Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

(1) Registration Statement (Form S-3 No. 333-193521) including the related Prospectus and Prospectus Supplement;

(2) Registration Statements (Form S-8 Nos. 333-183511, 333-124910, 333-143670, 333-160389, 333-176204 and 333-197071) pertaining to the 2005 Stock Incentive Plan;

(3) Registration Statements (Form S-8 Nos. 333-52277 and 333-120508) pertaining to its Amended and Restated 1996 Stock Incentive Plan;

of our reports dated March 16, 2015, with respect to the consolidated financial statements and schedule of Progenics Pharmaceuticals, Inc., and the effectiveness of internal control over financial reporting of Progenics Pharmaceuticals, Inc., included in the Company's Annual Report (Form 10-K) for the year ended December 31, 2014.

/s/ Ernst & Young LLP

Hartford, Connecticut

March 16, 2015