8. Restructuring

We reduced headcount in the third and fourth quarters of 2011, resulting in a restructuring accrual of $1.3 million for severance and related benefits which were paid through August 2012. We incurred other exit and contract termination costs, including expenses related to a lease amendment and consolidation of employees within reduced facility space. We also reduced headcount in the third quarter of 2012, resulting in a restructuring accrual of $1.9 million which was paid through August 2013, and the first quarter of 2013, resulting in an approximately $1.5 million restructuring accrual which was paid through the end of 2013. During the second quarter of 2013, we incurred other exit and contract termination costs, including lease termination and amendment and consolidation expenses ($1,359).

Activity in the restructuring accrual, which is included in accounts payable and accrued expenses in our Consolidated Balance Sheets, and in research and development and general and administrative expenses in the Consolidated Statements of Operations, is specified below.

	Severance and Related Benefits			Other Exit Costs			Contract Termination Costs			Total Restructuring Accrual
Balance at December 31, 2010	$	-		$	-		$	-		$	-
Additions, net		1,341			8			292			1,641
Payments		(770	)		(2	)		(138	)		(910	)
Balance at December 31, 2011		571			6			154			731
Additions, net		1,905			184			3			2,092
Payments		(1,663	)		(190	)		(157	)		(2,010	)
Balance at December 31, 2012		813			-			-			813
Additions, net		1,492			15			1,359			2,866
Payments		(2,305	)		(15	)		(1,359	)		(3,679	)
Balance at December 31, 2013	$	-		$	-		$	-		$	-