<?xml version="1.0" encoding="UTF-8"?>
<edgarSubmission xmlns="http://www.sec.gov/edgar/twentyfourf2filer" xmlns:feec="http://www.sec.gov/edgar/feecommon">
  <schemaVersion>X0101</schemaVersion>
  <headerData>
    <submissionType>24F-2NT</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <filer>
        <issuerCredentials>
          <cik>0000843781</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>
      <flags>
        <overrideInternetFlag>false</overrideInternetFlag>
        <confirmingCopyFlag>false</confirmingCopyFlag>
      </flags>
      <investmentCompanyType>N-1A</investmentCompanyType>
    </filerInfo>
  </headerData>
  <formData>
    <annualFilings>
      <annualFilingInfo>
        <item1>
          <nameOfIssuer>DREYFUS TREASURY SECURITIES CASH MANAGEMENT</nameOfIssuer>
          <addressOfIssuer>
            <street1>240 Greenwich Street</street1>
            <city>New York</city>
            <state>NY</state>
            <country>X1</country>
            <zipCode>10286</zipCode>
          </addressOfIssuer>
        </item1>
        <item2>
          <reportSeriesClass>
            <rptSeriesClassInfo>
              <seriesName>Dreyfus Treasury Securities Cash Management</seriesName>
              <seriesId>S000000113</seriesId>
              <classInfo>
                <className>Institutional Shares</className>
                <classId>C000000255</classId>
              </classInfo>
            </rptSeriesClassInfo>
          </reportSeriesClass>
        </item2>
        <item3>
          <investmentCompActFileNo>811-05718</investmentCompActFileNo>
          <securitiesActFileNumbers>
            <securitiesActFileNo>
              <fileNumber>033-25941</fileNumber>
            </securitiesActFileNo>
          </securitiesActFileNumbers>
        </item3>
        <item4>
          <lastDayOfFiscalYear>01/31/2022</lastDayOfFiscalYear>
          <isThisFormBeingFiledLate>false</isThisFormBeingFiledLate>
        </item4>
        <item5>
          <seriesOrClassId>C000000255</seriesOrClassId>
          <aggregateSalePriceOfSecuritiesSold>90065392005.00</aggregateSalePriceOfSecuritiesSold>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>85518309334.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>3280099634.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>
          <totalAvailableRedemptionCredits>88798408968.00</totalAvailableRedemptionCredits>
          <netSales>1266983037.00</netSales>
          <redemptionCreditsAvailableForUseInFutureYears>0.00</redemptionCreditsAvailableForUseInFutureYears>
          <multiplierForDeterminingRegistrationFee>0.0000927</multiplierForDeterminingRegistrationFee>
          <registrationFeeDue>117449.33</registrationFeeDue>
        </item5>
        <item6>
          <amountOfSecuritiesDeducted>0.00</amountOfSecuritiesDeducted>
          <numberOfSharesOrOtherUnitsRemainingUnsold>0.00</numberOfSharesOrOtherUnitsRemainingUnsold>
        </item6>
        <item7>
          <interestDue>0.00</interestDue>
        </item7>
        <item8>
          <totalOfRegistrationFeePlusAnyInterestDue>117449.33</totalOfRegistrationFeePlusAnyInterestDue>
        </item8>
        <signature>
          <signature>/s/ Deirdre Cunnane</signature>
          <nameAndTitle>Deirdre Cunnane, Vice President and Assistant Secretary</nameAndTitle>
          <signatureDate>04/12/2022</signatureDate>
        </signature>
      </annualFilingInfo>
      <annualFilingInfo>
        <item1>
          <nameOfIssuer>DREYFUS TREASURY SECURITIES CASH MANAGEMENT</nameOfIssuer>
          <addressOfIssuer>
            <street1>240 Greenwich Street</street1>
            <city>New York</city>
            <state>NY</state>
            <country>X1</country>
            <zipCode>10286</zipCode>
          </addressOfIssuer>
        </item1>
        <item2>
          <reportSeriesClass>
            <rptSeriesClassInfo>
              <seriesName>Dreyfus Treasury Securities Cash Management</seriesName>
              <seriesId>S000000113</seriesId>
              <classInfo>
                <className>Investor Shares</className>
                <classId>C000000256</classId>
              </classInfo>
            </rptSeriesClassInfo>
          </reportSeriesClass>
        </item2>
        <item3>
          <investmentCompActFileNo>811-05718</investmentCompActFileNo>
