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      <invstOrSec>
        <name>KAILERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KAILERA THERAPEUTICS INC COMMON STOCK</title>
        <cusip>482931102</cusip>
        <identifiers>
          <isin value="US4829311020"/>
          <ticker value="KLRA"/>
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        <balance>464174.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10648151.56000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>EXO IMAGING INC</name>
        <lei>N/A</lei>
        <title>EXO IMAGING INC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="INTERNAL" value="BYDK80T56"/>
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        <balance>19083.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7060.71000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ASTRAZENECA PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC ORD USD0.25</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="GB0009895292"/>
          <ticker value="AZN"/>
          <other otherDesc="SEDOL" value="0989529"/>
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        <balance>384355.00000000</balance>
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        <currencyConditional curCd="GBP" exchangeRt="0.74255588"/>
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        <pctVal>1.208302053544</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ELEVANCE HEALTH INC</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
        <title>ELEVANCE HEALTH INC COM</title>
        <cusip>036752103</cusip>
        <identifiers>
          <isin value="US0367521038"/>
          <ticker value="ELV"/>
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        <balance>234947.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>92378810.93000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>HOLOGIC INC</name>
        <lei>N/A</lei>
        <title>HOLOGIC INC</title>
        <cusip>436CVR021</cusip>
        <identifiers>
          <isin value="US436CVR0216"/>
          <ticker value="HOLX"/>
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        <balance>138368.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1383.68000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KALVISTA PHARMACEUTICALS INC</name>
        <lei>529900Q7IDA3WUGRZA51</lei>
        <title>KALVISTA PHARMACEUTICALS INC COM</title>
        <cusip>483497103</cusip>
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          <isin value="US4834971032"/>
          <ticker value="KALV"/>
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        <balance>212587.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MIRATI THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <cusip>604CVR027</cusip>
        <identifiers>
          <isin value="US604CVR0279"/>
          <ticker value="MRTX"/>
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        <balance>228510.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>180522.90000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ADARX PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>ADARX PHARMACEUTICALS INC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="INTERNAL" value="BRYLU84N2"/>
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        <balance>769230.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10892296.80000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AXSOME THERAPEUTICS INC</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>AXSOME THERAPEUTICS INC COM</title>
        <cusip>05464T104</cusip>
        <identifiers>
          <isin value="US05464T1043"/>
          <ticker value="AXSM"/>
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        <balance>38178.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8951977.44000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>HUMANA INC</name>
        <lei>529900YLDW34GJAO4J06</lei>
        <title>HUMANA INC COM</title>
        <cusip>444859102</cusip>
        <identifiers>
          <isin value="US4448591028"/>
          <ticker value="HUM"/>
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        <balance>178205.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>54427371.10000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>DYNE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DYNE THERAPEUTICS INC COM</title>
        <cusip>26818M108</cusip>
        <identifiers>
          <isin value="US26818M1080"/>
          <ticker value="DYN"/>
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        <balance>278934.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5391794.22000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>FREQUENCY THERAPEUTICS CVR</name>
        <lei>N/A</lei>
        <title>FREQUENCY THERAPEUTICS CVR</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="INTERNAL" value="358CVR025"/>
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        <balance>428010.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4.28000000</valUSD>
        <pctVal>0.000000072469</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>KYMERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KYMERA THERAPEUTICS INC COM</title>
        <cusip>501575104</cusip>
        <identifiers>
          <isin value="US5015751044"/>
          <ticker value="KYMR"/>
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        <balance>54173.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4410765.66000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CVS HEALTH CORP</name>
        <lei>549300EJG376EN5NQE29</lei>
        <title>CVS HEALTH CORP COM</title>
        <cusip>126650100</cusip>
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          <isin value="US1266501006"/>
          <ticker value="CVS"/>
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        <balance>459705.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>41823960.90000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ALCON AG</name>
        <lei>549300LDT5AP8S0NBM78</lei>
        <title>ALCON AG CHF0.04</title>
        <cusip>000000000</cusip>
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          <isin value="CH0432492467"/>
          <ticker value="ALC"/>
