the Person to whom a new Warrant for the unexercised portion of the rights hereunder is to be delivered. Such Exercise Agreement shall be dated the actual date of execution thereof. 1E. FRACTIONAL SHARES. If a fractional share of Common Stock would, but for the provisions of Paragraph 1A and Paragraph 1B, as the case may be, be issuable upon exercise of the rights represented by this Warrant, the Company shall, within ten business days after the date of the Exercise Time, deliver to the Purchaser a check payable to the Purchaser in lieu of such fractional share in an amount equal to the difference between the Market Price of such fractional share as of the date of the Exercise Time and the Exercise Price of such fractional share. Section 2. ADJUSTMENT OF EXERCISE PRICE AND NUMBER OF SHARES. In order to prevent dilution of the rights granted under this Warrant, the Exercise Price shall be subject to adjustment from time to time as provided in this Section 2, and the number of shares of Common Stock obtainable upon exercise of this Warrant shall be subject to adjustment from time to time as provided in this Section 2. 2A. ADJUSTMENT OF EXERCISE PRICE AND NUMBER OF SHARES UPON ISSUANCE OF COMMON STOCK. (i) If and whenever on or after the Date of Issuance of this Warrant the Company issues or sells, or in accordance with paragraph 2B is deemed to have issued or sold, any shares of Common Stock (other than the Excluded Stock) for a consideration per share less than the Exercise Price in effect immediately prior to such time, then immediately upon such issue or sale the Exercise Price shall be reduced to the Exercise Price determined by dividing (A) the sum of (y) the product derived by multiplying the Exercise Price in effect immediately prior to such issue or sale and the number of shares of Common Stock Deemed Outstanding immediately prior to such issue or sale plus (z) the consideration, if any, received by the Company upon such issue or sale, by (B) the number of shares of Common Stock Deemed Outstanding immediately after such issue or sale. (ii) Upon each such adjustment of the Exercise Price hereunder, the number of shares of Warrant Stock acquirable upon exercise of this Warrant shall be adjusted to the number of shares determined by multiplying the Exercise Price in effect immediately prior to such adjustment by the number of shares of Warrant Stock 6 acquirable upon exercise of this Warrant immediately prior to such adjustment and dividing the product thereof by the Exercise Price resulting from such adjustment. (iii) For purposes of this Section 2, "EXCLUDED STOCK" means (1) Common Stock issued or reserved for issuance by the Company as a dividend on Preferred Stock or upon any subdivision or split-up of the outstanding shares of any shares of capital stock of the Company or any recapitalization thereof, or upon conversion of any shares of Preferred Stock, (2) Common Stock issuable pursuant to any portion or warrants or other rights that are outstanding on the date of Issuance identified on SCHEDULE 3-2 - CAPITAL STOCK to the Purchase Agreement, (3) Common Stock of the Company issued or issuable in connection with a Board-approved acquisition of a business by the Company as a result of which the Company owns in excess of 50% of the voting power of such business, (4) Common Stock issued or issuable to employees, officers, consultants, directors or vendors of the Company or pursuant to any Board-approved employee, officer, consultant or director benefit plan, including without limitation any Board-approved stock option plan, and (5) Common Stock issued or issuable to (x) banks, savings and loan associations, equipment lessors or similar lending institutions in connection with such entities providing Board-approved credit facilities or equipment financings to the company or (y) any party to any technology transfer agreement, distribution agreement, marketing agreement or any other agreement similar thereto, with the Company, as approved by the Board. 2B. EFFECT ON EXERCISE PRICE OF CERTAIN EVENTS. For purposes of determining the adjusted Exercise Price under Paragraph 2A, the following shall be applicable: (i) ISSUANCE OF RIGHTS OR OPTIONS. If the company in any manner grants or sells any Options and the price per share for which Common Stock is issuable upon the exercise of such Options, or upon conversion or exchange of any Convertible Securities issuable upon exercise of such Options, is less than the Exercise Price in effect immediately prior to the time of the granting the sale of such Options, then the total maximum number of shares of Common Stock issuable upon the exercise of such Options, or upon conversion or exchange of the total maximum amount of such Convertible Securities issuable upon the exercise of such Options, shall be deemed to be outstanding and to have ben issued and sold by the Company at such time for such price per share. For purposes of this paragraph, the "PRICE PER SHARE FOR WHICH COMMON STOCK IS ISSUABLE UPON EXERCISE OF SUCH OPTIONS OR UPON CONVERSION OR EXCHANGE OF SUCH CONVERTIBLE SECURITIES" is determined by dividing (A) the result of (i) the total amount, if any, received or receivable by the Company as consideration for the granting or sale of such Options, plus (ii) the minimum aggregate amount of additional consideration payable to the Company upon the exercise of all such Option, plus (iii) in the case of such Options which are exercisable into Convertible Securities, the minimum aggregate amount of additional consideration, if any, payable to the Company upon the issuance or sale of such Convertible Securities and the conversation 7 or exchange thereof, by (B) the total maximum number of shares of Common Stock issuable upon exercise of such Options or upon the conversion or exchange of all such Convertible Securities issuable upon the exercise of such Options. No further adjustment of the Exercise Price shall be made upon the actual issuance of such Common Stock or of such Convertible securities upon the exercise of such Options or upon the actual issuance of such Common Stock upon conversion or exchange of such Convertible Securities. (ii) ISSUANCE OF CONVERTIBLE SECURITIES. If the Company in any manner issues or sells any Convertible Securities and the price per share for which Common Stock is issuable upon conversion or exchange thereof is less than the Exercise Price in effect immediately prior to the time of such issue or sale, then the maximum number of shares of Common Stock issuable upon conversion or exchange of such Convertible Securities shall be deemed to be outstanding and to have been issued and sold by the Company for such price per share. For the purposes of this paragraph, the "PRICE PER SHARE FOR WHICH COMMON STOCK IS ISSUABLE UPON CONVERSION OR EXCHANGE THEREOF" is determined by dividing (A) the result of (i) the total amount received or receivable by the Company as consideration for the issue or sale of such Convertible Securities, plus (ii) the minimum aggregate amount of additional consideration, if any, payable to the Company upon the conversation or exchange thereof, by (B) the total maximum number of shares of Common Stock issuable upon the conversion or exchange of all such Convertible Securities. No further adjustment of the Exercise Price shall be made upon the actual issue of such Common Stock upon conversion or exchange of such Convertible Securities, and if any such issue or sale of such Convertible Securities is made upon exercise of any Options for which adjustments of the Exercise Price had been or are to be made pursuant to other provisions of this Paragraph 2B, no further adjustment of the Exercise Price shall be made by reason of such issue or sale. (iii) CHANGE IN OPTION PRICE OR CONVERSION RATE. If the purchase price provided for in any Options, the additional consideration, if any, payable upon the issue, conversion or exchange of any Convertible Securities, or the rate at which any Convertible Securities are convertible into or exchangeable for Common Stock changes at any time, the Exercise Price in effect at the time of such change shall be adjusted immediately to the Exercise Price which would have been in effect at such time had such Options or Convertible Securities still outstanding provided for such changed purchase price, additional consideration or changed conversion rate, as the case may be, at the time initially granted, issued or sold and the number of shares of Warrant Stock shall be correspondingly adjusted; provided that if such adjustment would result in an increase of the Exercise Price then in effect, such adjustment shall not be effective until 30 days after written notice thereof has been given by the Company to all holders of the Warrants. For purposes of this Paragraph 2B, if the terms of any Option or Convertible Security which was outstanding as of the date of issuance of this Warrant are changed in the manner described in the immediately preceding sentence, 8 then such Option or Convertible Security and the Common Stock deemed issuable upon exercise, conversation or exchange thereof shall be deemed to have been issued as of the date of such change; provided that no such change shall at any time cause the Exercise Price hereunder to be increased. (iv) TREATMENT OF EXPIRED OPTIONS AND UNEXERCISED CONVERTIBLE SECURITIES. Upon the expiration of any Option or the termination of any right to convert or exchange any Convertible Securities without the exercise of such Option or right, the Exercise Price then in effect and the number of shares of Warrant Stock acquirable hereunder shall be adjusted immediately to the Exercise Price and the number of shares which would have ben in effect at the time of such expiration or termination had such Option or Convertible Securities to the extent outstanding immediately prior to such expiration or termination, never been issued; provided that if such expiration or termination would result in an increase in the Exercise Price then in effect, such increase shall no be effective until 30 days after written notice thereof has been given to all holders of the Warrants. For purposes of this Paragraph 2B, the expiration or termination of any Option or Convertible Security which was d as of the date of issuance f this Warrant shall not cause the Exercise Price hereunder to be adjusted unless, and only to the extent that, a change in the terms of such Option or Convertible Security caused it to be deemed t have been issued after the date of issuance of this Warrant. (v) CALCULATION OF CONSIDERATION RECEIVED. If any Common Stock, Options or Convertible Securities are issued or sold or deemed to have been issued or sold for cash, the consideration received therefor shall be deemed to be the gross amount (net of any underwriter, placement agent or broker discounts and commissions) received by the Company therefor. In case any Common Stock, Options or Convertible Securities are issued or sold for a consideration other than cash, the amount of the consideration other than cash received by the Company shall be the fair value of such consideration, except where such consideration consists of securities, in which case the amount of consideration received by the Company shall be the Market Price thereof as of the date of receipt. In case any Common Stock, Options or Convertible Securities are issued to the owners of the non-surviving entity in connection with any merger in which the Company is the surviving entity the amount of consideration therefor shall be deemed to be the fair value of such portion of the net assets and business of the non-surviving entity as is attributable to such Common Stock, Options or Convertible Securities, as the case may be. The fair value of any consideration other than cash or securities shall be determined jointly by the Company and the Registered Holders of the Warrants representing a majority of the shares of the Warrant Stock obtainable upon exercise of such Warrants. If such parties are unable to reach agreement within a reasonable period of time, such fair value shall be determined by an appraiser jointly selected by the Company and the Registered Holders of the Warrants representing a majority of the shares of Warrant Stock obtainable upon exercise of such Warrants. 9 The determination of such appraiser shall be final and binding on the Company and the Registered Holders of such Warrants, and the fees and expenses of such appraiser shall be paid by the Company. (vi) INTEGRATED TRANSACTIONS. In case any Option is issued in connection with the issue or sale of other securities of the Company, together comprising one integrated transaction in which no specific consideration is allocated to such Options by the parties thereto, the Options shall be deemed to have been issued without consideration. (vii) TREASURY SHARES. The number of shares of Common Stock outstanding at any given time does not include shares owned or held by or for the account of the Company or any subsidiary, and the disposition of any shares so owned or held shall be considered an issue or sale of Common Stock. (viii)RECORD DATE. If the Company takes a record of the holders of Common Stock for the purpose of entitling them (A) to receive a dividend or other distribution payable in Common Stock, Options or in Convertible Securities of (B) to subscribe for or purchase Common Stock, Options or Convertible Securities, then such record date shall be deemed to be the date of the issue or sale of the shares of Common Stock deemed to have been issued or sold upon the declaration of such dividend or the making of such other distribution or the date of the granting of such right of subscription or purchase, as the case may be. 2C. SUBDIVISION OR COMBINATION OF COMMON STOCK. If the Company at any time subdivides (by any stock split, stock dividend, recapitalization or otherwise) one or more classes of its outstanding shares of Common Stock into a greater number of shares, the Exercise Price in effect immediately prior to such subdivision shall be proportionately reduced and the number of shares of Warrant Stock obtainable upon exercise of this Warrant shall be proportionately increased. If the Company at any time combines (by reverse stock split or otherwise) one or more classes of its outstanding shares of Common Stock into a smaller number of shares, the Exercise Price in effect immediately prior to such combination shall be proportionately increased and the number of shares of Warrant Stock obtainable upon exercise of this Warrant shall be proportionately decreased. 2D. REORGANIZATION, RECLASSIFICATION, CONSOLIDATION, MERGER OR SALE. Any recapitalization, reorganization, reclassification, consolidation, merger, sale of all or substantially all of the Company's assets or other transaction, which in each case is effective in such a way that the holders of Common Stock are entitled to receive (either directly or upon subsequent liquidation) stock, securities or assets with respect to or in exchange for Common Stock is referred to herein as "ORGANIC CHANGE". Prior to the consummation of any Organic Change, the Company shall make appropriate provision 10 (in form and substance satisfactory to the Registered Holders of the Warrants representing a majority of the shares of Warrant Stock obtainable upon exercise of all Warrants then outstanding) to insure that each of the Registered Holders of the Warrants shall thereafter have the right to acquire and receive, in lieu of or addition to (as the case may be) the shares of Warrant Stock immediately theretofore acquirable and receivable upon the exercise of such holder's Warrant, such shares of stock, securities or assets as may be issued or payable with respect to or in exchange for the number of shares of Warrant Stock immediately theretofore acquirable and receivable upon exercise of such holder's Warrant had such Organic Change not taken place. In any such case, the Company shall make appropriate provision (in form and substance satisfactory to the Registered Holders of the Warrants representing a majority of the shares of Warrant Stock obtainable upon exercise of all of the Warrants then outstanding) with respect to such Registered Holders' rights and interests to insure that the provisions of this Section 2 and Sections 3 and 4 hereof shall thereafter be applicable to the Warrants (including, in the case of any such consolidation, merger or sale in which the successor entity or purchasing entity is other than the Company and in which the value for the Common Stock reflected by the terms of such consolidation, merger or sale is less than the Base Price in effect immediately prior to such consolidation, merger or sale, an immediate adjustment of the Exercise Price to the product of such Exercise Price immediately prior to such consolidation, merger or sale multiplied by the ratio of such value of the Common Stock divided by the Base Price in effect immediately prior to such consolidation, merger or sale and a corresponding immediate adjustment in the number of shares of Warrant Stock acquirable and receivable upon exercise of the Warrants). The Company shall not effect any such consolidation, merger or sale, unless prior to the consummation thereof, the successor entity (if other than the Company) resulting from consolidation or merger or the entity purchasing such assets assumes by written instrument (in form and substance satisfactory to the Registered Holders of the Warrants representing a majority of the Warrant Stock obtainable upon exercise of all of the Warrants then outstanding), the obligation to deliver to each such Registered Holder such shares of stock, securities or assets as, in accordance with the foregoing provisions, such Registered Holder may be entitled to acquire. 2E. CERTAIN EVENTS. If any event occurs of the type contemplated by the provisions of Section 2A but not expressly provided for by such provisions, then the Exercise Price and the number of shares of Warrant Stock obtainable upon exercise of this Warrant shall be adjusted by the Corporation's Board of Directors in good faith so as to protect the rights of the holders of the Warrants; provided that no such adjustment shall increase the Exercise Price or decrease the number of shares of Warrant Stock obtainable as otherwise determined pursuant to this Section 2. 2F. NOTICES. 11 (i) Immediately upon any adjustment of the Exercise Price, the Company shall give written notice thereof to the Registered Holder, setting forth in reasonable detail and certifying the calculation of such adjustment. (ii) The Company shall give written notice to the Registered Holder at least 20 days prior to the date on which the Company closes its books or takes a record (A) with respect to any dividend or distribution upon shares of Common Stock, (B) with respect to any pro rata subscription offer to holders of Common Stock or (C) for determining rights to vote with respect to any Organic Change, dissolution or liquidation. (iii) The Company shall also give written notice to the Registered Holders at least 20 days prior to the date on which any Organic Change, dissolution or liquidation shall take place. Section 3. LIQUIDATING DIVIDENDS. If the Company declares or pays a dividend upon shares of Common Stock payable otherwise than in cash out of earnings or earned surplus (determined in accordance with generally accepted accounting principles, consistently applied) except for a stock dividend payable in shares of Common Stock (a "LIQUIDATING DIVIDEND"), then the Company shall pay to the Registered Holder at the time of payment thereof the Liquidating Dividend which would have been paid to the Registered Holder on the Warrant Stock had this Warrant been fully exercised immediately prior to the date on which a record is taken for such Liquidating Dividend, or, if no record is taken, the date as of which the record holders of Common Stock entitled to such dividends are to be determined. Section 4. PURCHASE RIGHTS. If at any time the Company grants, issues or sells any Options, Convertible Securities or warrants, securities or other like property pro rate to the record holders of any class of Common Stock (the "PURCHASE RIGHTS"), then the Registered Holder shall be entitled to acquire, upon the terms applicable to such Purchase Rights, the aggregate Purchase Rights which such Registered Holder could have acquired if such Registered Holder had held the number of shares of Common Stock acquirable upon complete exercise of this Warrant immediately before the date on which a record is taken for the grant, issuance or sale of such Purchase Rights, or, if no such record is taken, the date as of which the record holders of Common Stock are to be determined for the grant, issue or sale of such Purchase Rights. Section 5. DEFINITIONS. The following terms have meanings set forth below: "BOARD" means the Company's Board of Directors. "COMMON STOCK" means the Company's Common Stock, $0.001 par value, and 12 except for purposes of the shares obtainable upon exercise of this Warrant, any capital stock of any class of the Company hereafter authorized which is not limited to a fixed sum or percentage of par or stated value in respect to the rights of the holders thereof to participate in dividends or in the distribution of assets upon any liquidation, dissolution or winding up of the Company. "COMMON STOCK DEEMED OUTSTANDING" means, at any given time, the number of shares of Common Stock actually outstanding at such time, plus the number of shares of Common Stock deemed to be outstanding pursuant to paragraphs 2B(i) and 2B(ii) hereof regardless of whether the Options or Convertible Securities are actually exercisable or convertible at such time. "CONVERTIBLE SECURITIES" means any stock or securities (directly or indirectly) convertible into or exchangeable for Common Stock. "MARKET PRICE" means as to any security the average of the closing prices of such security's sales on all domestic or foreign securities exchanges on which such security may at the time be listed, or, if there have been no sales on any such exchange on any day, the average of the highest bid and lowest asked prices on all such exchanges at the end of such day, or, if on any day such security is not so listed, the average of the representative bid and asked prices quoted in the Nasdaq National Market or Nasdaq Small Cap Market, as of 4:00 P.M., New York time, on such day, or, if on any day such security is not quoted in the Nasdaq National Market or the Nasdaq Small Cap Market (as applicable), the average of the highest bid and lowest asked prices on such day in the domestic over-the-counter market as reported by the National Quotation Bureau, Incorporated, or any similar successor organization, in each such case averaged over a period of 30 days consisting of the day as of which "MARKET PRICE" is being determined and the 29 consecutive business days prior to such day; provided that if such security is listed on any domestic securities exchange the term "BUSINESS DAYS" as used in this sentence means business days on which such exchange is open for trading. If at any time such security is not listed on any domestic securities exchange or quoted in the Nasdaq National Market System or the Nasdaq Small Cap Market or the domestic over-the-counter market, the "MARKET PRICE" shall be the fair value thereof determined jointly by the Company and the Registered Holders of Warrants representing a majority of the Common Stock purchasable upon exercise of all the Warrants then outstanding, provided that if such parties are unable to reach agreement within a reasonable period of time, such fair value shall be determined by an appraiser jointly selected by the Company and the Registered Holders of the Warrants representing a majority of the shares of Common Stock purchasable upon exercise of all the Warrants then outstanding. The determination of such appraiser shall be final and binding on the Company and the Registered Holders of the Warrants, and the fees and expenses of such appraiser shall be paid by the Company. 13 "OPTION" means any rights to subscribe for or purchase Common Stock or Convertible Securities. "PERSON" means an individual, a partnership, a joint venture, a corporation, a limited liability company, a trust, an unincorporated organization and a government or any department or agency thereof. "WARRANT STOCK" means Common Stock; provided that if there is a change such that the securities issuable upon exercise of the Warrants are issued by an entity other than the Company or there is a change in the type or class of securities so issuable, then the term "WARRANT STOCK" shall mean one share of the security issuable upon exercise of the Warrants if such security is issuable in shares, or shall mean the smallest unit in which such security is issuable if such security is not issuable in shares. Other capitalized terms used in this Warrant but not defined herein shall have the meanings set forth in the Purchase Agreement. Section 6. NO VOTING RIGHTS; LIMITATIONS OF LIABILITY. This Warrant shall not entitle the holder hereof to any voting rights or other rights as a stockholder of the Company. No provision hereof, in the absence of affirmative action by the Registered Holder to purchase Common Stock, and no enumeration herein of the rights or privileges of the Registered Holder shall give rise to any liability of such holder for the Exercise Price of Common Stock acquirable by exercise hereof or as a stockholder of the Company. Section 7. WARRANT TRANSFERABLE. Subject to the transfer conditions referred to in the legend endorsed hereon, this Warrant and all rights hereunder are transferable, in whole or in part, without charge to the Registered Holder, upon surrender of this Warrant with a properly executed Assignment (in the form of EXHIBIT I hereto) at the principal office of the Company. Section 8. WARRANT EXCHANGEABLE FOR DIFFERENT DENOMINATIONS. This Warrant is exchangeable, upon the surrender hereof by the Registered Holder at the principal office of the Company, for new Warrants of like tenor representing in the aggregate the purchase rights hereunder, and each of such new Warrants shall represent such portion of such rights as is designated by the Registered Holder at the time of such surrender. The date the Company initially issues this Warrant shall be deemed to be the "DATE OF ISSUANCE" hereof regardless of the number of times new certificates representing the unexpired and unexercised rights formerly represented by this Warrant shall be issued. All Warrants representing portions of the rights hereunder are referred to herein as the "WARRANTS." 14 Section 9. REPLACEMENT. Upon receipt of evidence reasonably satisfactory to the Company (an affidavit of the Registered Holder shall be satisfactory) of the ownership and the loss, theft, destruction or mutilation of any certificate evidencing this Warrant, and in the case of any such loss, theft or destruction, upon receipt of indemnity reasonably satisfactory to the Company (provided that if the holder is a financial institution or other institutional investor its own agreement shall be satisfactory), or in the case of any such mutilation upon surrender of such certificate of like kind representing the same rights represented by such loss, stolen, destroyed or mutilated certificate and dated the date of such loss, stolen, destroyed or mutilated certificate. Section 10. NOTICES. Except as otherwise expressly provided herein, all notices referred to in this Warrant shall be in writing and shall be delivered personally, sent by reputable overnight courier service (charges prepaid) or sent by registered or certified mail, return receipt requested, postage prepaid and shall b deemed to have been given when so delivered, sent or deposited in the U.S. Mail (i) to the Company, at its principal executive offices and (ii) to the Registered Holder of this Warrant, at such holder's address as it appears in the records of the Company (unless otherwise indicated by any such holder). Section 11. AMENDMENT AND WAIVER. Except as otherwise provided herein, the provisions of the Warrants may be amended and the Company may take any action herein prohibited, or omit to perform any act herein required to be performed by it, only if the Company has obtained the written consent of the Registered Holders of Warrants representing a majority of the shares of Common Stock obtainable upon exercise of all of the Warrants then outstanding; provided that no such action may change the Exercise Price of the Warrants or the number of shares or class of stock obtainable upon exercise of each Warrant without the written consent of the Registered Holders of Warrants representing at least 80% of the shares of Common Stock obtainable upon exercise of the Warrants then outstanding. Section 12. DESCRIPTIVE HEADINGS; GOVERNING LAW. The descriptive headings of the several Sections and paragraphs of this Warrant are inserted for convenience only and do not constitute a part of this Warrant. The corporation laws of the State of Delaware shall govern all issues concerning the rights of the Company and all rights of the Company's stockholders relative to the Company. All other questions concerning the construction, validity, enforcement and interpretation of this Warrant shall be governed by the internal law of the State of New York, without giving effect to any choice of law or conflict of law provision or rule (whether of the State of New York or any other jurisdictions) that would cause the application of the laws of any jurisdictions other than the State of New York. * * * * * * 15 IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by its duly authorized officer and to be dated the Date of Issuance. LIFECELL CORPORATION By Paul M. Frison President and Chief Executive Officer 16 EXHIBIT I ASSIGNMENT FOR VALUE RECEIVED,________________ hereby sells, assigns and transfers all of the rights of the undersigned under the attached Warrant (Certificate No. BW-______) with respect to the number of shares of the Common Stock covered thereby set forth below, unto: NAMES OF ASSIGNEE ADDRESS NO. OF SHARES Signature Witness 17 EXHIBIT B LIFECELL CORPORATION CERTIFICATE OF DESIGNATION OF SERIES B PREFERRED STOCK Pursuant to Section 151 of the General Corporation Law of the State of Delaware LifeCell Corporation (the "Corporation"), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware, does hereby certify: FIRST: That the Board of Directors of the Corporation, pursuant to a unanimous consent of the Board of Directors dated as of November 6, 1996, duly adopted the following resolution: RESOLVED, that pursuant to the authority expressly granted to and vested in the Board of Directors of the Corporation by the provisions of the Restated Certificate of Incorporation of the Corporation, out of the authorized but unissued shares of Preferred Stock of the Corporation this Board of Directors hereby creates a series of the Preferred Stock, par value $.001 per share (the "Preferred Stock"), of the Corporation, and this Board of Directors hereby fixes the powers, designations, preferences and relative, participating, optional or other special rights of the shares of such series, and the qualifications, limitations or restrictions thereof (in addition to the powers, designations, preferences and relative, participating, optional or other special rights, and the qualifications, limitations or restrictions thereof, set forth in the Restated Certificate of Incorporation of the Corporation which are applicable to Preferred Stock of all series) as follows: 1. DESIGNATION. The designation of the series shall be "Series B Preferred Stock" (the "Series B Preferred Stock"). 2. NUMBER. The number of shares constituting the Series B Preferred Stock shall be 182,205. 18 3. VOTING RIGHTS. (a) GENERAL. Each share of Series B Preferred Stock shall entitle the holder thereof to one vote for each share of Common Stock, $.001 par value per share, of the Corporation (the "Common Stock"), into which such share of Series B Preferred Stock is convertible on the record date for such vote on all matters submitted to a vote of the stockholders of the Corporation. (b) DIRECTORS. At any meeting of the stockholders of the Corporation held for the election of directors, the holders of Series B Preferred Stock, voting separately as a series, shall be entitled to elect three members of the Board of Directors of the Corporation. (c) OTHER. Without the vote or consent of the holders of at least a majority of the shares of Series B Preferred Stock then outstanding, the Corporation may not authorize or create any class or series of capital stock ranking prior to or on a parity with the Series B Preferred Stock either as to redemption or liquidation. 4. LIQUIDATION. (a) PREFERENCE. The Series B Preferred Stock shall rank on a parity with the Series A Preferred Stock, $.001 par value per share, of the Corporation (the "Series A Preferred Stock"), with respect to liquidation. All capital stock of the Corporation other than the Series A Preferred Stock and the Series B Preferred Stock is referred to herein as the "Junior Securities". In the event of any liquidation, 19 dissolution or winding up of the affairs of the Corporation, whether voluntary or involuntary, each holder of record of the issued and outstanding shares of Series B Preferred Stock shall be entitled to receive, out of the assets of the Corporation available for distribution to the holders of shares of Series B Preferred Stock, prior and in preference to any distribution of any of the assets of the Corporation to the holders of Junior Securities, an amount in cash equal to the aggregate Liquidation Value (as defined below) of all shares of Series B Preferred Stock then held by such holder, plus an amount equal to all dividends accrued and unpaid on such shares (whether or not declared) up to the date fixed for distribution. If, upon such liquidation, dissolution or winding up of the affairs of the Corporation, the assets of the Corporation distributable among the holders of Series B Preferred Stock, the Series A Preferred Stock and any other series of Preferred Stock ranking on a parity therewith in respect thereto or any class or series of capital stock of the Corporation ranking on a parity therewith in respect thereto shall be insufficient to permit the payment in full to all such holders of shares of the preferential amounts payable to them, then the entire assets of the Corporation available for distribution to such holders of such shares shall be distributed ratably among such holders in proportion to the respective amounts that would be payable per share if such assets were sufficient to permit payment in full. Not less than 30 days prior to the payment date stated therein, the Corporation shall mail written notice of any such liquidation, dissolution or winding up to each record holder of the Series B Preferred Stock, setting forth in reasonable detail the amount of proceeds to be paid with respect to each share of Series B Preferred Stock and each share of Common Stock in connection with such liquidation, dissolution or winding up. (b) After payment of the full amount to which they are entitled upon liquidation pursuant to Section 4(a), the holders of shares of Series B Preferred Stock shall be entitled to participate ratably in any distribution of any remaining assets of the Corporation legally available for distribution to the holders of Common Stock with the holders of record of the then issued and outstanding shares of Common Stock, as a single class, on the basis of the number of shares held by each such holder of Series B Preferred Stock (for the purposes of this Section 4(b), treating such shares of Series B Preferred Stock as if converted into shares of Common Stock pursuant to the provisions of this Certificate). (c) LIQUIDATION VALUE; ADJUSTMENTS. "The Liquidation Value" of any particular share of Series B Preferred Stock as of any particular date shall equal $100.00. The Liquidation Value shall be equitably adjusted by the Corporation to reflect any stock dividend, stock distribution, stock split or reverse stock split, combination of shares, subdivision of shares or reclassification of shares with respect to the Series B Preferred Stock. 