8-K

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
     PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

        Date of Report (Date of earliest event reported): August 23, 2006

                          Medefile International, Inc.
             (Exact name of registrant as specified in its charter)



            Nevada                   033-25126 D              85-0368333
(State or Other Jurisdiction      (Commission File        (I.R.S. Employer
       of Incorporation)              Number)           Identification Number)

                          2 Ridgedale Avenue, Suite 217
                             Cedar Knolls, NJ 07927
               (Address of principal executive offices) (zip code)

                                 (973) 993-8001
              (Registrant's telephone number, including area code)

                                   Copies to:
                            Richard A. Friedman, Esq.
                       Sichenzia Ross Friedman Ference LLP
                           1065 Avenue of the Americas
                            New York, New York 10018
                              Phone: (212) 930-9700
                               Fax: (212) 930-9725

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)
[ ] Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)
[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
Act (17 CFR 240.14d-2(b))
[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))



Item 5.02 Election of Directors


On August 23, 2006, the Board of Directors of Medefile International,  Inc. (the
"Company")  appointed  Anthony  Paquin to the Board of Directors of the Company.
There are no  understandings  or  arrangements  between Mr. Paquin and any other
person pursuant to which Mr. Paquin was selected as a director.  Mr. Paquin will
serve as an independent  member of the Audit and Compensation  Committees of the
Board of Directors.  Mr. Paquin does not have any family  relationship  with any
director,  executive  officer or person  nominated  or chosen by us to become an
officer or director.


From  February  2006 to the  present,  Mr.  Paquin has served as the founder and
Chief  Executive  Officer of The Paquin Group,  an alliance of  industry-leading
experts and  resources  created to assist  hospitals  in the  implementation  of
healthcare retail strategies. From December 2002 to January 2005, Mr. Paquin was
a self-employed  management  consultant,  specializing in management  consulting
services to senior leadership or major healthcare companies.  From March 1998 to
November 2002, Mr. Paquin was the chief  executive  officer of Medinex  Systems,
Inc.

In accordance with General  Instruction B.2 of Form 8-K, the information in this
Current Report on Form 8-K,  including  Exhibit 99.1,  shall not be deemed to be
"filed" for purposes of Section 18 of the  Securities  Exchange Act of 1934,  as
amended (the  "Exchange  Act"),  or otherwise  subject to the  liability of that
section,  and shall  not be  incorporated  by  reference  into any  registration
statement or other document  filed under the Act or the Exchange Act,  except as
shall be expressly set forth by specific reference in such filing.

Item 9.01 Financial Statements and Exhibits

(d) Exhibits

99.1     Press release dated August 23, 2006



                                   SIGNATURES

     Pursuant to the  requirements  of the  Securities and Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                    Medefile International, Inc.


Dated: August 28, 2006              By: /s/ Milton Hauser
                                        -----------------
                                    Name:    Milton Hauser
                                    Title:   President, Chief Executive Officer

EX-99

MedeFile International Expands Board of Directors With Appointment of Anthony
Paquin as Independent Member Wednesday

CEDAR KNOLLS, N.J., Aug. 23 /PRNewswire-FirstCall/ -- MedeFile International,
Inc. (OTC Bulletin Board: MDFI - News), a leader in portable electronic medical
records management, today announced that Anthony ("Tony") Paquin has been
appointed to serve as an independent member of the Company's Board of Directors
and as a member of the Audit and Compensation committees.

Commenting on his Board appointment, Paquin noted, "Considering its unique
market positioning and well-differentiated product and service offerings,
MedeFile represents a very compelling company with very promising growth
potential. I look forward to working closely with the Company's executive
leadership team to help maximize this potential while ensuring that only best
industry practices are adopted for its corporate oversight and shareholder
stewardship."

With over 20 years' experience leading the strategic direction of both private
and public companies in the insurance, technology and healthcare industries,
Paquin brings MedeFile proven expertise and skill in executive management,
effective teambuilding, strategic business development, mergers and
acquisitions, and corporate finance, among other areas. Currently, Paquin serves
as founder and Chief Executive Officer of The Paquin Group, an alliance of
industry-leading experts and resources created to assist hospitals in the
implementation of healthcare retail strategies. He previously founded and
managed one of the largest technology companies in the insurance sector and was
Chief Executive Officer of a Nasdaq-listed healthcare services company. In
addition, Paquin has extensive experience in public policy at both the state and
national levels and has participated in strategic sessions at the Naval War
College and ran for office in the United States House of Representatives.

"In light of MedeFile's objective to move onto a national exchange, we felt the
time was appropriate to begin expanding our Board of Directors to provide for
greater independent corporate governance and enhanced leadership. We are very
pleased to be welcoming Tony to our Board, and expect that his strong and
impressive background, coupled with his industry influence and resources in the
healthcare and technology arenas, will prove invaluable to MedeFile as we
progress our exciting business plan," stated Milton Hauser, Chairman and Chief
Executive Officer of MedeFile.


About MedeFile International, Inc.

Headquartered in New Jersey, MedeFile has developed a proprietary system for
gathering and digitizing medical records so that individuals can have a
comprehensive record of all of their medical visits. MedeFile's primary product
is the MedeFile system, a highly secure system for gathering and maintaining
medical records. The MedeFile system is designed to gather all of its members'
actual medical records and create a single, comprehensive medical record that is
accessible 24 hours a day, seven days a week. For more information about
MedeFile and the MedeFile system, visit http://www.medefile.com .

Safe Harbor Statement Under the Private Securities Litigation Act of 1995

With the exception of historical information, the matters discussed in this
press release are forward-looking statements that involve a number of risks and
uncertainties. The actual future results of MedeFile could differ significantly
from those statements. Factors that could cause actual results to differ
materially include risks and uncertainties such as the inability to finance the
Company's operations or expansion, inability to hire and retain qualified
personnel, changes in the general economic climate, including rising interest
rates, and unanticipated events such as terrorist activities. In some cases, you
can identify forward-looking statements by terminology such as "may," "will,"
"should," "expect," "plan," "anticipate," "believe," "estimate," "predict,"
"potential" or "continue," the negative of such terms, or other comparable
terminology. These statements are only predictions. Although we believe that the
expectations reflected in the forward-looking statements are reasonable, and
such statements should not be regarded as a representation by the Company, or
any other person, that such forward-looking statements will be achieved. We
undertake no duty to update any of the forward-looking statements, whether as a
result of new information, future events or otherwise. In light of the
foregoing, readers are cautioned not to place undue reliance on such
forward-looking statements. For further risk factors associated with our
Company, review our SEC filings.

                    FOR MORE INFORMATION, PLEASE CONTACT:
                  Investors/Stockbrokers/Institutions/Media
         Elite Financial Communications Group, LLC/Elite Media Group
            Dodi Handy, 407-585-1080 or via email at mdfi@efcg.net