          <other otherDesc="SEDOL" value="BJXBP41"/>
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        <balance>65553.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>GOLDFINCH BIO INC</name>
        <lei>N/A</lei>
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        <cusip>000000000</cusip>
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          <other otherDesc="INTERNAL" value="BRW5236Q2"/>
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        <balance>3115353.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DANAHER CORP</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>DANAHER CORP COM</title>
        <cusip>235851102</cusip>
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          <isin value="US2358511028"/>
          <ticker value="DHR"/>
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        <balance>645138.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>HCA HEALTHCARE INC</name>
        <lei>529900PH4ZGUH2MNEU89</lei>
        <title>HCA HEALTHCARE INC COM</title>
        <cusip>40412C101</cusip>
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          <isin value="US40412C1018"/>
          <ticker value="HCA"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>SAGIMET BIOSCIENCES INC</name>
        <lei>2549002OT2F8BV0VPD02</lei>
        <title>SAGIMET BIOSCIENCES INC COM SER A</title>
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          <isin value="US7867001049"/>
          <ticker value="SGMT"/>
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        <balance>585181.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>VAXCYTE INC</name>
        <lei>254900M7NMHTGASX8D95</lei>
        <title>VAXCYTE INC COM</title>
        <cusip>92243G108</cusip>
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          <isin value="US92243G1085"/>
          <ticker value="PCVX"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>BICARA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BICARA THERAPEUTICS INC COM</title>
        <cusip>055477103</cusip>
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          <isin value="US0554771032"/>
          <ticker value="BCAX"/>
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        <balance>160104.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>3482262.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>RADNET INC</name>
        <lei>529900RECG94V2IZJ970</lei>
        <title>RADNET INC COM</title>
        <cusip>750491102</cusip>
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          <isin value="US7504911022"/>
          <ticker value="RDNT"/>
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        <balance>108100.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>6002793.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>VERTEX PHARMACEUTICALS INC</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC COM</title>
        <cusip>92532F100</cusip>
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          <isin value="US92532F1003"/>
          <ticker value="VRTX"/>
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        <balance>361907.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>161967858.78000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>SYNDAX PHARMACEUTICALS INC</name>
        <lei>529900OF94TRHKZVBS87</lei>
        <title>SYNDAX PHARMACEUTICALS INC COM</title>
        <cusip>87164F105</cusip>
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          <isin value="US87164F1057"/>
          <ticker value="SNDX"/>
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        <balance>58560.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1147190.40000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>MBX BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>MBX BIOSCIENCES INC COM</title>
        <cusip>55287L101</cusip>
        <identifiers>
          <isin value="US55287L1017"/>
          <ticker value="MBX"/>
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        <balance>333350.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10490524.50000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>LARONDE INC</name>
        <lei>N/A</lei>
        <title>LARONDE INC</title>
        <cusip>000000000</cusip>
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          <other otherDesc="INTERNAL" value="BRWPUMHD2"/>
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        <balance>386520.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>INTUITIVE SURGICAL INC</name>
        <lei>54930052SRG011710797</lei>
        <title>INTUITIVE SURGICAL INC COM NEW</title>
        <cusip>46120E602</cusip>
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          <isin value="US46120E6023"/>
          <ticker value="ISRG"/>
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        <balance>271432.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>GENESIS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>GENESIS THERAPEUTICS INC</title>
        <cusip>000000000</cusip>
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          <other otherDesc="INTERNAL" value="BRYLVURU1"/>
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        <balance>823870.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC COM</title>
        <cusip>375558103</cusip>
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          <isin value="US3755581036"/>
          <ticker value="GILD"/>
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        <balance>1841333.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BLACKROCK LIQUIDITY FUNDS</name>
        <lei>5493007YVNX55LTRQ706</lei>
        <title>BLACKROCK LIQUIDITY FUNDS T FUND INSTL SHS</title>
        <cusip>09248U718</cusip>
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          <isin value="US09248U7182"/>
          <ticker value="TSTXX"/>
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        <balance>21272201.07000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARCUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC COM</title>
        <cusip>03969F109</cusip>
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          <isin value="US03969F1093"/>
          <ticker value="RCUS"/>