5. CONVERSION RIGHTS. The Series B Preferred Stock shall be convertible as follows: (a) OPTIONAL CONVERSION. Subject to and upon compliance with the provisions of this Section 5, the holder of any shares of Series B Preferred Stock shall have the right at such holder's option, at any time or from time to time, and without the payment of any additional consideration therefor, to convert any of such shares of Series B Preferred Stock into fully paid and nonassessable shares of Common Stock at the Conversion Price (as defined in Section 5(c) below) in effect on any Conversion Date (as defined in Section 5(d) below) upon the terms hereinafter set forth. (b) AUTOMATIC CONVERSION. Each outstanding share of Series B Preferred Stock shall automatically be converted, without any further act of the Corporation or its stockholders, at the Conversion Price then in effect, into fully paid and nonassessable shares of Common Stock on the earlier to occur of the following: (i) the date of the closing of an underwritten public offering pursuant to an effective registration statement under the Securities Act of 1933, as amended (the "Securities Act"), covering the offering and sale of Common Stock, or of any equity security that as a part of a unit includes Common Stock, for the account of the Corporation, in which the aggregate gross proceeds received by the Corporation, net of any underwriter discounts or commissions, equals or exceeds $20,000,000, and in which the public offering price per share of Common Stock equals or exceeds $9.30 (as equitably adjusted to reflect any stock dividend, stock distribution, stock split or reverse stock split, combination of shares, subdivision of shares or reclassification of shares); and 20 (ii) the date first occurring after the closing of an underwritten public offering pursuant to an effective registration statement under the Securities Act covering the offering and sale of Common Stock, or of any equity security that as a part of a unit includes Common Stock, for the account of the Corporation, in which the aggregate gross proceeds received by the Corporation, net of any underwriter discounts or commissions, equals or exceeds $20,000,000, on which the Current Market Price (as defined in the first sentence of Section 5(j) below) of the Common Stock equals or exceeds $9.30 (as equitably adjusted to reflect any stock dividend, stock distribution, stock split or reverse stock split, combination of shares, subdivision of shares or reclassification of shares). (c) NUMBER OF CONVERSION SHARES. Each share of Series B Preferred Stock shall be convertible pursuant to Sections 5(a) and 5(b) into a number of shares of Common Stock determined by dividing (i) the Liquidation Value (as it may be adjusted pursuant to Section 4(c) hereof) by (ii) the Conversion Price in effect on any Conversion Date. For the purposes of this Section 5, the term "Conversion Price" shall initially mean $3.10. In order to prevent dilution of the conversion rights granted under this Section 5, the Conversion Price shall be subject to adjustment from time to time pursuant to Section 5(f). (d) CONVERSION PROCEDURES. The holder of any shares of Series B Preferred Stock may exercise the conversion right specified in Section 5(a) by surrendering to the Corporation or any transfer agent of the Corporation the certificate or certificates for the shares to be converted, accompanied by written notice specifying the number of shares to be converted. Upon the occurrence of automatic conversion pursuant to Section 5(b), the outstanding shares of Series B Preferred Stock shall be converted automatically without any further action by the holders of such shares and whether or not the certificates representing such shares are surrendered to the Corporation or its transfer agent; provided that the Corporation shall not be obligated to issue to any holder certificates evidencing the shares of Common Stock issuable upon such conversion unless certificates evidencing such shares of Series B Preferred Stock are delivered either to the Corporation or any transfer agent of the Corporation. Conversion shall be deemed to have been effected on the date when delivery of notice of an election to convert and of certificates for shares being converted is made or on a date specified in Section 5(b), as the case may be, and such date is referred to herein as the "Conversion Date". Subject to the provisions of Section 5(f)(iv), as promptly as practicable thereafter (and after surrender of the certificate or certificates representing shares of Series B Preferred Stock to the Corporation or any transfer agent of the Corporation in the case of conversion pursuant to Section 5(b)) the Corporation shall issue and deliver to or upon the written order of such holder a certificate or certificates for the number of full shares of Common Stock to which such holder is entitled and a check or cash with respect to any fractional interest in a share of Common Stock as provided in Section 5(e). Subject to the provisions of Section 5(f)(iv), the person in whose name the certificate or certificates 21 for Common Stock are to be issued shall be deemed to have become a holder of record of such Common Stock on the applicable Conversion Date. Upon conversion of only a portion of the number of shares covered by a certificate representing shares of Series B Preferred Stock surrendered for conversion (in the case of conversion pursuant to Section 5(a)), the Corporation shall issue and deliver to or upon the written order of the holder of the certificate so surrendered for conversion, at the expense of the Corporation, a new certificate covering the number of shares of Series B Preferred Stock representing the unconverted portion of the certificate so surrendered. (e) FRACTIONAL SHARES. No fractional shares of Common Stock or scrip shall be issued upon conversion of shares of Series B Preferred Stock. If more than one share of Series B Preferred Stock shall be surrendered for conversion at any one time by the same holder or shall be held by the same holder at the time of any automatic conversion, the number of full shares of Common Stock issuable upon conversion thereof shall be computed on the basis of the aggregate number of shares so surrendered or held, as the case may be. Instead of any fractional shares of Common Stock which would otherwise be issuable upon conversion of any shares of Series B Preferred Stock, the Corporation shall pay out of funds legally available therefor a cash adjustment in respect of such fractional interest, rounded to the nearest one hundredth (1/100th) of a share, in an amount equal to that fractional interest of the then Current Market Price (as defined in Section 5(j) below), rounded to the nearest cent ($.01). (f) CONVERSION PRICE ADJUSTMENTS. The Conversion Price shall be subject to adjustment from time to time as follows: (i) If and whenever on or after the date of the original issuance of the Series B Preferred Stock, the Corporation issues or sells, or in accordance with Section 5(g) is deemed to have issued or sold, any shares of its Common Stock (other than Excluded Stock) for a consideration per share less than the Conversion Price in effect immediately prior to the time of such issue or sale, or deemed issue or sale then immediately upon such issue or sale or deemed issue or sale the Conversion Price shall be reduced to the Conversion Price determined by dividing (A) the sum of (1) the product derived by multiplying the Conversion Price in effect immediately prior to such issue or sale or deemed issue or sale by the number of shares of Common Stock Deemed Outstanding immediately prior to such issue or sale or deemed issue or sale, plus (2) the consideration, if any, received by the Corporation upon such issue or sale or deemed issue or sale, by (B) the number of shares of Common Stock Deemed Outstanding immediately after such issue or sale or deemed issue or sale. 22 (ii) For purposes of this Section 5, "Excluded Stock" means (A) Common Stock issued or reserved for issuance by the Company as a dividend on Preferred Stock or upon any subdivision or split-up of the outstanding shares of any shares of capital stock of the Company or any recapitalization thereof, or upon conversion of any shares of Preferred Stock, (B) Common Stock issuable pursuant to any options, warrants or other rights that are outstanding on the effective date of this Certificate, (C) Common Stock issued or issuable in connection with a Board-approved acquisition of a business by the Company as a result of which the Company owns in excess of 50% of the voting power of such business, (D) Common Stock issued or issuable to employees, officers, consultants, directors or vendors of the Company or pursuant to any Board-approved employee, officer, consultant or director benefit plan, including without limitation any stock option plan, and (E) Common Stock issued or issuable to (1) banks, savings and loan associations, equipment lessors or similar lending institutions in connection with such entities providing Board-approved credit facilities or equipment financings to the Company or (2) any party to any technology transfer agreement, distribution agreement, marketing agreement or any other agreement similar thereto, with the Company, as approved by the Board. For purposes of this Section 5, "Common Stock Deemed Outstanding" means, at any given time, the number of shares of Common Stock actually outstanding at such time, plus the number of shares of Common Stock deemed to be outstanding pursuant to Sections 5(g)(i) and 5(g)(ii) hereof regardless of whether Options (as defined below) or Convertible Securities (as defined below) are actually exercised or converted at such time. (iii) All calculations under this Section 5(f) shall be made to the nearest cent ($.01) or to the nearest one hundredth (1/100th) of a share, as the case may be. Any provision of this Section 5 to the contrary notwithstanding, no adjustment in the Conversion Price shall be made if the amount of such adjustment would be less than 1% of the then current Conversion Price until the end of the calendar year after such adjustment would otherwise have been required; but any such amount shall be carried forward and an adjustment with respect thereto shall be made at the time of and together with any subsequent adjustment which, together with such amount and any other amount or amounts so carried forward, shall aggregate 1% of the then current Conversion Price or more, provided that if the events giving rise to such adjustments occur within three months of each other, then such adjustments shall be calculated as if these events giving rise to them had occurred simultaneously on the date of the first such event. (iv) In any case in which the provisions of this Section 5(f) shall require that an adjustment shall become effective immediately after a record date for an event, the Corporation may defer until the occurrence of such event 23 (A) issuing to the holder of any share of Series B Preferred Stock converted after such record date and before the occurrence of such event the additional shares of Common Stock issuable upon such conversion by reason of the adjustment required by such event over and above the shares of Common Stock issuable upon such conversion before giving effect to such adjustment and (B) paying to such holder any amount of cash in lieu of a fractional share of Common Stock pursuant to Section 5(e); provided that the Corporation upon request shall deliver to such holder a due bill or other appropriate instrument evidencing such holder's right to receive such additional shares, and such cash, upon the occurrence of the event requiring such adjustment. (g) EFFECT ON CONVERSION PRICE OF CERTAIN EVENTS. For purposes of determining the adjusted Conversion Price under Section 5(f), the following shall be applicable: (i) ISSUANCE OF RIGHTS OR OPTIONS. If the Corporation in any manner grants or sells any rights to subscribe for or purchase Common Stock or Convertible Securities ("Options") and the price per share for which Common Stock is issuable upon the exercise of such Options, or upon conversion or exchange of any stock or securities (directly or indirectly) convertible into or exchangeable for Common Stock ("Convertible Securities") issuable upon exercise of such Options, is less than the Conversion Price in effect immediately prior to the time of the granting or sale of such Options, then the total maximum number of shares of Common Stock issuable upon the exercise of such Options or upon conversion or exchange of the total maximum amount of such Convertible Securities issuable upon the exercise of such Options shall be deemed to be outstanding and to have been issued and sold by the Corporation at the time of the granting or sale of such Options for such price per share. For purposes of this paragraph, the "price per share for which Common Stock is issuable" shall be determined by dividing (A) the total amount, if any, received or receivable by the Corporation as consideration for the granting or sale of such Options, plus the minimum aggregate amount of additional consideration payable to the Corporation upon exercise of all such Options, plus in the case of such Options which relate to Convertible Securities, the minimum aggregate amount of additional consideration, if any, payable to the Corporation upon the issuance or sale of such Convertible Securities and the conversion or exchange thereof, by (B) the total maximum number of shares of Common Stock issuable upon the exercise of such Options or upon the conversion or exchange of all such Convertible Securities issuable upon the exercise of such Options. No further adjustment of the Conversion Price shall be made when Convertible Securities are actually issued upon the exercise of such Options or when Common Stock is actually issued upon the exercise of such Options or the conversion or exchange of such Convertible Securities. 24 (ii) ISSUANCE OF CONVERTIBLE SECURITIES. If the Corporation in any manner issues or sells any Convertible Securities and the price per share for which Common Stock is issuable upon conversion or exchange thereof is less than the Conversion Price in effect immediately prior to the time of such issue or sale, then the maximum number of shares of Common Stock issuable upon conversion or exchange of such Convertible Securities shall be deemed to be outstanding and to have been issued and sold by the Corporation at the time of the issuance or sale of such Convertible Securities for such price per share. For the purposes of this paragraph, the "price per share for which Common Stock is issuable" shall be determined by dividing (A) the total amount received or receivable by the Corporation as consideration for the issue or sale of such Convertible Securities, plus the minimum aggregate amount of additional consideration, if any, payable to the Corporation upon the conversion or exchange thereof, by (B) the total maximum number of shares of Common Stock issuable upon the conversion or exchange of all such Convertible Securities. No further adjustment of the Conversion Price shall be made when Common Stock is actually issued upon the conversion or exchange of such Convertible Securities, and if any such issue or sale of such Convertible Securities is made upon exercise of any Options for which adjustments of the Conversion Price had been or are to be made pursuant to other provisions of this Section 5(g), no further adjustment of the Conversion Price shall be made by reason of such issue or sale. (iii) CHANGE IN OPTION PRICE OR CONVERSION RATE. If the purchase price provided for in any Options, the additional consideration, if any, payable upon the conversion or exchange of any Convertible Securities or the rate at which any Convertible Securities are convertible into or exchangeable for Common Stock changes at any time, the Conversion Price in effect at the time of such change shall be immediately adjusted to the Conversion Price which would have been in effect at such time had such Options or Convertible Securities still outstanding provided for such changed purchase price, additional consideration or conversion rate, as the case may be, at the time initially granted, issued or sold; provided that if such adjustment would result in an increase of the Conversion Price then in effect, such adjustment shall not be effective until 30 days after written notice thereof has been given by the Corporation to all holders of the Series B Preferred Stock. For purposes of this Section 5(g), if the terms of any Option or Convertible Security which was outstanding as of the date of issuance of the Series B Preferred Stock are changed in the manner described in the immediately preceding sentence, then such Option or Convertible Security and the Common Stock deemed issuable upon exercise, conversion or exchange thereof shall be deemed to have been issued as of the date of such change. (iv) TREATMENT OF EXPIRED OPTIONS AND UNEXERCISED CONVERTIBLE 25 SECURITIES. Upon the expiration of any Option or the termination of any right to convert or exchange any Convertible Security without the exercise of any such Option or right, the Conversion Price then in effect hereunder shall be adjusted immediately to the Conversion Price which would have been in effect at the time of such expiration or termination had such Option or Convertible Security, to the extent outstanding immediately prior to such expiration or termination, never been issued; provided that if such expiration or termination would result in an increase in the Conversion Price in effect, such increase shall not be effective until 30 days after written notice thereof has been given to all holders of the Series B Preferred Stock. For purposes of this Section 5(g), the expiration or termination of any Option or Convertible Security which was outstanding as of the date of issuance of the Series B Preferred Stock shall not cause the Conversion Price hereunder to be adjusted unless, and only to the extent that, a change in the terms of such Option or Convertible Security caused it to be deemed to have been issued after the date of issuance of the Series B Preferred Stock. (v) CALCULATION OF CONSIDERATION RECEIVED. If any Common Stock, Option or Convertible Security is issued or sold or deemed to have been issued or sold for cash, the consideration received therefor shall be deemed to be the gross amount received by the Corporation therefor (net of any underwriter, placement agent or broker discounts and commissions). If any Common Stock, Option or Convertible Security is issued or sold for a consideration other than cash, the amount of the consideration other than cash received by the Corporation shall be the fair value of such consideration, except where such consideration consists of securities, in which case the amount of consideration received by the Corporation shall be the Current Market Price thereof as of the date of receipt. If any Common Stock, Option or Convertible Security is issued to the owners of the non-surviving entity in connection with any merger in which the Corporation is the surviving corporation, the amount of consideration therefor shall be deemed to be the fair value of such portion of the net assets and business of the non-surviving entity as is attributable to such Common Stock, Option or Convertible Security, as the case may be. The fair value of any consideration other than cash and securities shall be determined jointly by the Corporation and the holders of a majority of the outstanding Series B Preferred Stock. If such parties are unable to reach an agreement within a reasonable period of time, the fair value of such consideration shall be determined by an independent appraiser experienced in valuing such type of consideration jointly selected by the Corporation and the holders of a majority of the outstanding Series B Preferred Stock. The determination of such appraiser shall be final and binding upon the parties, and the fees and expenses of such appraiser shall be borne by the Corporation. (vi) INTEGRATED TRANSACTIONS. In case any Option is issued in 26 connection with the issue or sale of other securities of the Corporation, together comprising one integrated transaction in which no specific consideration is allocated to such Option by the parties thereto, the Option shall be deemed to have been issued for a consideration of $.01. (vii) TREASURY SHARES. For the purpose of this Section 5, the number of shares of Common Stock outstanding at any given time shall not include shares owned or held by or for the account of the Corporation or any subsidiary, and the disposition of any shares so owned or held shall be considered an issue or sale of Common Stock. (viii)RECORD DATE. If the Corporation takes a record of the holders of Common Stock for the purpose of entitling them (A) to receive a dividend or other distribution payable in Common Stock, Options or in Convertible Securities or (B) to subscribe for or purchase Common Stock, Options or Convertible Securities, then such record date shall be deemed to be the date of the issue or sale of the shares of Common Stock deemed to have been issued or sold upon the declaration of such dividend or upon the making of such other distribution or the date of the granting of such right of subscription or purchase, as the case may be. (h) SUBDIVISION OR COMBINATION OF COMMON STOCK. If the Corporation at any time subdivides (by any stock split, stock dividend, recapitalization or otherwise) one or more classes of its outstanding shares of Common Stock into a greater number of shares, the Conversion Price in effect immediately prior to such subdivision shall be proportionately reduced, and if the Corporation at any time combines (by reverse stock split or otherwise) one or more classes of its outstanding shares of Common Stock into a smaller number of shares, the Conversion Price in effect immediately prior to such combination shall be proportionately increased. (i) REORGANIZATION, RECLASSIFICATION, CONSOLIDATION, MERGER OR SALE. Any recapitalization, reorganization, reclassification, consolidation, merger, sale of all or substantially all of the Corporation's assets or other transaction, in each case which is effected in such a manner that the holders of Common Stock are entitled to receive (either directly or upon subsequent liquidation) stock, securities or assets with respect to or in exchange for Common Stock, is referred to herein as an "Organic Change". Prior to the consummation of any Organic Change, the Corporation shall make appropriate provisions (in form and substance satisfactory to the holders of a majority of the Series B Preferred Stock then outstanding) to insure that each of the holders of Series B Preferred Stock shall thereafter have the right to acquire and receive, in lieu of or in addition to (as the case may be) the shares of Common Stock immediately theretofore acquirable and receivable upon the conversion of such holder's Series B Preferred Stock, such shares of stock, securities or assets as such holder would have received in connection with such Organic Change if such holder had converted its 27 Series B Preferred Stock immediately prior to such Organic Change. In each such case, the Corporation shall also make appropriate provisions (in form and substance satisfactory to the holders of a majority of the Series B Preferred Stock then outstanding) to insure that the provisions of this Section 5 and Sections 4, 6 and 7 hereof shall thereafter be applicable to the Series B Preferred Stock (including, in the case of any such consolidation, merger or sale in which the successor entity or purchasing entity is other than the Corporation, an immediate adjustment of the Conversion Price to the value for the Common Stock reflected by the terms of such consolidation, merger or sale, and a corresponding immediate adjustment in the number of shares of Common Stock acquirable and receivable upon conversion of Series B Preferred Stock, if the value so reflected is less than the Conversion Price in effect immediately prior to such consolidation, merger or sale). The Corporation shall not effect any such consolidation, merger or sale, unless prior to the consummation thereof, the successor entity (if other than the Corporation) resulting from consolidation or merger or the entity purchasing such assets assumes by written instrument (in form and substance satisfactory to the holders of a majority of the Series B Preferred Stock then outstanding), the obligation to deliver to each such holder such shares of stock, securities or assets as, in accordance with the foregoing provisions, such holder may be entitled to acquire. (j) CURRENT MARKET PRICE. The "Current Market Price" means as to any security the average of the closing prices of such security's sales on all domestic or foreign securities exchanges on which such security may at the time be listed, or, if there have been no sales on any such exchange on any day, the average of the highest bid and lowest asked prices on all such exchanges at the end of such day, or, if on any such day security is not so listed, the average of the representative bid and asked prices quoted in the NASDAQ National Market or NASDAQ SmallCap Market, as of 4:00 P.M., New York time, on such day, or, if on any day such security is not quoted in the NASDAQ National Market or the NASDAQ SmallCap Market (as applicable), the average of the highest bid and lowest asked prices on such day in the domestic over-the-counter market as reported by the National Quotation Bureau, Incorporated, or any similar successor organization, in each such case averaged over a period of 30 days consisting of the day as of which "Current Market Price" is being determined and the 29 consecutive business days prior to such day; provided that if such security is listed on any domestic securities exchange the term "business days" as used in this sentence means business days on which such exchange is open for trading. If at any time such security is not listed on any domestic securities exchange or quoted in the NASDAQ National Market or the NASDAQ SmallCap Market or the domestic over-the-counter market, the "Current Market Price" shall be the fair value thereof determined jointly by the Corporation and the holders of shares of Series B Preferred Stock representing a majority of the shares of Series B Preferred Stock 28 then outstanding; provided that if such parties are unable to reach agreement within a reasonable period of time, such fair value shall be determined by an appraiser jointly selected by the Corporation and the holders of shares of Series B Preferred Stock representing a majority of the shares of shares of Series B Preferred Stock then outstanding. The determination of such appraiser shall be final and binding on the Corporation and the holders of the shares of Series B Preferred Stock and the fees and expenses of such appraiser shall be paid by the Corporation. (k) STATEMENT REGARDING ADJUSTMENTS. Whenever the Conversion Price shall be adjusted as provided in this Section 5, the Corporation shall forthwith file, at the office of any transfer agent for the Series B Preferred Stock and at the principal office of the Corporation, a statement showing in detail the method of calculation of such adjustment, the facts requiring such adjustment and the Conversion Price that shall be in effect after such adjustment, and the Corporation shall also cause a copy of such statement to be sent by mail, first class postage prepaid, to each holder of shares of Series B Preferred Stock at its address appearing on the Corporation's records. Each such statement shall be signed by the Corporation's chief financial officer. Where appropriate, such copy may be given in advance and may be included as part of a notice required to be mailed under the provisions of Section 5(l). (l) NOTICE TO HOLDERS. In the event the Corporation shall propose to take any action of the type described in this Section 5, the Corporation shall give notice to each holder of shares of Series B Preferred Stock in the manner set forth in Section 5(k), which notice shall specify the record date, if any, with respect to any such action and the approximate date on which such action is to take place. Such notice shall also set forth such facts with respect thereto as shall be reasonably necessary to indicate the effect of such action (to the extent such effect may be known at the date of such notice) on the Conversion Price and the number, kind or class of shares or other securities or property which shall be deliverable upon conversion of shares of Series B Preferred Stock. In the case of any action which would require the fixing of a record date, such notice shall be given at least ten calendar days prior to the date so fixed, and in the case of all other action, such notice shall be given at least 15 calendar days prior to the taking of such proposed action. Failure to give such notice, or any defect therein, shall not affect the legality or validity of any such action. (m) COSTS. The Corporation shall pay all documentary, stamp, transfer or other transactional taxes attributable to the issuance or delivery of shares of Common Stock upon conversion of any shares of Series B Preferred Stock; provided that the Corporation shall not be required to pay any taxes which may be payable in respect of any transfer involved in the issuance or delivery of any certificate for such shares in a name other than that of the holder of the shares of Series B Preferred Stock in respect of which such shares are being issued. (n) DIVIDENDS UPON CONVERSION. In connection with any conversion of shares of Series B Preferred Stock, the Corporation shall pay accrued and unpaid dividends thereon in accordance with the provisions of Section 7(d). 29 (o) CERTAIN EVENTS. If any event occurs of the type contemplated by the provisions of Section 5(f)(i) but not expressly provided for by such provisions, then the Conversion Price shall be adjusted by the Corporation's Board of Directors in good faith so as to protect the rights of the holders of Series B Preferred Stock; provided that no such adjustment shall increase the Conversion Price as otherwise determined pursuant to this Section 5 or decrease the number of shares of Common Stock issuable upon conversion of each share of Series B Preferred Stock. 6. PURCHASE RIGHTS. If at any time the Corporation grants, issues or sells any Options, Convertible Securities or rights to purchase stock, warrants, securities or other property pro rata to the record holders of any class of Common Stock (the "Purchase Rights"), then each holder of Series B Preferred Stock shall be entitled to acquire, upon the terms applicable to such Purchase Rights, the aggregate Purchase Rights which such holder could have acquired if such holder had held the number of shares of Common Stock acquirable upon conversion of such holder's Series B Preferred Stock immediately before the date on which a record is taken for the grant, issuance or sale of such Purchase Rights, or if no such record is taken, the date as of which the record holders of Common Stock are to be determined for the grant, issue or sale of such Purchase Rights. 7. DIVIDENDS. (a) GENERAL. (i) The Series B Preferred Stock shall rank on parity with the Series A Preferred Stock with respect to dividends. During the period commencing on the date on which the first share of Series B Preferred Stock is issued and terminating on the fifth anniversary of such date, the holders of the Series B Preferred Stock shall be entitled to receive, when and as declared by the Board of Directors out of funds legally available therefor, cumulative dividends per share of Series B Preferred Stock at the rate per annum equal to the greater of (A), if any shares of Series A Preferred Stock are then outstanding, the per annum rate of dividends per share of Series A Preferred Stock then payable thereon, (B) $6.00 (as shall be equitably adjusted to reflect any stock dividend, stock distribution, stock split or reverse stock split, combination of shares, subdivision of shares or reclassification of shares with respect to the Series A Preferred Stock or Series B Preferred Stock, as the case may be) and (C) the per annum rate of dividends per share paid by the Corporation on the Common Stock. (ii) Dividends on the Series B Preferred Stock will accrue on each March 31, June 30, September 30 and December 31, occurring after the date of original issuance (each such date being referred to herein as an "Accrual Date" and 30 the three-month period or portion thereof, as the case may be, ending on an Accrual Date being referred to herein as an "Accrual Period"), whether or not such dividends have been declared, and whether or not there are funds of the Corporation legally available for the payment of dividends, and will cease accruing on September 30, 2001. Dividends will be paid (when and as declared by the Board of Directors of the Corporation) quarterly, in arrears, on each February 15, May 15, August 15 and November 15, occurring in 1997, 1998, 1999, 2000 and 2001. Each such dividend shall be paid to the holders of record of shares of the Series B Preferred Stock as they appear on the stock register of the Corporation on such record date not exceeding 45 nor less than ten calendar days preceding the payment date thereof, as shall be fixed by the Board of Directors of the Corporation. Dividends on account of arrears for any past dividend periods may be declared and paid at any time, without reference to any regular dividend payment date, to holders of record on such date, not exceeding 45 nor less than ten calendar days preceding the payment date thereof, as may be fixed by the Board of Directors of the Corporation. Holders of shares of Series B Preferred Stock at the close of business on a dividend payment record date will be entitled to receive the dividend payable with respect to such shares on the corresponding dividend payment date notwithstanding the conversion thereof or the Corporation's default on payment of the dividend due on such dividend payment date. For shares of Series B Preferred Stock surrendered for conversion during the period from the close of business on any dividend payment record date to the opening of business on the corresponding dividend payment date, the Corporation shall pay the dividend to the holder of such shares on the dividend payment record date. Except as so provided above and in Section 7(d) below, no payment or adjustment will be made on account of accrued or unpaid dividends upon conversion of shares of Series B Preferred Stock. (iii) The Corporation shall pay the dividends on the Series B Preferred Stock described in Section 7(a)(i), at the Corporation's option and in its sole discretion, out of funds legally available therefor (A) in cash, (B) in shares of Series B Preferred Stock having an aggregate Liquidation Value (as shall be equitably adjusted to reflect any stock dividend, stock distribution, stock split or reverse stock split, combination of shares, subdivision of shares or reclassification of shares with respect to the Series B Preferred Stock) at the time of such payment equal to the amount of the dividend to be paid, or (C) in any combination of cash and shares of Series B Preferred Stock that the Corporation may determine in its sole discretion, with the number of shares of Series B Preferred Stock to be distributed in connection therewith to be calculated on the basis set forth in Section 7(a)(iii)(B). (iv) No fractional shares of Series B Preferred Stock or scrip shall be issued upon payment of any dividends in shares of Series B Preferred Stock. If more than one share of Series B Preferred Stock shall be held by the same holder at the time of any dividend payment date, the number of full shares of Series B Preferred Stock issuable upon payment of such dividends shall be computed on the basis of the aggregate dividend amount that the Corporation has determined to pay in Series B 31 Preferred Stock shares. Instead of any fractional shares of Series B Preferred Stock which would otherwise be issuable upon payment of such dividends, the Corporation shall pay out of funds legally available therefor a cash adjustment in respect of such fractional interest, rounded to the nearest one hundredth (1/100th) of a share, in an amount equal to that fractional interest of the Liquidation Value (as shall be equitably adjusted to reflect any stock dividend, stock distribution, stock split or reverse stock split, combination of shares, subdivision of shares or reclassification of shares with respect to the Series B Preferred Stock), rounded to the nearest cent ($.01). (b) ALLOCATION OF DIVIDENDS. Dividends on the Series B Preferred Stock, if paid, or if declared and set apart for payment, must be paid or declared and set apart for payment on all outstanding shares of Series B Preferred Stock contemporaneously. In the event dividends on the Series B Preferred Stock and any other series of Preferred Stock ranking on a parity therewith in respect thereto or any other class or series of capital stock of the Corporation ranking on a parity therewith in respect thereto are declared and paid in an amount less than all accumulated and current dividends on all of such shares, the total amount declared and paid shall be allocated among all of such shares so that the per share dividend to be declared and paid on each share is the same percentage of the sum of the accumulated dividends for each such share. In the event dividends are declared and paid on the Series B Preferred Stock in a combination of cash and shares of Series B Preferred Stock, the percentage of the dividend paid in cash and the percentage of the dividend paid in stock must be the same for each share of Series B Preferred Stock. (c) DIVIDENDS ON CONVERSION. (i) Immediately prior to the conversion of any shares of Series B Preferred Stock into Common Stock, all accrued and unpaid dividends payable pursuant to Section 7 (whether or not declared) on such shares so converted (prorated until the date of conversion in respect of the Accrual Period in which such date occurs) shall be payable, at the Corporation's option and in its sole discretion, out of funds legally available therefor (A) in cash, (B) in shares of Series B Preferred Stock, such that the number of shares of Series B Preferred Stock to be distributed with respect to the portion of the dividend attributable to each Accrual Period shall have an aggregate Liquidation Value (as shall be equitably adjusted to reflect any stock dividend, stock distribution, stock split or reverse stock split, combination of shares, subdivision of shares or reclassification of shares with respect to the Series B Preferred Stock) at the time of such payment equal to the amount of the dividend to be paid, or (C) in any combination of cash and shares of Series B Preferred Stock that the Corporation may determine in its sole discretion, with the number of shares of Common Stock to be distributed in connection therewith to be calculated on the basis set forth in Section 7(c)(i)(B). (ii) No fractional shares of Series B Preferred Stock or scrip shall 32 be issued upon payment of any dividends in shares of Series B Preferred Stock upon conversion of any shares of Series B Preferred Stock. If more than one share of Series B Preferred Stock shall be surrendered for conversion at any one time by the same holder, or shall be held by the same holder at the time of any automatic conversion, the number of full shares of Series B Preferred Stock issuable upon payment of such dividends shall be computed on the basis of the aggregate dividend amount that the Corporation has determined to pay in Series B Preferred Stock shares. Instead of any fractional shares of Series B Preferred Stock which would otherwise be issuable upon payment of such dividends, the Corporation shall pay out of funds legally available therefor a cash adjustment in respect of such fractional interest, rounded to the nearest one hundredth (1/100th) of a share, in an amount equal to that fractional interest of the Liquidation Value (as shall be equitably adjusted to reflect any stock dividend, stock distribution, stock split or reverse stock split, combination of shares, subdivision of shares or reclassification of shares with respect to the Series B Preferred Stock), rounded to the nearest cent ($.01). 