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Note 2 - Summary of Significant Accounting Policies (Details Textual) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Jan. 01, 2019
Revenue from Contract with Customer, Including Assessed Tax $ 15,126 $ 5,613 $ 9,966 $ 4,281 $ 3,238 $ 5,317 $ 3,878 $ 3,189 $ 34,986 $ 15,622 $ 11,698  
Accounts Receivable, after Allowance for Credit Loss, Current, Total 15,976       3,803       15,976 3,803    
Restricted Cash and Cash Equivalents, Noncurrent, Total 3,016       1,534       3,016 1,534 1,522  
Accounts Receivable, Allowance for Credit Loss, Current 0       0       0 0    
Goodwill, Impairment Loss                 0 0    
Impairment of Intangible Assets (Excluding Goodwill), Total                 0 0    
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)                 23,200  
Operating Lease, Liability, Total 15,604               15,604      
Operating Lease, Right-of-Use Asset 13,493             13,493    
Accounting Standards Update 2016-02 [Member]                        
Operating Lease, Liability, Total                       $ 15,300
Operating Lease, Right-of-Use Asset                       $ 13,500
The 1404 Program [Member]                        
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)                   23,200    
Money Market Funds [Member]                        
Cash Equivalents, at Carrying Value, Total 35,800       136,100       35,800 136,100    
Bank Time Deposits [Member]                        
Cash Equivalents, at Carrying Value, Total $ 6,200       $ 1,600       6,200 1,600    
License and Other [Member]                        
Revenue from Contract with Customer, Including Assessed Tax                 16,457 $ 714 $ 733  
License and Other [Member] | RELISTOR License Agreement [Member]                        
Revenue from Contract with Customer, Including Assessed Tax                 10,000      
Excess of Achievement of US Net Sales                 100,000      
License and Other [Member] | aBSI agreement [Member]                        
Revenue from Contract with Customer, Including Assessed Tax                 4,000      
License and Other [Member] | License Agreement with Bayer [Member]                        
Revenue from Contract with Customer, Including Assessed Tax                 $ 2,000