NPORT-P false 0000844779 XXXXXXXX S000001877 C000037661 C000004916 C000172900 C000004913 C000004914 C000004912 BlackRock Funds 811-05742 0000844779 549300OZUEVJZHOBFP42 100 Bellevue Parkway Wilmington 19809 800-441-7762 BlackRock Health Sciences Opportunities Portfolio S000001877 VN6DJGBO8DKY0GTM4883 2023-05-31 2022-08-31 N 9003753480.15 122155124.62 8881598355.53 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 N Prothena Corp PLC 5299009ZXQ8NIIJ8OL30 000000000 283257.00000000 NS USD 7809395.49000000 0.087927816338 Long EC CORP IE N 1 N N Point Biopharma Global Inc N/A 730541109 499734.00000000 NS USD 4872406.50000000 0.054859568120 Long EC CORP US N 1 N N Medtronic PLC 549300GX3ZBSQWUXY261 000000000 2002837.00000000 NS USD 176089429.04000000 1.982632201898 Long EC CORP IE N 1 N N N Daiichi Sankyo Co Ltd 353800XGIU2IHQGC9504 000000000 1783500.00000000 NS 53597397.73000000 0.603465677961 Long EC CORP JP N 2 N N N Dexcom Inc 549300YSK3QDSFR5EU59 252131107 732503.00000000 NS USD 60219071.63000000 0.678020658213 Long EC CORP US N 1 N N MERCK & CO INC 4YV9Y5M8S0BRK1RP0397 58933Y105 3591664.00000000 NS USD 306584439.04000000 3.451906140848 Long EC CORP US N 1 N N N Novocure Ltd 213800YPP55UMHWA4826 000000000 188610.00000000 NS USD 15490539.30000000 0.174411616917 Long EC CORP JE N 1 N N Biogen Inc W8J5WZB5IY3K0NDQT671 09062X103 351243.00000000 NS USD 68625857.34000000 0.772674631219 Long EC CORP US N 1 N N N UNITEDHEALTH GROUP INC 549300GHBMY8T5GXDE41 91324P102 1850624.00000000 NS USD 961084561.92000000 10.82107660634 Long EC CORP US N 1 N N N Quest Diagnostics Inc 8MCWUBXQ0WE04KMXBX50 74834L100 953348.00000000 NS USD 119464037.88000000 1.345073635373 Long EC CORP US N 1 N N N Argenx SE 7245009C5FZE6G9ODQ71 04016X101 117442.00000000 NS USD 44377808.54000000 0.499660159844 Long EC CORP NL N 1 N N N Waters Corp 5T547R1474YC9HOD8Q74 941848103 175735.00000000 NS USD 52474471.00000000 0.590822382407 Long EC CORP US N 1 N N N West Pharmaceutical Services I 5493007NKRGM1RJQ1P16 955306105 47940.00000000 NS USD 14223318.60000000 0.160143681696 Long EC CORP US N 1 N N N TScan Therapeutics Inc N/A 89854M101 551194.00000000 NS USD 1515783.50000000 0.017066562113 Long EC CORP US N 1 N N N AGILENT TECHNOLOGIES INC QUIX8Y7A2WP0XRMW7G29 00846U101 1016163.00000000 NS USD 130322904.75000000 1.467336165554 Long EC CORP US N 1 N N N Align Technology Inc 549300N5YSE0U3LCP840 016255101 63695.00000000 NS USD 15522471.50000000 0.174771149050 Long EC CORP US N 1 N N N AstraZeneca PLC PY6ZZQWO2IZFZC3IOL08 000000000 1233214.00000000 NS 152539123.64000000 1.717473787193 Long EC CORP GB N 2 N N N SAREPTA THERAPEUTICS INC 549300IKDPIED8J8IG21 803607100 301019.00000000 NS USD 32925458.22000000 0.370715460235 Long EC CORP US N 1 N N N Monte Rosa Therapeutics Inc N/A 61225M102 533603.00000000 NS USD 4226135.76000000 0.047583054207 Long EC CORP US N 1 N N CAREMAX INC N/A 14171W111 88432.00000000 NC USD 145912.80000000 0.001642866454 N/A DE CORP US N 1 CAREMAX