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        <balance>572430.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DAIICHI SANKYO COMPANY LTD</name>
        <lei>353800XGIU2IHQGC9504</lei>
        <title>DAIICHI SANKYO COMPANY LTD NPV</title>
        <cusip>000000000</cusip>
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          <isin value="JP3475350009"/>
          <ticker value="4568"/>
          <other otherDesc="SEDOL" value="B0J7D91"/>
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        <balance>673800.00000000</balance>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>REGENERON PHARMACEUTICALS INC</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC COM</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
          <ticker value="REGN"/>
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        <balance>87659.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BIONTECH SE</name>
        <lei>894500UZJ5LG1F8J1U58</lei>
        <title>BIONTECH SE SPONSORED ADS</title>
        <cusip>09075V102</cusip>
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          <isin value="US09075V1026"/>
          <ticker value="BNTX"/>
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        <balance>41921.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALLOGENE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC COM</title>
        <cusip>019770106</cusip>
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          <isin value="US0197701065"/>
          <ticker value="ALLO"/>
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        <balance>1208862.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GOSSAMER BIO INC</name>
        <lei>549300ZOC0N2W6PSFR58</lei>
        <title>GOSSAMER BIO INC COM</title>
        <cusip>38341P102</cusip>
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          <isin value="US38341P1021"/>
          <ticker value="GOSS"/>
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        <balance>365199.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>KODIAK SCIENCES INC</name>
        <lei>254900IXI5NI8C9OQE24</lei>
        <title>KODIAK SCIENCES INC COM</title>
        <cusip>50015M109</cusip>
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          <isin value="US50015M1099"/>
          <ticker value="KOD"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>STRYKER CORP</name>
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        <title>STRYKER CORP COM</title>
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          <ticker value="SYK"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>ARCELLX INC</name>
        <lei>N/A</lei>
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        <cusip>03940C100</cusip>
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          <ticker value="ACLX"/>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>EYEPOINT INC</name>
        <lei>549300QE1RU34T50MR69</lei>
        <title>EYEPOINT INC COM NEW</title>
        <cusip>30233G209</cusip>
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          <ticker value="EYPT"/>
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        <balance>186478.00000000</balance>
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        <curCd>USD</curCd>
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        <fairValLevel>1</fairValLevel>
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        <name>UPSTREAM BIO INC</name>
        <lei>N/A</lei>
        <title>UPSTREAM BIO INC COM</title>
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          <ticker value="UPB"/>
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        <balance>341675.00000000</balance>
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        <fairValLevel>1</fairValLevel>
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        <name>INSITRO INC</name>
        <lei>N/A</lei>
        <title>INSITRO INC</title>
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        <fairValLevel>3</fairValLevel>
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        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>MODERNA INC COM</title>
        <cusip>60770K107</cusip>
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          <ticker value="MRNA"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SWIFT HEALTH SYSTEMS INC</name>
        <lei>N/A</lei>
        <title>SWIFT HEALTH SYSTEMS INC</title>
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        <balance>1700.00500000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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        <name>CYTOKINETICS INC</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC COM NEW</title>
        <cusip>23282W605</cusip>
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          <ticker value="CYTK"/>
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        <balance>575188.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>44151430.88000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BIOHAVEN LTD</name>
        <lei>N/A</lei>
        <title>BIOHAVEN LTD COM</title>
        <cusip>000000000</cusip>
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          <isin value="VGG1110E1079"/>
          <ticker value="BHVN"/>
          <other otherDesc="SEDOL" value="BPLZ7S5"/>
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        <balance>348832.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>3840640.32000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
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        <name>BRISTOL-MYERS SQUIBB COMPANY</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>BRISTOL-MYERS SQUIBB COMPANY COM</title>
        <cusip>110122108</cusip>
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      <invstOrSec>
        <name>NOVARTIS AG</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>JOHNSON &amp; JOHNSON</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MCKESSON CORP</name>
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        <fairValLevel>1</fairValLevel>
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        <name>STOKE THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>KARTOS THERAPEUTICS INC</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>AKTIS ONCOLOGY INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>MEDLINE INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ABBVIE INC</name>
