Note 3 - Income Taxes - Income Tax Rate Reconciliation (Details)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Provision at the U.S. federal statutory rate	21.00%	21.00%
State taxes, net of federal benefit	4.90%	4.70%
Foreign tax rate differential	0.20%	(0.60%)
Valuation allowance	105.60%	(4.90%)
Chile outside basis differential	(0.80%)	0.00%
Italy IRES/IREP	0.00%	(3.80%)
Accrual to return	2.10%	(5.80%)
Research and development credit	11.20%	5.40%
State rate change	0.90%	(1.40%)
Share based compensation	(9.00%)	(6.70%)
Net Operating Loss expiration	(144.30%)	0.00%
Other Deferred true up	6.40%	(6.60%)
Global Intangible Low-Taxed Income (GILTI) inclusion	0.00%	(4.40%)
Other	(1.10%)	(1.70%)
Income tax expense effective rate	(2.90%)	(4.80%)