INC N/A Call Purchased CareMax Inc CareMax Inc 1.00000000 11.50000000 USD 2025-07-16 XXXX 6818.11000000 N N N AmerisourceBergen Corp AI8GXW8LG5WK7E9UD086 03073E105 869425.00000000 NS USD 127422928.00000000 1.434684646831 Long EC CORP US N 1 N N N AstraZeneca PLC PY6ZZQWO2IZFZC3IOL08 046353108 398642.00000000 NS USD 24867287.96000000 0.279986630385 Long EC CORP GB N 1 N N N Cellarity, Inc. series B N/A 000000000 858333.00000000 NS USD 3433332.00000000 0.038656690637 Long EC CORP US Y 3 N N N ICON PLC 6354008SRQGEMC4XFI67 000000000 156850.00000000 NS USD 32911835.50000000 0.370562078834 Long EC CORP IE N 1 N N Affinivax Inc., N/A 000000000 122824.00000000 NS USD 1642156.88000000 0.018489429652 Long EC CORP US Y 3 N N N Cooper Cos Inc/The QJKMVPIGLH7530PCUE20 216648402 81897.00000000 NS USD 23540473.68000000 0.265047717062 Long EC CORP US N 1 N N N Sage Therapeutics Inc 5493000JX4BJS9W6CN35 78667J108 320005.00000000 NS USD 12051388.30000000 0.135689408793 Long EC CORP US N 1 N N N Exact Sciences Corp 549300VM3X1FYD4N9Z14 30063P105 263958.00000000 NS USD 9383706.90000000 0.105653357924 Long EC CORP US N 1 N N N INTUITIVE SURGICAL INC 54930052SRG011710797 46120E602 482254.00000000 NS USD 99218937.96000000 1.117129304752 Long EC CORP US N 1 N N N Tenaya Therapeutics Inc N/A 87990A106 431076.00000000 NS USD 1892423.64000000 0.021307241830 Long EC CORP US N 1 N N Alkermes PLC N/A 000000000 356424.00000000 NS USD 8436556.08000000 0.094989164588 Long EC CORP IE N 1 N N N LHC Group Inc 5299009NPLWAMRQYZX73 50187A107 368131.00000000 NS USD 59442112.57000000 0.669272693838 Long EC CORP US N 1 N N N ABBOTT LABORATORIES HQD377W2YR662HK5JX27 002824100 3304073.00000000 NS USD 339163093.45000000 3.818716855607 Long EC CORP US N 1 N N N LARONDE INC SERIES B N/A 000000000 386520.00000000 NS USD 9740304.00000000 0.109668368351 Long EC CORP US Y 3 N N N BOSTON SCIENTIFIC CORP Y6ZDD9FP4P8JSSJMW954 101137107 5589273.00000000 NS USD 225303594.63000000 2.536746040646 Long EC CORP US N 1 N N N Sigilon Therapeutics Inc N/A 82657L107 332626.00000000 NS USD 206760.32000000 0.002327962960 Long EC CORP US N 1 N N EDWARDS LIFESCIENCES CORP YA13X31F3V31L8TMPR58 28176E108 691234.00000000 NS USD 62280183.40000000 0.701227199282 Long EC CORP US N 1 N N N Swift Health Systems Inc., SERIES D N/A 000000000 1700345.00000000 NS USD 3638738.30000000 0.040969408369 Long EC CORP US Y 3 N N N ZOETIS INC 549300HD9Q1LOC9KLJ48 98978V103 1215671.00000000 NS USD 190288981.63000000 2.142508296510 Long EC CORP US N 1 N N N BLACKROCK LIQUIDITY FUNDS T-FUND PORTFOLIO 5493002L9DNZ83RX7V61 09248U718 39657945.09000000 NS USD 39657945.09000000 0.446518109719 Long STIV RF US N 1 N N N Zimmer Biomet Holdings Inc 2P2YLDVPES3BXQ1FRB91 98956P102 239113.00000000 NS USD 25422494.16000000 0.286237827273 Long EC CORP US N 1 N N N NEVRO CORP 254900SH91I4BOYKUE38 64157F103 701343.00000000 NS USD 31784864.76000000 0.357873250823 Long EC CORP US N 1 N N N Seagen Inc N/A 81181C104 341700.00000000 NS