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          <isin value="US00287Y1091"/>
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        <fairValLevel>1</fairValLevel>
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        <name>ANNEXON INC</name>
        <lei>N/A</lei>
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          <ticker value="ANNX"/>
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        <fairValLevel>1</fairValLevel>
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        <name>EDWARDS LIFESCIENCES CORP</name>
        <lei>YA13X31F3V31L8TMPR58</lei>
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        <name>WEST PHARMACEUTICAL SERVICES INC</name>
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        <name>ORUKA THERAPEUTICS INC</name>
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        <name>QUEST DIAGNOSTICS INC</name>
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        <name>EIKON THERAPEUTICS INC</name>
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        <name>INCYTE CORP</name>
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        <name>NEUROCRINE BIOSCIENCES INC</name>
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        <name>MAZE THERAPEUTICS INC</name>
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        <name>IQVIA HOLDINGS INC</name>
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        <name>APOGEE THERAPEUTICS INC</name>
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        <name>BLUEPRINT MEDICINES CORP</name>
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        <title>BLUEPRINT MEDICINES CORP NPV</title>
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        <name>THERMO FISHER SCIENTIFIC INC</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>THERMO FISHER SCIENTIFIC INC COM</title>
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          <ticker value="TMO"/>
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        <name>BOSTON SCIENTIFIC CORP</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
        <title>BOSTON SCIENTIFIC CORP COM</title>
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          <ticker value="BSX"/>
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        <name>MAPLIGHT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MAPLIGHT THERAPEUTICS INC COM</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>NUVALENT INC</name>
        <lei>N/A</lei>
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      <invstOrSec>
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      <invstOrSec>
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        <name>GLAUKOS CORP</name>
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        <name>BRIDGEBIO ONCOLOGY THERAPEUTICS INC</name>
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        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOCORE HOLDINGS PLC</name>
        <lei>213800IUE3DFS84BVN18</lei>
        <title>IMMUNOCORE HOLDINGS PLC ADS</title>
        <cusip>45258D105</cusip>
        <identifiers>
          <isin value="US45258D1054"/>
          <ticker value="IMCR"/>
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        <balance>188691.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5451282.99000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>UNITEDHEALTH GROUP INC</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UNITEDHEALTH GROUP INC COM</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
          <ticker value="UNH"/>
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        <balance>947412.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>360310257.72000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>PROTAGONIST THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>PROTAGONIST THERAPEUTICS INC COM</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
          <ticker value="PTGX"/>
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        <balance>370408.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36877820.48000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SCHOLAR ROCK HOLDING CORP</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>SCHOLAR ROCK HOLDING CORP COM</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
          <ticker value="SRRK"/>
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        <balance>226209.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11152103.70000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>NOVOCURE LTD COM USD0.00</title>
        <cusip>000000000</cusip>
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          <isin value="JE00BYSS4X48"/>
          <ticker value="NVCR"/>
          <other otherDesc="SEDOL" value="BYSS4X4"/>
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        <balance>574295.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9785986.80000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CELLARITY INC</name>
        <lei>N/A</lei>
        <title>CELLARITY INC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="INTERNAL" value="BRWE8YSX0"/>
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        <balance>858333.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>497833.14000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>PFIZER INC</name>
        <lei>765LHXWGK1KXCLTFYQ30</lei>
        <title>PFIZER INC COM</title>
        <cusip>717081103</cusip>
        <identifiers>
          <isin value="US7170811035"/>
          <ticker value="PFE"/>
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        <balance>5899018.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>154436291.24000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CORVUS PHARMACEUTICALS INC</name>
        <lei>549300I3AVJ8F75NCX65</lei>
        <title>CORVUS PHARMACEUTICALS INC COM</title>
        <cusip>221015100</cusip>
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          <isin value="US2210151005"/>
          <ticker value="CRVS"/>
