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Net Loss Per Common Share (Tables)
12 Months Ended
Dec. 31, 2015
Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
      December 31,     December 31,  
      2015     2014  
  Warrants   2,191,487     2,191,487  
  Options   1,734,429     1,800,226  
  Series A Preferred Stock   933,333     933,333  
  Series E Preferred Stock   7,254,997     7,365,283  
  Convertible promissory note and interest   1,964,337     1,895,765  
  Total   14,078,583     14,186,094  
Unissued Common Stock for Possible Future Issuance [Table Text Block]
      December 31,     December 31,  
      2015     2014  
 

Exercise of stock warrants

  2,191,487     2,191,487  
 

Exercise and future grants of stock options

  3,928,870     3,986,074  
 

Conversion of preferred stock

  8,188,330     8,298,616  
 

Issuable shares from conversion of promissory notes and interest

  1,964,337     1,895,765  
 

Total

  16,273,024     16,371,942