8. REACQUIRED SHARES. Any shares of Series B Preferred Stock redeemed, purchased, converted or otherwise acquired by the Corporation in any manner whatsoever shall not be reissued as part of such series and shall be retired promptly after the acquisition thereof. All such shares shall upon their retirement and the filing of any certificate required in connection therewith pursuant to the Delaware General Corporation Law become authorized but unissued shares of Preferred Stock. SECOND: That said determination of the powers, designation, preferences and the relative, participating, optional or other rights, and the qualifications, limitations or restrictions thereof, relating to said series of Preferred Stock, was duly made by the Board of Directors of the Corporation pursuant to the provisions of the Restated Certificate of Incorporation of the Corporation, as amended, and in accordance with the provisions of Section 151 of the General Corporation Law of the State of Delaware. 33 IN WITNESS WHEREOF, said Corporation has caused this Certificate to be signed by Paul M. Frison, its President, on this 13th day of November, 1996. LIFECELL CORPORATION By Paul M. Frison, President 34 EXHIBIT C VOTING AGREEMENT THIS VOTING AGREEMENT (this "AGREEMENT") is made as of November 18, 1996 among LifeCell Corporation, a Delaware corporation (the "COMPANY"), the Investors (as defined below) and Allstate Insurance Company ("ALLSTATE," and together with the Investors, the "STOCKHOLDERS"). Vector Later-Stage Equity Fund, L.P., CIBC Wood Gundy Ventures, Inc., and the other Persons identified as "Investors" on ANNEX A attached hereto other than Allstate (collectively, the "INVESTORS") and the Company are entering into a Securities Purchase Agreement simultaneously with the execution of this Agreement (the "PURCHASE AGREEMENT"), pursuant to which the Investors are purchasing shares of the Company's Series B Preferred Stock, par value $.001 per share ("SERIES B PREFERRED"), and warrants to purchase shares of the Company's common stock, par value $.001 per share (each, a "WARRANT"). Immediately after the consummation of the transactions contemplated in the Purchase Agreement, Allstate owns approximately 21% of the voting stock of the Company. Under the Certificate of Designation (as defined in the Purchase Agreement), the Investors have the right to designate three representatives (the "INVESTOR REPRESENTATIVES") to the Company's board of directors (the "BOARD"), and, in connection with the issuance and sale of the Securities to the Investors, the Company and the Stockholders have agreed as to the composition of the entirety of the Board. The Investors desire to enter into this Agreement for the purpose of determining the Investor Directors and the Additional Outside Directors (as defined below), the Company desires to enter into this Agreement for the purpose of determining the Company Directors (as defined below), the Initial Outside Director (as defined below) and the Additional Outside Directors, Allstate desires to enter into this Agreement for the purpose of determining the composition of the Board upon consummation of the issuance of the Series B Preferred Stock to the Investors, and execution and delivery of this Agreement is a condition to consummation of the transaction contemplated in the Purchase Agreement. The Company and the Stockholders hereby agree as follows: CERTAIN DEFINITIONS. Capitalized terms used but not defined herein shall have the meanings assigned such terms in the Purchase Agreement. "STOCKHOLDER SHARES" means, as of any particular time, (i) any Common 35 Stock purchased or otherwise acquired by any Stockholder, (ii) any Common Stock issued or issuable directly or indirectly upon conversion of Preferred Stock or upon exercise of Warrants, in each case, owned by a Stockholder, (iii) any capital stock or other equity securities issued or issuable directly or indirectly with respect to Common Stock referred to in clause (i) or clause (ii) above by way of stock dividend or stock split or in connection with a combination of shares, recapitalization, merger, consolidation or other reorganization. For purposes of this Agreement, any Person who holds Preferred Stock or Warrants shall be deemed to be a Stockholder and the holder of Stockholder Shares issued or issuable upon conversion of such Preferred Stock or exercise of such Warrants (as the case may be) in connection with the transfer thereof or otherwise and regardless of any restriction or limitation on the conversion or exercise thereof. BOARD OF DIRECTORS. 1. From and after the date of this Agreement, each holder of Stockholder Shares shall vote all of its Stockholder Shares and shall take all other necessary or desirable actions within its control (whether in its capacity as a stockholder or as an officer or director of the Company or otherwise, and including, without limitation, attendance at meetings in person or by proxy for the purposes of obtaining a quorum and execution of written consents in lieu of meetings), and the Company shall take all necessary and desirable actions within its control (including, without limitation, calling special Board and stockholder meetings), so that: (a) the maximum authorized number of directors on the Board shall be established initially at nine directors and shall be reduced in accordance with clauses (viii) and (ix) of this Section 2; (b) the following individuals shall be elected to the Board: (i) three representatives (the "INVESTOR DIRECTORS") designated by holders of a majority of the Underlying Common Stock (the "MAJORITY INVESTORS"), which Investor Directors shall include one representative designated by Vector (the "VECTOR REPRESENTATIVE"), which Vector Representative shall initially be K. Flynn McDonald, one representative designated by CIBC-WG (the "CIBC-WG REPRESENTATIVE"), which CIBC-WG Representative shall initially be Lori G. Koffman, and one representative (the "MAJORITY INVESTORS REPRESENTATIVE") selected by the Majority Investors; (ii) the Chief Executive Officer (who shall initially be Paul M. Frison) and Stephen A. Livesey (each, a "COMPANY DIRECTOR") and Michael Cahr (the "INITIAL OUTSIDE DIRECTOR"); 36 (iii) two representatives jointly designated by the Investor Directors, and the Company Directors (which designations shall take into account recommendations of a top tier executive search firm jointly selected by the Investor Directors and the Company Directors) (the "ADDITIONAL OUTSIDE DIRECTORS"), which Additional Outside Directors are neither members of the Company's management nor an employee or an officer of the Company; and (iv) one representative (the "MEDTRONIC DIRECTOR") designated by Medtronic, Inc., a Minnesota corporation ("MEDTRONIC"); (c) the removal from the Board (with or without cause) of any Vector Representative, any CIBC-WG Representative or any Majority Investors Representative shall be at the written request of Vector, CIBC-WG or the Majority Investors, respectively, but only upon such written request and under no other circumstances; (d) the removal from the Board (with or without cause) of any Company Director or the Initial Outside Director shall be at the written request of the majority of the other directors then in office, but only upon such written request and under no other circumstances; (e) the removal from the Board (with or without cause) of the Medtronic Director shall be only in accordance with and as contemplated by Section 6.3 of the Investment Agreement dated May 3, 1994 between the Company and Medtronic (the "MEDTRONIC INVESTMENT AGREEMENT"); provided that the Company shall not agree to any amendment to such Section 6.3 without the prior consent of the Majority Investors; (f) in the event that any Investor Director or any Additional Outside Director designated hereunder for any reason ceases to serve as a member of the Board during his or her term of office, the resulting vacancy on the Board shall be filled in the manner set forth above in clause (ii) of this Section 2 by a representative designated by the same group that designated the member that will no longer serve on the Board; provided that if such group fails to designate a representative to fill such vacancy, the election of an individual to fill such vacancy shall be accomplished in accordance with the Company's bylaws and applicable law; provided, further, that the Stockholders shall thereafter vote to remove such individual if the group which failed to designate a representative to fill such vacancy pursuant to this Section 2 so directs; (g) in the event that the Initial Outside Director for any reason ceases to serve as a member of the Board during his term of office, the resulting vacancy shall be filled by the vote of a majority of the other directors then in office; 37 (h) in the event that any Company Director (other than the Chief Executive Officer) for any reason ceases to serve as a member of the Board during his term of office, the resulting vacancy shall not be filled and the number of authorized directors on the Board shall be reduced by the number of such directors who have ceased to serve on the Board; and (i) at such time when Medtronic no longer has the right to appoint a director pursuant to Section 6.3 of the Medtronic Investors Agreement, the number of authorized directors on the Board shall be reduced by one and the resulting directorship shall not be filled. 2. The Company shall pay all out-of-pocket travel and other expenses incurred by each director in connection with attending the meetings of the Board or any committee thereof. So long as any Investor Director serves on the Board and for 3 years thereafter, the Company shall maintain directors and officers indemnity insurance coverage satisfactory to the Majority Investors, and the Company's certificate of incorporation and bylaws shall provide for indemnification and exculpation of directors to the fullest extent permitted under applicable law. REPRESENTATIONS AND WARRANTIES. Each Stockholder represents and warrants that (i) such Stockholder is the record owner of the number and type of shares of the Company's capital stock indicated opposite its name on ANNEX A hereto, (ii) this Agreement has been duly authorized, executed and delivered by such Stockholder and constitutes the valid and binding obligation of such Stockholder, enforceable in accordance with its terms, and (iii) such Stockholder has not granted and is not a party to any proxy, voting trust or other agreement which is inconsistent with, conflicts with or violates any provision of this Agreement. STOCKHOLDER COVENANT. No holder of Stockholder Shares shall grant any proxy or become party to any voting trust or other agreement which is inconsistent with, conflicts with or violates any provision of this Agreement. TERMINATION. This Agreement shall terminate at the later of (i) such time when all of the shares of Series B Preferred have been converted and (ii) such time when the Company no longer has any obligation to deliver financial and other information to certain Investors pursuant to Section 6.8 of the Purchase Agreement; provided that, notwithstanding the foregoing, Allstate's obligations under this Agreement shall terminate on the second anniversary of this Agreement. COUNTERPARTS. This Agreement may be executed in multiple counterparts, each of which shall be an original and all of which taken together shall constitute one and the same agreement. REMEDIES. Each Stockholder shall be entitled to enforce its rights under 38 this Agreement specifically, to recover damages by reason of any breach of any provision of this Agreement and to exercise all other rights existing in their favor. Each Stockholder hereby acknowledges that money damages would not be an adequate remedy for any breach of the provisions of this Agreement and that each Stockholder may in its sole discretion apply to any court of law or equity of competent jurisdiction for specific performance and/or injunctive relief (without posting a bond or other security) in order to enforce or prevent any violation of the provisions of this Agreement. NOTICES. Any notice provided for in this Agreement shall be in writing and shall be either personally delivered, or mailed first class mail (postage prepaid) or sent by reputable overnight courier service (charges prepaid) to the Stockholder at the address indicated on the schedules hereto or at such address or to the attention of such other person (including any subsequent holder of Stockholder Shares) as the recipient party has specified by prior written notice to the sending party. Notices shall be deemed to have been given hereunder when delivered personally, three days after deposit in the U.S. mail and one day after deposit with a reputable overnight courier service. AMENDMENT AND WAIVER. This Agreement may be amended, modified and supplemented, and compliance with any term, covenant, agreement or condition contained herein may be waived either generally or in particular instances, and either retroactively or prospectively, only by a written instrument executed by (a) the Company and (b) the Majority Investors. No course of dealing between or among any persons having any interest in this Agreement will be deemed effective to modify, amend or discharge any part of this Agreement or any rights or obligations of any person under or by reason of this Agreement. GOVERNING LAW. THE CORPORATE LAW OF THE STATE OF DELAWARE SHALL GOVERN ALL ISSUES AND QUESTIONS CONCERNING THE RIGHTS OF THE COMPANY AND THE RIGHTS OF THE STOCKHOLDERS RELATIVE TO THE COMPANY. ALL OTHER ISSUES AND QUESTIONS CONCERNING THE CONSTRUCTION, VALIDITY, INTERPRETATION AND ENFORCEABILITY OF THIS AGREEMENT AND THE EXHIBITS AND SCHEDULES HERETO SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK, WITHOUT GIVING EFFECT TO ANY CHOICE OF LAW OR CONFLICT OF LAW RULES OR PROVISIONS (WHETHER OF THE STATE OF NEW YORK OR ANY OTHER JURISDICTION) THAT WOULD CAUSE THE APPLICATION OF THE LAWS OF ANY JURISDICTION OTHER THAN THE STATE OF NEW YORK. DESCRIPTIVE HEADINGS. The descriptive headings of this Agreement are inserted for convenience only and do not constitute a part of this Agreement. * * * * 39 IN WITNESS WHEREOF, the Company and the Stockholders have executed this Agreement on the day and year first above written. LIFECELL CORPORATION By Paul M. Frison President and Chief Executive Officer VECTOR LATER-STAGE EQUITY FUND, L.P. By Vector Fund Management, L.P., its General Partner By Name: Title: CIBC WOOD GUNDY VENTURES, INC. By Name: Title: 40 ALLSTATE INSURANCE COMPANY By By Its Authorized Signatories 41 STOCKHOLDERS -- ANNEX A Name and Address Stockholder - ---------------- ----------- CIBC Wood Gundy Ventures, Inc. 44,800 shares of Series B Preferred 425 Lexington Avenue New York, NY 10017 The Woodlands Venture Capital Company 2,500 shares of Series B Preferred 2201 Timberloch Place 482,068 shares of Common Stock The Woodlands, TX 77380 15,000 shares of Series A Preferred P. William Curreri, M.D. 400 shares of Series B Preferred 217 Berwyn Drive, W. #222 8,238 shares of Common Stock Mobile, AL 36608 1,250 shares of Series A Preferred Christopher C. Kraft, Jr. 250 shares of Series B Preferred Smith Barney Inc. KEO P/S Custodian 1,738 shares of Common Stock Acct: 721-66059-10-022 1,250 shares of Series A Preferred 14919 Village Elm Street Houston, TX 77062 Michael H. Richmond 400 shares of Series B Preferred 20 E. Wedgewood Glen The Woodlands, TX 77381 Stephen Livesey 250 shares of Series B Preferred 3606 Research Forest Drive 100,529 shares of Common Stock The Woodlands, TX 77381 Michael E. Cahr 500 shares of Series B Preferred 1051 Saxony Drive Highland Park, IL 60035 Technology Funding Medical Partners I, L.P. 2,500 shares of Series B Preferred 2000 Alameda de las Pulgas San Mateo, CA 94403 Vector Later-Stage Equity Fund, L.P. 40,000 shares of Series B Preferred 1751 Lake Cook road, Suite 350 Deerfield, IL 60015 42 William J. McCluskey 186 shares of Series B Preferred 25 Wisconsin Street Long Beach, NY 11561 David Saks 500 shares of Series B Preferred 2 Knollcliff Road Woodcliff Lake, NJ 07675 Joseph Battipaglia 150 shares of Series B Preferred 77 Water Street (10th Floor) New York, NY 10005 S.B.S.F. Biotechnology Partners, L.P. 1,000 shares of Series B Preferred c/o Lisa Tuckerman Spears Benzak Salomon & Farrell 45 Rockefeller Plaza -- 33rd Floor New York, NY 10111 S.B.S.F. Biotechnology Fund, L.P. 9,000 shares of Series B Preferred c/o Lisa Tuckerman Spears Benzak Salomon & Farrell 45 Rockefeller Plaza -- 33rd Floor New York, NY 10111 Jerome Schachter 500 shares of Series B Preferred 2926 Leanne Court Northbrook, IL 60062 Paul B. Ankin and Lois F. Ankin, JTWROS 250 shares of Series B Preferred 4233 W. Grove Skokie, IL 60076 David and Mary Jane Harris, JTWROS 200 shares of Series B Preferred 174 Pacific Street, Apt. 2A Brooklyn, NY 11021 43 Richard L. Serrano 50 shares of Series B Preferred 64 Brighton Avenue Bloomfield, NJ 07003 Charles and Donna Greenberg, JTWROS 1,500 shares of Series B Preferred 503 Pinehurst Court Roslyn, NY 11576 Michael Gironta 1,000 shares of Series B Preferred 89 Ridgewood Avenue Glen Ridge NJ 07028 Joseph A. Russo 155 shares of Series B Preferred 3 Midwood Avenue Verona, NJ 07044 John D. Goldberg 310 shares of Series B Preferred 2500 East Hallandale Beach Blvd. Suite 500 Hallandale, FL 33009-4838 Robert Sablowsky 465 shares of Series B Preferred 150 East 69th Street, 16A New York, NY 10021 William J. Strazzullo 80 shares of Series B Preferred 750 Columbus Avenue, 4C New York, NY 10025 Stephen G. Weiss 330 shares of Series B Preferred 115 Ravin Oaks Lane Highland Park, IL 60035 Barry Richter 250 shares of Series B Preferred Tideway Sandspoint, NY 11050 44 Chinook Equities, Inc. 500 shares of Series B Preferred 147 East 48th Street New York, NY 10017 Daniel and Elaine Kleinberg, JTWROS 267 shares of Series B Preferred 3 Centennial Road Livingston, NJ 07039 Douglas Kleinberg 248 shares of Series B Preferred 200 East 95th Street, Apt. 126 New York, NY 10128 Evan Kleinberg IRA, 155 shares of Series B Preferred Gruntal & Co., Inc., Custodian Dated July 19, 1996 3 Centennial Road Livingston, NJ 07039 45 John Latshaw 930 shares of Series B Preferred 5049 Wornall #2 C Kansas City, MO 64112 B. Michael Pisani 775 shares of Series B Preferred 44 Lake Road Short Hills, NJ 07078 John Cirrito 250 shares of Series B Preferred 29 Rambling Drive Scotch Plains, NJ 07076 James C. Gale, Trustee 620 shares of Series B Preferred F/B/O Ariana J. Gale The James C. Gale Trust, dated November 21, 1986 315 West 106th Street, Apt. 4A New York, NY 10025 James C. Gale and Judith S. Haselton JTWROS 1,550 shares of Series B Preferred 315 West 106th Street, Apt. 4A New York, NY 10025 John S. Bai 217 shares of Series B Preferred 30 West 61st, 27A New York, NY 10023 Ronald Koenig 310 shares of Series B Preferred 114 No. Village Way Jupiter, FL 33458 Robert M. Adams 1,550 shares of Series B Preferred P.O. Box 998 Plandome, NY 11030 Edward A. Kerbs 310 shares of Series B Preferred 8 South Cherry Lane Rumson, NJ 07760 46 Bernard B. Salzman IRA, 55 shares of Series B Preferred Gruntal & Co., Inc., Custodian Dated May 14, 1982 Acct: 215-67321-1-3-231 20 S. Charles Street Baltimore, MD 21201 Don A. Sanders 620 shares of Series B Preferred 3100 Texas Commerce Tower Houston, TX 77002 Jeffrey Keeler 87 shares of Series B Preferred 577 W. 50th Street Miami Beach, FL 33140 Harbour Court L.P., II 250 shares of Series B Preferred 253 W. 73rd St., Apt. 6D New York, NY 10023 Attention: Jonathan Greenwald Namax Corp. 2,000 shares of Series B Preferred 666 Dundee Road, Suite 1801 Northbrook, IL 60062 Attention: Mark Rice, President Sheldon Drobny 500 shares of Series B Preferred 95 Revere Drive, Suite A Northbrook, IL 60062 Perry H. Bacon 620 shares of Series B Preferred 5300 Mission Woods Road Shawnee Mission, KS 66205 James J. Pelts 500 shares of Series B Preferred 29 East Madison Street, Suite 1505 Chicago, IL 60602 Robert Weinstein 217 shares of Series B Preferred 155 West 68th Street 24C New York, NY 10023 47 The Marcus L. Koblitz Trust, 25 shares of Series B Preferred Michael J. Koblitz, Trustee Est. April 14, 1992 12 Downey Drive Tenafly, NJ 07670 The Lauren J. Koblitz Trust, 25 shares of Series B Preferred Michael J. Koblitz, Trustee Est. April 14, 1992 12 Downey Drive Tenafly, NJ 07670 Pharmaceutical & Medical Technology Fund 3,000 shares of Series B Preferred 300 Park Avenue New York, NY 10022 Strategic Healthcare Fund 1,000 shares of Series B Preferred 300 Park Avenue New York, NY 10022 Michael J. Koblitz 50 shares of Series B Preferred 12 Downey Drive Tenafly, NJ 07670 Allstate Insurance Company Investment Department Allstate Plaza South 650 761,397 shares of Common Stock Northbrook, IL 60062 200,000 shares of Series A Prefer 48 EXHIBIT D REGISTRATION RIGHTS AGREEMENT REGISTRATION RIGHTS AGREEMENT (this "AGREEMENT"), dated as of November 18, 1996, by and among each of the persons named on SCHEDULE 1 annexed hereto (each, an "INVESTOR" and collectively, the "INVESTORS"), Gruntal & Co., Incorporated ("GRUNTAL), and LifeCell Corporation, a Delaware corporation (the "COMPANY"). W I T N E S S E T H: WHEREAS, the Investors and the Company have entered into that certain Securities Purchase Agreement, dated as of the date hereof (the "PURCHASE AGREEMENT"), whereby the Investors have purchased (a) an aggregate of 124,157 shares of the Series B Preferred Stock, par value $.001 per share (the "SERIES B PREFERRED STOCK"), of the Company and (b) warrants (the "WARRANTS"; together with the Series B Preferred Stock, the "SECURITIES") to purchase an aggregate of 2,803,530 shares (the "WARRANT SHARES") of common stock, par value $.001 per share ("COMMON STOCK"), of the Company. WHEREAS, the Company has on the date hereof granted to Gruntal, the Company's placement agent in connection with the transactions evidenced by the Purchase Agreement, a warrant (the "GRUNTAL WARRANT") to purchase 354,734 shares (the "GRUNTAL WARRANT SHARES") of Common Stock in connection with such transactions. WHEREAS, the Company desires to grant registration rights to (a) the Investors with respect to the Warrant Shares and the shares of Common Stock into which the Series B Preferred Stock is convertible and (b) Gruntal with respect to the Gruntal Warrant Shares. NOW, THEREFORE, in consideration of the premises and mutual covenants and conditions contained herein and of other good and valuable consideration, the receipt and adequacy of which is hereby acknowledged, Company and the Investors agree as follows: ARTICLE 12. DEFINITIONS All terms not defined herein or below shall have the meanings ascribed thereto in the Purchase Agreement. "EXCHANGE ACT" means the Securities Exchange Act of 1934, as amended, or any similar federal statute, and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. "HOLDER" means an Investor or Gruntal, in either case, in its capacity as a holder of Registrable Securities. "NASD" shall mean the National Association of Securities Dealers, Inc. "REGISTRABLE SECURITIES" means (i) the Warrant Shares, (ii) the shares of Common Stock issued upon the conversion of shares of the Series B Preferred Stock issued pursuant to the Purchase Agreement, (iii) the Gruntal Warrant Shares, (iv) any shares of Common Stock issuable to the Investors pursuant to the right of first refusal set forth in Section 5 of the Purchase Agreement, and (v) any additional shares of Common Stock acquired by the Holder by way of a dividend, stock split or other distribution in respect of the Series B Preferred Stock. As to any particular Registrable Securities, once issued, such securities shall cease to be Registrable Securities at such time when (x) a registration statement with respect to the sale of such securities has been declared effective by the Commission and such securities have been disposed of pursuant to such effective registration statement, (y) such securities have been distributed to the public pursuant to the provisions of Rule 144, or (z) such securities have ceased to be outstanding. For purposes of this Agreement, a Person shall be deemed to be a Holder of Registrable Securities, and the Registrable Securities shall be deemed to be in existence, and such Person shall be entitled to exercise the rights of a Holder of such Registrable Securities hereunder, whenever such Person has the right to acquire, directly or indirectly, such Registrable Securities (upon conversion or exercise in connection with a transfer of securities or otherwise, but disregarding any restrictions or limitations upon the exercise of such right), whether or not such acquisition has actually been effected. "SECURITIES ACT" means the Securities Act of 1933, as amended, or any similar federal statute, and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. "SELLING HOLDER" means an Investor or Gruntal, in either case, in its capacity as a seller of Registrable Securities pursuant to a registration statement under the Securities Act. "UNDERWRITER" means a securities dealer who purchases any Registrable Securities as principal in an underwritten offering and not as part of such dealer's market-making activities. ARTICLE 13. 2 REGISTRATION RIGHTS SECTION 13.1 SHELF REGISTRATION. (a) GENERAL. The Company covenants and agrees with the Investors and Gruntal that the Company will (i) prepare and file with the Commission no later than the 75th day following the Closing Date a registration statement under the Securities Act with respect to the public offering of the Registrable Securities referred to in clauses (i), (ii) and (iii) of the definition of Registrable Securities contained in Article I hereof (a "SHELF REGISTRATION"), (ii) use its best efforts (as used herein the term "best efforts" shall have the meaning commonly accorded such term as used in registration rights agreements similar to this Agreement) to have any such registration statement declared effective as soon as practicable and in any event no later than the 180th day following the Closing Date and (iii) prepare and file such post-effective amendment or amendments to such registration statement with respect to Registrable Securities referred to in clauses (iv) and (v) of the definition of Registrable Securities contained in Article I hereof. The Company hereby agrees to timely file all reports required under the Exchange Act for so long as the Company is obligated to maintain the effectiveness of the registration statement. Once the registration statement described in this subsection (a) has been declared effective, the Company shall maintain the registration statement in effect until (x) all Registrable Securities have been sold pursuant thereto or (y) no securities are outstanding that constitute Registrable Securities. (b) EFFECTIVE REGISTRATION. The Shelf Registration shall not be deemed to have been effected unless it has been declared effective by the Commission; PROVIDED, that if, after the registration statement has become effective, the offering of shares of Common Stock pursuant to such Shelf Registration is or becomes the subject of any stop order, injunction or other order or requirement of the Commission or any other governmental or administrative agency, or if any court prevents or otherwise limits the sale of the shares of Common Stock pursuant to the Shelf Registration at any time within 180 days after the effective date of the registration statement, the Shelf Registration shall not be deemed to have been effected. If the Shelf Registration (i) is deemed not to have been effected or (ii) does not remain effective for a period of at least 180 days beyond the effective date thereof or, with respect to an underwritten offering of Registrable Securities, until 45 days after the commencement of the distribution by the Holders of the Registrable Securities included in such registration statement, then the Company shall continue to be obligated to effect such Shelf Registration pursuant to this Section 2.1. (c) OTHER HOLDERS. No securities other than Registrable Securities shall be included in the Shelf Registration. (d) SELECTION OF UNDERWRITER. If the Selling Holders so elect at any time, the offering of such Registrable Securities pursuant to such Shelf Registration shall be 3 in the form of an underwritten offering and, if necessary, the Company shall amend the Shelf Registration to reflect such method of offering. The Selling Holder holding the largest number of Registrable Securities to be sold in such underwritten offering shall select one nationally recognized investment banker to act as the lead managing Underwriter in connection with such offering; and the Selling Holder holding the second largest number of Registrable Securities to be sold in such underwritten offering may at its option select one nationally recognized investment banker to act as the co-managing Underwriter in connection with such offering. SECTION 13.2 PIGGY-BACK REGISTRATION. (a) GENERAL. If at any time the Company proposes to file a registration statement under the Securities Act with respect to an offering by the Company for its own account or for the account of any of its respective security holders (other than a registration statement on Form S-4 or S-8, or any substitute forms thereof that may be adopted by the Commission), a registration pursuant to Section 2.1 or any demand registration provided for pursuant to that certain Underwriters Warrant Agreement dated March 6, 1992, pursuant to which certain registration rights were granted to Robert Todd Financial Corporation), then the Company shall give prompt written notice of such proposed filing to the Holders of Registrable Securities as soon as practicable (but in no event less than twenty (20) days before the anticipated filing date), and such notice shall offer such Holders the opportunity to register such number of Registrable Securities as each such Holder may request (which request shall specify the Registrable Securities intended to be disposed of by such Holder) (a "PIGGY-BACK REGISTRATION"). The Company shall use its best efforts to cause the managing Underwriter or Underwriters of a proposed underwritten offering to permit the Registrable Securities requested to be included in a Piggy-Back Registration to be included on the same terms and conditions as any similar securities of the Company or any other security holder included therein and to permit the sale or other disposition of such Registrable Securities in accordance with the intended method of distribution thereof. Any Holder shall have the right to withdraw its request for inclusion of its Registrable Securities in any registration statement pursuant to this Section 2.2 by giving written notice to the Company of its request to withdraw. The Company may withdraw a Piggy-Back Registration at any time prior to the time it becomes effective. No registration effected under this Section 2.2, and no failure to effect a registration under this Section 2.2, shall relieve the Company of its obligation to effect a Shelf Registration pursuant to Section 2.1, and no failure to effect a registration under this Section 2.2 and to complete the sale of Registrable Securities in connection therewith shall relieve the Company of any other obligation under this Agreement (including, without limitation, the Company's obligations under Sections 3.2 and 4.1). (b) REDUCTION. Notwithstanding anything to the contrary contained herein, if the managing Underwriter or Underwriters of any underwritten offering described in this Section 2.2 have informed, in writing, the Holders of the Registrable 4 Securities requesting inclusion in such offering that it is their opinion that the total number of shares which the Company, Holders of Registrable Securities and any other holders of securities of the Company desiring to participate in such registration intend to include in such offering is such as to materially and adversely affect the success of such offering, then the number of shares to be offered shall be reduced or limited in the following order of priority: FIRST, the number of shares to be offered by all other holders of securities of the Company (other than the Holders of Registrable Securities and other holders of securities of the Company who have registration rights, as set forth on SCHEDULE 2.2(b) annexed hereto (collectively, the "OTHER HOLDERS")) to the extent necessary to reduce the total number of shares as recommended by such managing Underwriters; and SECOND, if further reduction or limitation is required, the number of shares to be offered for the account of the Holders and the Other Holders shall be reduced or limited on a PRO RATA basis in proportion to the relative number of securities of the Holders and Other Holders participating in such registration. If, as a result of the proration provisions of this Section 2.2, any Holder shall not be entitled to include at least 50% of the Registrable Securities in a Piggy-Back Registration in which such Holder has requested to be included, such Holder may elect to withdraw his, her or its request to include such Holder's Registrable Securities in such registration (a "WITHDRAWAL ELECTION"); PROVIDED, HOWEVER, that a Withdrawal Election shall be irrevocable and, after making a Withdrawal Election, a Holder shall no longer have any right to include Registrable Securities in the Piggy-Back Registration as to which such Withdrawal Election was made. ARTICLE 14. REGISTRATION PROCEDURES SECTION 14.1 FILINGS; INFORMATION. In connection with the Shelf Registration (including any underwritten public offering pursuant to Section 2.1(d) hereof) or any Piggyback Registration, the Company will use its best efforts to effect the registration and the sale of such Registrable Securities in accordance with the intended method of disposition thereof as quickly as practicable, and in connection with any such request: (a) REGISTRATION STATEMENTS. The Company will prepare and file with the Commission a registration statement with respect to such Registrable Securities (which, in the case of any underwritten public offering, shall include such additional information in the prospectus included therein as shall be reasonably requested by the managing Underwriter or Underwriters) and use its best efforts to cause such registration statement to become and remain effective until the completion of the distribution or until the Company's obligations otherwise terminate hereunder. (b) AMENDMENTS AND SUPPLEMENTS. The Company will prepare and file with the Commission such amendments and supplements to such registration statement and the prospectus used in connection therewith as may be necessary to keep such registration statement effective for the period specified in subsection (a) 5 above and as to comply with the provisions of the Securities Act with respect to the disposition of all Registrable Securities covered by such registration statement in accordance with the intended method of disposition set forth in such registration statement for such period. (c) COPIES FOR REVIEW. The Company will, as far in advance as practical, prior to