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        <balance>110424.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1370361.84000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BRIGHT MINDS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>BRIGHT MINDS BIOSCIENCES INC COM NEW</title>
        <cusip>10919W405</cusip>
        <identifiers>
          <isin value="CA10919W4056"/>
          <ticker value="DRUG"/>
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        <balance>95655.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8424335.85000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>EXELIXIS INC</name>
        <lei>254900PJQB59O2O95R37</lei>
        <title>EXELIXIS INC COM</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
          <ticker value="EXEL"/>
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        <balance>231652.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11693792.96000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AMGEN INC</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC COM</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
          <ticker value="AMGN"/>
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        <balance>590203.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>198774468.37000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ALNYLAM PHARMACEUTICALS INC</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>ALNYLAM PHARMACEUTICALS INC COM</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
          <ticker value="ALNY"/>
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        <balance>94913.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>28661827.74000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BRIDGEBIO PHARMA INC</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>BRIDGEBIO PHARMA INC COM</title>
        <cusip>10806X102</cusip>
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          <isin value="US10806X1028"/>
          <ticker value="BBIO"/>
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        <balance>86968.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA NPV</title>
        <cusip>000000000</cusip>
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          <isin value="BE0003739530"/>
          <ticker value="UCB"/>
          <other otherDesc="SEDOL" value="5596991"/>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>ELI LILLY &amp; COMPANY</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY &amp; COMPANY COM</title>
        <cusip>532457108</cusip>
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          <isin value="US5324571083"/>
          <ticker value="LLY"/>
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        <balance>656650.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>725598250.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BRUKER CORP</name>
        <lei>LEBZ6VLQ6I8XB1NHVY15</lei>
        <title>BRUKER CORP COM</title>
        <cusip>116794108</cusip>
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          <isin value="US1167941087"/>
          <ticker value="BRKR"/>
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        <balance>471949.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>27793076.61000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DENALI THERAPEUTICS INC</name>
        <lei>549300ZTQ2HO18L3Q830</lei>
        <title>DENALI THERAPEUTICS INC COM</title>
        <cusip>24823R105</cusip>
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          <isin value="US24823R1059"/>
          <ticker value="DNLI"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ERASCA INC</name>
        <lei>N/A</lei>
        <title>ERASCA INC COM</title>
        <cusip>29479A108</cusip>
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          <isin value="US29479A1088"/>
          <ticker value="ERAS"/>
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        <balance>709864.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ZEALAND PHARMA A/S</name>
        <lei>549300ITBB1ULBL4CZ12</lei>
        <title>ZEALAND PHARMA A/S DKK1</title>
        <cusip>000000000</cusip>
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          <isin value="DK0060257814"/>
          <ticker value="ZEAL"/>
          <other otherDesc="SEDOL" value="B0SDJB4"/>
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        <currencyConditional curCd="DKK" exchangeRt="6.40775000"/>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>4D MOLECULAR THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>4D MOLECULAR THERAPEUTICS INC COM</title>
        <cusip>35104E100</cusip>
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          <isin value="US35104E1001"/>
          <ticker value="FDMT"/>
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        <balance>126274.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1251375.34000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SUMMIT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SUMMIT THERAPEUTICS INC COM</title>
        <cusip>86627T108</cusip>
        <identifiers>
          <isin value="US86627T1088"/>
          <ticker value="SMMT"/>
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        <balance>276987.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>4858351.98000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MOONLAKE IMMUNOTHERAPEUTICS</name>
        <lei>N/A</lei>
        <title>MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD</title>
        <cusip>61559X104</cusip>
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          <isin value="KY61559X1045"/>
          <ticker value="MLTX"/>
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        <balance>161391.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>3095479.38000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>KAILERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KAILERA THERAPEUTICS INC</title>
        <cusip>000000000</cusip>
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        <fairValLevel>1</fairValLevel>
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        <name>CHARLES RIVER LABORATORIES INTERNATIONAL INC</name>
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        <name>BIOMARIN PHARMACEUTICAL INC</name>
