<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13D" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13D/A</submissionType>
    <previousAccessionNumber>0000902664-24-004633</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001365341</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>4</amendmentNo>
      <securitiesClassTitle>Ordinary shares, par value $0.20 per share</securitiesClassTitle>
      <dateOfEvent>03/12/2026</dateOfEvent>
      <previouslyFiledFlag>false</previouslyFiledFlag>
      <issuerInfo>
        <issuerCIK>0000845982</issuerCIK>
        <issuerCusips>
          <issuerCusipNumber>83175M205</issuerCusipNumber>
        </issuerCusips>
        <issuerName>Smith &amp; Nephew plc</issuerName>
        <address>
          <com:street1>BUILDING 5, CROXLEY PARK</com:street1>
          <com:street2>HATTERS LANE</com:street2>
          <com:city>WATFORD, HERTFORDSHIRE</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>WD18 8YE</com:zipCode>
        </address>
      </issuerInfo>
      <authorizedPersons>
        <notificationInfo>
          <personName>Norma O'Sullivan</personName>
          <personPhoneNum>44 1534 828 514</personPhoneNum>
          <personAddress>
            <com:street1>Cevian Capital II GP LTD</com:street1>
            <com:street2>Whiteley Chambers, Don Street</com:street2>
            <com:city>St. Helier</com:city>
            <com:stateOrCountry>Y9</com:stateOrCountry>
            <com:zipCode>JE2 4TR</com:zipCode>
          </personAddress>
        </notificationInfo>
        <notificationInfo>
          <personName>Ele Klein &amp; Adriana Schwartz</personName>
          <personPhoneNum>212-756-2000</personPhoneNum>
          <personAddress>
            <com:street1>McDermott Will &amp; Schulte LLP</com:street1>
            <com:street2>919 Third Avenue</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10022</com:zipCode>
          </personAddress>
        </notificationInfo>
      </authorizedPersons>
    </coverPageHeader>
    <reportingPersons>
      <reportingPersonInfo>
        <reportingPersonCIK>0001365341</reportingPersonCIK>
        <reportingPersonNoCIK>N</reportingPersonNoCIK>
        <reportingPersonName>Cevian Capital II GP LTD</reportingPersonName>
        <memberOfGroup>b</memberOfGroup>
        <fundType>AF</fundType>
        <legalProceedings>N</legalProceedings>
        <citizenshipOrOrganization>Y9</citizenshipOrOrganization>
        <soleVotingPower>81687136.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>81687136.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
        <aggregateAmountOwned>81687136.00</aggregateAmountOwned>
        <isAggregateExcludeShares>N</isAggregateExcludeShares>
        <percentOfClass>9.6</percentOfClass>
        <typeOfReportingPerson>IA</typeOfReportingPerson>
        <typeOfReportingPerson>OO</typeOfReportingPerson>
      </reportingPersonInfo>
    </reportingPersons>
    <items1To7>
      <item1>
        <securityTitle>Ordinary shares, par value $0.20 per share</securityTitle>
        <issuerName>Smith &amp; Nephew plc</issuerName>
        <issuerPrincipalAddress>
          <com:street1>BUILDING 5, CROXLEY PARK</com:street1>
          <com:street2>HATTERS LANE</com:street2>
          <com:city>WATFORD, HERTFORDSHIRE</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>WD18 8YE</com:zipCode>
        </issuerPrincipalAddress>
        <commentText>This Amendment No. 4 ("Amendment No. 4") amends and supplements the statement on Schedule 13D filed with the Securities and Exchange Commission on July 9, 2024 (the "Original Schedule 13D", and the Original Schedule 13D as amended, the "Schedule 13D"), with respect to the Ordinary shares, par value $0.20 per share (the "Ordinary Shares"), of Smith &amp; Nephew plc, a public limited company incorporated under the laws of England and Wales (the "Issuer"). This Amendment No. 4 amends and restates Items 3 and 5(a)-(c) as set forth below. Capitalized terms used herein and not otherwise defined in this Amendment No. 4 have the meanings set forth in the Schedule 13D.</commentText>
      </item1>
      <item3>
        <fundsSource>As of the date hereof, the Reporting Person has purchased for the account of the Cevian Funds an aggregate of 81,687,136 Ordinary Shares for an aggregate consideration (including brokerage commission) of approximately USD $1,095,708,998. The Cevian Funds funded these purchases out of their general working capital. The Ordinary Shares were purchased using British Pounds. For the purposes of this Schedule 13D, a conversion rate of USD $1.32385 for each GBP 1.00 was used.</fundsSource>
      </item3>
      <item5>
        <percentageOfClassSecurities>See rows (11) and (13) of the cover page to this Schedule 13D for the aggregate number of Ordinary Shares and percentages of the Ordinary Shares beneficially owned by the Reporting Person. The percentage reported in this Schedule 13D is calculated based upon 849,889,305 Ordinary Shares reported to be outstanding as of February 28, 2026, in the Issuer's Report of Foreign Private Issuer on Form 6-K filed with the Securities and Exchange Commission on March 2, 2026.</percentageOfClassSecurities>
        <numberOfShares>See rows (7) through (10) of the cover page to this Schedule 13D for the number of Ordinary Shares as to which the Reporting Person has the sole power to vote or direct the vote and sole power to dispose or to direct the disposition.</numberOfShares>
        <transactionDesc>The transactions in the Ordinary Shares by the Reporting Person for the benefit of the Cevian Funds within the past sixty (60) days are set forth in Schedule B, and are incorporated herein by reference.</transactionDesc>
      </item5>
    </items1To7>
    <signatureInfo>
      <signaturePerson>
        <signatureReportingPerson>Cevian Capital II GP LTD</signatureReportingPerson>
        <signatureDetails>
          <signature>/s/ Norma O'Sullivan</signature>
          <title>Norma O'Sullivan, Director</title>
          <date>03/16/2026</date>
        </signatureDetails>
      </signaturePerson>
    </signatureInfo>
  </formData>

</edgarSubmission>