          <securitiesActFileNumbers>
            <securitiesActFileNo>
              <fileNumber>033-25941</fileNumber>
            </securitiesActFileNo>
          </securitiesActFileNumbers>
        </item3>
        <item4>
          <lastDayOfFiscalYear>01/31/2022</lastDayOfFiscalYear>
          <isThisFormBeingFiledLate>false</isThisFormBeingFiledLate>
        </item4>
        <item5>
          <seriesOrClassId>C000000256</seriesOrClassId>
          <aggregateSalePriceOfSecuritiesSold>4664211151.00</aggregateSalePriceOfSecuritiesSold>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>4579246489.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>6064592954.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>
          <totalAvailableRedemptionCredits>10643839443.00</totalAvailableRedemptionCredits>
          <netSales>0.00</netSales>
          <redemptionCreditsAvailableForUseInFutureYears>(5979628292.00)</redemptionCreditsAvailableForUseInFutureYears>
          <multiplierForDeterminingRegistrationFee>0.0000927</multiplierForDeterminingRegistrationFee>
          <registrationFeeDue>0.00</registrationFeeDue>
        </item5>
        <item6>
          <amountOfSecuritiesDeducted>0.00</amountOfSecuritiesDeducted>
          <numberOfSharesOrOtherUnitsRemainingUnsold>0.00</numberOfSharesOrOtherUnitsRemainingUnsold>
        </item6>
        <item7>
          <interestDue>0.00</interestDue>
        </item7>
        <item8>
          <totalOfRegistrationFeePlusAnyInterestDue>0.00</totalOfRegistrationFeePlusAnyInterestDue>
        </item8>
        <signature>
          <signature>/s/ Deirdre Cunnane</signature>
          <nameAndTitle>Deirdre Cunnane, Vice President and Assistant Secretary</nameAndTitle>
          <signatureDate>04/12/2022</signatureDate>
        </signature>
      </annualFilingInfo>
      <annualFilingInfo>
        <item1>
          <nameOfIssuer>DREYFUS TREASURY SECURITIES CASH MANAGEMENT</nameOfIssuer>
          <addressOfIssuer>
            <street1>240 Greenwich Street</street1>
            <city>New York</city>
            <state>NY</state>
            <country>X1</country>
            <zipCode>10286</zipCode>
          </addressOfIssuer>
        </item1>
        <item2>
          <reportSeriesClass>
            <rptSeriesClassInfo>
              <seriesName>Dreyfus Treasury Securities Cash Management</seriesName>
              <seriesId>S000000113</seriesId>
              <classInfo>
                <className>Administrative Shares</className>
                <classId>C000000257</classId>
              </classInfo>
            </rptSeriesClassInfo>
          </reportSeriesClass>
        </item2>
        <item3>
          <investmentCompActFileNo>811-05718</investmentCompActFileNo>
          <securitiesActFileNumbers>
            <securitiesActFileNo>
              <fileNumber>033-25941</fileNumber>
            </securitiesActFileNo>
          </securitiesActFileNumbers>
        </item3>
        <item4>
          <lastDayOfFiscalYear>01/31/2022</lastDayOfFiscalYear>
          <isThisFormBeingFiledLate>false</isThisFormBeingFiledLate>
        </item4>
        <item5>
          <seriesOrClassId>C000000257</seriesOrClassId>
          <aggregateSalePriceOfSecuritiesSold>22911019326.00</aggregateSalePriceOfSecuritiesSold>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>17612795641.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>0.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>
          <totalAvailableRedemptionCredits>17612795641.00</totalAvailableRedemptionCredits>
          <netSales>5298223685.00</netSales>
          <redemptionCreditsAvailableForUseInFutureYears>0.00</redemptionCreditsAvailableForUseInFutureYears>
          <multiplierForDeterminingRegistrationFee>0.0000927</multiplierForDeterminingRegistrationFee>
          <registrationFeeDue>491145.34</registrationFeeDue>
        </item5>
        <item6>
          <amountOfSecuritiesDeducted>0.00</amountOfSecuritiesDeducted>
          <numberOfSharesOrOtherUnitsRemainingUnsold>0.00</numberOfSharesOrOtherUnitsRemainingUnsold>
        </item6>
        <item7>
          <interestDue>0.00</interestDue>
        </item7>
        <item8>
          <totalOfRegistrationFeePlusAnyInterestDue>491145.34</totalOfRegistrationFeePlusAnyInterestDue>