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        <cusip>09061G101</cusip>
        <identifiers>
          <isin value="US09061G1013"/>
          <ticker value="BMRN"/>
        </identifiers>
        <balance>322635.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18483759.15000000</valUSD>
        <pctVal>0.312971018013</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VIRIDIAN THERAPEUTICS INC</name>
        <lei>549300C775BNYF550E70</lei>
        <title>VIRIDIAN THERAPEUTICS INC COM</title>
        <cusip>92790C104</cusip>
        <identifiers>
          <isin value="US92790C1045"/>
          <ticker value="VRDN"/>
        </identifiers>
        <balance>516095.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9093593.90000000</valUSD>
        <pctVal>0.153974703803</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PALVELLA THERAPEUTICS INC</name>
        <lei>254900AJDH8PAOOI5T33</lei>
        <title>PALVELLA THERAPEUTICS INC COM</title>
        <cusip>697947109</cusip>
        <identifiers>
          <isin value="US6979471090"/>
          <ticker value="PVLA"/>
        </identifiers>
        <balance>50716.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6007817.36000000</valUSD>
        <pctVal>0.101725666296</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINA INC</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>ILLUMINA INC COM</title>
        <cusip>452327109</cusip>
        <identifiers>
          <isin value="US4523271090"/>
          <ticker value="ILMN"/>
        </identifiers>
        <balance>145933.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23781241.68000000</valUSD>
        <pctVal>0.402669140937</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PENUMBRA INC</name>
        <lei>549300RGE06P3ECANU72</lei>
        <title>PENUMBRA INC COM</title>
        <cusip>70975L107</cusip>
        <identifiers>
          <isin value="US70975L1070"/>
          <ticker value="PEN"/>
        </identifiers>
        <balance>133216.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42402652.80000000</valUSD>
        <pctVal>0.717970911956</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>METTLER-TOLEDO INTERNATIONAL INC</name>
        <lei>5493000BD5GJNUDIUG10</lei>
        <title>METTLER-TOLEDO INTERNATIONAL INC COM</title>
        <cusip>592688105</cusip>
        <identifiers>
          <isin value="US5926881054"/>
          <ticker value="MTD"/>
        </identifiers>
        <balance>6058.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7151953.64000000</valUSD>
        <pctVal>0.121098429888</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DIANTHUS THERAPEUTICS INC</name>
        <lei>549300Z3N6ODPCOFC890</lei>
        <title>DIANTHUS THERAPEUTICS INC COM</title>
        <cusip>252828108</cusip>
        <identifiers>
          <isin value="US2528281080"/>
          <ticker value="DNTH"/>
        </identifiers>
        <balance>186482.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17344690.82000000</valUSD>
        <pctVal>0.293684066050</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ULTRAGENYX PHARMACEUTICAL INC</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>ULTRAGENYX PHARMACEUTICAL INC COM</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
          <ticker value="RARE"/>
        </identifiers>
        <balance>130855.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3132668.70000000</valUSD>
        <pctVal>0.053043025727</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARGENX SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>ARGENX SE SPONSORED ADR</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
          <ticker value="ARGX"/>
        </identifiers>
        <balance>88995.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>74398930.05000000</valUSD>
        <pctVal>1.259738816543</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NATERA INC</name>
        <lei>529900CQ3OZ0A0VYVU59</lei>
        <title>NATERA INC COM</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
          <ticker value="NTRA"/>
        </identifiers>
        <balance>46190.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10317460.30000000</valUSD>
        <pctVal>0.174697475075</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AFFINIVAX INC</name>
        <lei>N/A</lei>
        <title>AFFINIVAX INC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="INTERNAL" value="BRY5YZ4R4"/>
        </identifiers>
        <balance>122824.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>449535.84000000</valUSD>
        <pctVal>0.007611638321</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DEFINIUM THERAPEUTICS INC</name>
        <lei>549300QY8KN1O6RPFJ13</lei>
        <title>DEFINIUM THERAPEUTICS INC COM SHS</title>
        <cusip>24477V105</cusip>
        <identifiers>
          <isin value="CA24477V1058"/>
          <ticker value="DFTX"/>
        </identifiers>
        <balance>81265.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1965800.35000000</valUSD>
        <pctVal>0.033285357797</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WAVE LIFE SCIENCES LTD</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD COM NPV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
          <ticker value="WVE"/>
          <other otherDesc="SEDOL" value="BYZG9R0"/>
        </identifiers>
        <balance>345882.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2275903.56000000</valUSD>
        <pctVal>0.038536092593</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MADRIGAL PHARMACEUTICALS INC</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>MADRIGAL PHARMACEUTICALS INC COM</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
          <ticker value="MDGL"/>
        </identifiers>
        <balance>27588.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13718684.76000000</valUSD>
        <pctVal>0.232287745166</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>


    </explntrNotes>
    <signature>
      <ncom:dateSigned>2026-07-25</ncom:dateSigned>
      <ncom:nameOfApplicant>BlackRock Funds</ncom:nameOfApplicant>
      <ncom:signature>Chuck Pulsfort</ncom:signature>
      <ncom:signerName>Chuck Pulsfort</ncom:signerName>
      <ncom:title>Assistant Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
