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Summary Prospectus Supplement

February 9, 2022

Morgan Stanley Institutional Fund, Inc.

Supplement dated February 9, 2022 to the Morgan Stanley Institutional Fund, Inc. Summary Prospectus dated April 30, 2021

Global Real Estate Portfolio (Class IR) (the "Fund")

Sven van Kemenade and Michiel te Paske will no longer serve as portfolio managers of the Fund. Accordingly, at such time, all references to Mr. van Kemenade and Mr. te Paske will be removed from the Fund's Summary Prospectus.

The section of the Summary Prospectus entitled "Fund Management—Portfolio Managers" is hereby deleted and replaced with the following:

Portfolio Managers. The Fund is managed by members of the Global Listed Real Assets team. Information about the members jointly and primarily responsible for the day-to-day management of the Fund is shown below:

Name

 

Title with Adviser/Sub-Adviser(s)

  Date Began
Managing Fund
 

Laurel Durkay

 

Managing Director of the Adviser

 

December 2020

 

Angeline Ho

 

Managing Director of MSIM Company

 

August 2006

 

Desmond Foong

 

Managing Director of MSIM Company

 

April 2015

 

Simon Robson Brown

 

Managing Director of MSIM Limited

 

February 2022

 

Please retain this supplement for future reference.

  IFIGREIRCLSUMPRO 2/22