filing a registration statement or prospectus or any amendment or supplement thereto, furnish copies of such registration statement as proposed to be filed, together with exhibits thereto, to (i) each Selling Holder, (ii) not more than one counsel representing all Selling Holders, to be selected by a majority-in-interest of such Selling Holders, and (iii) each Underwriter, if any, of the Registrable Securities covered by such registration statement, which documents will be subject to review and approval by the foregoing within five (5) days after delivery, and thereafter as far in advance as practical, furnish to such Selling Holders, counsel and Underwriters, if any, for their review and comment such number of copies of such registration statement, each amendment and supplement thereto (in each case including all exhibits thereto and documents incorporated by reference therein), the prospectus included in such registration statement (including each preliminary prospectus) and such other documents or information as such Selling Holders, counsel or Underwriters may reasonably request in order to facilitate the disposition of the Registrable Securities owned by such Selling Holders. (d) STOP ORDERS. After the filing of the registration statement, the Company will promptly notify each Selling Holder of Registrable Securities covered by such registration statement of any stop order issued or threatened by the Commission and take all reasonable actions required to prevent the entry of such stop order or to remove it if entered. (e) BLUE SKY. The Company will use its best efforts to (i) register or qualify the Registrable Securities under such other securities or blue sky laws of such jurisdictions in the United States as any Selling Holder reasonably (in light of such Selling Holder's intended plan of distribution) requests, and (ii) cause such Registrable Securities to be registered with or approved by such other governmental agencies or authorities in the United States as may be necessary by virtue of the business and operations of the Company and do any and all other acts and things that may be reasonably necessary or advisable to enable such Selling Holder to consummate the disposition of the Registrable Securities owned by such Selling Holder; PROVIDED, that the Company will not be required to (x) qualify generally to do business in any jurisdiction where it would not otherwise be required to qualify but for this subsection (e), (y) subject itself to taxation in any such jurisdiction or (z) consent to general service of process in any such jurisdiction. (f) CERTAIN EVENTS. The Company will immediately notify each Selling Holder, at any time when a prospectus relating thereto is required to be delivered under the Securities Act, of the occurrence of an event requiring the preparation of a 6 supplement or amendment to such prospectus so that, as thereafter delivered to the Holders of such Registrable Securities, such prospectus will not contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading and promptly make available to each Selling Holder any such supplement or amendment. The Company will promptly prepare and if required, cause to become effective, such supplement or amendment and deliver sufficient copies thereof to each Selling Holder. (g) AGREEMENTS. The Company and the Selling Holders will enter into customary agreements (including, if applicable, an underwriting agreement in customary form and which is reasonably satisfactory to the Company) and take such other actions as are reasonably required in order to expedite or facilitate the disposition of such Registrable Securities; and the Selling Holders may, at their option, require that any or all of the representations, warranties and covenants of the Company or to or for the benefit of such Underwriters also be made to and for the benefit of such Selling Holders. (h) DUE DILIGENCE. The Company will make available to each Selling Holder (and their counsel) and each Underwriter, if any, subject to restrictions imposed by the United States federal government or any agency or instrumentality thereof, copies of all correspondence between the Commission and the Company, its counsel or auditors and will also make available for inspection by any Selling Holder, any Underwriter participating in any disposition pursuant to such registration statement and any attorney, accountant or other professional retained by any such Selling Holder or Underwriter (collectively, the "INSPECTORS"), all financial and other records, pertinent corporate documents and properties of the Company (collectively, the "RECORDS") as shall be reasonably necessary to enable them to exercise their due diligence responsibility, and cause the Company's officers and employees to supply all information reasonably requested by any Inspectors in connection with such registration statement. Records which the Company determines, in good faith, to be confidential and which it notifies the Inspectors are confidential shall not be disclosed by the Inspectors unless (i) the disclosure of such Records is necessary to avoid or correct a misstatement or omission in such registration statement or (ii) the disclosure or release of such Records is requested or required pursuant to oral questions, interrogatories, requests for information or documents or a subpoena or other order from a court of competent jurisdiction or other process; PROVIDED, that prior to any disclosure or release pursuant to clause (ii), the Inspectors shall provide the Company with prompt notice of any such request or requirement so that the Company may seek an appropriate protective order or waive such Inspectors' obligation not to disclose such Records; and, PROVIDED FURTHER, that if failing the entry of a protective order or the waiver by the Company permitting the disclosure or release of such Records, the Inspectors, upon advice of counsel, are compelled to disclose such Records, the Inspectors may disclose that portion of the Records which counsel has advised the Inspectors that the Inspectors are compelled to disclose. Each Selling Holder agrees 7 that information obtained by it solely as a result of such inspections (not including any information obtained from a third party who, insofar as is known to the Selling Holder after reasonable inquiry, is not prohibited from providing such information by a contractual, legal or fiduciary obligation to the Company) shall be deemed confidential and shall not be used by it as the basis for any market transactions in the securities of the Company or its affiliates (as defined in Rule 405 promulgated under the Securities Act) unless and until such information is made generally available to the public. Each Selling Holder further agrees that it will, upon learning that disclosure of such Records is sought in a court of competent jurisdiction, give notice to the Company and allow the Company, at its expense, to undertake appropriate action to prevent disclosure of the Records deemed confidential. (i) SALES EFFORTS. In connection with an underwritten offering, the Company will participate, to the extent reasonably requested by the managing Underwriter for the offering or the Selling Holders, in customary efforts to sell the securities under the offering, including, without limitation, participating in "road shows"; PROVIDED, that the Company shall not be obligated to participate in more than one such offering in any 12-month period. The Company may require each Selling Holder to promptly furnish in writing to the Company such information regarding the distribution of the Registrable Securities as the Company may from time to time reasonably request and such other information as may be legally required in connection with such registration including, without limitation, all such information as may be requested by the Commission or the NASD. The Company may exclude from such registration any Holder who fails to provide such information. Each Selling Holder agrees that, upon receipt of any notice from the Company of the happening of any event of the kind described in subsection (f) hereof, such Selling Holder will forthwith discontinue disposition of Registrable Securities pursuant to the registration statement covering such Registrable Securities until such Selling Holder's receipt of the copies of the supplemented or amended prospectus contemplated by subsection (f) hereof, and, if so directed by the Company, such Selling Holder will deliver to the Company all copies, other than permanent file copies then in such Selling Holder's possession, of the most recent prospectus covering such Registrable Securities at the time of receipt of such notice. SECTION 14.2 REGISTRATION EXPENSES. In connection with the Shelf Registration and any Piggy-Back Registration, the Company shall pay the following registration expenses incurred in connection with the registration thereunder (the "REGISTRATION EXPENSES"): (i) all registration and filing fees, (ii) fees and expenses of compliance with securities or blue sky laws (including reasonable fees and disbursements of counsel in connection with blue sky qualifications of the Registrable Securities), (iii) processing, duplicating and printing expenses, (iv) the Company's internal expenses (including, without limitation, all salaries and expenses of its officers 8 and employees performing legal or accounting duties), (v) the fees and expenses incurred in connection with the listing of the Registrable Securities, (vi) reasonable fees and disbursements of counsel for the Company and customary fees and expenses for independent certified public accountants retained by the Company (including the expenses of any comfort letters or costs associated with the delivery by independent certified public accountants of a comfort letter or comfort letters requested but not the cost of any audit other than a year end audit), (vii) the reasonable fees and expenses of any special experts retained by the Company in connection with such registration, (viii) reasonable fees and expenses of one firm of counsel for the Holders to be selected by the Holders of at least 66.67% of the Registrable Securities to be included in such registration, and (ix) any other fees and disbursements of underwriters customarily paid by issuers or sellers of securities. The Company shall have no obligation to pay any other underwriting fees, discounts or commissions attributable to the sale of Registrable Securities, or the cost of any special audit required, such costs to be borne by the Holder or Holders making the request. SECTION 27.3 ADVICE BY COMPANY. The Company will keep each Holder advised as to the completion of any registration contemplated in this Agreement. At its expense, the Company will furnish promptly to each Holder such number or copies of prospectuses (including preliminary prospectuses), and all amendments and supplements thereto, in conformity with the requirements of the Securities Act, and such other documents as any such Holder from time to time may reasonably request. ARTICLE 15. INDEMNIFICATION AND CONTRIBUTION SECTION 15.1 INDEMNIFICATION BY THE COMPANY. The Company shall, to the full extent permitted by law, indemnify and hold harmless each Selling Holder, its partners, officers, directors, employees and agents, and each person, if any, who controls such Selling Holder within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act, together with the partners, officers, directors, employees and agents of such controlling person (collectively, "HOLDER COVERED PERSONS"), from and against any loss, claim, damage, liability, reasonable attorneys' fees, cost or expense and costs and expenses of investigating and defending any such claim, joint or several, and any action in respect thereof (collectively, the "DAMAGES"), to which any such Holder Covered Person may become subject under the Securities Act or otherwise, insofar as such Damages (or actions or proceedings, whether commenced or threatened, in respect thereof) arise out of, or are based upon, any untrue statement or alleged untrue statement of a material fact contained in any registration statement or prospectus relating to the Registrable Securities or any amendment or supplement thereto, or arises out of, or are based upon, any omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading, or any violation by the Company of any federal or state securities law or 9 any rule or regulation thereof, except insofar as the same are based upon information furnished in writing to the Company by a Selling Holder expressly for use therein, and shall reimburse each Holder Covered Person for any legal and other expenses reasonably incurred by that Holder Covered Person in investigating or defending or preparing to defend against any such Damages or proceedings; PROVIDED, HOWEVER, that the Company shall not be liable to any Selling Holder to the extent that any such Damages (or action or proceeding in respect thereof) arise out of or are based upon any untrue statement or omission made in any preliminary prospectus if (i) such Selling Holder failed to send or deliver a copy of the final prospectus with or prior to the delivery of written confirmation of the sale by such Selling Holder to the person asserting the claim from which such Damages arise, and (ii) the final prospectus would have corrected such untrue statement or such omission; PROVIDED FURTHER, that the Company shall not be liable to any Selling Holder in any such case to the extent that any such Damages arise out of or are based upon any untrue statement or omission in any prospectus if (x) such untrue statement or omission is corrected in an amendment or supplement to such prospectus, and (y) having previously been furnished by or on behalf of the Company with copies of such prospectus as so amended or supplemented, such Selling Holder thereafter fails to deliver such prospectus as so amended or supplemented prior to or concurrently with the sale of a Registrable Security to the person asserting the claim from which such Damages arise. The Company also agrees to indemnify any Underwriters of the Registrable Securities, their officers and directors and each person who controls any such Underwriters on substantially the same basis as that of the indemnification of the Selling Holders provided in this Section 4.1. SECTION 15.2 INDEMNIFICATION BY SELLING HOLDERS. Each Selling Holder shall, to the full extent permitted by law, severally but not jointly, indemnify and hold harmless the Company, its officers, directors, employees and agents and each person, if any, who controls the Company within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act, together with the partners, officers, directors, employees and agents of such controlling person (collectively, "COMPANY COVERED PERSONS"), to the same extent as the foregoing indemnity from the Company to such Selling Holder, but only with reference to information related to such Selling Holder, or its plan of distribution, furnished in writing by such Selling Holder or on such Selling Holder's behalf expressly for use in any registration statement or prospectus relating to the Registrable Securities, or any amendment or supplement thereto, or any preliminary prospectus and the aggregate amount which may be recovered from any Selling Holder pursuant to the indemnification provided for in this Section 4.2 in connection with any registration and sale of Registrable Securities shall be limited to the total proceeds received by such Holder from the sale of such Registrable Securities. In case any action or proceeding shall be brought against any Company Covered Person in respect of which indemnity may be sought against such Selling Holder, such Selling Holder shall have the rights and duties given to the Company Covered Persons, and the Company Covered Persons shall have the rights and duties given to such Selling Holder, by Section 4.1. Each Selling Holder also 10 agrees to indemnify and hold harmless any Underwriters of the Registrable Securities, their officers and directors and each person who controls such Underwriters on substantially the same basis as that of the indemnification of the Company provided in this Section 4.2. The Company shall be entitled to receive indemnities from Underwriters, selling brokers, dealer managers and similar securities industry professionals participating in the distribution, to the same extent as provided above, with respect to information so furnished in writing by such persons specifically for inclusion in any prospectus or registration statement. SECTION 15.3 CONDUCT OF INDEMNIFICATION PROCEEDINGS. Promptly after receipt by any person in respect of which indemnity may be sought pursuant to Section 4.1 or 4.2 (an "INDEMNIFIED PARTY") of notice of any claim or the commencement of any action, the Indemnified Party shall, if a claim in respect thereof is to be made against the person against whom such indemnity may be sought (an "INDEMNIFYING PARTY"), notify the Indemnifying Party in writing of the claim or the commencement of such action; PROVIDED that the failure to notify the Indemnifying Party shall not relieve it from any liability which it may have to an Indemnified Party otherwise than under Section 4.1 or 4.2 and except to the extent of any actual prejudice resulting therefrom. If any such claim or action shall be brought against an Indemnified Party, and it shall notify the Indemnifying Party thereof, the Indemnifying Party shall be entitled to participate therein, and, to the extent that it wishes, jointly with any other similarly notified Indemnifying Party, to assume the defense thereof with counsel reasonably satisfactory to the Indemnified Party. After notice from the Indemnifying Party to the Indemnified Party of its election to assume the defense of such claim or action, the Indemnifying Party shall not be liable to the Indemnified Party for any legal or other expenses subsequently incurred by the Indemnified Party in connection with the defense thereof other than reasonable costs of investigation; PROVIDED that the Indemnified Party shall have the right to employ separate counsel to represent the Indemnified Party and its Controlling Persons who may be subject to liability arising out of any claim in respect of which indemnity may be sought by the Indemnified Party against the Indemnifying Party, but the fees and expenses of such counsel shall be for the account of such Indemnified 11 Party unless (i) the Indemnifying Party and the Indemnified Party shall have mutually agreed to the retention of such counsel or (ii) in the reasonable judgment of the Company and such Indemnified Party, representation of both parties by the same counsel would be inappropriate due to actual or potential conflicts of interest between them, it being understood, however, that the Indemnifying Party shall not, in connection with any one such claim or action or separate but substantially similar or related claims or actions in the same jurisdiction arising out of the same general allegations or circumstances, be liable for the fees and expenses of more than one separate firm of attorneys (together with appropriate local counsel) at any time for all Indemnified Parties, or for fees and expenses that are not reasonable. No Indemnifying Party shall, without the prior written consent of the Indemnified Party, effect any settlement of any claim or pending or threatened proceeding in respect of which the Indemnified Party is or could have been a party and indemnity could have been sought hereunder by such Indemnified Party, unless such settlement includes an unconditional release of such Indemnified Party from all liability arising out of such claim or proceeding. Whether or not the defense of any claim or action is assumed by the Indemnifying Party, such Indemnifying Party will not be subject to any liability for any settlement made without its consent, which consent will not be unreasonably withheld. SECTION 15.4 CONTRIBUTION. If the indemnification provided for in this Article 4 is unavailable to the Indemnified Parties in respect of any Damages referred to herein, then each Indemnifying Party, in lieu of indemnifying such Indemnified Party, shall contribute to the amount paid or payable by such Indemnified Party as a result of such Damages (i) as between the Company and the Selling Holders on the one hand and the Underwriters on the other, in such proportion as is appropriate to reflect the relative benefits received by the Company and the Selling Holders on the one hand and the Underwriters on the other from the offering of the Registrable Securities, or if such allocation is not permitted by applicable law, in such proportion as is appropriate to reflect not only the relative benefits but also the relative fault of the Company and the Selling Holders on the one hand and of the Underwriters on the other in connection with the statements or omissions which resulted in such Damages, as well as any other relevant equitable considerations, and (ii) as between the Company on the one hand and each Selling Holder on the other, in such proportion as is appropriate to reflect the relative fault of the Company and of each Selling Holder in connection with such statements or omissions, as well as any other relevant equitable considerations. The relative benefits received by the Company and the Selling Holders on the one hand and the Underwriters on the other shall be deemed to be in the same proportion as the total proceeds from the offering (net of underwriting discounts and commissions but before deducting expenses) received by the Company and the Selling Holders bear to the total underwriting discounts and commissions received by the Underwriters, in each case as set forth in the table on the cover page of the prospectus. The relative fault of the Company and the Selling Holders on the one hand and of the Underwriters on the other shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by the Company and the Selling Holders or by the Underwriters. The relative fault of the Company on the one hand and of each Selling Holder on the other shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by such party, and the parties' relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. The Company and the Selling Holders agree that it would not be just and equitable if contribution pursuant to this Section 4.4 were determined by PRO RATA allocation (even if the Underwriters were treated as one entity for such purpose) or by any other method of allocation which does not take account of the equitable considerations referred to in the immediately preceding paragraph. The amount paid 12 or payable by an Indemnified Party as a result of the Damages referred to in the immediately preceding paragraph shall be deemed to include, subject to the limitations set forth above, any legal or other expenses reasonably incurred by such Indemnified Party in connection with investigating or defending any such action or claim. Notwithstanding the provisions of this Section 4.4, no Underwriter shall be required to contribute any amount in excess of the amount by which the total price at which the Registrable Securities underwritten by it and distributed to the public were offered to the public exceeds the amount of any damages which such Underwriter has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission, and no Selling Holder shall be required to contribute any amount in excess of the amount by which the total price at which the Registrable Securities of such Selling Holder were offered to the public (less underwriting discounts and commissions) exceeds the amount of any damages which such Selling Holder has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission. No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation. Each Selling Holder's obligations to contribute pursuant to this Section 4.4 is several in the proportion that the proceeds of the offering received by such Selling Holder bears to the total proceeds of the offering received by all the Selling Holders and not joint. ARTICLE 16. MISCELLANEOUS SECTION 16.1 OTHER REGISTRATION RIGHTS; HOLDBACK. The Company represents and warrants to the Holders that, except as set forth on SCHEDULE 2.2(b), there is not in effect on the date hereof any agreement by the Company pursuant to which any holders of securities of the Company have a right to cause the Company to register or qualify such securities under the Securities Act or any securities or blue sky laws of any jurisdiction that would conflict in any material respect with any provision of this Agreement. The Company shall not in the future grant to any owner or purchaser of shares of capital stock of the Company registration rights unless (a) such registration rights are made subordinate to the rights granted hereunder so that each Holder shall have priority to participate in any piggy-back registration with respect to such other shares of capital stock of the Company and (b) if the offering by the Holders is underwritten, such owner or purchaser agrees not to sell any shares of capital stock of the Company during the period commencing ten (10) days prior to any such underwritten offering and ending ninety (90) days following any such underwritten offering (or for such shorter period of time as is sufficient and appropriate, in the opinion of any managing Underwriter(s)). If requested by managing Underwriter(s) in any such registration, the Company shall request the directors and executive officers of the Company to execute and deliver similar holdback agreements. SECTION 16.2 PARTICIPATION IN UNDERWRITTEN REGISTRATIONS. No person may participate in any underwritten registration hereunder unless such person 13 (a) agrees to sell such person's securities on the basis provided in any underwriting arrangements approved by the persons entitled hereunder to approve such arrangements, and (b) completes and executes all questionnaires, powers of attorney, indemnities, underwriting agreements and other documents reasonably required under the terms of such underwriting arrangements and these registration rights. Notwithstanding the foregoing, no Holder of Registrable Securities shall be required to make any representations or warranties to or agreements with the Company or the Underwriters other than those customarily made by selling stockholders in such registrations, including without limitation representations, warranties or agreements regarding such Holder and its ownership of the securities being registered on its behalf and such Holder's intended method of distribution and any other representation required by law. SECTION 16.3 HOLDBACK AGREEMENT. For so long as the Holder has the right to have Registrable Securities included in any registration pursuant to this Agreement, the Holder agrees in connection with any underwritten registration of the Company's securities, upon the request of the Underwriters managing such underwritten offering of the Company's securities, not to effect any public sale or distribution (including any sale pursuant to Rule 144 under the Securities Act) of any Registrable Securities without the prior written consent of the Company or such Underwriters, as the case may be, within ten (10) days prior to or ninety (90) days after the effective date of such registration, as the Company or the Underwriters may specify. SECTION 16.4 SUSPENSION OF TRADING. After the Company has filed any registration statement pursuant to this Agreement, and if such registration shall be in connection with an underwritten offering of the Company's securities, upon the request of the managing Underwriter or Underwriters the Company may suspend the sale of Common Stock for up to ninety (90) days; PROVIDED, HOWEVER, that no such suspension shall occur on more than one occasion within any one year period. SECTION 16.5 RULE 144 AND 144A. The Company covenants that it will file any reports required to be filed by it under the Securities Act and the Exchange Act and that it will take such further action as any Holder may reasonably request, all to the extent required from time to time to enable Holders to sell Registrable Securities without registration under the Securities Act within the limitation of the exemptions provided by (a) Rule 144 or Rule 144A under the Securities Act, as such Rules may be amended from time to time, or (b) any similar rule or regulation hereafter adopted by the Commission. Upon the request of any Holder, the Company will deliver to such Holder a written statement as to whether it has complied with such requirements. SECTION 16.6 SUSPENSION OF OBLIGATION TO FILE. Notwithstanding the provisions of Section 3.1(a), the Company's obligations to file a registration statement, or cause such registration statement to become and remain effective, shall be 14 suspended for a period not to exceed 90 days if there exists at the time material non-public information relating to the Company that, in the reasonable opinion of the Company, should not be disclosed. SECTION 16.7 GENERAL. (a) GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAW OF THE STATE OF NEW YORK, WITHOUT GIVING EFFECT TO PRINCIPLES OF CONFLICTS OF LAW. (b) NOTICES. All notices or other communications shall be in writing and shall be personally served or mailed, registered or certified, return receipt requested, postage prepaid (or by a substantially similar method), or delivered by a reputable overnight courier service with charges prepaid, or transmitted by hand delivery or facsimile, addressed as set forth below, or such other address as such party shall have specified most recently by written notice: If to the Company: LifeCell Corporation 3606 Research Forest Drive The Woodlands, Texas 77381 Attention: President Telephone: (713) 367-5368 Telecopy: (713) 363-3360 with a copy to: Fulbright & Jaworski L.L.P. 1301 McKinney Street, Suite 5100 Houston, Texas 77010-3095 Attention: Robert E. Wilson, Esq. Telephone: (713) 651-5151 Telecopy: (713) 651-5246 Notice to any Holder shall be sent to the address listed on SCHEDULE 1 or to such other address which the Holder shall have provided in writing in accordance with this Section 5.7(b). Notice shall be deemed given or delivered on the date of service or transmission if personally served or transmitted by telecopier (with telephonic confirmation of receipt). Notice otherwise sent as provided herein shall be deemed given or delivered on the third business day following the date of postmark or on the next business day following delivery of such notice to a reputable overnight courier service. 15 (c) BINDING EFFECT. This Agreement and all of the provisions hereof shall be binding upon and inure to the benefit of the parties hereto and their respective heirs, successors and permitted assigns. (d) NO WAIVER. No failure on the part of the Company or the Investors in exercising any right, power or privilege granted hereunder shall operate as a waiver thereof or of any other right, power or privilege, nor shall any single or partial exercise of such right, power or privilege preclude any other or further exercise thereof or of any other right, power or privilege. (e) ENTIRE AGREEMENT. This Agreement sets forth the entire agreement among the parties hereto with respect to the subject matter hereof, and supersedes any prior oral or written agreements among the parties. (f) HEADINGS. The headings of this Agreement are solely for the convenience of the parties and shall not affect the interpretation or effect of any terms or provisions hereof. (g) COUNTERPARTS. This Agreement may be executed in two or more counterparts, each of which shall be deemed to be an original, but all of which together shall constitute one and the same document. (h) SEVERABILITY. In the event that any court or any governmental authority or agency declares all or any part of any Section of this Agreement to be unlawful or invalid, such unlawfulness or invalidity shall not serve to invalidate any other Section of this Agreement, and in the event that only a portion of any Section is so declared to be unlawful or invalid, such unlawfulness or invalidity shall not serve to invalidate the balance of such Section. (i) AMENDMENTS AND WAIVERS. This Agreement may be amended, modified and supplemented, and compliance with any term, covenant, agreement or condition contained herein may be waived either generally or in particular instances, only by a written instrument executed by the Company and the holders of at least a majority of the then outstanding Registrable Securities (for this purpose, treating (i) the Series B Preferred Stock as if it had been converted into Common Stock and (ii) each of the Warrants and the Gruntal Warrant that is then exercisable pursuant to its terms as if it had been exercised in full). No course of dealing between or among any persons having any interest in this Agreement will be deemed effective to modify, amend or discharge any part of this Agreement or any rights or obligations of any person under or by reason of this Agreement. (j) FURTHER ASSURANCES. Each party shall cooperate and take such action as may be reasonably requested by another party in order to carry out 16 the provisions and purposes of this Agreement and the transactions contemplated hereby. (k) REMEDIES. In the event of a breach or a threatened breach by any party to this Agreement of its obligations under this Agreement, any party injured or to be injured by such breach will be entitled to specific performance of its rights under this Agreement or to injunctive relief, in addition to being entitled to exercise all rights provided in this Agreement and granted by law. The parties agree that the provisions of this Agreement shall be specifically enforceable, it being agreed by the parties that the remedy at law, inducing monetary damages, for breach of any such provision will be inadequate compensation for any loss and that any defense or objection in any action for specific performance or injunctive relief that a remedy at law would be adequate is waived. * * * * * 17 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first above written. LIFECELL CORPORATION By _____________________________________________ Paul M. Frison President and Chief Executive Officer VECTOR LATER-STAGE EQUITY FUND, L.P. By Vector Fund Management, L.P., its General Partner By Its CIBC WOOD GUNDY VENTURES, INC. By Name: Title: 18 GRUNTAL & CO., INCORPORATED By Name: Title: 19 SCHEDULE 1 INVESTORS Vector Later-Stage Equity Fund, L.P. Charles and Donna Greenberg 1751 Lake Cook Road, Suite 350 503 Pinehurst Court Deerfield, Illinois 60015 Roslyn, NY 11576 CIBC Wood Gundy Ventures, Inc. Michael Gironta 425 Lexington Avenue 89 Ridgewood Avenue New York, New York 10017 Glen Ridge, NJ 07028 The Woodlands Venture Capital Company Joseph A. Russo 2201 Timberloch Place 3 Midwood Avenue The Woodlands, TX 77380 Verona, NJ 07044 SBSF Biotechnology Fund, L.P. John D. Goldberg c/o Lisa Tuckerman 2500 East Hallandale Beach Blvd. Spears Benzak Salomon & Farrell Suite 500 45 Rockefeller Plaza -- 33rd Floor Hallandale, FL 33009-4838 New York, NY 10111 Robert Sablowsky SBSF Biotechnology Partners, L.P. 150 East 69th Street, 16A c/o Lisa Tuckerman New York, NY 10021 Spears Benzak Salomon & Farrell 45 Rockefeller Plaza -- 33rd Floor William J. Strazzullo New York, NY 10111 750 Columbus Avenue, 4C New York, NY 10025 Jerome Schachter 2926 Leanne Court Joseph Battipaglia Northbrook, IL 60062 77 Water Street (10th Floor) New York, NY 10005 Paul B. Ankin and Lois F. Ankin, as joint tenants Stephen G. Weiss 4233 W. Grove 115 Ravin Oaks Lane Skokie, IL 60076 Highland Park, IL 60035 David and Mary Jane Harris Barry Richter 174 Pacific Street, Apt. 2A Tideway Brooklyn, NY 11201 Sandspoint, NY 11050 Richard L. Serrano 64 Brighton Avenue Bloomfield, NJ 07003 20 Chinook Equities, Inc. John S. Bai 147 East 48th Street 30 West 61st, 27A New York, NY 10017 New York, NY 10023 Daniel and Elaine Kleinberg William J. McCluskey 3 Centennial Road 25 Wisconsin Street Livingston, NJ 07039 Long Beach, NY 11561 Douglas Kleinberg David F. Saks 200 East 95th Street, Apt. 126 2 Knollcliff Road New York, NY 10128 Woodcliff Lake, NJ 07675 Evan Kleinberg IRA P. William Curreri, M.D. Gruntal & Co. Custodian 217 Berwyn Drive, W. #222 3 Centennial Road Mobile, Alabama 36608 Livingston, NJ 07039 Christopher C. Kraft, Jr. John Latshaw Smith Barney Inc. KEO P/S Custodian 5049 Wornall #2C 14919 Village Elm Street Kansas City, MO 64112 Houston, TX 77062 B. Michael Pisani Michael H. Richmond 44 Lake Road 20 E. Wedgewood Glen Short Hills, NJ 07078 The Woodlands, TX 77381 John Cirrito Stephen Livesey 29 Rambling Drive 3606 Research Forest Drive Scotch Plains, NJ 07076 The Woodlands, TX 77381 James C. Gale, Trustee F/B/O Ariana J. Gale Michael E. Cahr 315 W. 106th Street, Apt. 4A 1051 Saxony Drive New York, NY 10025 Highland Park, IL 60035 James C. Gale and Judith S. Haselton Technology Funding Medical 315 West 106th Street, Apt. 4A Partners I, L.P. New York, NY 10025 2000 Alameda de las Pulgas San Mateo, CA 94403 Robert Weinstein 155 West 68th Street, 24C New York, NY 10023 21 Ronald Koenig James J. Pelts 114 No. Village Way 29 East Madison Street, Suite 1505 Jupiter, Florida 33458 Chicago, IL 60602 Robert M. Adams The Marcus L. Koblitz Trust P.O. Box 998 Michael J. Koblitz, Trustee Plandome, NY 11030 12 Downey Drive Tenafly, NJ 07670 Edward A. Kerbs 8 South Cherry Lane The Lauren J. Koblitz Trust, Rumson, NJ 07760 Michael J. Koblitz, Trustee 12 Downey Drive Bernard B. Salzman IRA, Tenafly, NJ 07670 Gruntal & Co., Inc., Custodian 20 S. Charles Street Pharmaceutical & Medical Technology Fund Baltimore, MD 21201 300 Park Avenue New York, NY 10022 Don A. Sanders 3100 Texas Commerce Tower Strategic Healthcare Fund Houston, TX 77002 300 Park Avenue New York, NY 10022 Jeffrey Keeler 577 W. 50th Street Michael J. Koblitz Miami Beach, FL 33140 12 Downey Drive Tenafly, NJ 07670 Harbour Court L.P., II 253 W. 73rd St., Apt. 6D New York, NY 10023 Attention: Jonathan Greenwald Namax Corp. 666 Dundee Road, Suite 1801 Northbrook, IL 60062 Attention: Mark Rice, President Sheldon Drobny 95 Revere Drive, Suite A Northbrook, IL 60062 Perry H. Bacon 5300 Mission Woods Road Shawnee Mission, KS 66205 22 SCHEDULE 2.2(b) OTHER REGISTRATION RIGHTS The holders of capital stock listed below pursuant to the Amended and Restated Registration Rights Agreement, dated February 26, 1992, as amended, by and among the Company and the holders of capital stock of the Company identified therein: Allstate Insurance Company The Woodlands Venture Fund, L.P. Tenneco Insurance Ventures, Inc. The Woodlands Venture Capital Company Board of Regents of the University of Texas System Technology Funding Partners III, L.P. Paul M. Frison Robert Todd Financial Corporation pursuant to the Underwriter's Warrant Agreement, dated March 6, 1992, between the Company and Robert Todd Financial Corporation, as amended by First Amendment to Underwriter's Warrant Agreement, dated January 23, 1993, by and between the Company and Robert Todd Financial Corporation. Medtronic, Inc. pursuant to the Investment Agreement, dated March 3, 1994, as amended, between the Company and Medtronic, Inc. 23 EXHIBIT E FORM OF OPINION OF COUNSEL 18 November 1996 The Investors listed on SCHEDULE 1 to the Securities Purchase Agreement dated as of November 18, 1996, between LifeCell Corporation and the Investors Gruntal & Co., Incorporated 14 Wall Street New York, New York 10005 Ladies and Gentlemen: We have acted as counsel to LifeCell Corporation, a Delaware corporation (the "Company"), in connection with the transactions contemplated by the Securities Purchase Agreement dated as of November 18, 1996 (the "Securities Purchase Agreement"), between the Company and the persons named in SCHEDULE 1 thereto (the "Investors") and the Sales Agency Agreement dated October 29, 1996 (the "Sales Agency Agreement"), between the Company and Gruntal & Co., Incorporated ("Gruntal"). The Securities Purchase Agreement and the Sales Agency Agreement each relate to the sale by the Company of an aggregate of 124,157 shares of its Series B Preferred Stock, $.001 par value per share (the "Series B Preferred Stock"), and stock purchase warrants exercisable for an aggregate of 2,803,530 shares of the Company's Common Stock, $.001 par value per share (the "Common Stock"). Each capitalized term not otherwise defined herein shall have the meaning given to it in the Securities Purchase Agreement. We have examined the Securities Purchase Agreement, the other Transaction Documents, the Sales Agency Agreement and the Agent's Warrant (as defined in the Sales Agency Agreement) (together, the Sales Agency Agreement and the Agent's Warrant are referred to herein as the "Gruntal Documents") and originals, or copies certified or otherwise identified to our satisfaction, of such corporate records, certificates of officers of the Company, certificates and facsimile transmissions of public officials and such other documents as we have deemed necessary or appropriate for the purpose of this opinion. As to questions of fact material to this opinion, we have, to the extent we deemed appropriate, relied on certificates of officers of the Company and on certificates and facsimile transmissions of government officials. We have assumed the genuineness of all signatures, the authenticity of all documents, records and instruments examined by us and the correctness of all statements of fact contained 1 therein. We also have examined and relied upon representations as to factual matters contained in the Securities Purchase Agreement and the Sales Agency Agreement and in certificates of officers of the Company delivered pursuant thereto. Based upon the foregoing, and in reliance thereon, and having due regard for such legal considerations as we deem relevant, and subject in all respects to the assumptions, exceptions, qualifications and limitations herein set forth, we are of the opinion that: 1. The Company has been duly incorporated and organized and is validly existing and in good standing under the laws of the State of Delaware. 