Report of Independent Registered Public Accounting
Firm

To the Shareholders and Board of Trustees of
Morgan Stanley Institutional Fund, Inc:
In planning and performing our audits of the financial
statements of Active International Allocation Portfolio,
Advantage Portfolio, Asia Opportunity Portfolio,
Emerging Markets Breakout Nations Portfolio,
Emerging Markets Fixed Income Opportunities
Portfolio, Emerging Markets Leaders Portfolio,
Emerging Markets Portfolio, Emerging Markets Small
Cap Portfolio, Frontier Markets Portfolio, Global
Advantage Portfolio, Global Concentrated Portfolio,
Global Concentrated Real Estate Portfolio, Global Core
Portfolio, Global Counterpoint Portfolio, Global
Endurance Portfolio, Global Franchise Portfolio, Global
Infrastructure Portfolio, Global Opportunity Portfolio,
Global Quality Portfolio, Global Real Estate Portfolio,
Growth Portfolio, International Advantage Portfolio,
International Equity Portfolio, International Opportunity
Portfolio, International Real Estate Portfolio, Real
Assets Portfolio, Small Company Growth Portfolio, US
Core Portfolio, U.S. Real Estate Portfolio, and the
consolidated financial statements of Multi-Asset
Portfolio (collectively, the "Funds") (thirty of the
portfolios constituting Morgan Stanley Institutional
Fund, Inc., (the "Company")) as of and for the year or
period ended December 31, 2018, in accordance with the
standards of the Public Company Accounting Oversight
Board (United States), we considered the Company's
internal control over financial reporting, including
controls over safeguarding securities, as a basis for
designing our auditing procedures for the purpose of
expressing our opinion on the financial statements and to
comply with the requirements of Form N-CEN, but not
for the purpose of expressing an opinion on the
effectiveness of the Company's internal control over
financial reporting. Accordingly, we express no such
opinion.
The management of the Company is responsible for
establishing and maintaining effective internal control
over financial reporting. In fulfilling this responsibility,
estimates and judgments by management are required to
assess the expected benefits and related costs of controls.
A company's internal control over financial reporting is
a process designed to provide reasonable assurance
regarding the reliability of financial reporting and the
preparation of financial statements for external purposes
in accordance with U.S. generally accepted accounting
principles. A company's internal control over financial
reporting includes those policies and procedures that (1)
pertain to the maintenance of records that, in reasonable
detail, accurately and fairly reflect the transactions and
dispositions of the assets of the company; (2) provide
reasonable assurance that transactions are recorded as
necessary to permit preparation of financial statements in
accordance with U.S. generally accepted accounting
principles, and that receipts and expenditures of the
company are being made only in accordance with
authorizations of management and directors of the
company; and (3) provide reasonable assurance
regarding prevention or timely detection of unauthorized
acquisition, use or disposition of a company's assets that
could have a material effect on the financial statements.

Because of its inherent limitations, internal control over
financial reporting may not prevent or detect
misstatements. Also, projections of any evaluation of
effectiveness to future periods are subject to the risk that
controls may become inadequate because of changes in
conditions, or that the degree of compliance with the
policies or procedures may deteriorate.

A deficiency in internal control over financial reporting
exists when the design or operation of a control does not
allow management or employees, in the normal course
of performing their assigned functions, to prevent or
detect misstatements on a timely basis. A material
weakness is a deficiency, or a combination of
deficiencies, in internal control over financial reporting,
such that there is a reasonable possibility that a material
misstatement of the company's annual or interim
financial statements will not be prevented or detected on
a timely basis.

Our consideration of the Company's internal control
over financial reporting was for the limited purpose
described in the first paragraph and would not
necessarily disclose all deficiencies in internal control
that might be material weaknesses under standards
established by the Public Company Accounting
Oversight Board (United States).

However, we noted no deficiencies in the Company's
internal control over financial reporting and its
operation, including controls over safeguarding
securities, that we consider to be a material weakness as
defined above as of December 31, 2018.

This report is intended solely for the information and use
of management and the Board of Trustees of Morgan
Stanley Institutional Fund, Inc. and the Securities and
Exchange Commission and is not intended to be and
should not be used by anyone other than these specified
parties.




/s/ ERNST & YOUNG LLP





Boston, Massachusetts
February 26, 2019