CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Revenues:
Royalty income	$ 728	$ 1,240	$ 4,181	$ 1,767
Collaboration revenue	136	2,855	521	76,398
Research grants	243	1,681	417	4,346
Other revenues	10	28	44	88
Total revenues	1,117	5,804	5,163	82,599
Expenses:
Research and development	7,551	12,406	26,417	44,887
License fees - research and development	510	114	660	566
Royalty expense	73	147	420	274
General and administrative	4,007	4,064	11,753	14,213
Depreciation and amortization	291	520	1,063	1,581
Total expenses	12,432	17,251	40,313	61,521
Operating (loss) income	(11,315)	(11,447)	(35,150)	21,078
Other income:
Interest income	14	15	43	49
Total other income	14	15	43	49
Net (loss) income	$ (11,301)	$ (11,432)	$ (35,107)	$ 21,127
Net (loss) income per share - basic	$ (0.33)	$ (0.34)	$ (1.04)	$ 0.63
Weighted-average shares - basic	33,848	33,710	33,803	33,501
Net (loss) income per share - diluted	$ (0.33)	$ (0.34)	$ (1.04)	$ 0.63
Weighted-average shares - diluted	33,848	33,710	33,803	33,664