Note 2 - Liquidity and Basis of Presentation (Details Textual) - USD ($)	3 Months Ended								12 Months Ended
	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2017	Dec. 31, 2016
Net Income (Loss) Attributable to Parent, Total	$ (5,899,706)	$ (4,407,067)	$ (1,875,446)	$ (2,728,440)	$ (2,106,846)	$ (1,810,425)	$ (3,185,359)	$ (537,142)	$ (14,910,659)	$ (7,639,772)
Net Cash Provided by (Used in) Operating Activities, Total									(2,108,388)	(2,732,089)
Assets, Current, Total	280,839				1,802,839				280,839	1,802,839
Liabilities, Current, Total	1,233,077				$ 1,817,875				1,233,077	$ 1,817,875
Accrued Bonuses, Current	204,700								204,700
Accounts Payable to Compounder	158,700								158,700
Accrued Director Expense	15,000								15,000
Current Liabilities [Member]
Disputed Accrued Expenses	156,200								156,200
Payment in Kind (PIK) Note [Member]
Interest Payable	$ 57,334								$ 57,334