2. The Company is duly qualified as a foreign corporation to transact business in, and is in good standing in, the State of Texas. 3. The Company has all necessary corporate power and authority to execute, deliver and perform its obligations under each of the Transaction Documents and Gruntal Documents, and the Company has all necessary corporate power and authority to own its properties and to conduct its business as described in the Memorandum. 4. Each of the Transaction Documents and Gruntal Documents has been duly authorized, executed and delivered by the Company, and each such agreement or instrument is a valid and binding obligation of the Company, enforceable against the Company in accordance with its terms. 5. The Certificate of Designation has been duly adopted by the Company's Board of Directors, has been duly filed with the Secretary of State of Delaware and has become effective under the laws of the State of Delaware, and, upon issuance thereof in accordance with the Securities Purchase Agreement or Certificate of Designation, as the case may be, shares of Series B Preferred Stock will bear the designations, powers, preferences and relative, participating, optional and other special rights, and the qualifications, limitations or restrictions thereof, set forth in the Certificate of Designation. 6. Upon issuance thereof in accordance with the Securities Purchase Agreement, each share of Series B Preferred Stock issued to an Investor at the Closing will be validly issued and outstanding, fully paid and nonassessable, and there are no statutory or, to our knowledge, contractual preemptive rights of stockholders or rights of first refusal with respect to the issuance of such share of Series B Preferred Stock. 7. The certificates representing shares of Series B Preferred Stock purchased by the Investors at the Closing have been duly authorized by the Company and are in due and proper form under the Delaware General Corporation Law. 8. The shares of Common Stock issuable upon conversion of the Series B Preferred Stock have been duly authorized and reserved for issuance by the Company, there are no statutory or, to our knowledge, contractual preemptive rights of stockholders or rights of first refusal with respect to the issuance of such shares of Common Stock and the shares of Common Stock to be issued upon conversion of the Series B Preferred Stock shall upon such issuance in accordance with the terms of the Certificate of Designation be validly issued, fully paid and nonassessable. 2 9. The shares of Common Stock issuable upon exercise of the Warrants have been duly authorized and reserved for issuance by the Company, there are no statutory or, to our knowledge, contractual preemptive rights of stockholders or rights of first refusal with respect to the issuance of such shares of Common Stock and the shares of Common Stock to be issued upon exercise of the Warrants shall upon such issuance in accordance with the respective terms of each such Warrant be validly issued, fully paid and nonassessable. 10. The shares of Common Stock issuable upon exercise of the Agent's Warrant have been duly authorized and reserved for issuance by the Company, there are no statutory or, to our knowledge, contractual preemptive rights of stockholders or rights of first refusal with respect to the issuance of such shares of Common Stock and the shares of Common Stock to be issued upon exercise of the Agent's Warrant shall upon such issuance in accordance with the terms of the Agent's Warrant be validly issued, fully paid and nonassessable. 11. Other than as set forth in SCHEDULE 3.4-CONFLICTS to the Agreement, as may be required pursuant to the "Blue Sky" provisions of any applicable state securities laws and the filing of a Form D pursuant to Regulation D under the Securities Act, the execution and delivery by the Company of the Transaction Documents and the Gruntal Documents, the offering, sale and issuance of the shares of Series B Preferred Stock, the issuance of shares of Common Stock upon conversion of the Series B Preferred Stock, the issuance of shares of Common Stock upon exercise of the Warrants, the issuance of shares of Common Stock upon exercise of the Agent's Warrant and the fulfillment of and the compliance with the respective terms thereof by the Company do not and shall not (a) conflict with or result in a breach of the terms, conditions or provisions of, (b) constitute a default under, (c) result in the creation of any lien, mortgage, security interest, charge or other encumbrance upon the Company's capital stock or assets pursuant to, (d) give any third party the right to accelerate any obligation under, (e) result in a violation of or (f) require any authorization, consent, approval, exemption or other action by or notice to any court or administrative or governmental body pursuant to, the Certificate of Incorporation, the Certificate of Designation, the By-Laws, any law, statute, rule or regulation to which the Company is subject, or, to our knowledge, any agreement, instrument, order, judgment or decree to which the Company is subject. 12. The offering, sale and issuance of shares of Series B Preferred Stock and the Warrants under the Securities Purchase Agreement, the issuance of shares of Common Stock upon conversion of the Series B Preferred Stock and the issuance of shares of Common Stock upon exercise of the Warrants (assuming for such purpose that such shares were issued on the Closing Date) do not require registration under the Securities Act. 13. The offering, sale and issuance of the Agent's Warrant under the Sales Agency Agreement and the issuance of shares of Common Stock upon exercise of the Agent's Warrant (assuming for such purpose that such shares were issued on the Closing Date) do not require registration under the Securities Act. 14. The Company has authorized capital stock consisting of 25,000,000 shares of Common Stock and 2,000,000 shares of Preferred Stock of which 300,000 shares have been designated as Series A Preferred Stock and 182,205 shares have been designated as Series B Preferred Stock. All of the issued and outstanding shares of Common Stock and Series A Preferred Stock have been duly authorized and validly issued and are fully paid and nonassessable. 3 15. Except as set forth on SCHEDULE 3.2--CAPITAL STOCK to the Agreement, to our knowledge, there are no (a) outstanding shares of capital stock or securities convertible into or exchangeable or exercisable for shares of the Company's capital stock or for shares of stock or securities convertible into or exchangeable or exercisable for shares of the Company's capital stock, (b) outstanding options for the purchase of, or any agreements providing for the issuance (contingent or otherwise) of, or any commitments or claims of any character relating to, any such capital stock or any shares of stock or securities convertible into or exchangeable or exercisable for any such capital stock, or (c) obligations (contingent or otherwise) of the Company to repurchase, exchange or otherwise acquire or retire any shares of such capital stock or any shares of stock or securities convertible into or exchangeable or exercisable for any such capital stock, except pursuant to the Securities Purchase Agreement, the Certificate of Incorporation or the Certificate of Designation. The opinions rendered in numbered paragraph 4 above regarding the enforceability of the Transaction Documents and the Gruntal Documents are subject to the following: (a) The enforceability of the Transaction Documents and the Gruntal Documents may be limited or adversely affected by (i) bankruptcy, insolvency, reorganization, moratorium, liquidation, rearrangement, probate, conservatorship, fraudulent transfer, fraudulent conveyance and other similar laws (including court decisions) now or hereafter in effect and affecting the rights and remedies of creditors generally or providing for the relief of debtors, (ii) the refusal of a particular court to grant equitable remedies, including, but without limiting the generality of the foregoing, specific performance and injunctive relief and (iii) general principles of equity (regardless of whether such remedies are sought in a proceeding in equity or at law). (b) In rendering such opinions, we express no opinion as to the enforceability of any provisions of any Transaction Document or Gruntal Document (i) restricting access of any Person to courts or to legal or equitable remedies, (ii) purporting to waive or affect rights, claims, defenses or other benefits bestowed by law to the extent that any of the same cannot be waived or so affected, (iii) relating to rights to indemnity or contribution to the extent prohibited by public policy or to the extent indemnification or contribution is required for losses or expenses caused by gross negligence, willful misconduct, fraud or illegal action on the part of an indemnified party, (iv) purporting to waive or to otherwise affect the rights of third parties or (v) to the extent that the Company's obligations would require the Company's directors to take action inconsistent with their fiduciary duties or would require the taking of any action within the control of the Company's stockholders other than parties to the Transaction Documents or the Gruntal Documents. In rendering the opinions expressed in numbered paragraph 4 above, we have assumed that each of the parties (other than the Company) to the Transaction Documents and the Gruntal Documents and the other documents and instruments relied upon by us has all requisite power and authority validly to execute and deliver the documents or instruments to which it is a party and to effect the transactions contemplated thereby. 4 In rendering the opinions expressed in numbered paragraph 11 above with respect to any law, statute, rule or regulation, our opinion is based on a review of laws, rules and regulations, which, in our experience, are normally applicable to transactions of the type contemplated by the Transaction Documents and the Gruntal Documents. In rendering the opinions expressed in numbered paragraph 11 above with respect to any agreement or instrument, our opinion is limited to the agreements and instruments listed or referred to in SCHEDULE 3.14- CONTRACTS to the Securities Purchase Agreement (other than those agreements or instruments listed or referred to in ANNEX 3.13 to SCHEDULE 3.13-PROPRIETARY RIGHTS to the Securities Purchase Agreement or SCHEDULE 3.18- INSURANCE to the Securities Purchase Agreement). In rendering the opinions expressed in numbered paragraph 12 above, we have relied upon the representations and warranties of each Investor set forth in Section 4 of the Securities Purchase Agreement and the representations and warranties of Gruntal set forth in Sections 5(b)(i) through (iv) of the Sales Agency Agreement and assumed that such representations and warranties were true and accurate as of the Closing Date. In rendering the opinions expressed in numbered paragraph 13 above, we have relied upon the representations and warranties of Gruntal set forth in Sections 5(b)(v) and (vi) of the Sales Agency Agreement and assumed that such representations and warranties were true and accurate as of the Closing Date. References herein to the "internal laws" of a jurisdiction are to the laws of that jurisdiction, other than that jurisdiction's conflict-of-law statutes and rules. The opinions expressed herein relate solely to, are based solely upon and are limited exclusively to the internal laws of the State of New York, the internal laws of the State of Texas, the Delaware General Corporation Law and federal laws of the United States of America, to the extent applicable. This letter and the opinions expressed herein are furnished pursuant to Section 7.10 of the Securities Purchase Agreement and Section 8(a)(iv) of the Sales Agency Agreement and are solely for the benefit of, and may be relied upon only by, the Investors, Gruntal and KeyCorp Shareholder Services, Inc., transfer agent and registrar for the Series B Preferred Stock. This letter and the opinions expressed herein may not be used or relied upon by any Investor, Gruntal or KeyCorp Shareholder Services, Inc. for any other purpose and may not be relied upon for any purpose by any other person without our prior written consent. Very truly yours, Fulbright & Jaworski L.L.P. 5
EX-10.16 6 EXHIBIT 10.16 VOTING AGREEMENT THIS VOTING AGREEMENT (this "AGREEMENT") is made as of November 18, 1996 among LifeCell Corporation, a Delaware corporation (the "COMPANY"), the Investors (as defined below) and Allstate Insurance Company ("ALLSTATE," and together with the Investors, the "STOCKHOLDERS"). Vector Later-Stage Equity Fund, L.P., CIBC Wood Gundy Ventures, Inc., and the other Persons identified as "Investors" on ANNEX A attached hereto other than Allstate (collectively, the "INVESTORS") and the Company are entering into a Securities Purchase Agreement simultaneously with the execution of this Agreement (the "PURCHASE AGREEMENT"), pursuant to which the Investors are purchasing shares of the Company's Series B Preferred Stock, par value $.001 per share ("SERIES B PREFERRED"), and warrants to purchase shares of the Company's common stock, par value $.001 per share (each, a "WARRANT"). Immediately after the consummation of the transactions contemplated in the Purchase Agreement, Allstate owns approximately 21% of the voting stock of the Company. Under the Certificate of Designation (as defined in the Purchase Agreement), the Investors have the right to designate three representatives (the "INVESTOR REPRESENTATIVES") to the Company's board of directors (the "BOARD"), and, in connection with the issuance and sale of the Securities to the Investors, the Company and the Stockholders have agreed as to the composition of the entirety of the Board. The Investors desire to enter into this Agreement for the purpose of determining the Investor Directors and the Additional Outside Directors (as defined below), the Company desires to enter into this Agreement for the purpose of determining the Company Directors (as defined below), the Initial Outside Director (as defined below) and the Additional Outside Directors, Allstate desires to enter into this Agreement for the purpose of determining the composition of the Board upon consummation of the issuance of the Series B Preferred Stock to the Investors, and execution and delivery of this Agreement is a condition to consummation of the transaction contemplated in the Purchase Agreement. The Company and the Stockholders hereby agree as follows: 1. CERTAIN DEFINITIONS. Capitalized terms used but not defined herein shall have the meanings assigned such terms in the Purchase Agreement. "STOCKHOLDER SHARES" means, as of any particular time, (i) any Common Stock purchased or otherwise acquired by any Stockholder, (ii) any Common Stock issued or issuable directly or indirectly upon conversion of Preferred Stock or upon exercise of Warrants, in each case, owned by a Stockholder, (iii) any capital stock or other equity securities issued or issuable directly or indirectly with respect to Common Stock referred to in clause (i) or clause (ii) above by way of stock dividend or stock split or in connection with a combination of shares, recapitalization, merger, consolidation or other reorganization. For purposes of this Agreement, any Person who holds - 1 - Preferred Stock or Warrants shall be deemed to be a Stockholder and the holder of Stockholder Shares issued or issuable upon conversion of such Preferred Stock or exercise of such Warrants (as the case may be) in connection with the transfer thereof or otherwise and regardless of any restriction or limitation on the conversion or exercise thereof. 2. BOARD OF DIRECTORS. (a) From and after the date of this Agreement, each holder of Stockholder Shares shall vote all of its Stockholder Shares and shall take all other necessary or desirable actions within its control (whether in its capacity as a stockholder or as an officer or director of the Company or otherwise, and including, without limitation, attendance at meetings in person or by proxy for the purposes of obtaining a quorum and execution of written consents in lieu of meetings), and the Company shall take all necessary and desirable actions within its control (including, without limitation, calling special Board and stockholder meetings), so that: (i) the maximum authorized number of directors on the Board shall be established initially at nine directors and shall be reduced in accordance with clauses (viii) and (ix) of this Section 2; (ii) the following individuals shall be elected to the Board: (A) three representatives (the "INVESTOR DIRECTORS") designated by holders of a majority of the Underlying Common Stock (the "MAJORITY INVESTORS"), which Investor Directors shall include one representative designated by Vector (the "VECTOR REPRESENTATIVE"), which Vector Representative shall initially be K. Flynn McDonald, one representative designated by CIBC-WG (the "CIBC-WG REPRESENTATIVE"), which CIBC- WG Representative shall initially be Lori G. Koffman, and one representative (the "MAJORITY INVESTORS REPRESENTATIVE") selected by the Majority Investors; (B) the Chief Executive Officer (who shall initially be Paul M. Frison) and Stephen A. Livesey (each, a "COMPANY DIRECTOR") and Michael Cahr (the "INITIAL OUTSIDE DIRECTOR"); (C) two representatives jointly designated by the Investor Directors, and the Company Directors (which designations shall take into account recommendations of a top tier executive search firm jointly selected by the Investor Directors and the Company Directors) (the "ADDITIONAL OUTSIDE DIRECTORS"), which Additional Outside Directors are neither members of the Company's management nor an employee or an officer of the Company; and (D) one representative (the "MEDTRONIC DIRECTOR") designated by Medtronic, Inc., a Minnesota corporation ("MEDTRONIC"); - 2 - (iii) the removal from the Board (with or without cause) of any Vector Representative, any CIBC-WG Representative or any Majority Investors Representative shall be at the written request of Vector, CIBC-WG or the Majority Investors, respectively, but only upon such written request and under no other circumstances; (iv) the removal from the Board (with or without cause) of any Company Director or the Initial Outside Director shall be at the written request of the majority of the other directors then in office, but only upon such written request and under no other circumstances; (v) the removal from the Board (with or without cause) of the Medtronic Director shall be only in accordance with and as contemplated by Section 6.3 of the Investment Agreement dated May 3, 1994 between the Company and Medtronic (the "MEDTRONIC INVESTMENT AGREEMENT"); provided that the Company shall not agree to any amendment to such Section 6.3 without the prior consent of the Majority Investors; (vi) in the event that any Investor Director or any Additional Outside Director designated hereunder for any reason ceases to serve as a member of the Board during his or her term of office, the resulting vacancy on the Board shall be filled in the manner set forth above in clause (ii) of this Section 2 by a representative designated by the same group that designated the member that will no longer serve on the Board; provided that if such group fails to designate a representative to fill such vacancy, the election of an individual to fill such vacancy shall be accomplished in accordance with the Company's bylaws and applicable law; provided, further, that the Stockholders shall thereafter vote to remove such individual if the group which failed to designate a representative to fill such vacancy pursuant to this Section 2 so directs; (vii) in the event that the Initial Outside Director for any reason ceases to serve as a member of the Board during his term of office, the resulting vacancy shall be filled by the vote of a majority of the other directors then in office; (viii) in the event that any Company Director (other than the Chief Executive Officer) for any reason ceases to serve as a member of the Board during his term of office, the resulting vacancy shall not be filled and the number of authorized directors on the Board shall be reduced by the number of such directors who have ceased to serve on the Board; and (ix) at such time when Medtronic no longer has the right to appoint a director pursuant to Section 6.3 of the Medtronic Investors Agreement, the number of authorized directors on the Board shall be reduced by one and the resulting directorship shall not be filled. (b) The Company shall pay all out-of-pocket travel and other expenses incurred by each director in connection with attending the meetings of the Board or any committee thereof. So long as any Investor Director serves on the Board and for 3 years thereafter, the Company shall maintain directors and officers indemnity insurance coverage satisfactory to the Majority Investors, and the Company's certificate of incorporation and bylaws shall provide for indemnification and exculpation of directors to the fullest extent permitted under applicable law. - 3 - 3. REPRESENTATIONS AND WARRANTIES. Each Stockholder represents and warrants that (i) such Stockholder is the record owner of the number and type of shares of the Company's capital stock indicated opposite its name on ANNEX A hereto, (ii) this Agreement has been duly authorized, executed and delivered by such Stockholder and constitutes the valid and binding obligation of such Stockholder, enforceable in accordance with its terms, and (iii) such Stockholder has not granted and is not a party to any proxy, voting trust or other agreement which is inconsistent with, conflicts with or violates any provision of this Agreement. 4. STOCKHOLDER COVENANT. No holder of Stockholder Shares shall grant any proxy or become party to any voting trust or other agreement which is inconsistent with, conflicts with or violates any provision of this Agreement. 5. TERMINATION. This Agreement shall terminate at the later of (i) such time when all of the shares of Series B Preferred have been converted and (ii) such time when the Company no longer has any obligation to deliver financial and other information to certain Investors pursuant to Section 6.8 of the Purchase Agreement; provided that, notwithstanding the foregoing, Allstate's obligations under this Agreement shall terminate on the second anniversary of this Agreement. 6. COUNTERPARTS. This Agreement may be executed in multiple counterparts, each of which shall be an original and all of which taken together shall constitute one and the same agree ment. 7. REMEDIES. Each Stockholder shall be entitled to enforce its rights under this Agreement specifically, to recover damages by reason of any breach of any provision of this Agreement and to exercise all other rights existing in their favor. Each Stockholder hereby acknowledges that money damages would not be an adequate remedy for any breach of the provisions of this Agreement and that each Stockholder may in its sole discretion apply to any court of law or equity of competent jurisdiction for specific performance and/or injunctive relief (without posting a bond or other security) in order to enforce or prevent any violation of the provisions of this Agreement. 8. NOTICES. Any notice provided for in this Agreement shall be in writing and shall be either personally delivered, or mailed first class mail (postage prepaid) or sent by reputable overnight courier service (charges prepaid) to the Stockholder at the address indicated on the schedules hereto or at such address or to the attention of such other person (including any subsequent holder of Stockholder Shares) as the recipient party has specified by prior written notice to the sending party. Notices shall be deemed to have been given hereunder when delivered personally, three days after deposit in the U.S. mail and one day after deposit with a reputable overnight courier service. 9. AMENDMENT AND WAIVER. This Agreement may be amended, modified and supplemented, and compliance with any term, covenant, agreement or condition contained herein may be waived either generally or in particular instances, and either retroactively or prospectively, only by a written instrument executed by (a) the Company and (b) the Majority Investors. No course - 4 - of dealing between or among any persons having any interest in this Agreement will be deemed effective to modify, amend or discharge any part of this Agreement or any rights or obligations of any person under or by reason of this Agreement. 10. GOVERNING LAW. THE CORPORATE LAW OF THE STATE OF DELAWARE SHALL GOVERN ALL ISSUES AND QUESTIONS CONCERNING THE RIGHTS OF THE COMPANY AND THE RIGHTS OF THE STOCKHOLDERS RELATIVE TO THE COMPANY. ALL OTHER ISSUES AND QUESTIONS CONCERNING THE CONSTRUCTION, VALIDITY, INTERPRETATION AND ENFORCEABILITY OF THIS AGREEMENT AND THE EXHIBITS AND SCHEDULES HERETO SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK, WITHOUT GIVING EFFECT TO ANY CHOICE OF LAW OR CONFLICT OF LAW RULES OR PROVISIONS (WHETHER OF THE STATE OF NEW YORK OR ANY OTHER JURISDICTION) THAT WOULD CAUSE THE APPLICATION OF THE LAWS OF ANY JURISDICTION OTHER THAN THE STATE OF NEW YORK. 11. DESCRIPTIVE HEADINGS. The descriptive headings of this Agreement are inserted for convenience only and do not constitute a part of this Agreement. * * * * - 5 - IN WITNESS WHEREOF, the Company and the Stockholders have executed this Agreement on the day and year first above written. LIFECELL CORPORATION By PAUL M. FRISON Paul M. Frison President and Chief Executive Officer VECTOR LATER-STAGE EQUITY FUND, L.P. By Vector Fund Management, L.P., its General Partner By Unreadable Signature Name:__________________ Title:President CIBC WOOD GUNDY VENTURES, INC. By/s/LORI KOFFMAN Name:Lori Koffman Title:Managing Director ALLSTATE INSURANCE COMPANY ByUnreadable Signature By________________________ Its Authorized Signatories [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ DON E. ROOSE, JR. (Signature) Name:Don E. Roose, Jr. Vice President and Controller [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 6th day of November, 1996. /S/ STEPHEN LIVESEY (Signature) Name:Stephen Livesey [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ CHRISTOPHER C. KRAFT JR. (Signature) Name: Christopher C. Kraft Jr. [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ P. WILLIAM CURRERI, M.D. (Signature) Name: P. William Curreri [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ DAVID SAKS (Signature) Name: David Saks [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JOHN S. BAI (Signature) Name: John S. Bai [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ ROBERT WEINSTEIN (Signature) Name: Robert Weinstein [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JAMES C. GALE JUDITH S. HASELTON (Signature) Name: James C. Gale & Judith S. Haselton [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JAMES C. GALE, TRUSTEE (Signature) Name: James C. Gale, Trustee F/B/O Ariana J. Gale [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /S/ JOHN CIRRITO (Signature) Name:John Cirrito [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ B. MICHAEL PISANI (Signature) Name: B. Michael Pisani [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /S/ JOHN LATSHAW (Signature) Name:John Latshaw [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ EVAN KLEINBERG (Signature) Name: Evan Kleinberg [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ DOUGLAS KLEINBERG (Signature) Name:Douglas Kleinberg [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ DANIEL KLEINBERG ELAINE KLEINBERG (Signature) Name:Daniel & Elaine Kleinberg [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ ALLEN L. BOORSTEIN (Signature) Name: Allen L. Boorstein General Partner Chinook Equities [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /S/ BARRY RICHTER (Signature) Name:Barry Richter [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ STEPHEN G. WEISS (Signature) Name:Stephen G. Weiss [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JOSEPH BATTIPAGLIA (Signature) Name:Joseph Battipaglia [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ WILLIAM J. STRAZZULLO (Signature) Name:William J. Strazzullo [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ ROBERT SABLOWSKY (Signature) Name:Robert Sablowsky [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /S/ JOHN D. GOLDBERG (Signature) Name:John D. Goldberg [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JOSEPH A. RUSSO (Signature) Name:Joseph A. Russo [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 31st day of October, 1996. /S/ MICHAEL GIRONTA (Signature) Name: Michael Gironta [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ DONNA GREENBERG CHARLES L. GREENBERG (Signature) Name: Donna Greenberg Charles L. Greenberg [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ RICHARD L. SERRANO (Signature) Name:Richard L. Serrano [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ DAVID HARRIS MARY JANE HARRIS (Signature) Name:David Harris Mary Jane Harris [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ PAUL B. ANKIN LOIS F. ANKIN (Signature) Name:Paul B. Ankin & Lois F. Ankin [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JEROME SCHACHTER (Signature) Name: Jerome Schachter [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JEROME SCHACHTER (Signature) Name: Jerome Schachter [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ LISA B. TUCKERMAN (Signature) Name: Lisa B. Tuckerman Managing Director of the General Partner S.B.S.F. Biotechnology Partners, L.P. [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ MICHAEL J. KOBLITZ (Signature) Name: Michael J. Koblitz Trustee [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ SHELDON DROBNY (Signature) Name: Sheldon Drobny [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 5th day of November, 1996. /S/ PERRY H. BACON (Signature) Name: Perry H. Bacon [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ JAMES J. PELTS (Signature) Name: James J. Pelts [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ ROBERT WEINSTEIN (Signature) Name: Robert Weinstein [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /S/ THOMAS J. TOY (Signature) Name: Technology Funding Medical Partners, L.L.P. [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /S/ RONALD KOENIG (Signature) Name: Ronald Koenig [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ ROBERT M. ADAMS (Signature) Name: Robert M. Adams [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ F.A. KERBS (Signature) Name: F.A. Kerbs [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ BERNARD B. SALZMAN (Signature) Name: Bernard B. Salzman IRA, Gruntal & Co., Inc., Custodian [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ MICHAEL H. RICHMOND (Signature) Name: Michael H. Richmond [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 2nd day of November, 1996. /S/ MICHAEL E. CAHR Signature) Name: Michael E. Cahr [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 11th day of November, 1996. /S/ DON A. SANDERS (Signature) Name: Don A. Sanders [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ JEFFREY KEELER (Signature) Name: Jeffrey R. Keeler [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ JONATHAN GREENWALD - GENERAL PARTNER (Signature) Name: Jonathan Greenwald - General Partner [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ MARK RICE (Signature) Name: Mark Rice - Namax Corp - President [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ LISA B. TUCKERMAN (Signature) Name: Lisa B. Tuckerman Managing Director of the General Partner S.B.S.C. Biotechnology Fund, L.P. [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 6th day of November, 1996. /S/ FREDERIC GREENBERG (Signature) Name: Frederic Greenberg [VOTING AGREEMENT] SIGNATURE PAGE TO VOTING AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 6th day of November, 1996. /S/ MICHAEL J. KOBLITZ (Signature) Name: Michael J. Koblitz STOCKHOLDERS -- ANNEX A Stockholder
