CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2015	Jun. 30, 2014	Jun. 30, 2015	Jun. 30, 2014
Revenues:
Royalty income	$ 1,773	$ 1,367	$ 1,947	$ 2,102
Collaboration revenue	145	72	210	1,121
Other revenues	19	38	28	69
Total revenues	1,937	1,477	2,185	3,292
Expenses:
Research and development	6,362	7,848	12,825	14,767
License fees - research and development	178	180	162	270
Royalty expense	178	147	220	229
General and administrative	5,998	3,856	9,591	7,261
Depreciation and amortization	129	133	261	277
Change in contingent consideration liability	800	400	1,100	900
Total expenses	13,645	12,564	24,159	23,704
Operating loss	(11,708)	(11,087)	(21,974)	(20,412)
Other income:
Interest income	11	13	23	25
Total other income	11	13	23	25
Net loss before income tax benefit	(11,697)	(11,074)	(21,951)	(20,387)
Income tax benefit	0	1	0	1
Net loss	$ (11,697)	$ (11,073)	$ (21,951)	$ (20,386)
Net loss per share - basic and diluted	$ (0.17)	$ (0.16)	$ (0.32)	$ (0.31)
Weighted-average shares - basic and diluted	69,647	69,561	69,642	66,775