USD 52720893.00000000 0.593596905529 Long EC CORP US N 1 N N N Genmab A/S 529900MTJPDPE4MHJ122 000000000 42470.00000000 NS 15117886.45000000 0.170215831034 Long EC CORP DK N 2 N N N STATE STREET GLOBAL MARKETS, LLC 549300FDEDF5ORXCMQ56 000000000 1.00000000 NC USD -123804.56000000 -0.00139394459 N/A DFE CORP US N 2 STATE STREET GLOBAL MARKETS, LLC 549300FDEDF5ORXCMQ56 -7735600.00000000 CHF 7799640.51000000 USD 2022-09-15 -123804.56000000 N N N Johnson & Johnson 549300G0CFPGEF6X2043 478160104 2800738.00000000 NS USD 451871068.92000000 5.087722398960 Long EC CORP US N 1 N N N NUVATION BIO INC N/A 67080N119 77354.00000000 NC USD 20483.34000000 0.000230626731 N/A DE CORP US N 1 NUVATION BIO INC N/A Call Purchased Nuvation Bio Inc Nuvation Bio Inc 1.00000000 11.50000000 USD 2027-07-07 XXXX -146657.00000000 N N N ABIOMED Inc 5493001EZN4ZTB4Z5887 003654100 243643.00000000 NS USD 63171757.04000000 0.711265636107 Long EC CORP US N 1 N N N Bausch + Lomb Corp 549300NY6OZM39SO6475 071705107 1268266.00000000 NS USD 18871798.08000000 0.212482002952 Long EC CORP CA N 1 N N Moderna Inc 549300EI6OKH5K5Q2G38 60770K107 473419.00000000 NS USD 62619131.13000000 0.705043491310 Long EC CORP US N 1 N N N Ultragenyx Pharmaceutical Inc 529900EV44GVDN1DCX77 90400D108 99990.00000000 NS USD 4768523.10000000 0.053689920542 Long EC CORP US N 1 N N N HCA Healthcare Inc 529900PH4ZGUH2MNEU89 40412C101 132351.00000000 NS USD 26188292.37000000 0.294860129018 Long EC CORP US N 1 N N N Legend Biotech Corp 254900EIUFZTW136H859 52490G102 227561.00000000 NS USD 10579310.89000000 0.119114943803 Long EC CORP US N 1 N N QIAGEN NV 54930036WK3GMCN17Z57 000000000 406956.00000000 NS USD 18488011.08000000 0.208160855061 Long EC CORP NL N 1 N N N Omnicell Inc 5493008RH0GTKHHPZI77 68213N109 110704.00000000 NS USD 11323912.16000000 0.127498584226 Long EC CORP US N 1 N N Immunocore Holdings PLC 213800IUE3DFS84BVN18 45258D105 181355.00000000 NS USD 9577357.55000000 0.107833716034 Long EC CORP GB N 1 N N Alcon Inc 549300LDT5AP8S0NBM78 000000000 861808.00000000 NS USD 56603549.44000000 0.637312645473 Long EC CORP CH N 1 N N N Neurogene, Inc. Series B N/A 000000000 2090000.00000000 NS USD 5099600.00000000 0.057417593048 Long EC CORP US Y 3 N N N THERMO FISHER SCIENTIFIC INC HCHV7422L5HDJZCRFL38 883556102 706312.00000000 NS USD 385166059.84000000 4.336675049037 Long EC CORP US N 1 N N N HEALTH ASSURANCE ACQUISITION CORP N/A 42226W117 242734.00000000 NC USD 24613.23000000 0.000277126132 N/A DE CORP US N 1 HEALTH ASSURANCE ACQUISITION CORP N/A Call Purchased Health Assurance Acquisition C Health Assurance Acquisition Corp 1.00000000 11.50000000 USD 2025-11-12 XXXX -858054.97000000 N N N AMGEN INC 62QBXGPJ34PQ72Z12S66 031162100 1087435.00000000 NS USD 261310630.50000000 2.942157706752 Long EC CORP US N 1 N N N VERTEX PHARMACEUTICALS INC 54930015RAQRRZ5ZGJ91 92532F100 714739.00000000 NS USD 201384860.64000000 2.267439401992 Long EC CORP US N 1 N N N REVOLUTION Medicines Inc 549300JU3X0LBCQ65892 