Name and Address Shares - ----------------------------------------------- ------------------------------------ CIBC Wood Gundy Ventures, Inc. 44,800 shares of Series B Preferred 425 Lexington Avenue New York, NY 10017 The Woodlands Venture Capital Company 2,500 shares of Series B Preferred 2201 Timberloch Place 482,068 shares of Common Stock The Woodlands, TX 77380 15,000 shares of Series A Preferred P. William Curreri, M.D. 400 shares of Series B Preferred 217 Berwyn Drive, W. #222 8,238 shares of Common Stock Mobile, AL 36608 1,250 shares of Series A Preferred Christopher C. Kraft, Jr. 250 shares of Series B Preferred Smith Barney Inc. KEO P/S Custodian 1,738 shares of Common Stock Acct: 721-66059-10-022 1,250 shares of Series A Preferred 14919 Village Elm Street Houston, TX 77062 Michael H. Richmond 400 shares of Series B Preferred 20 E. Wedgewood Glen The Woodlands, TX 77381 Stephen Livesey 250 shares of Series B Preferred 3606 Research Forest Drive 100,529 shares of Common Stock The Woodlands, TX 77381 Michael E. Cahr 500 shares of Series B Preferred 1051 Saxony Drive Highland Park, IL 60035 Technology Funding Medical Partners I, L.P. 2,500 shares of Series B Preferred 2000 Alameda de las Pulgas San Mateo, CA 94403 Vector Later-Stage Equity Fund, L.P. 40,000 shares of Series B Preferred 1751 Lake Cook road, Suite 350 Deerfield, IL 60015 William J. McCluskey 186 shares of Series B Preferred 25 Wisconsin Street Long Beach, NY 11561 David Saks 500 shares of Series B Preferred 2 Knollcliff Road Woodcliff Lake, NJ 07675
Stockholder Name and Address Shares - ----------------------------------------------- ------------------------------------- Joseph Battipaglia 150 shares of Series B Preferred 77 Water Street (10th Floor) New York, NY 10005 S.B.S.F. Biotechnology Partners, L.P. 1,000 shares of Series B Preferred c/o Lisa Tuckerman Spears Benzak Salomon & Farrell 45 Rockefeller Plaza -- 33rd Floor New York, NY 10111 S.B.S.F. Biotechnology Fund, L.P. 9,000 shares of Series B Preferred c/o Lisa Tuckerman Spears Benzak Salomon & Farrell 45 Rockefeller Plaza -- 33rd Floor New York, NY 10111 Jerome Schachter 500 shares of Series B Preferred 2926 Leanne Court Northbrook, IL 60062 Paul B. Ankin and Lois F. Ankin, JTWROS 250 shares of Series B Preferred 4233 W. Grove Skokie, IL 60076 David and Mary Jane Harris, JTWROS 200 shares of Series B Preferred 174 Pacific Street, Apt. 2A Brooklyn, NY 11021 Richard L. Serrano 50 shares of Series B Preferred 64 Brighton Avenue Bloomfield, NJ 07003 Charles and Donna Greenberg, JTWROS 1,500 shares of Series B Preferred 503 Pinehurst Court Roslyn, NY 11576 Michael Gironta 1,000 shares of Series B Preferred 89 Ridgewood Avenue Glen Ridge NJ 07028 Joseph A. Russo 155 shares of Series B Preferred 3 Midwood Avenue Verona, NJ 07044 John D. Goldberg 310 shares of Series B Preferred 2500 East Hallandale Beach Blvd. Suite 500 Hallandale, FL 33009-4838
Stockholder Name and Address Shares - ----------------------------------------------- ------------------------------------- Robert Sablowsky 465 shares of Series B Preferred 150 East 69th Street, 16A New York, NY 10021 William J. Strazzullo 80 shares of Series B Preferred 750 Columbus Avenue, 4C New York, NY 10025 Stephen G. Weiss 330 shares of Series B Preferred 115 Ravin Oaks Lane Highland Park, IL 60035 Barry Richter 250 shares of Series B Preferred Tideway Sandspoint, NY 11050 Chinook Equities, Inc. 500 shares of Series B Preferred 147 East 48th Street New York, NY 10017 Daniel and Elaine Kleinberg, JTWROS 267 shares of Series B Preferred 3 Centennial Road Livingston, NJ 07039 Douglas Kleinberg 248 shares of Series B Preferred 200 East 95th Street, Apt. 126 New York, NY 10128 Evan Kleinberg IRA, 155 shares of Series B Preferred Gruntal & Co., Inc., Custodian Dated July 19, 1996 3 Centennial Road Livingston, NJ 07039 John Latshaw 930 shares of Series B Preferred 5049 Wornall #2 C Kansas City, MO 64112 B. Michael Pisani 775 shares of Series B Preferred 44 Lake Road Short Hills, NJ 07078 John Cirrito 250 shares of Series B Preferred 29 Rambling Drive Scotch Plains, NJ 07076
Stockholder Name and Address Shares - ----------------------------------------------- ------------------------------------- James C. Gale, Trustee 620 shares of Series B Preferred F/B/O Ariana J. Gale The James C. Gale Trust, dated November 21, 1986 315 West 106th Street, Apt. 4A New York, NY 10025 James C. Gale and Judith S. Haselton JTWROS 1,550 shares of Series B Preferred 315 West 106th Street, Apt. 4A New York, NY 10025 John S. Bai 217 shares of Series B Preferred 30 West 61st, 27A New York, NY 10023 Ronald Koenig 310 shares of Series B Preferred 114 No. Village Way Jupiter, FL 33458 Robert M. Adams 1,550 shares of Series B Preferred P.O. Box 998 Plandome, NY 11030 Edward A. Kerbs 310 shares of Series B Preferred 8 South Cherry Lane Rumson, NJ 07760 Bernard B. Salzman IRA, 55 shares of Series B Preferred Gruntal & Co., Inc., Custodian Dated May 14, 1982 Acct: 215-67321-1-3-231 20 S. Charles Street Baltimore, MD 21201 Don A. Sanders 620 shares of Series B Preferred 3100 Texas Commerce Tower Houston, TX 77002 Jeffrey Keeler 87 shares of Series B Preferred 577 W. 50th Street Miami Beach, FL 33140 Harbour Court L.P., II 250 shares of Series B Preferred 253 W. 73rd St., Apt. 6D New York, NY 10023 Attention: Jonathan Greenwald
Stockholder Name and Address Shares - ----------------------------------------------- ------------------------------------- Namax Corp. 2,000 shares of Series B Preferred 666 Dundee Road, Suite 1801 Northbrook, IL 60062 Attention: Mark Rice, President Sheldon Drobny 500 shares of Series B Preferred 95 Revere Drive, Suite A Northbrook, IL 60062 Perry H. Bacon 620 shares of Series B Preferred 5300 Mission Woods Road Shawnee Mission, KS 66205 James J. Pelts 500 shares of Series B Preferred 29 East Madison Street, Suite 1505 Chicago, IL 60602 Robert Weinstein 217 shares of Series B Preferred 155 West 68th Street 24C New York, NY 10023 The Marcus L. Koblitz Trust, 25 shares of Series B Preferred Michael J. Koblitz, Trustee Est. April 14, 1992 12 Downey Drive Tenafly, NJ 07670 The Lauren J. Koblitz Trust, 25 shares of Series B Preferred Michael J. Koblitz, Trustee Est. April 14, 1992 12 Downey Drive Tenafly, NJ 07670 Pharmaceutical & Medical Technology Fund 3,000 shares of Series B Preferred 300 Park Avenue New York, NY 10022 Strategic Healthcare Fund 1,000 shares of Series B Preferred 300 Park Avenue New York, NY 10022 Michael J. Koblitz 50 shares of Series B Preferred 12 Downey Drive Tenafly, NJ 07670 Allstate Insurance Company Investment Department Allstate Plaza South 650 761,397 shares of Common Stock Northbrook, IL 60062 200,000 shares of Series A Preferred
EX-10.17 7 EXHIBIT 10.17 REGISTRATION RIGHTS AGREEMENT REGISTRATION RIGHTS AGREEMENT (this "AGREEMENT"), dated as of November 18, 1996, by and among each of the persons named on SCHEDULE 1 annexed hereto (each, an "INVESTOR" and collectively, the "INVESTORS"), Gruntal & Co., Incorporated ("GRUNTAL), and LifeCell Corporation, a Delaware corporation (the "COMPANY"). W I T N E S S E T H: WHEREAS, the Investors and the Company have entered into that certain Securities Purchase Agreement, dated as of the date hereof (the "PURCHASE AGREEMENT"), whereby the Investors have purchased (a) an aggregate of 124,157 shares of the Series B Preferred Stock, par value $.001 per share (the "SERIES B PREFERRED STOCK"), of the Company and (b) warrants (the "WARRANTS"; together with the Series B Preferred Stock, the "SECURITIES") to purchase an aggregate of 2,803,530 shares (the "WARRANT SHARES") of common stock, par value $.001 per share ("COMMON STOCK"), of the Company. WHEREAS, the Company has on the date hereof granted to Gruntal, the Company's placement agent in connection with the transactions evidenced by the Purchase Agreement, a warrant (the "GRUNTAL WARRANT") to purchase 354,734 shares (the "GRUNTAL WARRANT SHARES") of Common Stock in connection with such transactions. WHEREAS, the Company desires to grant registration rights to (a) the Investors with respect to the Warrant Shares and the shares of Common Stock into which the Series B Preferred Stock is convertible and (b) Gruntal with respect to the Gruntal Warrant Shares. NOW, THEREFORE, in consideration of the premises and mutual covenants and conditions contained herein and of other good and valuable consideration, the receipt and adequacy of which is hereby acknowledged, Company and the Investors agree as follows: ARTICLE 1. DEFINITIONS All terms not defined herein or below shall have the meanings ascribed thereto in the Purchase Agreement. "EXCHANGE ACT" means the Securities Exchange Act of 1934, as amended, or any similar federal statute, and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. "HOLDER" means an Investor or Gruntal, in either case, in its capacity as a holder of Registrable Securities. "NASD" shall mean the National Association of Securities Dealers, Inc. "REGISTRABLE SECURITIES" means (i) the Warrant Shares, (ii) the shares of Common Stock issued upon the conversion of shares of the Series B Preferred Stock issued pursuant to the Purchase Agreement, (iii) the Gruntal Warrant Shares, (iv) any shares of Common Stock issuable to the Investors pursuant to the right of first refusal set forth in Section 5 of the Purchase Agreement, and (v) any additional shares of Common Stock acquired by the Holder by way of a dividend, stock split or other distribution in respect of the Series B Preferred Stock. As to any particular Registrable Securities, once issued, such securities shall cease to be Registrable Securities at such time when (x) a registration statement with respect to the sale of such securities has been declared effective by the Commission and such securities have been disposed of pursuant to such effective registration statement, (y) such securities have been distributed to the public pursuant to the provisions of Rule 144, or (z) such securities have ceased to be outstanding. For purposes of this Agreement, a Person shall be deemed to be a Holder of Registrable Securities, and the Registrable Securities shall be deemed to be in existence, and such Person shall be entitled to exercise the rights of a Holder of such Registrable Securities hereunder, whenever such Person has the right to acquire, directly or indirectly, such Registrable Securities (upon conversion or exercise in connection with a transfer of securities or otherwise, but disregarding any restrictions or limitations upon the exercise of such right), whether or not such acquisition has actually been effected. "SECURITIES ACT" means the Securities Act of 1933, as amended, or any similar federal statute, and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. "SELLING HOLDER" means an Investor or Gruntal, in either case, in its capacity as a seller of Registrable Securities pursuant to a registration statement under the Securities Act. "UNDERWRITER" means a securities dealer who purchases any Registrable Securities as principal in an underwritten offering and not as part of such dealer's market-making activities. ARTICLE 2. REGISTRATION RIGHTS SECTION 2.1 SHELF REGISTRATION. (a) GENERAL. The Company covenants and agrees with the Investors and Gruntal that the Company will (i) prepare and file with the Commission no later than the 75th day following the Closing Date a registration statement under the Securities Act with respect to the public offering of the Registrable Securities referred to in clauses (i), (ii) and (iii) of the definition of Registrable Securities contained in Article I hereof (a "SHELF REGISTRATION"), (ii) use its best efforts (as used herein the term "best efforts" shall have the meaning commonly accorded such term as used in registration rights agreements similar to this Agreement) to have any such registration statement declared effective as soon as practicable and in any event no later than the 180th day following the Closing Date and (iii) prepare and file such post-effective amendment or amendments to such registration statement with respect to Registrable Securities referred to in clauses (iv) and (v) of the definition of Registrable Securities contained in Article I hereof. The Company hereby agrees to timely file all reports required under the Exchange Act for so long as the Company is obligated to maintain the effectiveness of the registration statement. Once the registration statement described - 2 - in this subsection (a) has been declared effective, the Company shall maintain the registration statement in effect until (x) all Registrable Securities have been sold pursuant thereto or (y) no securities are outstanding that constitute Registrable Securities. (b) EFFECTIVE REGISTRATION. The Shelf Registration shall not be deemed to have been effected unless it has been declared effective by the Commission; PROVIDED, that if, after the registration statement has become effective, the offering of shares of Common Stock pursuant to such Shelf Registration is or becomes the subject of any stop order, injunction or other order or requirement of the Commission or any other governmental or administrative agency, or if any court prevents or otherwise limits the sale of the shares of Common Stock pursuant to the Shelf Registration at any time within 180 days after the effective date of the registration statement, the Shelf Registration shall not be deemed to have been effected. If the Shelf Registration (i) is deemed not to have been effected or (ii) does not remain effective for a period of at least 180 days beyond the effective date thereof or, with respect to an underwritten offering of Registrable Securities, until 45 days after the commencement of the distribution by the Holders of the Registrable Securities included in such registration statement, then the Company shall continue to be obligated to effect such Shelf Registration pursuant to this Section 2.1. (c) OTHER HOLDERS. No securities other than Registrable Securities shall be included in the Shelf Registration. (d) SELECTION OF UNDERWRITER. If the Selling Holders so elect at any time, the offering of such Registrable Securities pursuant to such Shelf Registration shall be in the form of an underwritten offering and, if necessary, the Company shall amend the Shelf Registration to reflect such method of offering. The Selling Holder holding the largest number of Registrable Securities to be sold in such underwritten offering shall select one nationally recognized investment banker to act as the lead managing Underwriter in connection with such offering; and the Selling Holder holding the second largest number of Registrable Securities to be sold in such underwritten offering may at its option select one nationally recognized investment banker to act as the co-managing Underwriter in connection with such offering. SECTION 2.2 PIGGY-BACK REGISTRATION. (a) GENERAL. If at any time the Company proposes to file a registration statement under the Securities Act with respect to an offering by the Company for its own account or for the account of any of its respective security holders (other than a registration statement on Form S-4 or S-8, or any substitute forms thereof that may be adopted by the Commission), a registration pursuant to Section 2.1 or any demand registration provided for pursuant to that certain Underwriters Warrant Agreement dated March 6, 1992, pursuant to which certain registration rights were granted to Robert Todd Financial Corporation), then the Company shall give prompt written notice of such proposed filing to the Holders of Registrable Securities as soon as practicable (but in no event less than twenty (20) days before the anticipated filing date), and such notice shall offer such Holders the opportunity to register such number of Registrable Securities as each such Holder may request (which request shall specify the Registrable Securities intended to be disposed of by such Holder) (a "PIGGY-BACK REGISTRATION"). The Company shall use its best efforts to cause the managing Underwriter or Underwriters of a proposed underwritten offering to permit the Registrable Securities requested to - 3 - be included in a Piggy-Back Registration to be included on the same terms and conditions as any similar securities of the Company or any other security holder included therein and to permit the sale or other disposition of such Registrable Securities in accordance with the intended method of distribution thereof. Any Holder shall have the right to withdraw its request for inclusion of its Registrable Securities in any registration statement pursuant to this Section 2.2 by giving written notice to the Company of its request to withdraw. The Company may withdraw a Piggy-Back Registration at any time prior to the time it becomes effective. No registration effected under this Section 2.2, and no failure to effect a registration under this Section 2.2, shall relieve the Company of its obligation to effect a Shelf Registration pursuant to Section 2.1, and no failure to effect a registration under this Section 2.2 and to complete the sale of Registrable Securities in connection therewith shall relieve the Company of any other obligation under this Agreement (including, without limitation, the Company's obligations under Sections 3.2 and 4.1). (b) REDUCTION. Notwithstanding anything to the contrary contained herein, if the managing Underwriter or Underwriters of any underwritten offering described in this Section 2.2 have informed, in writing, the Holders of the Registrable Securities requesting inclusion in such offering that it is their opinion that the total number of shares which the Company, Holders of Registrable Securities and any other holders of securities of the Company desiring to participate in such registration intend to include in such offering is such as to materially and adversely affect the success of such offering, then the number of shares to be offered shall be reduced or limited in the following order of priority: FIRST, the number of shares to be offered by all other holders of securities of the Company (other than the Holders of Registrable Securities and other holders of securities of the Company who have registration rights, as set forth on SCHEDULE 2.2(B) annexed hereto (collectively, the "OTHER HOLDERS")) to the extent necessary to reduce the total number of shares as recommended by such managing Underwriters; and SECOND, if further reduction or limitation is required, the number of shares to be offered for the account of the Holders and the Other Holders shall be reduced or limited on a PRO RATA basis in proportion to the relative number of securities of the Holders and Other Holders participating in such registration. If, as a result of the proration provisions of this Section 2.2, any Holder shall not be entitled to include at least 50% of the Registrable Securities in a Piggy-Back Registration in which such Holder has requested to be included, such Holder may elect to withdraw his, her or its request to include such Holder's Registrable Securities in such registration (a "WITHDRAWAL ELECTION"); PROVIDED, HOWEVER, that a Withdrawal Election shall be irrevocable and, after making a Withdrawal Election, a Holder shall no longer have any right to include Registrable Securities in the Piggy-Back Registration as to which such Withdrawal Election was made. ARTICLE 3. REGISTRATION PROCEDURES SECTION 3.1 FILINGS; INFORMATION. In connection with the Shelf Registration (including any underwritten public offering pursuant to Section 2.1(d) hereof) or any Piggyback Registration, the Company will use its best efforts to effect the registration and the sale of such Registrable Securities in accordance with the intended method of disposition thereof as quickly as practicable, and in connection with any such request: - 4 - (a) REGISTRATION STATEMENTS. The Company will prepare and file with the Commission a registration statement with respect to such Registrable Securities (which, in the case of any underwritten public offering, shall include such additional information in the prospectus included therein as shall be reasonably requested by the managing Underwriter or Underwriters) and use its best efforts to cause such registration statement to become and remain effective until the completion of the distribution or until the Company's obligations otherwise terminate hereunder. (b) AMENDMENTS AND SUPPLEMENTS. The Company will prepare and file with the Commission such amendments and supplements to such registration statement and the prospectus used in connection therewith as may be necessary to keep such registration statement effective for the period specified in subsection (a) above and as to comply with the provisions of the Securities Act with respect to the disposition of all Registrable Securities covered by such registration statement in accordance with the intended method of disposition set forth in such registration statement for such period. (c) COPIES FOR REVIEW. The Company will, as far in advance as practical, prior to filing a registration statement or prospectus or any amendment or supplement thereto, furnish copies of such registration statement as proposed to be filed, together with exhibits thereto, to (i) each Selling Holder, (ii) not more than one counsel representing all Selling Holders, to be selected by a majority-in-interest of such Selling Holders, and (iii) each Underwriter, if any, of the Registrable Securities covered by such registration statement, which documents will be subject to review and approval by the foregoing within five (5) days after delivery, and thereafter as far in advance as practical, furnish to such Selling Holders, counsel and Underwriters, if any, for their review and comment such number of copies of such registration statement, each amendment and supplement thereto (in each case including all exhibits thereto and documents incorporated by reference therein), the prospectus included in such registration statement (including each preliminary prospectus) and such other documents or information as such Selling Holders, counsel or Underwriters may reasonably request in order to facilitate the disposition of the Registrable Securities owned by such Selling Holders. (d) STOP ORDERS. After the filing of the registration statement, the Company will promptly notify each Selling Holder of Registrable Securities covered by such registration statement of any stop order issued or threatened by the Commission and take all reasonable actions required to prevent the entry of such stop order or to remove it if entered. (e) BLUE SKY. The Company will use its best efforts to (i) register or qualify the Registrable Securities under such other securities or blue sky laws of such jurisdictions in the United States as any Selling Holder reasonably (in light of such Selling Holder's intended plan of distribution) requests, and (ii) cause such Registrable Securities to be registered with or approved by such other governmental agencies or authorities in the United States as may be necessary by virtue of the business and operations of the Company and do any and all other acts and things that may be reasonably necessary or advisable to enable such Selling Holder to consummate the disposition of the Registrable Securities owned by such Selling Holder; PROVIDED, that the Company will not be required to (x) qualify generally to do business in any jurisdiction where it would not otherwise be required to qualify but for this subsection (e), (y) subject itself to taxation in any such jurisdiction or (z) consent to general service of process in any such jurisdiction. - 5 - (f) CERTAIN EVENTS. The Company will immediately notify each Selling Holder, at any time when a prospectus relating thereto is required to be delivered under the Securities Act, of the occurrence of an event requiring the preparation of a supplement or amendment to such prospectus so that, as thereafter delivered to the Holders of such Registrable Securities, such prospectus will not contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading and promptly make available to each Selling Holder any such supplement or amendment. The Company will promptly prepare and if required, cause to become effective, such supplement or amendment and deliver sufficient copies thereof to each Selling Holder. (g) AGREEMENTS. The Company and the Selling Holders will enter into customary agreements (including, if applicable, an underwriting agreement in customary form and which is reasonably satisfactory to the Company) and take such other actions as are reasonably required in order to expedite or facilitate the disposition of such Registrable Securities; and the Selling Holders may, at their option, require that any or all of the representations, warranties and covenants of the Company or to or for the benefit of such Underwriters also be made to and for the benefit of such Selling Holders. (h) DUE DILIGENCE. The Company will make available to each Selling Holder (and their counsel) and each Underwriter, if any, subject to restrictions imposed by the United States federal government or any agency or instrumentality thereof, copies of all correspondence between the Commission and the Company, its counsel or auditors and will also make available for inspection by any Selling Holder, any Underwriter participating in any disposition pursuant to such registration statement and any attorney, accountant or other professional retained by any such Selling Holder or Underwriter (collectively, the "INSPECTORS"), all financial and other records, pertinent corporate documents and properties of the Company (collectively, the "RECORDS") as shall be reasonably necessary to enable them to exercise their due diligence responsibility, and cause the Company's officers and employees to supply all information reasonably requested by any Inspectors in connection with such registration statement. Records which the Company determines, in good faith, to be confidential and which it notifies the Inspectors are confidential shall not be disclosed by the Inspectors unless (i) the disclosure of such Records is necessary to avoid or correct a misstatement or omission in such registration statement or (ii) the disclosure or release of such Records is requested or required pursuant to oral questions, interrogatories, requests for information or documents or a subpoena or other order from a court of competent jurisdiction or other process; PROVIDED, that prior to any disclosure or release pursuant to clause (ii), the Inspectors shall provide the Company with prompt notice of any such request or requirement so that the Company may seek an appropriate protective order or waive such Inspectors' obligation not to disclose such Records; and, PROVIDED FURTHER, that if failing the entry of a protective order or the waiver by the Company permitting the disclosure or release of such Records, the Inspectors, upon advice of counsel, are compelled to disclose such Records, the Inspectors may disclose that portion of the Records which counsel has advised the Inspectors that the Inspectors are compelled to disclose. Each Selling Holder agrees that information obtained by it solely as a result of such inspections (not including any information obtained from a third party who, insofar as is known to the Selling Holder after reasonable inquiry, is not prohibited from providing such information by a contractual, legal or fiduciary obligation to the Company) shall be deemed confidential and shall not be used by it as the - 6 - basis for any market transactions in the securities of the Company or its affiliates (as defined in Rule 405 promulgated under the Securities Act) unless and until such information is made generally available to the public. Each Selling Holder further agrees that it will, upon learning that disclosure of such Records is sought in a court of competent jurisdiction, give notice to the Company and allow the Company, at its expense, to undertake appropriate action to prevent disclosure of the Records deemed confidential. (i) SALES EFFORTS. In connection with an underwritten offering, the Company will participate, to the extent reasonably requested by the managing Underwriter for the offering or the Selling Holders, in customary efforts to sell the securities under the offering, including, without limitation, participating in "road shows"; PROVIDED, that the Company shall not be obligated to participate in more than one such offering in any 12-month period. The Company may require each Selling Holder to promptly furnish in writing to the Company such information regarding the distribution of the Registrable Securities as the Company may from time to time reasonably request and such other information as may be legally required in connection with such registration including, without limitation, all such information as may be requested by the Commission or the NASD. The Company may exclude from such registration any Holder who fails to provide such information. Each Selling Holder agrees that, upon receipt of any notice from the Company of the happening of any event of the kind described in subsection (f) hereof, such Selling Holder will forthwith discontinue disposition of Registrable Securities pursuant to the registration statement covering such Registrable Securities until such Selling Holder's receipt of the copies of the supplemented or amended prospectus contemplated by subsection (f) hereof, and, if so directed by the Company, such Selling Holder will deliver to the Company all copies, other than permanent file copies then in such Selling Holder's possession, of the most recent prospectus covering such Registrable Securities at the time of receipt of such notice. SECTION 3.2 REGISTRATION EXPENSES. In connection with the Shelf Registration and any Piggy-Back Registration, the Company shall pay the following registration expenses incurred in connection with the registration thereunder (the "REGISTRATION EXPENSES"): (i) all registration and filing fees, (ii) fees and expenses of compliance with securities or blue sky laws (including reasonable fees and disbursements of counsel in connection with blue sky qualifications of the Registrable Securities), (iii) processing, duplicating and printing expenses, (iv) the Company's internal expenses (including, without limitation, all salaries and expenses of its officers and employees performing legal or accounting duties), (v) the fees and expenses incurred in connection with the listing of the Registrable Securities, (vi) reasonable fees and disbursements of counsel for the Company and customary fees and expenses for independent certified public accountants retained by the Company (including the expenses of any comfort letters or costs associated with the delivery by independent certified public accountants of a comfort letter or comfort letters requested but not the cost of any audit other than a year end audit), (vii) the reasonable fees and expenses of any special experts retained by the Company in connection with such registration, (viii) reasonable fees and expenses of one firm of counsel for the Holders to be selected by the Holders of at least 66.67% of the Registrable Securities to be included in such registration, and (ix) any other fees and disbursements of underwriters customarily paid by issuers or sellers of securities. The Company - 7 - shall have no obligation to pay any other underwriting fees, discounts or commissions attributable to the sale of Registrable Securities, or the cost of any special audit required, such costs to be borne by the Holder or Holders making the request. SECTION 3.3 ADVICE BY COMPANY. The Company will keep each Holder advised as to the completion of any registration contemplated in this Agreement. At its expense, the Company will furnish promptly to each Holder such number or copies of prospectuses (including preliminary prospectuses), and all amendments and supplements thereto, in conformity with the requirements of the Securities Act, and such other documents as any such Holder from time to time may reasonably request. ARTICLE 4. INDEMNIFICATION AND CONTRIBUTION SECTION 4.1 INDEMNIFICATION BY THE COMPANY. The Company shall, to the full extent permitted by law, indemnify and hold harmless each Selling Holder, its partners, officers, directors, employees and agents, and each person, if any, who controls such Selling Holder within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act, together with the partners, officers, directors, employees and agents of such controlling person (collectively, "HOLDER COVERED PERSONS"), from and against any loss, claim, damage, liability, reasonable attorneys' fees, cost or expense and costs and expenses of investigating and defending any such claim, joint or several, and any action in respect thereof (collectively, the "DAMAGES"), to which any such Holder Covered Person may become subject under the Securities Act or otherwise, insofar as such Damages (or actions or proceedings, whether commenced or threatened, in respect thereof) arise out of, or are based upon, any untrue statement or alleged untrue statement of a material fact contained in any registration statement or prospectus relating to the Registrable Securities or any amendment or supplement thereto, or arises out of, or are based upon, any omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading, or any violation by the Company of any federal or state securities law or any rule or regulation thereof, except insofar as the same are based upon information furnished in writing to the Company by a Selling Holder expressly for use therein, and shall reimburse each Holder Covered Person for any legal and other expenses reasonably incurred by that Holder Covered Person in investigating or defending or preparing to defend against any such Damages or proceedings; PROVIDED, HOWEVER, that the Company shall not be liable to any Selling Holder to the extent that any such Damages (or action or proceeding in respect thereof) arise out of or are based upon any untrue statement or omission made in any preliminary prospectus if (i) such Selling Holder failed to send or deliver a copy of the final prospectus with or prior to the delivery of written confirmation of the sale by such Selling Holder to the person asserting the claim from which such Damages arise, and (ii) the final prospectus would have corrected such untrue statement or such omission; PROVIDED FURTHER, that the Company shall not be liable to any Selling Holder in any such case to the extent that any such Damages arise out of or are based upon any untrue statement or omission in any prospectus if (x) such untrue statement or omission is corrected in an amendment or supplement to such prospectus, and (y) having previously been furnished by or on behalf of the Company with copies of such prospectus as so amended or supplemented, such Selling Holder thereafter fails to deliver such prospectus as so amended or supplemented prior to or concurrently with the sale of a Registrable Security to the person asserting - 8 - the claim from which such Damages arise. The Company also agrees to indemnify any Underwriters of the Registrable Securities, their officers and directors and each person who controls any such Underwriters on substantially the same basis as that of the indemnification of the Selling Holders provided in this Section 4.1. SECTION 4.2 INDEMNIFICATION BY SELLING HOLDERS. Each Selling Holder shall, to the full extent permitted by law, severally but not jointly, indemnify and hold harmless the Company, its officers, directors, employees and agents and each person, if any, who controls the Company within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act, together with the partners, officers, directors, employees and agents of such controlling person (collectively, "COMPANY COVERED PERSONS"), to the same extent as the foregoing indemnity from the Company to such Selling Holder, but only with reference to information related to such Selling Holder, or its plan of distribution, furnished in writing by such Selling Holder or on such Selling Holder's behalf expressly for use in any registration statement or prospectus relating to the Registrable Securities, or any amendment or supplement thereto, or any preliminary prospectus and the aggregate amount which may be recovered from any Selling Holder pursuant to the indemnification provided for in this Section 4.2 in connection with any registration and sale of Registrable Securities shall be limited to the total proceeds received by such Holder from the sale of such Registrable Securities. In case any action or proceeding shall be brought against any Company Covered Person in respect of which indemnity may be sought against such Selling Holder, such Selling Holder shall have the rights and duties given to the Company Covered Persons, and the Company Covered Persons shall have the rights and duties given to such Selling Holder, by Section 4.1. Each Selling Holder also agrees to indemnify and hold harmless any Underwriters of the Registrable Securities, their officers and directors and each person who controls such Underwriters on substantially the same basis as that of the indemnification of the Company provided in this Section 4.2. The Company shall be entitled to receive indemnities from Underwriters, selling brokers, dealer managers and similar securities industry professionals participating in the distribution, to the same extent as provided above, with respect to information so furnished in writing by such persons specifically for inclusion in any prospectus or registration statement. SECTION 4.3 CONDUCT OF INDEMNIFICATION