Note 13 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2019

Notes Tables

Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]

	2019			2018			2017
Current taxes:
United States	$	-		$	(2	)	$	3
Foreign		-			-			-
State		11			(82	)		(16	)
Total current taxes	$	11		$	(84	)	$	(13	)
Deferred taxes:
United States	$	9		$	(1,188	)	$	(8,777	)
Foreign		-			-			-
State		(3	)		(360	)		(2,882	)
Total deferred taxes	$	6		$	(1,548	)	$	(11,659	)
(Benefit from) provision for income taxes	$	17		$	(1,632	)	$	(11,672	)

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

	2019			2018
Deferred tax assets:
Research & Experimental and Orphan Drug tax credit carry-forwards	$	38,180		$	35,435
NYS investment tax credit carry-forwards		929			1,282
Net operation loss carry-forwards		200,738			188,588
Capitalized research and development expenditures		-			1,066
Stock compensation		5,365			5,236
Section 163j disallowed interest		1,243			695
Lease liability		3,380			-
Other items		743			124
Total gross deferred tax assets		250,578			232,426
Less valuation allowance		(246,297	)		(232,174	)
Deferred tax assets		4,281			252
Deferred tax liabilities:
Indefinite-lived intangibles		(195	)		(136	)
Right-of-use lease asset		(2,964	)		-
Depreciation and amortization		(1,156	)		(144	)
Deferred tax liabilities		(4,315	)		(280	)
Net deferred tax liability	$	(34	)	$	(28	)

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

	2019			2018			2017
U.S. Federal statutory rate		21.0	%		21.0	%		34.0	%
State income taxes, net of Federal benefit		0.3	%		0.9	%		1.5	%
Foreign rate differential		0.0	%		0.0	%		(0.6	%)
Research and experimental and Orphan Drug tax credit		3.4	%		2.3	%		6.4	%
Effect of federal and state tax rate changes		(0.4	%)		0.3	%		(6.1	%)
Tax Reform Impact		0.0	%		0.0	%		13.9	%
Change in fair value of contingent consideration liability		(0.3	%)		1.8	%		(1.4	%)
Stock option shortfalls		(0.9	%)		(2.2	%)		(3.1	%)
NOL expiration		(1.2	%)		0.0	%		0.0	%
Other		(1.4	%)		(0.5	%)		(0.1	%)
Change in valuation allowance		(20.5	%)		(21.2	%)		(25.9	%)
Effective tax rate		(0.03	%)		2.4	%		18.6	%

Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]

	2019			2018
Beginning uncertain tax benefits	$	1,944		$	1,951
Prior year - increases (decreases)		-			-
Current year - increases (decreases)		-			-
Settlements		-			-
Expired statuses		(72	)		(7	)
Ending uncertain tax benefits	$	1,872		$	1,944