76155X100 305798.00000000 NS USD 6369772.34000000 0.071718761477 Long EC CORP US N 1 N N ANTHEM INC 8MYN82XMYQH89CTMTH67 036752103 587422.00000000 NS USD 284964286.42000000 3.208479769213 Long EC CORP US N 1 N N N MoonLake Immunotherapeutics N/A 61559X104 226542.00000000 NS USD 1825928.52000000 0.020558557670 Long EC CORP US N 1 N N Alnylam Pharmaceuticals Inc 529900S3ZI14OWRJII50 02043Q107 250177.00000000 NS USD 51704080.59000000 0.582148376004 Long EC CORP US N 1 N N MONEY MARKET SERIES LLC N/A 000000000 87427967.62600000 NS USD 87436710.42000000 0.984470440115 Long STIV RF US N N/A N N Arcutis Biotherapeutics Inc N/A 03969K108 799932.00000000 NS USD 21558167.40000000 0.242728465497 Long EC CORP US N 1 N N N Danaher Corp S4BKK9OTCEWQ3YHPFM11 235851102 1116113.00000000 NS USD 301250059.83000000 3.391845113581 Long EC CORP US N 1 N N N IsoPlexis Corp N/A 465005106 554988.00000000 NS USD 1076676.72000000 0.012122555838 Long EC CORP US N 1 N N N BRISTOL-MYERS SQUIBB CO HLYYNH7UQUORYSJQCN42 110122108 1272525.00000000 NS USD 85780910.25000000 0.965827397459 Long EC CORP US N 1 N N N Insitro, Series C N/A 000000000 592636.00000000 NS USD 8130965.92000000 0.091548453268 Long EC CORP US Y 3 N N N McKesson Corp 549300WZWOM80UCFSF54 58155Q103 382710.00000000 NS USD 140454570.00000000 1.581410962054 Long EC CORP US N 1 N N N Guardant Health Inc 254900M8C3E5VC8BR186 40131M109 208529.00000000 NS USD 10438961.74000000 0.117534719789 Long EC CORP US N 1 N N BIOMARIN PHARMACEUTICAL INC NSLL8ITTRR0J5HEMR848 09061G101 491040.00000000 NS USD 43800768.00000000 0.493163124999 Long EC CORP US N 1 N N N PMV Pharmaceuticals Inc N/A 69353Y103 306148.00000000 NS USD 4261580.16000000 0.047982131024 Long EC CORP US N 1 N N Goldfinch Bio, Inc. SERIES B N/A 000000000 3518800.00000000 NS USD 4328124.00000000 0.048731363733 Long EC CORP US Y 3 N N N Design Therapeutics Inc N/A 25056L103 257492.00000000 NS USD 5216787.92000000 0.058737039338 Long EC CORP US N 1 N N N Rapid Micro Biosystems Inc N/A 75340L104 377456.00000000 NS USD 1256928.48000000 0.014152052701 Long EC CORP US N 1 N N Quanta Dialysis Technologies Ltd SERIES D N/A 000000000 80024425.00000000 NS 6507506.22000000 0.073269539552 Long EC CORP GB Y 3 N N N Henry Schein Inc VGO3WGL8H45T73F4RR92 806407102 231507.00000000 NS USD 16994928.87000000 0.191349892099 Long EC CORP US N 1 N N N ELI LILLY & CO FRDRIPF3EKNDJ2CQJL29 532457108 1425371.00000000 NS USD 429364506.33000000 4.834315729472 Long EC CORP US N 1 N N N Avantor Inc N/A 05352A100 1282066.00000000 NS USD 31936264.06000000 0.359577891068 Long EC CORP US N 1 N N N Carbon Health Technologies Inc. N/A 000000000 16855.00000000 NS USD 16842190.20000000 0.189630171572 Long EP CORP US Y 3 N N N Regeneron Pharmaceuticals Inc 549300RCBFWIRX3HYQ56 75886F107 159017.00000000 NS USD 92398418.02000000 1.040335470275 Long EC CORP US N 1 N N N Exo Imaging, Inc. SERIES C N/A 000000000 1908330.00000000 NS USD 8625651.60000000 0.097118235420 Long EC CORP US