        </item8>
        <signature>
          <signature>/s/ Deirdre Cunnane</signature>
          <nameAndTitle>Deirdre Cunnane, Vice President and Assistant Secretary</nameAndTitle>
          <signatureDate>04/12/2022</signatureDate>
        </signature>
      </annualFilingInfo>
      <annualFilingInfo>
        <item1>
          <nameOfIssuer>DREYFUS TREASURY SECURITIES CASH MANAGEMENT</nameOfIssuer>
          <addressOfIssuer>
            <street1>240 Greenwich Street</street1>
            <city>New York</city>
            <state>NY</state>
            <country>X1</country>
            <zipCode>10286</zipCode>
          </addressOfIssuer>
        </item1>
        <item2>
          <reportSeriesClass>
            <rptSeriesClassInfo>
              <seriesName>Dreyfus Treasury Securities Cash Management</seriesName>
              <seriesId>S000000113</seriesId>
              <classInfo>
                <className>Participant Shares</className>
                <classId>C000000258</classId>
              </classInfo>
            </rptSeriesClassInfo>
          </reportSeriesClass>
        </item2>
        <item3>
          <investmentCompActFileNo>811-05718</investmentCompActFileNo>
          <securitiesActFileNumbers>
            <securitiesActFileNo>
              <fileNumber>033-25941</fileNumber>
            </securitiesActFileNo>
          </securitiesActFileNumbers>
        </item3>
        <item4>
          <lastDayOfFiscalYear>01/31/2022</lastDayOfFiscalYear>
          <isThisFormBeingFiledLate>false</isThisFormBeingFiledLate>
        </item4>
        <item5>
          <seriesOrClassId>C000000258</seriesOrClassId>
          <aggregateSalePriceOfSecuritiesSold>20509199834.00</aggregateSalePriceOfSecuritiesSold>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>19371319781.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>1773770524.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>
          <totalAvailableRedemptionCredits>21145090305.00</totalAvailableRedemptionCredits>
          <netSales>0.00</netSales>
          <redemptionCreditsAvailableForUseInFutureYears>(635890471.00)</redemptionCreditsAvailableForUseInFutureYears>
          <multiplierForDeterminingRegistrationFee>0.0000927</multiplierForDeterminingRegistrationFee>
          <registrationFeeDue>0.00</registrationFeeDue>
        </item5>
        <item6>
          <amountOfSecuritiesDeducted>0.00</amountOfSecuritiesDeducted>
          <numberOfSharesOrOtherUnitsRemainingUnsold>0.00</numberOfSharesOrOtherUnitsRemainingUnsold>
        </item6>
        <item7>
          <interestDue>0.00</interestDue>
        </item7>
        <item8>
          <totalOfRegistrationFeePlusAnyInterestDue>0.00</totalOfRegistrationFeePlusAnyInterestDue>
        </item8>
        <signature>
          <signature>/s/ Deirdre Cunnane</signature>
          <nameAndTitle>Deirdre Cunnane, Vice President and Assistant Secretary</nameAndTitle>
          <signatureDate>04/12/2022</signatureDate>
        </signature>
      </annualFilingInfo>
      <annualFilingInfo>
        <item1>
          <nameOfIssuer>DREYFUS TREASURY SECURITIES CASH MANAGEMENT</nameOfIssuer>
          <addressOfIssuer>
            <street1>240 Greenwich Street</street1>
            <city>New York</city>
            <state>NY</state>
            <country>X1</country>
            <zipCode>10286</zipCode>
          </addressOfIssuer>
        </item1>
        <item2>
          <reportSeriesClass>
            <rptSeriesClassInfo>
              <seriesName>Dreyfus Treasury Securities Cash Management</seriesName>
              <seriesId>S000000113</seriesId>
              <classInfo>
                <className>Service Shares</className>
                <classId>C000223305</classId>
              </classInfo>
            </rptSeriesClassInfo>
          </reportSeriesClass>
        </item2>
        <item3>
          <investmentCompActFileNo>811-05718</investmentCompActFileNo>
          <securitiesActFileNumbers>
            <securitiesActFileNo>
              <fileNumber>033-25941</fileNumber>
            </securitiesActFileNo>
          </securitiesActFileNumbers>
        </item3>
        <item4>
          <lastDayOfFiscalYear>01/31/2022</lastDayOfFiscalYear>
          <isThisFormBeingFiledLate>false</isThisFormBeingFiledLate>
