CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013
Revenues:
Royalty income	$ 1,367	$ 1,176	$ 2,102	$ 2,333
Collaboration revenue	72	514	1,121	1,367
Research grants	0	77	0	275
Other revenues	38	34	69	52
Total revenues	1,477	1,801	3,292	4,027
Expenses:
Research and development	7,848	9,585	14,767	18,300
License fees - research and development	180	153	270	223
Royalty expense	147	119	229	235
General and administrative	4,256	3,899	8,161	8,219
Depreciation and amortization	133	318	277	595
Total expenses	12,564	14,074	23,704	27,572
Operating loss	(11,087)	(12,273)	(20,412)	(23,545)
Other income:
Interest income	13	10	25	24
Total other income	13	10	25	24
Net loss before income tax benefit	(11,074)	(12,263)	(20,387)	(23,521)
Income tax benefit	1	0	1	0
Net loss	$ (11,073)	$ (12,263)	$ (20,386)	$ (23,521)
Net loss per share - basic and diluted	$ (0.17)	$ (0.24)	$ (0.31)	$ (0.46)
Weighted-average shares - basic and diluted	63,743	51,481	66,775	50,802