Y 3 N N N Rhythm Pharmaceuticals Inc 529900JPNWXQ8DPLA551 76243J105 389120.00000000 NS USD 8794112.00000000 0.099014970593 Long EC CORP US N 1 N N N Nautilus Biotechnology Inc N/A 63909J108 308716.00000000 NS USD 682262.36000000 0.007681752007 Long EC CORP US N 1 N N PFIZER INC 765LHXWGK1KXCLTFYQ30 717081103 7552149.00000000 NS USD 341583699.27000000 3.845971024543 Long EC CORP US N 1 N N N Ionis Pharmaceuticals Inc 549300SI4ZGLG0BLUZ92 462222100 257120.00000000 NS USD 10932742.40000000 0.123094312108 Long EC CORP US N 1 N N Hansoh Pharmaceutical Group Co 254900Q6MR00EBXTPF42 000000000 16248176.00000000 NS 32417333.45000000 0.364994364216 Long EC CORP CN N 2 N N N Decibel Therapeutics Inc N/A 24343R106 897801.00000000 NS USD 4435136.94000000 0.049936247536 Long EC CORP US N 1 N N N Encompass Health Corp 549300FVRPM9DRQZRG64 29261A100 749047.00000000 NS USD 36381212.79000000 0.409624611850 Long EC CORP US N 1 N N N INCYTE CORP 549300Z4WN6JVZ3T4680 45337C102 458365.00000000 NS USD 32282646.95000000 0.363477897307 Long EC CORP US N 1 N N N MedTech Acquisition Corp/NY N/A 58507N105 831621.00000000 NS USD 8233047.90000000 0.092697818235 Long EC CORP US N 1 N N N Penumbra Inc 549300RGE06P3ECANU72 70975L107 169320.00000000 NS USD 27797264.40000000 0.312975922658 Long EC CORP US N 1 N N GILEAD SCIENCES INC 549300WTZWR07K8MNV44 375558103 2540277.00000000 NS USD 161231381.19000000 1.815341954633 Long EC CORP US N 1 N N N Cigna Corp 549300VIWYMSIGT1U456 125523100 776446.00000000 NS USD 220083618.70000000 2.477973106754 Long EC CORP US N 1 N N N Sanofi 549300E9PC51EN656011 000000000 569766.00000000 NS 46578279.05000000 0.524435773669 Long EC CORP FR N 2 N N N Immuneering Corp N/A 45254E107 264380.00000000 NS USD 1475240.40000000 0.016610077836 Long EC CORP US N 1 N N CENTENE CORP 549300Z7JJ4TQSQGT333 15135B101 1150045.00000000 NS USD 103205038.30000000 1.162009743840 Long EC CORP US N 1 N N N Cerevel Therapeutics Holdings 254900RJNIRS9COSQR41 15678U128 312854.00000000 NS USD 9104051.40000000 0.102504651027 Long EC CORP US N 1 N N N 10X Genomics Inc 5493003Z6741WNLG7H43 88025U109 144213.00000000 NS USD 4757586.87000000 0.053566786962 Long EC CORP US N 1 N N N Roche Holding AG 549300U41AUUVOAAOB37 000000000 93399.00000000 NS 30097047.59000000 0.338869721250 Long EC CORP CH N 2 N N N BAXTER INTERNATIONAL INC J5OIVXX3P24RJRW5CK77 071813109 1168311.00000000 NS USD 67131150.06000000 0.755845371212 Long EC CORP US N 1 N N N Insulet Corp 549300TZTYD2PYN92D43 45784P101 117707.00000000 NS USD 30070607.29000000 0.338572023708 Long EC CORP US N 1 N N iRhythm Technologies Inc 549300FJI72RJGDQS384 450056106 36545.00000000 NS USD 5388560.25000000 0.060671064309 Long EC CORP US N 1 N N Afferent Pharmaceuticals, Inc. N/A 000000000 3420640.00000000 NS USD 2668099.20000000 0.030040754976 Long EP CORP US Y 3 N N N Karuna Therapeutics Inc N/A 48576A100 58390.00000000 NS USD 14892953.40000000 0.167683257042 Long EC CORP US N 1 N N Neurocrine Biosciences Inc 