PROCEEDINGS. Promptly after receipt by any person in respect of which indemnity may be sought pursuant to Section 4.1 or 4.2 (an "INDEMNIFIED PARTY") of notice of any claim or the commencement of any action, the Indemnified Party shall, if a claim in respect thereof is to be made against the person against whom such indemnity may be sought (an "INDEMNIFYING PARTY"), notify the Indemnifying Party in writing of the claim or the commencement of such action; PROVIDED that the failure to notify the Indemnifying Party shall not relieve it from any liability which it may have to an Indemnified Party otherwise than under Section 4.1 or 4.2 and except to the extent of any actual prejudice resulting therefrom. If any such claim or action shall be brought against an Indemnified Party, and it shall notify the Indemnifying Party thereof, the Indemnifying Party shall be entitled to participate therein, and, to the extent that it wishes, jointly with any other similarly notified Indemnifying Party, to assume the defense thereof with counsel reasonably satisfactory to the Indemnified Party. After notice from the Indemnifying Party to the Indemnified Party of its election to assume the defense of such claim or action, the Indemnifying Party shall not be liable to the Indemnified Party for any legal or other expenses subsequently incurred by the Indemnified Party in connection with the defense thereof other than reasonable costs of investigation; PROVIDED that the Indemnified Party shall have the right to employ - 9 - separate counsel to represent the Indemnified Party and its Controlling Persons who may be subject to liability arising out of any claim in respect of which indemnity may be sought by the Indemnified Party against the Indemnifying Party, but the fees and expenses of such counsel shall be for the account of such Indemnified Party unless (i) the Indemnifying Party and the Indemnified Party shall have mutually agreed to the retention of such counsel or (ii) in the reasonable judgment of the Company and such Indemnified Party, representation of both parties by the same counsel would be inappropriate due to actual or potential conflicts of interest between them, it being understood, however, that the Indemnifying Party shall not, in connection with any one such claim or action or separate but substantially similar or related claims or actions in the same jurisdiction arising out of the same general allegations or circumstances, be liable for the fees and expenses of more than one separate firm of attorneys (together with appropriate local counsel) at any time for all Indemnified Parties, or for fees and expenses that are not reasonable. No Indemnifying Party shall, without the prior written consent of the Indemnified Party, effect any settlement of any claim or pending or threatened proceeding in respect of which the Indemnified Party is or could have been a party and indemnity could have been sought hereunder by such Indemnified Party, unless such settlement includes an unconditional release of such Indemnified Party from all liability arising out of such claim or proceeding. Whether or not the defense of any claim or action is assumed by the Indemnifying Party, such Indemnifying Party will not be subject to any liability for any settlement made without its consent, which consent will not be unreasonably withheld. SECTION 4.4 CONTRIBUTION. If the indemnification provided for in this Article 4 is unavailable to the Indemnified Parties in respect of any Damages referred to herein, then each Indemnifying Party, in lieu of indemnifying such Indemnified Party, shall contribute to the amount paid or payable by such Indemnified Party as a result of such Damages (i) as between the Company and the Selling Holders on the one hand and the Underwriters on the other, in such proportion as is appropriate to reflect the relative benefits received by the Company and the Selling Holders on the one hand and the Underwriters on the other from the offering of the Registrable Securities, or if such allocation is not permitted by applicable law, in such proportion as is appropriate to reflect not only the relative benefits but also the relative fault of the Company and the Selling Holders on the one hand and of the Underwriters on the other in connection with the statements or omissions which resulted in such Damages, as well as any other relevant equitable considerations, and (ii) as between the Company on the one hand and each Selling Holder on the other, in such proportion as is appropriate to reflect the relative fault of the Company and of each Selling Holder in connection with such statements or omissions, as well as any other relevant equitable considerations. The relative benefits received by the Company and the Selling Holders on the one hand and the Underwriters on the other shall be deemed to be in the same proportion as the total proceeds from the offering (net of underwriting discounts and commissions but before deducting expenses) received by the Company and the Selling Holders bear to the total underwriting discounts and commissions received by the Underwriters, in each case as set forth in the table on the cover page of the prospectus. The relative fault of the Company and the Selling Holders on the one hand and of the Underwriters on the other shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by the Company and the Selling Holders or by the Underwriters. The relative fault of the Company on the one hand and of each Selling Holder on the other shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information - 10 - supplied by such party, and the parties' relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. The Company and the Selling Holders agree that it would not be just and equitable if contribution pursuant to this Section 4.4 were determined by PRO RATA allocation (even if the Underwriters were treated as one entity for such purpose) or by any other method of allocation which does not take account of the equitable considerations referred to in the immediately preceding paragraph. The amount paid or payable by an Indemnified Party as a result of the Damages referred to in the immediately preceding paragraph shall be deemed to include, subject to the limitations set forth above, any legal or other expenses reasonably incurred by such Indemnified Party in connection with investigating or defending any such action or claim. Notwithstanding the provisions of this Section 4.4, no Underwriter shall be required to contribute any amount in excess of the amount by which the total price at which the Registrable Securities underwritten by it and distributed to the public were offered to the public exceeds the amount of any damages which such Underwriter has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission, and no Selling Holder shall be required to contribute any amount in excess of the amount by which the total price at which the Registrable Securities of such Selling Holder were offered to the public (less underwriting discounts and commissions) exceeds the amount of any damages which such Selling Holder has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission. No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation. Each Selling Holder's obligations to contribute pursuant to this Section 4.4 is several in the proportion that the proceeds of the offering received by such Selling Holder bears to the total proceeds of the offering received by all the Selling Holders and not joint. ARTICLE 5. MISCELLANEOUS SECTION 5.1 OTHER REGISTRATION RIGHTS; HOLDBACK. The Company represents and warrants to the Holders that, except as set forth on SCHEDULE 2.2(B), there is not in effect on the date hereof any agreement by the Company pursuant to which any holders of securities of the Company have a right to cause the Company to register or qualify such securities under the Securities Act or any securities or blue sky laws of any jurisdiction that would conflict in any material respect with any provision of this Agreement. The Company shall not in the future grant to any owner or purchaser of shares of capital stock of the Company registration rights unless (a) such registration rights are made subordinate to the rights granted hereunder so that each Holder shall have priority to participate in any piggy-back registration with respect to such other shares of capital stock of the Company and (b) if the offering by the Holders is underwritten, such owner or purchaser agrees not to sell any shares of capital stock of the Company during the period commencing ten (10) days prior to any such underwritten offering and ending ninety (90) days following any such underwritten offering (or for such shorter period of time as is sufficient and appropriate, in the opinion of any managing Underwriter(s)). If requested by managing Underwriter(s) in any such registration, the Company shall request the directors and executive officers of the Company to execute and deliver similar holdback agreements. - 11 - SECTION 5.2 PARTICIPATION IN UNDERWRITTEN REGISTRATIONS. No person may participate in any underwritten registration hereunder unless such person (a) agrees to sell such person's securities on the basis provided in any underwriting arrangements approved by the persons entitled hereunder to approve such arrangements, and (b) completes and executes all questionnaires, powers of attorney, indemnities, underwriting agreements and other documents reasonably required under the terms of such underwriting arrangements and these registration rights. Notwithstanding the foregoing, no Holder of Registrable Securities shall be required to make any representations or warranties to or agreements with the Company or the Underwriters other than those customarily made by selling stockholders in such registrations, including without limitation representations, warranties or agreements regarding such Holder and its ownership of the securities being registered on its behalf and such Holder's intended method of distribution and any other representation required by law. SECTION 5.3 HOLDBACK AGREEMENT. For so long as the Holder has the right to have Registrable Securities included in any registration pursuant to this Agreement, the Holder agrees in connection with any underwritten registration of the Company's securities, upon the request of the Underwriters managing such underwritten offering of the Company's securities, not to effect any public sale or distribution (including any sale pursuant to Rule 144 under the Securities Act) of any Registrable Securities without the prior written consent of the Company or such Underwriters, as the case may be, within ten (10) days prior to or ninety (90) days after the effective date of such registration, as the Company or the Underwriters may specify. SECTION 5.4 SUSPENSION OF TRADING. After the Company has filed any registration statement pursuant to this Agreement, and if such registration shall be in connection with an underwritten offering of the Company's securities, upon the request of the managing Underwriter or Underwriters the Company may suspend the sale of Common Stock for up to ninety (90) days; PROVIDED, HOWEVER, that no such suspension shall occur on more than one occasion within any one year period. SECTION 5.5 RULE 144 AND 144A. The Company covenants that it will file any reports required to be filed by it under the Securities Act and the Exchange Act and that it will take such further action as any Holder may reasonably request, all to the extent required from time to time to enable Holders to sell Registrable Securities without registration under the Securities Act within the limitation of the exemptions provided by (a) Rule 144 or Rule 144A under the Securities Act, as such Rules may be amended from time to time, or (b) any similar rule or regulation hereafter adopted by the Commission. Upon the request of any Holder, the Company will deliver to such Holder a written statement as to whether it has complied with such requirements. SECTION 5.6 SUSPENSION OF OBLIGATION TO FILE. Notwithstanding the provisions of Section 3.1(a), the Company's obligations to file a registration statement, or cause such registration statement to become and remain effective, shall be suspended for a period not to exceed 90 days if there exists at the time material non-public information relating to the Company that, in the reasonable opinion of the Company, should not be disclosed. SECTION 5.7 GENERAL. - 12 - (a) GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAW OF THE STATE OF NEW YORK, WITHOUT GIVING EFFECT TO PRINCIPLES OF CONFLICTS OF LAW. (b) NOTICES. All notices or other communications shall be in writing and shall be personally served or mailed, registered or certified, return receipt requested, postage prepaid (or by a substantially similar method), or delivered by a reputable overnight courier service with charges prepaid, or transmitted by hand delivery or facsimile, addressed as set forth below, or such other address as such party shall have specified most recently by written notice: If to the Company: LifeCell Corporation 3606 Research Forest Drive The Woodlands, Texas 77381 Attention: President Telephone: (713) 367-5368 Telecopy: (713) 363-3360 with a copy to: Fulbright & Jaworski L.L.P. 1301 McKinney Street, Suite 5100 Houston, Texas 77010-3095 Attention: Robert E. Wilson, Esq. Telephone: (713) 651-5151 Telecopy: (713) 651-5246 Notice to any Holder shall be sent to the address listed on SCHEDULE 1 or to such other address which the Holder shall have provided in writing in accordance with this Section 5.7(b). Notice shall be deemed given or delivered on the date of service or transmission if personally served or transmitted by telecopier (with telephonic confirmation of receipt). Notice otherwise sent as provided herein shall be deemed given or delivered on the third business day following the date of postmark or on the next business day following delivery of such notice to a reputable overnight courier service. (c) BINDING EFFECT. This Agreement and all of the provisions hereof shall be binding upon and inure to the benefit of the parties hereto and their respective heirs, successors and permitted assigns. (d) NO WAIVER. No failure on the part of the Company or the Investors in exercising any right, power or privilege granted hereunder shall operate as a waiver thereof or of any other right, power or privilege, nor shall any single or partial exercise of such right, power or privilege preclude any other or further exercise thereof or of any other right, power or privilege. - 13 - (e) ENTIRE AGREEMENT. This Agreement sets forth the entire agreement among the parties hereto with respect to the subject matter hereof, and supersedes any prior oral or written agreements among the parties. (f) HEADINGS. The headings of this Agreement are solely for the convenience of the parties and shall not affect the interpretation or effect of any terms or provisions hereof. (g) COUNTERPARTS. This Agreement may be executed in two or more counterparts, each of which shall be deemed to be an original, but all of which together shall constitute one and the same document. (h) SEVERABILITY. In the event that any court or any governmental authority or agency declares all or any part of any Section of this Agreement to be unlawful or invalid, such unlawfulness or invalidity shall not serve to invalidate any other Section of this Agreement, and in the event that only a portion of any Section is so declared to be unlawful or invalid, such unlawfulness or invalidity shall not serve to invalidate the balance of such Section. (i) AMENDMENTS AND WAIVERS. This Agreement may be amended, modified and supplemented, and compliance with any term, covenant, agreement or condition contained herein may be waived either generally or in particular instances, only by a written instrument executed by the Company and the holders of at least a majority of the then outstanding Registrable Securities (for this purpose, treating (i) the Series B Preferred Stock as if it had been converted into Common Stock and (ii) each of the Warrants and the Gruntal Warrant that is then exercisable pursuant to its terms as if it had been exercised in full). No course of dealing between or among any persons having any interest in this Agreement will be deemed effective to modify, amend or discharge any part of this Agreement or any rights or obligations of any person under or by reason of this Agreement. (j) FURTHER ASSURANCES. Each party shall cooperate and take such action as may be reasonably requested by another party in order to carry out the provisions and purposes of this Agreement and the transactions contemplated hereby. (k) REMEDIES. In the event of a breach or a threatened breach by any party to this Agreement of its obligations under this Agreement, any party injured or to be injured by such breach will be entitled to specific performance of its rights under this Agreement or to injunctive relief, in addition to being entitled to exercise all rights provided in this Agreement and granted by law. The parties agree that the provisions of this Agreement shall be specifically enforceable, it being agreed by the parties that the remedy at law, inducing monetary damages, for breach of any such provision will be inadequate compensation for any loss and that any defense or objection in any action for specific performance or injunctive relief that a remedy at law would be adequate is waived. * * * * * - 14 - IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first above written. LIFECELL CORPORATION By /s/PAUL M. FRISON Paul M. Frison President and Chief Executive Officer VECTOR LATER-STAGE EQUITY FUND, L.P. By Vector Fund Management, L.P., its General Partner By Unreadable Signature Its President CIBC WOOD GUNDY VENTURES, INC. By /s/LORI KOFFMAN Name:Lori Koffman Title:Managing Director - 15 - GRUNTAL & CO., INCORPORATED By Name: Title: - 16 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ DAVID SAKS (Signature) Name: David Saks - 17 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. The Woodlands Venture Capital Company By: /S/ DON E. ROOSE, JR. (Signature) Name: Don E. Roose, Jr. Vice President and Controller - 18 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ CHRISTOPHER C. KRAFT, JR. (Signature) Name: Christopher C. Kraft, Jr. - 19 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ P. WILLIAM CURRERI, M.D. (Signature) Name: P. William Curreri - 20 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 6th day of November, 1996. /S/ STEPHEN LIVESEY (Signature) Name: Stephen Livesey - 21 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ LISA B. TUCKERMAN (Signature) Name: Lisa B. Tuckerman Managing Director of the General Partner, S.B.S.F. Biotechnology Partners, L.P. - 22 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JEROME SCHACHTER (Signature) Name: Jerome Schachter - 23 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JOHN S. BAI (Signature) Name: John S. Bai - 24 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ ROBERT WEINSTEIN (Signature) Name: Robert Weinstein - 25 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JAMES C. GALE /S/ JUDITH S. HASELTON (Signature) Name: James C. Gale Judith S. Haselton - 26 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JAMES C. GALE, TRUSTEE (Signature) Name: James C. Gale, Trustee F/B/O Ariana J. Gale - 27 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /S/ JOHN CIRRITO (Signature) Name: John Cirrito - 28 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ B. MICHAEL PISANI (Signature) Name: B. Michael Pisani - 29 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /S/ JOHN LATSHAW (Signature) Name: John Latshaw - 30 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ EVAN KLEINBERG (Signature) Name: Evan Kleinberg - 31 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ DOUGLAS KLEINBERG (Signature) Name: Douglas Kleinberg - 32 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ DANIEL KLEINBERG /S/ ELAINE KLEINBERG (Signature) Name: Daniel & Elaine Kleinberg - 33 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ ALLEN L. BOORSTEIN (Signature) Name: Allen L. Boorstein, General Partner Chinook Equities - 34 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /S/ BARRY RICHTER (Signature) Name: Barry Richter - 35 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ STEPHEN G. WEISS (Signature) Name: Stephen G. Weiss - 36 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JOSEPH BATTIPAGLIA (Signature) Name: Joseph Battipaglia - 37 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ WILLIAM J. STRAZZULLO (Signature) Name: William J. Strazullo - 38 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ ROBERT SABLOWSKY (Signature) Name: Robert Sablowsky - 39 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /S/ JOHN D. GOLDBERG (Signature) Name: John D. Goldberg - 40 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JOSEPH A. RUSSO (Signature) Name: Jospeh A. Russo - 41 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 31st day of October, 1996. /S/ MICHAEL GIRONTA (Signature) Name: Michael Gironta - 42 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ DONNA GREENBERG /S/ CHARLES L. GREENBERG (Signature) Name: Donna Greenberg Charles L. Greenberg - 43 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ RICHARD L. SERRANO (Signature) Name: Richard L. Serrano - 44 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. /S/ DAVID HARRIS /S/ MARY JANE HARRIS (Signature) Name: David Harris Mary Jane Harris - 45 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ PAUL B. ANKIN /S/ LOIS F. ANKIN (Signature) Name: Paul B. Ankin & Lois F. Ankin - 46 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ JEROME SCHACHTER (Signature) Name: Jerome Schachter - 47 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ MICHAEL J. KOBLITZ (Signature) Name: Michael J. Koblitz, as Trustee - 48 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ SHELDON DROBNY (Signature) Name: Sheldon Drobny - 49 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 5th day of November, 1996. /S/ PERRY H. BACON (Signature) Name: Perry H. Bacon - 50 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ JAMES J. PELTS (Signature) Name: James J. Pelts - 51 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ ROBERT WEINSTEIN (Signature) Name: Robert Weinstein - 52 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this ____ day of November, 1996. TECHNOLOGY FUNDING MEDICAL PARTNERS L.L.P. By: Technology Funding, Inc. Managing General Partner By:/S/ THOMAS J. TOY Name: Thomas J. Toy Vice President - 53 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 2nd day of November, 1996. /S/ RONALD KOENIG (Signature) Name: Ronald Koenig - 54 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ ROBERT M. ADAMS (Signature) Name: Robert M. Adams - 55 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ E. A. KERBS (Signature) Name: E. A. Kerbs - 56 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/Bernard B. Salzman (Signature) Name: Bernard B. Salzman IRA Gruntal & Co. Custodian - 57 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ MICHAEL H. RICHMOND (Signature) Name: Michael H. Richmond - 58 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 2nd day of November, 1996. /S/ MICHAEL E. CAHR (Signature) Name: Michael E. Cahr - 59 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 11th day of November, 1996. /S/ DON E. SANDERS (Signature) Name: Don E. Sanders - 60 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ JEFFREY R. KEELER (Signature) Name: Jeffrey R. Keeler - 61 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ JONATHAN GREENWALD AS GENERAL PARTNER (Signature) Name: Jonathan Greenwald as General Partner - 62 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 4th day of November, 1996. /S/ MARK RICE (Signature) Name: Mark Rice Namax Corp. - President - 63 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 1st day of November, 1996. /S/ LISA B. TUCKERMAN (Signature) Name: Lisa B. Tuckerman Managing Director of the General Partner, S.B.S.F. Biotechnology Fund, L.P. - 64 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 6th day of November, 1996. /S/ FREDERIC GREENBERG (Signature) Name: Frederic Greenberg - 65 - [REGISTRATION RIGHTS AGREEMENT] SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT BETWEEN LIFECELL CORPORATION (THE "COMPANY") AND CERTAIN INVESTORS, RELATING TO THE SALE OF THE COMPANY'S SERIES B PREFERRED STOCK AND WARRANTS AS DESCRIBED IN THE COMPANY'S PRIVATE PLACEMENT MEMORANDUM, DATED OCTOBER 29, 1996. The undersigned hereby authorizes Gruntal & Co., Incorporated to deliver this signature page to the Company at the closing of the offering of the Company's offering of Series B Preferred Stock. Dated this 6th day of November, 1996. /S/ MICHAEL J. KOBLITZ (Signature) Name: Michael J. Koblitz - 66 - SCHEDULE 1 INVESTORS Vector Later-Stage Equity Fund, L.P. 1751 Lake Cook Road, Suite 350 Deerfield, Illinois 60015 CIBC Wood Gundy Ventures, Inc. 425 Lexington Avenue New York, New York 10017 The Woodlands Venture Capital Company 2201 Timberloch Place The Woodlands, TX 77380 SBSF Biotechnology Fund, L.P. c/o Lisa Tuckerman Spears Benzak Salomon & Farrell 45 Rockefeller Plaza -- 33rd Floor New York, NY 10111 SBSF Biotechnology Partners, L.P. c/o Lisa Tuckerman Spears Benzak Salomon & Farrell 45 Rockefeller Plaza -- 33rd Floor New York, NY 10111 Jerome Schachter 2926 Leanne Court Northbrook, IL 60062 Paul B. Ankin and Lois F. Ankin, as joint tenants 4233 W. Grove Skokie, IL 60076 David and Mary Jane Harris 174 Pacific Street, Apt. 2A Brooklyn, NY 11201 Richard L. Serrano 64 Brighton Avenue Bloomfield, NJ 07003 Charles and Donna Greenberg 503 Pinehurst Court Roslyn, NY 11576 Michael Gironta 89 Ridgewood Avenue Glen Ridge, NJ 07028 Joseph A. Russo 3 Midwood Avenue Verona, NJ 07044 John D. Goldberg 2500 East Hallandale Beach Blvd. Suite 500 Hallandale, FL 33009-4838 Robert Sablowsky 150 East 69th Street, 16A New York, NY 10021 William J. Strazzullo 750 Columbus Avenue, 4C New York, NY 10025 Joseph Battipaglia 77 Water Street (10th Floor) New York, NY 10005 Stephen G. Weiss 115 Ravin Oaks Lane Highland Park, IL 60035 Barry Richter Tideway Sandspoint, NY 11050 Chinook Equities, Inc. 147 East 48th Street - 67 - New York, NY 10017 Daniel and Elaine Kleinberg 3 Centennial Road Livingston, NJ 07039 Douglas Kleinberg 200 East 95th Street, Apt. 126 New York, NY 10128 Evan Kleinberg IRA Gruntal & Co. Custodian 3 Centennial Road Livingston, NJ 07039 John Latshaw 5049 Wornall #2C Kansas City, MO 64112 B. Michael Pisani 44 Lake Road Short Hills, NJ 07078 John Cirrito 29 Rambling Drive Scotch Plains, NJ 07076 James C. Gale, Trustee F/B/O Ariana J. Gale 315 W. 106th Street, Apt. 4A New York, NY 10025 James C. Gale and Judith S. Haselton 315 West 106th Street, Apt. 4A New York, NY 10025 Robert Weinstein 155 West 68th Street, 24C New York, NY 10023 John S. Bai 30 West 61st, 27A New York, NY 10023 William J. McCluskey 25 Wisconsin Street Long Beach, NY 11561 - 68 - David F. Saks 2 Knollcliff Road Woodcliff Lake, NJ 07675 P. William Curreri, M.D. 217 Berwyn Drive, W. #222 Mobile, Alabama 36608 Christopher C. Kraft, Jr. Smith Barney Inc. KEO P/S Custodian 14919 Village Elm Street Houston, TX 77062 Michael H. Richmond 20 E. Wedgewood Glen The Woodlands, TX 77381 Stephen Livesey 3606 Research Forest Drive The Woodlands, TX 77381 Michael E. Cahr 1051 Saxony Drive Highland Park, IL 60035 Technology Funding Medical Partners I, L.P. 2000 Alameda de las Pulgas San Mateo, CA 94403 Ronald Koenig 114 No. Village Way Jupiter, Florida 33458 Robert M. Adams P.O. Box 998 Plandome, NY 11030 Edward A. Kerbs 8 South Cherry Lane Rumson, NJ 07760 Bernard B. Salzman IRA, Gruntal & Co., Inc., Custodian 20 S. Charles Street Baltimore, MD 21201 Don A. Sanders 3100 Texas Commerce Tower Houston, TX 77002 Jeffrey Keeler 577 W. 50th Street Miami Beach, FL 33140 Harbour Court L.P., II 253 W. 73rd St., Apt. 6D New York, NY 10023 Attention: Jonathan Greenwald Namax Corp. 666 Dundee Road, Suite 1801 Northbrook, IL 60062 Attention: Mark Rice, President Sheldon Drobny 95 Revere Drive, Suite A Northbrook, IL 60062 Perry H. Bacon 5300 Mission Woods Road Shawnee Mission, KS 66205 James J. Pelts 29 East Madison Street, Suite 1505 Chicago, IL 60602 The Marcus L. Koblitz Trust Michael J. Koblitz, Trustee 12 Downey Drive Tenafly, NJ 07670 The Lauren J. Koblitz Trust, Michael J. Koblitz, Trustee 12 Downey Drive Tenafly, NJ 07670 - 69 - Pharmaceutical & Medical Technology Fund 300 Park Avenue New York, NY 10022 Strategic Healthcare Fund 300 Park Avenue New York, NY 10022 Michael J. Koblitz 12 Downey Drive Tenafly, NJ 07670 SCHEDULE 2.2(B) OTHER REGISTRATION RIGHTS The holders of capital stock listed below pursuant to the Amended and Restated Registration Rights Agreement, dated February 26, 1992, as amended, by and among the Company and the holders of capital stock of the Company identified therein: Allstate Insurance Company The Woodlands Venture Fund, L.P. Tenneco Insurance Ventures, Inc. The Woodlands Venture Capital Company Board of Regents of the University of Texas System Technology Funding Partners III, L.P. Paul M. Frison Robert Todd Financial Corporation pursuant to the Underwriter's Warrant Agreement, dated March 6, 1992, between the Company and Robert Todd Financial Corporation, as amended by First Amendment to Underwriter's Warrant Agreement, dated January 23, 1993, by and between the Company and Robert Todd Financial Corporation. Medtronic, Inc. pursuant to the Investment Agreement, dated March 3, 1994, as amended, between the Company and Medtronic, Inc. - 70 - EX-10.18 8 EXHIBIT 10.18 This Warrant was originally issued on November 18, 1996, and such issuance was not registered under the Securities Act of 1933, as amended. The transfer of this Warrant and the securities obtainable upon exercise thereof is subject to the conditions on transfer specified in the Securities Purchase Agreement, dated as of November 18, 1996 (as amended and modified from time to time), between the issuer hereof (the "COMPANY") and the initial holder hereof, and the Company reserves the right to refuse the transfer of such security until such conditions have been fulfilled with respect to such transfer. Upon written request, a copy of such conditions shall be furnished by the Company to the holder hereof without charge. LIFECELL CORPORATION STOCK PURCHASE WARRANT Date of Issuance: November 18, 1996 Certificate No. BW-___ FOR VALUE RECEIVED, LIFECELL Corporation, a Delaware corporation (the "COMPANY"), hereby grants to _________________________________________ or its registered assigns (the "REGISTERED HOLDER") the right to purchase from the Company __________ shares of the Company's Common Stock, par value $.001 per share ("COMMON STOCK"), at a price per share of $4.13 (as adjusted from time to time hereunder, the "EXERCISE PRICE"). This Warrant is one of several warrants (collectively, the "WARRANTS") issued by the Company to certain investors pursuant to the Securities Purchase Agreement, dated as of November 18, 1996 (the "PURCHASE AGREEMENT"). Certain capitalized terms used herein are defined in Section 5 hereof. The amount and kind of securities obtainable pursuant to the rights granted hereunder and the purchase price for such securities are subject to adjustment pursuant to the provisions contained in this Warrant. This Warrant is subject to the following provisions: Section 1. EXERCISE OF WARRANT. 1A. EXERCISE PERIOD. Subject to the provisions of Paragraph 1B, the Registered Holder may exercise, in whole or in part (but not as to a fractional share of Common Stock), the purchase rights represented by this Warrant at any time and from time to time after the Date of Issuance to and including the fifth anniversary thereof (the "EXERCISE PERIOD"). The Company shall give the Registered Holder written notice of the expiration of the rights hereunder at least 30 days but not more than 90 days prior to the end of the Exercise Period. In the event the Company fails to give the Registered Holder such notice, the Exercise Period shall continue until and terminate on the thirtieth calendar day following the day the Company gives such notice. 1 1B. MANDATORY EXERCISE. Notwithstanding the provisions of Paragraph 1A, during the period commencing with the second anniversary of the Date of Issuance through the Exercise Period (the "MANDATORY EXERCISE PERIOD"), upon written notice from the Company evidencing that the Current Market Price equals or exceeds an amount equal to three times the then Exercise Price (the "MANDATORY EXERCISE NOTICE"), the Registered Holder shall exercise all (but not as to any fractional share of Common Stock) of the purchase rights represented by this Warrant; provided that, notwithstanding the foregoing, the Registered Holder shall have no obligation pursuant to this Paragraph 1B to exercise any portion of the purchase rights represented by this Warrant on any date if on such date or at any time during the 30 consecutive trading day period ending immediately prior to such date the Common Stock is not listed or admitted to trading on any national securities exchange and is not traded over the counter and reported by Nasdaq or any comparable system. for purposes of this paragraph, "CURRENT MARKET PRICE" means, at any date during the Mandatory Exercise Period, the average of the daily closing price per share of Common Stock for the 30 consecutive trading day period during the Mandatory Exercise Period ending on the trading day immediately before such date ( as adjusted for any stock dividend, split, combination or reclassification that took effect during such 30 trading day period). The closing price for each day shall be the last reported sale price on the principal national securities exchange on which Common Stock is listed or admitted to trading or if not listed or admitted to trading on any national securities exchange, as reported by Nasdaq, if such security is traded over the counter and quoted in the Nasdaq National Market or Nasdaq Small Cap Market, or if such equity security is so traded, but not so quoted, the closing bid price of Common Stock as reported by Nasdaq or any comparable system. The Registered Holder shall be required to exercise pursuant to Paragraph 1C all of the then unexercised purchase rights represented by this Warrant no earlier than the 30th day following the Registered Holder's receipt of the Mandatory Exercise Notice. 1C. EXERCISE PROCEDURE. (i) This Warrant shall be deemed to have been exercised at such time when the Company has received all of the following items (the "EXERCISE TIME"): (a) a completed Exercise Agreement, as described in Paragraph 1D, executed by the Person exercising all or part of the purchase rights represented by this Warrant (the "PURCHASER"); (b) this Warrant; (c) if this Warrant is not registered in the name of the Purchaser, an Assignment or Assignments in the form set forth in EXHIBIT I hereto evidencing the assignment of this Warrant to the Purchaser, in which case the Registered Holder shall have complied with the provisions set forth in Section 7 hereof; and 2 (d) either (1) a check payable to the Company in an amount equal to the product of the Exercise Price multiplied by the number of shares of Common Stock being purchased upon such exercise (the "AGGREGATE EXERCISE PRICE"), (2) the surrender to the Company of debt or equity securities of the Company or any of its wholly-owned Subsidiaries having a Market Price equal to the Aggregate Exercise Price of the shares of Common Stock being purchased upon such exercise (provided that for purposes of this subparagraph 1C(i)(d), the Market Price of any note or other debt security or any preferred stock shall be deemed to be equal to the aggregate outstanding principal amount or liquidation value thereof plus all accrued and unpaid interest thereon or accrued or declared and unpaid dividends thereon) or (3) a written notice to the Company that the Purchaser is exercising this Warrant (or a portion thereof) by authorizing the Company to withhold from issuance a number of shares of Common Stock issuable upon such exercise of this Warrant which when multiplied by the Market Price of the Common Stock is equal to the Aggregate Exercise Price (and such withheld shares shall no longer be issuable under this Warrant). (ii) Certificates for shares of Common Stock purchased upon exercise of this Warrant shall be delivered by the Company to the Purchaser as soon as practicable but in any event within ten business days after the date of the Exercise Time. Unless this Warrant has expired or all of the purchase rights represented hereby have been exercised, the Company shall prepare a new Warrant, substantially identical hereto, representing the rights formerly represented by this Warrant which have not expired or been exercised and shall within such ten-day period, deliver such new Warrant to the Person designated for delivery in the Exercise Agreement. (iii) The shares of Common Stock issuable upon the exercise of this Warrant shall be deemed to have been issued to the Purchaser at the Exercise Time, and the Purchaser shall be deemed for all purposes to have become the record holder of such shares of Common Stock at the Exercise Time. (iv) The issuance of certificates for shares of Common Stock issued upon exercise of this Warrant shall be made without charge to the Registered Holder for any issuance tax in respect thereof or other cost incurred by the Company in connection with such exercise and the related issuance of shares of Common Stock. Each share of Common Stock issuable upon exercise of this Warrant shall, upon payment of the Exercise Price therefor, be fully paid and nonassessable and free from all liens and charges with respect to the issuance thereof. (v) The Company shall not close its books against the transfer of this Warrant or of any share of Common Stock issued or issuable upon the exercise of this Warrant in any manner which interferes with the timely exercise of this Warrant. The Company shall from time to time take all such action as may be necessary to assure that the par value per share of the unissued Common Stock acquirable upon exercise of this Warrant is at all times equal to or less than the Exercise Price then in effect. 