        </item4>
        <item5>
          <seriesOrClassId>C000223305</seriesOrClassId>
          <aggregateSalePriceOfSecuritiesSold>2547706838.00</aggregateSalePriceOfSecuritiesSold>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>2400561428.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>0.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>
          <totalAvailableRedemptionCredits>2400561428.00</totalAvailableRedemptionCredits>
          <netSales>147145410.00</netSales>
          <redemptionCreditsAvailableForUseInFutureYears>0.00</redemptionCreditsAvailableForUseInFutureYears>
          <multiplierForDeterminingRegistrationFee>0.0000927</multiplierForDeterminingRegistrationFee>
          <registrationFeeDue>13640.38</registrationFeeDue>
        </item5>
        <item6>
          <amountOfSecuritiesDeducted>0.00</amountOfSecuritiesDeducted>
          <numberOfSharesOrOtherUnitsRemainingUnsold>0.00</numberOfSharesOrOtherUnitsRemainingUnsold>
        </item6>
        <item7>
          <interestDue>0.00</interestDue>
        </item7>
        <item8>
          <totalOfRegistrationFeePlusAnyInterestDue>13640.38</totalOfRegistrationFeePlusAnyInterestDue>
        </item8>
        <signature>
          <signature>/s/ Deirdre Cunnane</signature>
          <nameAndTitle>Deirdre Cunnane, Vice President and Assistant Secretary</nameAndTitle>
          <signatureDate>04/12/2022</signatureDate>
        </signature>
      </annualFilingInfo>
      <annualFilingInfo>
        <item1>
          <nameOfIssuer>DREYFUS TREASURY SECURITIES CASH MANAGEMENT</nameOfIssuer>
          <addressOfIssuer>
            <street1>240 Greenwich Street</street1>
            <city>New York</city>
            <state>NY</state>
            <country>X1</country>
            <zipCode>10286</zipCode>
          </addressOfIssuer>
        </item1>
        <item2>
          <reportSeriesClass>
            <rptSeriesClassInfo>
              <seriesName>Dreyfus Treasury Securities Cash Management</seriesName>
              <seriesId>S000000113</seriesId>
              <classInfo>
                <className>Wealth Shares</className>
                <classId>C000223306</classId>
              </classInfo>
            </rptSeriesClassInfo>
          </reportSeriesClass>
        </item2>
        <item3>
          <investmentCompActFileNo>811-05718</investmentCompActFileNo>
          <securitiesActFileNumbers>
            <securitiesActFileNo>
              <fileNumber>033-25941</fileNumber>
            </securitiesActFileNo>
          </securitiesActFileNumbers>
        </item3>
        <item4>
          <lastDayOfFiscalYear>01/31/2022</lastDayOfFiscalYear>
          <isThisFormBeingFiledLate>false</isThisFormBeingFiledLate>
        </item4>
        <item5>
          <seriesOrClassId>C000223306</seriesOrClassId>
          <aggregateSalePriceOfSecuritiesSold>127957629.00</aggregateSalePriceOfSecuritiesSold>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>134892387.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>
          <aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>0.00</aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>
          <totalAvailableRedemptionCredits>134892387.00</totalAvailableRedemptionCredits>
          <netSales>0.00</netSales>
          <redemptionCreditsAvailableForUseInFutureYears>(6934758.00)</redemptionCreditsAvailableForUseInFutureYears>
          <multiplierForDeterminingRegistrationFee>0.0000927</multiplierForDeterminingRegistrationFee>
          <registrationFeeDue>0.00</registrationFeeDue>
        </item5>
        <item6>
          <amountOfSecuritiesDeducted>0.00</amountOfSecuritiesDeducted>
          <numberOfSharesOrOtherUnitsRemainingUnsold>0.00</numberOfSharesOrOtherUnitsRemainingUnsold>
        </item6>
        <item7>
          <interestDue>0.00</interestDue>
        </item7>
        <item8>
          <totalOfRegistrationFeePlusAnyInterestDue>0.00</totalOfRegistrationFeePlusAnyInterestDue>
        </item8>
        <signature>
          <signature>/s/ Deirdre Cunnane</signature>
          <nameAndTitle>Deirdre Cunnane, Vice President and Assistant Secretary</nameAndTitle>
          <signatureDate>04/12/2022</signatureDate>
        </signature>
      </annualFilingInfo>
    </annualFilings>
  </formData>
</edgarSubmission>