549300FECER0XBN49756 64125C109 395980.00000000 NS USD 41431387.40000000 0.466485712835 Long EC CORP US N 1 N N N AMEDISYS INC 5299001RBS9GK9STN379 023436108 367363.00000000 NS USD 43514147.35000000 0.489935995843 Long EC CORP US N 1 N N N Ambrx Biopharma Inc N/A 02290A102 842148.00000000 NS USD 1389544.20000000 0.015645204211 Long EC CORP US N 1 N N N Horizon Therapeutics Plc 529900P0GSQ79OOZEV53 000000000 363736.00000000 NS USD 21536808.56000000 0.242487981305 Long EC CORP US N 1 N N N STATE STREET GLOBAL MARKETS, LLC 549300FDEDF5ORXCMQ56 000000000 1.00000000 NC USD 1969481.66000000 0.022174856159 N/A DFE CORP US N 2 STATE STREET GLOBAL MARKETS, LLC 549300FDEDF5ORXCMQ56 -37750000.00000000 GBP 45836487.90000000 USD 2022-09-15 1969481.66000000 N N N Imago Biosciences Inc N/A 45250K107 907400.00000000 NS USD 13184522.00000000 0.148447627017 Long EC CORP US N 1 N N Health Assurance Acquisition C N/A 42226W109 1747926.00000000 NS USD 17374384.44000000 0.195622271403 Long EC CORP US N 1 N N N Agiliti Inc N/A 00848J104 1425142.00000000 NS USD 22887780.52000000 0.257698891616 Long EC CORP US N 1 N N Health Sciences Acquisitions C N/A 000000000 262308.00000000 NS USD 2581110.72000000 0.029061331268 Long EC CORP US N 1 N N N IQVIA Holdings Inc 549300W3R20NM4KQPH86 46266C105 394897.00000000 NS USD 83978796.02000000 0.945536970467 Long EC CORP US N 1 N N N STATE STREET GLOBAL MARKETS, LLC 549300FDEDF5ORXCMQ56 000000000 1.00000000 NC USD 2168568.03000000 0.024416416315 N/A DFE CORP US N 2 STATE STREET GLOBAL MARKETS, LLC 549300FDEDF5ORXCMQ56 -52211700.00000000 EUR 54692048.14000000 USD 2022-09-15 2168568.03000000 N N N Blueprint Medicines Corp 5299004CC60O9T5HVM83 09627Y109 127385.00000000 NS USD 9327129.70000000 0.105016341953 Long EC CORP US N 1 N N N Catalent Inc N/A 148806102 243855.00000000 NS USD 21459240.00000000 0.241614618686 Long EC CORP US N 1 N N N Mersana Therapeutics Inc 529900VWD5VDZ7PVOS22 59045L106 880543.00000000 NS USD 6604072.50000000 0.074356801958 Long EC CORP US N 1 N N N RESMED INC 529900T3QE5253CCXF22 761152107 334912.00000000 NS USD 73653847.04000000 0.829285947096 Long EC CORP US N 1 N N N AbbVie Inc FR5LCKFTG8054YNNRU85 00287Y109 2162165.00000000 NS USD 290724705.90000000 3.273337683852 Long EC CORP US N 1 N N N CVS Health Corp 549300EJG376EN5NQE29 126650100 642555.00000000 NS USD 63066773.25000000 0.710083598981 Long EC CORP US N 1 N N N Enanta Pharmaceuticals Inc 529900SSN4DODDQSN594 29251M106 57153.00000000 NS USD 3479474.64000000 0.039176221449 Long EC CORP US N 1 N N Acumen Pharmaceuticals Inc N/A 00509G209 772313.00000000 NS USD 4394460.97000000 0.049478267245 Long EC CORP US N 1 N N N STRYKER CORP 5493002F0SC4JTBU5137 863667101 637345.00000000 NS USD 130783194.00000000 1.472518670229 Long EC CORP US N 1 N N N Genmab A/S 529900MTJPDPE4MHJ122 372303206 289405.00000000 NS USD 10270983.45000000 0.115643412805 Long EC CORP DK N 1 N N 2022-10-26 BlackRock Funds Ann Frechette Ann Frechette Assistant Treasurer XXXX