3 (vi) The Company shall assist and cooperate with the Registered Holder or the Purchaser, as the case may be, in connection with any governmental filings or any governmental approvals required to be made or obtained by the Registered Holder or the Purchaser, as the case may be, prior to or in connection with any exercise of this Warrant (including, without limitation, making any filings required to be made by the Company). (vii) Notwithstanding any other provision hereof, if an exercise of any portion of this Warrant is to be made in connection with a registered public offering or the sale of the Company, such exercise may, at the election of the holder hereof, be conditioned upon the consummation of the public offering or sale of the Company in which case such exercise shall not be deemed to be effective until the consummation of such transaction. (viii) The Company shall at all times reserve and keep available out of its authorized but unissued shares of Common Stock solely for the purpose of issuance upon the exercise of the Warrants, such number of shares of Common Stock issuable upon the exercise of all outstanding Warrants. All shares of Common Stock which are so issuable shall, when issued, be duly and validly issued, fully paid and nonassessable and free from all taxes, liens and charges. The Company shall take all such actions as may be necessary to assure that all such shares of Common Stock may be so issued without violation of any applicable law or governmental regulation or any requirements of any domestic or foreign securities exchange upon which shares of Common Stock may be listed (except for official notice of issuance which shall be immediately delivered by the Company upon each such issuance) including without limitation, the Nasdaq National Market or the Nasdaq Small Cap Market (as the case may be). The Company shall not take any action which would cause the number of authorized but unissued shares of Common Stock to be less than the number of such shares required to be reserved hereunder for issuance upon exercise of the Warrants. 1D. EXERCISE AGREEMENT. Upon any exercise of this Warrant, the Exercise Agreement shall be substantially in the form set forth in EXHIBIT II hereto, except that if the shares of Common Stock are not to be issued in the name of the Person in whose name this Warrant is registered, the Exercise Agreement shall also state the name of the Person to whom the certificates for the shares of Common Stock are to be issued, and if the number of shares of Common Stock to be issued does not include all shares of Common Stock purchasable hereunder, it shall also state the name of the Person to whom a new Warrant for the unexercised portion of the rights hereunder is to be delivered. Such Exercise Agreement shall be dated the actual date of execution thereof. 1E. FRACTIONAL SHARES. If a fractional share of Common Stock would, but for the provisions of Paragraph 1A and Paragraph 1B, as the case may be, be issuable upon exercise of the rights represented by this Warrant, the Company shall, within ten business days after the date of the Exercise Time, deliver to the Purchaser a check payable to the Purchaser in lieu of such fractional share in an amount equal to the difference between the Market Price of such fractional share as of the date of the Exercise Time and the Exercise Price of such fractional share. 4 Section 2. ADJUSTMENT OF EXERCISE PRICE AND NUMBER OF SHARES. In order to prevent dilution of the rights granted under this Warrant, the Exercise Price shall be subject to adjustment from time to time as provided in this Section 2, and the number of shares of Common Stock obtainable upon exercise of this Warrant shall be subject to adjustment from time to time as provided in this Section 2. 2A. ADJUSTMENT OF EXERCISE PRICE AND NUMBER OF SHARES UPON ISSUANCE OF COMMON STOCK. (i) If and whenever on or after the Date of Issuance of this Warrant the Company issues or sells, or in accordance with paragraph 2B is deemed to have issued or sold, any shares of Common Stock (other than the Excluded Stock) for a consideration per share less than the Exercise Price in effect immediately prior to such time, then immediately upon such issue or sale the Exercise Price shall be reduced to the Exercise Price determined by dividing (A) the sum of (y) the product derived by multiplying the Exercise Price in effect immediately prior to such issue or sale and the number of shares of Common Stock Deemed Outstanding immediately prior to such issue or sale plus (z) the consideration, if any, received by the Company upon such issue or sale, by (B) the number of shares of Common Stock Deemed Outstanding immediately after such issue or sale. (ii) Upon each such adjustment of the Exercise Price hereunder, the number of shares of Warrant Stock acquirable upon exercise of this Warrant shall be adjusted to the number of shares determined by multiplying the Exercise Price in effect immediately prior to such adjustment by the number of shares of Warrant Stock acquirable upon exercise of this Warrant immediately prior to such adjustment and dividing the product thereof by the Exercise Price resulting from such adjustment. (iii) For purposes of this Section 2, "EXCLUDED STOCK" means (1) Common Stock issued or reserved for issuance by the Company as a dividend on Preferred Stock or upon any subdivision or split-up of the outstanding shares of any shares of capital stock of the Company or any recapitalization thereof, or upon conversion of any shares of Preferred Stock, (2) Common Stock issuable pursuant to any portion or warrants or other rights that are outstanding on the date of Issuance identified on SCHEDULE 3-2 CAPITAL STOCK to the Purchase Agreement, (3) Common Stock of the Company issued or issuable in connection with a Board-approved acquisition of a business by the Company as a result of which the Company owns in excess of 50% of the voting power of such business, (4) Common Stock issued or issuable to employees, officers, consultants, directors or vendors of the Company or pursuant to any Board-approved employee, officer, consultant or director benefit plan, including without limitation any Board-approved stock option plan, and (5) Common Stock issued or issuable to (x) banks, savings and loan associations, equipment lessors or similar lending institutions in connection with such entities providing Board-approved credit facilities or equipment financings to the company or (y) any party to any technology transfer agreement, 5 distribution agreement, marketing agreement or any other agreement similar thereto, with the Company, as approved by the Board. 2B. EFFECT ON EXERCISE PRICE OF CERTAIN EVENTS. For purposes of determining the adjusted Exercise Price under Paragraph 2A, the following shall be applicable: (i) ISSUANCE OF RIGHTS OR OPTIONS. If the company in any manner grants or sells any Options and the price per share for which Common Stock is issuable upon the exercise of such Options, or upon conversion or exchange of any Convertible Securities issuable upon exercise of such Options, is less than the Exercise Price in effect immediately prior to the time of the granting the sale of such Options, then the total maximum number of shares of Common Stock issuable upon the exercise of such Options, or upon conversion or exchange of the total maximum amount of such Convertible Securities issuable upon the exercise of such Options, shall be deemed to be outstanding and to have ben issued and sold by the Company at such time for such price per share. For purposes of this paragraph, the "PRICE PER SHARE FOR WHICH COMMON STOCK IS ISSUABLE UPON EXERCISE OF SUCH OPTIONS OR UPON CONVERSION OR EXCHANGE OF SUCH CONVERTIBLE SECURITIES" is determined by dividing (A) the result of (i) the total amount, if any, received or receivable by the Company as consideration for the granting or sale of such Options, plus (ii) the minimum aggregate amount of additional consideration payable to the Company upon the exercise of all such Option, plus (iii) in the case of such Options which are exercisable into Convertible Securities, the minimum aggregate amount of additional consideration, if any, payable to the Company upon the issuance or sale of such Convertible Securities and the conversation or exchange thereof, by (B) the total maximum number of shares of Common Stock issuable upon exercise of such Options or upon the conversion or exchange of all such Convertible Securities issuable upon the exercise of such Options. No further adjustment of the Exercise Price shall be made upon the actual issuance of such Common Stock or of such Convertible securities upon the exercise of such Options or upon the actual issuance of such Common Stock upon conversion or exchange of such Convertible Securities. (ii) ISSUANCE OF CONVERTIBLE SECURITIES. If the Company in any manner issues or sells any Convertible Securities and the price per share for which Common Stock is issuable upon conversion or exchange thereof is less than the Exercise Price in effect immediately prior to the time of such issue or sale, then the maximum number of shares of Common Stock issuable upon conversion or exchange of such Convertible Securities shall be deemed to be outstanding and to have been issued and sold by the Company for such price per share. For the purposes of this paragraph, the "PRICE PER SHARE FOR WHICH COMMON STOCK IS ISSUABLE UPON CONVERSION OR EXCHANGE THEREOF" is determined by dividing (A) the result of (i) the total amount received or receivable by the Company as consideration for the issue or sale of such Convertible Securities, plus (ii) the minimum aggregate amount of additional consideration, if any, payable to the Company upon the conversation or exchange thereof, by (B) the total maximum number of shares of Common Stock issuable upon the conversion or exchange of all such Convertible Securities. No further adjustment of the Exercise Price shall be made upon the actual issue of such Common Stock upon conversion or exchange of such 6 Convertible Securities, and if any such issue or sale of such Convertible Securities is made upon exercise of any Options for which adjustments of the Exercise Price had been or are to be made pursuant to other provisions of this Paragraph 2B, no further adjustment of the Exercise Price shall be made by reason of such issue or sale. (iii) CHANGE IN OPTION PRICE OR CONVERSION RATE. If the purchase price provided for in any Options, the additional consideration, if any, payable upon the issue, conversion or exchange of any Convertible Securities, or the rate at which any Convertible Securities are convertible into or exchangeable for Common Stock changes at any time, the Exercise Price in effect at the time of such change shall be adjusted immediately to the Exercise Price which would have been in effect at such time had such Options or Convertible Securities still outstanding provided for such changed purchase price, additional consideration or changed conversion rate, as the case may be, at the time initially granted, issued or sold and the number of shares of Warrant Stock shall be correspondingly adjusted; provided that if such adjustment would result in an increase of the Exercise Price then in effect, such adjustment shall not be effective until 30 days after written notice thereof has been given by the Company to all holders of the Warrants. For purposes of this Paragraph 2B, if the terms of any Option or Convertible Security which was outstanding as of the date of issuance of this Warrant are changed in the manner described in the immediately preceding sentence, then such Option or Convertible Security and the Common Stock deemed issuable upon exercise, conversation or exchange thereof shall be deemed to have been issued as of the date of such change; provided that no such change shall at any time cause the Exercise Price hereunder to be increased. (iv) TREATMENT OF EXPIRED OPTIONS AND UNEXERCISED CONVERTIBLE SECURITIES. Upon the expiration of any Option or the termination of any right to convert or exchange any Convertible Securities without the exercise of such Option or right, the Exercise Price then in effect and the number of shares of Warrant Stock acquirable hereunder shall be adjusted immediately to the Exercise Price and the number of shares which would have been in effect at the time of such expiration or termination had such Option or Convertible Securities to the extent outstanding immediately prior to such expiration or termination, never been issued; provided that if such expiration or termination would result in an increase in the Exercise Price then in effect, such increase shall not be effective until 30 days after written notice thereof has been given to all holders of the Warrants. For purposes of this Paragraph 2B, the expiration or termination of any Option or Convertible Security which was d as of the date of issuance of this Warrant shall not cause the Exercise Price hereunder to be adjusted unless, and only to the extent that, a change in the terms of such Option or Convertible Security caused it to be deemed to have been issued after the date of issuance of this Warrant. (v) CALCULATION OF CONSIDERATION RECEIVED. If any Common Stock, Options or Convertible Securities are issued or sold or deemed to have been issued or sold for cash, the consideration received therefor shall be deemed to be the gross amount (net of any underwriter, placement agent or broker discounts and commissions) received by the Company therefor. In case any Common Stock, Options or Convertible 7 Securities are issued or sold for a consideration other than cash, the amount of the consideration other than cash received by the Company shall be the fair value of such consideration, except where such consideration consists of securities, in which case the amount of consideration received by the Company shall be the Market Price thereof as of the date of receipt. In case any Common Stock, Options or Convertible Securities are issued to the owners of the non-surviving entity in connection with any merger in which the Company is the surviving entity the amount of consideration therefor shall be deemed to be the fair value of such portion of the net assets and business of the nonsurviving entity as is attributable to such Common Stock, Options or Convertible Securities, as the case may be. The fair value of any consideration other than cash or securities shall be determined jointly by the Company and the Registered Holders of the Warrants representing a majority of the shares of the Warrant Stock obtainable upon exercise of such Warrants. If such parties are unable to reach agreement within a reasonable period of time, such fair value shall be determined by an appraiser jointly selected by the Company and the Registered Holders of the Warrants representing a majority of the shares of Warrant Stock obtainable upon exercise of such Warrants. The determination of such appraiser shall be final and binding on the Company and the Registered Holders of such Warrants, and the fees and expenses of such appraiser shall be paid by the Company. (vi) INTEGRATED TRANSACTIONS. In case any Option is issued in connection with the issue or sale of other securities of the Company, together comprising one integrated transaction in which no specific consideration is allocated to such Options by the parties thereto, the Options shall be deemed to have been issued without consideration. (vii) TREASURY SHARES. The number of shares of Common Stock outstanding at any given time does not include shares owned or held by or for the account of the Company or any subsidiary, and the disposition of any shares so owned or held shall be considered an issue or sale of Common Stock. (viii) RECORD DATE. If the Company takes a record of the holders of Common Stock for the purpose of entitling them (A) to receive a dividend or other distribution payable in Common Stock, Options or in Convertible Securities of (B) to subscribe for or purchase Common Stock, Options or Convertible Securities, then such record date shall be deemed to be the date of the issue or sale of the shares of Common Stock deemed to have been issued or sold upon the declaration of such dividend or the making of such other distribution or the date of the granting of such right of subscription or purchase, as the case may be. 2C. SUBDIVISION OR COMBINATION OF COMMON STOCK. If the Company at any time subdivides (by any stock split, stock dividend, recapitalization or otherwise) one or more classes of its outstanding shares of Common Stock into a greater number of shares, the Exercise Price in effect immediately prior to such subdivision shall be proportionately reduced and the number of shares of Warrant Stock obtainable upon exercise of this Warrant shall be proportionately increased. If the Company at any time combines (by reverse stock split or otherwise) one or more classes of its outstanding 8 shares of Common Stock into a smaller number of shares, the Exercise Price in effect immediately prior to such combination shall be proportionately increased and the number of shares of Warrant Stock obtainable upon exercise of this Warrant shall be proportionately decreased. 2D. REORGANIZATION, RECLASSIFICATION, CONSOLIDATION, MERGER OR SALE. Any recapitalization, reorganization, reclassification, consolidation, merger, sale of all or substantially all of the Company's assets or other transaction, which in each case is effective in such a way that the holders of Common Stock are entitled to receive (either directly or upon subsequent liquidation) stock, securities or assets with respect to or in exchange for Common Stock is referred to herein as "ORGANIC CHANGE". Prior to the consummation of any Organic Change, the Company shall make appropriate provision (in form and substance satisfactory to the Registered Holders of the Warrants representing a majority of the shares of Warrant Stock obtainable upon exercise of all Warrants then outstanding) to insure that each of the Registered Holders of the Warrants shall thereafter have the right to acquire and receive, in lieu of or addition to (as the case may be) the shares of Warrant Stock immediately theretofore acquirable and receivable upon the exercise of such holder's Warrant, such shares of stock, securities or assets as may be issued or payable with respect to or in exchange for the number of shares of Warrant Stock immediately theretofore acquirable and receivable upon exercise of such holder's Warrant had such Organic Change not taken place. In any such case, the Company shall make appropriate provision (in form and substance satisfactory to the Registered Holders of the Warrants representing a majority of the shares of Warrant Stock obtainable upon exercise of all of the Warrants then outstanding) with respect to such Registered Holders' rights and interests to insure that the provisions of this Section 2 and Sections 3 and 4 hereof shall thereafter be applicable to the Warrants (including, in the case of any such consolidation, merger or sale in which the successor entity or purchasing entity is other than the Company and in which the value for the Common Stock reflected by the terms of such consolidation, merger or sale is less than the Base Price in effect immediately prior to such consolidation, merger or sale, an immediate adjustment of the Exercise Price to the product of such Exercise Price immediately prior to such consolidation, merger or sale multiplied by the ratio of such value of the Common Stock divided by the Base Price in effect immediately prior to such consolidation, merger or sale and a corresponding immediate adjustment in the number of shares of Warrant Stock acquirable and receivable upon exercise of the Warrants). The Company shall not effect any such consolidation, merger or sale, unless prior to the consummation thereof, the successor entity (if other than the Company) resulting from consolidation or merger or the entity purchasing such assets assumes by written instrument (in form and substance satisfactory to the Registered Holders of the Warrants representing a majority of the Warrant Stock obtainable upon exercise of all of the Warrants then outstanding), the obligation to deliver to each such Registered Holder such shares of stock, securities or assets as, in accordance with the foregoing provisions, such Registered Holder may be entitled to acquire. 2E. CERTAIN EVENTS. If any event occurs of the type contemplated by the provisions of Section 2A but not expressly provided for by such provisions, then the 9 Exercise Price and the number of shares of Warrant Stock obtainable upon exercise of this Warrant shall be adjusted by the Corporation's Board of Directors in good faith so as to protect the rights of the holders of the Warrants; provided that no such adjustment shall increase the Exercise Price or decrease the number of shares of Warrant Stock obtainable as otherwise determined pursuant to this Section 2. 2F. NOTICES. (i) Immediately upon any adjustment of the Exercise Price, the Company shall give written notice thereof to the Registered Holder, setting forth in reasonable detail and certifying the calculation of such adjustment. (ii) The Company shall give written notice to the Registered Holder at least 20 days prior to the date on which the Company closes its books or takes a record (A) with respect to any dividend or distribution upon shares of Common Stock, (B) with respect to any pro rata subscription offer to holders of Common Stock or (C) for determining rights to vote with respect to any Organic Change, dissolution or liquidation. (iii) The Company shall also give written notice to the Registered Holders at least 20 days prior to the date on which any Organic Change, dissolution or liquidation shall take place. Section 3. LIQUIDATING DIVIDENDS. If the Company declares or pays a dividend upon shares of Common Stock payable otherwise than in cash out of earnings or earned surplus (determined in accordance with generally accepted accounting principles, consistently applied) except for a stock dividend payable in shares of Common Stock (a "LIQUIDATING DIVIDEND"), then the Company shall pay to the Registered Holder at the time of payment thereof the Liquidating Dividend which would have been paid to the Registered Holder on the Warrant Stock had this Warrant been fully exercised immediately prior to the date on which a record is taken for such Liquidating Dividend, or, if no record is taken, the date as of which the record holders of Common Stock entitled to such dividends are to be determined. Section 4. PURCHASE RIGHTS. If at any time the Company grants, issues or sells any Options, Convertible Securities or warrants, securities or other like property pro rate to the record holders of any class of Common Stock (the "PURCHASE RIGHTS"), then the Registered Holder shall be entitled to acquire, upon the terms applicable to such Purchase Rights, the aggregate Purchase Rights which such Registered Holder could have acquired if such Registered Holder had held the number of shares of Common Stock acquirable upon complete exercise of this Warrant immediately before the date on which a record is taken for the grant, issuance or sale of such Purchase Rights, or, if no such record is taken, the date as of which the record holders of Common Stock are to be determined for the grant, issue or sale of such Purchase Rights. Section 5. DEFINITIONS. The following terms have meanings set forth below: 10 "BOARD" means the Company's Board of Directors. "COMMON STOCK" means the Company's Common Stock, $0.001 par value, and except for purposes of the shares obtainable upon exercise of this Warrant, any capital stock of any class of the Company hereafter authorized which is not limited to a fixed sum or percentage of par or stated value in respect to the rights of the holders thereof to participate in dividends or in the distribution of assets upon any liquidation, dissolution or winding up of the Company. "COMMON STOCK DEEMED OUTSTANDING" means, at any given time, the number of shares of Common Stock actually outstanding at such time, plus the number of shares of Common Stock deemed to be outstanding pursuant to paragraphs 2B(i) and 2B(ii) hereof regardless of whether the Options or Convertible Securities are actually exercisable or convertible at such time. "CONVERTIBLE SECURITIES" means any stock or securities (directly or indirectly) convertible into or exchangeable for Common Stock. "MARKET PRICE" means as to any security the average of the closing prices of such security's sales on all domestic or foreign securities exchanges on which such security may at the time be listed, or, if there have been no sales on any such exchange on any day, the average of the highest bid and lowest asked prices on all such exchanges at the end of such day, or, if on any day such security is not so listed, the average of the representative bid and asked prices quoted in the Nasdaq National Market or Nasdaq Small Cap Market, as of 4:00 P.M., New York time, on such day, or, if on any day such security is not quoted in the Nasdaq National Market or the Nasdaq Small Cap Market (as applicable), the average of the highest bid and lowest asked prices on such day in the domestic over-the-counter market as reported by the National Quotation Bureau, Incorporated, or any similar successor organization, in each such case averaged over a period of 30 days consisting of the day as of which "MARKET PRICE" is being determined and the 29 consecutive business days prior to such day; provided that if such security is listed on any domestic securities exchange the term "BUSINESS DAYS" as used in this sentence means business days on which such exchange is open for trading. If at any time such security is not listed on any domestic securities exchange or quoted in the Nasdaq National Market System or the Nasdaq Small Cap Market or the domestic over-the-counter market, the "MARKET PRICE" shall be the fair value thereof determined jointly by the Company and the Registered Holders of Warrants representing a majority of the Common Stock purchasable upon exercise of all the Warrants then outstanding, provided that if such parties are unable to reach agreement within a reasonable period of time, such fair value shall be determined by an appraiser jointly selected by the Company and the Registered Holders of the Warrants representing a majority of the shares of Common Stock purchasable upon exercise of all the Warrants then outstanding. The determination of such appraiser shall be final and binding on the Company and the Registered Holders of the Warrants, and the fees and expenses of such appraiser shall be paid by the Company. 11 "OPTION" means any rights to subscribe for or purchase Common Stock or Convertible Securities. "PERSON" means an individual, a partnership, a joint venture, a corporation, a limited liability company, a trust, an unincorporated organization and a government or any department or agency thereof. "WARRANT STOCK" means Common Stock; provided that if there is a change such that the securities issuable upon exercise of the Warrants are issued by an entity other than the Company or there is a change in the type or class of securities so issuable, then the term "WARRANT STOCK" shall mean one share of the security issuable upon exercise of the Warrants if such security is issuable in shares, or shall mean the smallest unit in which such security is issuable if such security is not issuable in shares. Other capitalized terms used in this Warrant but not defined herein shall have the meanings set forth in the Purchase Agreement. Section 6. NO VOTING RIGHTS; LIMITATIONS OF LIABILITY. This Warrant shall not entitle the holder hereof to any voting rights or other rights as a stockholder of the Company. No provision hereof, in the absence of affirmative action by the Registered Holder to purchase Common Stock, and no enumeration herein of the rights or privileges of the Registered Holder shall give rise to any liability of such holder for the Exercise Price of Common Stock acquirable by exercise hereof or as a stockholder of the Company. Section 7. WARRANT TRANSFERABLE. Subject to the transfer conditions referred to in the legend endorsed hereon, this Warrant and all rights hereunder are transferable, in whole or in part, without charge to the Registered Holder, upon surrender of this Warrant with a properly executed Assignment (in the form of EXHIBIT I hereto) at the principal office of the Company. Section 8. WARRANT EXCHANGEABLE FOR DIFFERENT DENOMINATIONS. This Warrant is exchangeable, upon the surrender hereof by the Registered Holder at the principal office of the Company, for new Warrants of like tenor representing in the aggregate the purchase rights hereunder, and each of such new Warrants shall represent such portion of such rights as is designated by the Registered Holder at the time of such surrender. The date the Company initially issues this Warrant shall be deemed to be the "DATE OF ISSUANCE" hereof regardless of the number of times new certificates representing the unexpired and unexercised rights formerly represented by this Warrant shall be issued. All Warrants representing portions of the rights hereunder are referred to herein as the "WARRANTS." Section 9. REPLACEMENT. Upon receipt of evidence reasonably satisfactory to the Company (an affidavit of the Registered Holder shall be satisfactory) of the ownership and the loss, theft, destruction or mutilation of any certificate evidencing this Warrant, and in the case of any such loss, theft or destruction, upon receipt of indemnity reasonably satisfactory to the Company (provided that if the holder is a financial 12 institution or other institutional investor its own agreement shall be satisfactory), or in the case of any such mutilation upon surrender of such certificate of like kind representing the same rights represented by such loss, stolen, destroyed or mutilated certificate and dated the date of such loss, stolen, destroyed or mutilated certificate. Section 10. NOTICES. Except as otherwise expressly provided herein, all notices referred to in this Warrant shall be in writing and shall be delivered personally, sent by reputable overnight courier service (charges prepaid) or sent by registered or certified mail, return receipt requested, postage prepaid and shall b deemed to have been given when so delivered, sent or deposited in the U.S. Mail (i) to the Company, at its principal executive offices and (ii) to the Registered Holder of this Warrant, at such holder's address as it appears in the records of the Company (unless otherwise indicated by any such holder). Section 11. AMENDMENT AND WAIVER. Except as otherwise provided herein, the provisions of the Warrants may be amended and the Company may take any action herein prohibited, or omit to perform any act herein required to be performed by it, only if the Company has obtained the written consent of the Registered Holders of Warrants representing a majority of the shares of Common Stock obtainable upon exercise of all of the Warrants then outstanding; provided that no such action may change the Exercise Price of the Warrants or the number of shares or class of stock obtainable upon exercise of each Warrant without the written consent of the Registered Holders of Warrants representing at least 80% of the shares of Common Stock obtainable upon exercise of the Warrants then outstanding. Section 12. DESCRIPTIVE HEADINGS; GOVERNING LAW. The descriptive headings of the several Sections and paragraphs of this Warrant are inserted for convenience only and do not constitute a part of this Warrant. The corporation laws of the State of Delaware shall govern all issues concerning the rights of the Company and all rights of the Company's stockholders relative to the Company. All other questions concerning the construction, validity, enforcement and interpretation of this Warrant shall be governed by the internal law of the State of New York, without giving effect to any choice of law or conflict of law provision or rule (whether of the State of New York or any other jurisdictions) that would cause the application of the laws of any jurisdictions other than the State of New York. * * * * * * 13 IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by its duly authorized officer and to be dated the Date of Issuance. LIFECELL CORPORATION By /s/ PAUL M. FRISON Paul M. Frison President and Chief Executive Officer 14 EXHIBIT I ASSIGNMENT FOR VALUE RECEIVED, __________________hereby sells, assigns and transfers all of the rights of the undersigned under the attached Warrant (Certificate No. BW- ) with respect to the number of shares of the Common Stock covered thereby set forth below, unto: NAMES OF ASSIGNEE ADDRESS NO. OF SHARES Signature Witness 15 EXHIBIT II EXERCISE AGREEMENT To: Dated: The undersigned, pursuant to the provisions set forth in the attached Warrant (Certificate No. BW- ), hereby agrees to subscribe for the purchase of shares of the Common Stock covered by such Warrant and makes payment herewith in full therefor at the price per share provided by such Warrant. Signature Witness 16 SCHEDULE 10.19 TO EXHIBIT 10.19 NAME NO. OF SHARES CIBC Wood Gundy Ventures, Inc. 1,011,612 The Woodlands Venture Capital Company 56,451 P. William Curreri, M.D. 9,032 Christopher C. Kraft, Jr., 5,645 Smith Barney Inc. KEO P/S Custodian Michael H. Richmond 9,032 Stephen Livesey 5,645 Michael E. Cahr 11,290 Technology Funding Medical Partners I, L.P. 56,451 Vector Later-Stage Equity Fund, L.P. 903,225 William J. McCluskey 4,200 David Saks 11,290 Joseph Battipaglia 3,387 S.B.S.F. Biotechnology Partners, L.P. 22,580 S.B.S.F. Biotechnology Fund, L.P. 203,225 Jerome Schachter 11,290 Paul B. Ankin and Lois F. Ankin 5,645 David and Mary Jane Harris 4,516 Richard L. Serrano 1,129 Charles and Donna Greenberg 33,870 Michael Gironta 22,580 Joseph A. Russo 3,500 John D. Goldberg 7,000 Robert Sablowsky 10,500 William J. Strazzullo 1,806 Stephen G. Weiss 7,451 Barry Richter 5,645 NAME NO. OF SHARES Chinook Equities, Inc. 11,290 Daniel and Elaine Kleinberg 6,029 Douglas Kleinberg 5,600 Evan Kleinberg IRA, 3,500 Gruntal & Co., Inc., Custodian John Latshaw 21,000 B. Michael Pisani 17,500 John Cirrito 5,645 James C. Gale, Trustee F/B/O Ariana J. Gale 14,000 The James C. Gale Trust James C. Gale and Judith S. Haselton 35,000 John S. Bai 4,900 Ronald Koenig 7,000 Robert M. Adams 35,000 Edward A. Kerbs 7,000 Bernard B. Salzman IRA, 1,241 Gruntal & Co., Inc., Custodian Don A. Sanders 14,000 Jeffrey Keeler 1,964 Harbour Court L.P., II 5,645 Namax Corp. 45,161 Sheldon Drobny 11,290 Perry H. Bacon 14,000 James J. Pelts 11,290 Robert Weinstein 4,900 The Marcus L. Koblitz Trust, Michael J. Koblitz, 564 Trustee The Lauren J. Koblitz Trust, Michael J. Koblitz, 564 Trustee Pharmaceutical & Medical Technology Fund 67,741 -2- Strategic Healthcare Fund 22,580 Michael J. Koblitz 1,129 -3- EX-11.1 9 EXHIBIT 11.1 YEAR TO DATE ENDED DECEMBER 31, 1996 WEIGHTED AVERAGE SHARES OUTSTANDING: - -------------------------------------------------------------------------------- Weighted Average Shares Outstanding at December 31, 1996 4,542,519 ========= Before effect of preferred dividends. accretion of preferred stock and warrant exercises ($4,089,714) ($0.90) Effect of preferred dividends, accretion of preferred stock and warrant exercises (1,071,035) (0.24) Loss per share after effect of preferred dividends, accretion of preferred stock and warrant ---------------------- exercises ($5,160,749) ($1.14) ====================== EX-23.1 10 EXHIBIT 23.1 CONSENT OF PUBLIC ACCOUNTANTS As independent public accountants, we hereby consent to the incorporation of our report included in this Form 10-K, into the Company's previously filed Registration Statements File No. 33-90740 and File No. 333-20093. ARTHUR ANDERSEN LLP Houston, Texas March 31, 1997 EX-27.1 11
5 12-MOS DEC-31-1996 DEC-31-1996 10,748,250 0 436,839 0 839,821 12,077,690 1,623,666 1,145,568 12,890,015 1,192,911 0 0 5,291,599 4,900 4,900,605 12,890,015 2,012,205 2,945,570 1,281,353 2,214,718 4,955,648 0 0 (4,089,714) 0 (4,089,714) 0 0 0 (4,089,714) (1.14) 0
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