UNITED STATES 

SECURITIES AND EXCHANGE COMMISSION 

Washington, D.C. 20549 

FORM N-Q 

QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT 

INVESTMENT COMPANY 

Investment Company Act file number 811-5718 

Dreyfus Treasury Prime Cash Management 

(Exact name of Registrant as specified in charter) 

c/o The Dreyfus Corporation 

200 Park Avenue 

New York, New York 10166 

(Address of principal executive offices) (Zip code) 

Mark N. Jacobs, Esq. 

200 Park Avenue 

New York, New York 10166 

(Name and address of agent for service) 

Registrant's telephone number, including area code: (212) 922-6000 

Date of fiscal year end:	1/31
Date of reporting period:	4/30/07

FORM N-Q

Item 1. Schedule of Investments.

STATEMENT OF INVESTMENTS 

Dreyfus Treasury Prime Cash Management 

April 30, 2007 (Unaudited) 

	Annualized
	Yield on Date	Principal
U.S. Treasury Bills--46.6%	of Purchase (%)	Amount ($)	Value ($)
5/3/07	5.04	233,000,000	232,935,522
5/10/07	4.83	1,000,000	998,795
5/17/07	5.08	294,000,000	293,352,547
5/31/07	5.05	100,000,000	99,590,000
6/7/07	4.96	49,000,000	48,756,252
8/2/07	4.87	10,000,000	9,875,742
10/11/07	5.00	170,000,000	166,243,303
Total U.S. Treasury Bills
(cost $851,752,161)			851,752,161
U.S. Treasury Notes--53.1%
5/15/07	4.89	149,000,000	148,893,005
5/15/07	4.92	300,000,000	299,922,086
7/31/07	4.95	499,000,000	497,588,312
8/15/07	4.97	25,000,000	24,835,867
Total U.S. Treasury Notes
(cost $971,239,270)			971,239,270
Total Investments (cost $1,822,991,431)		99.7%	1,822,991,431
Cash and Receivables (Net)		.3%	5,142,120
Net Assets		100.0%	1,828,133,551

Securities valuation policies and other investment related disclosures are hereby incorporated by reference to the annual and semi-annual reports previously filed with the Securities and Exchange Commission on Form N-CSR.

Item 2. Controls and Procedures.

(a) The Registrant's principal executive and principal financial officers have concluded, based on their evaluation of the Registrant's disclosure controls and procedures as of a date within 90 days of the filing date of this report, that the Registrant's disclosure controls and procedures are reasonably designed to ensure that information required to be disclosed by the Registrant on Form N-Q is recorded, processed, summarized and reported within the required time periods and that information required to be disclosed by the Registrant in the reports that it files or submits on Form N-Q is accumulated and communicated to the Registrant's management, including its principal executive and principal financial officers, as appropriate to allow timely decisions regarding required disclosure.

(b) There were no changes to the Registrant's internal control over financial reporting that occurred during the Registrant's most recently ended fiscal quarter that have materially affected, or are reasonably likely to materially affect, the Registrant's internal control over financial reporting.

Item 3. Exhibits.

(a) Certifications of principal executive and principal financial officers as required by Rule 30a-2(a) 

under the Investment Company Act of 1940. 

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the Registrant has duly caused this Report to be signed on its behalf by the undersigned, thereunto duly authorized.

Dreyfus Treasury Prime Cash Management
By:	/s/ J. David Officer
	J. David Officer
	President
Date:	June 19, 2007
Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of
1940, this Report has been signed below by the following persons on behalf of the Registrant and in the
capacities and on the dates indicated.
By:	/s/ J. David Officer
	J. David Officer
	President
Date:	June 19, 2007
By:	/s/ James Windels
	James Windels
	Treasurer
Date:	June 19, 2007
EXHIBIT INDEX
	(a) Certifications of principal executive and principal financial officers as required by Rule 30a-
	2(a) under the Investment Company Act of 1940. (EX-99.CERT)