Note 8 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2025

Notes Tables

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

	2025			2024
Deferred tax assets:
Net operating loss carryforward	$	35,197,253		$	30,374,640
Research and development tax credit carryforward		6,709,611			5,506,154
Stock-based compensation expense		965,107			676,250
Accrued expenses		47,212			256,540
Total deferred tax assets		42,919,183			36,813,584
Deferred tax liabilities
Depreciation		18,298			29,812
Net deferred tax assets		42,900,885			36,783,772
Valuation allowance		(42,900,885	)		(36,783,772	)
Net deferred tax asset after reduction for valuation allowance	$	0		$	0

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

	2025			2024
U.S. federal statutory rate applied to pretax loss		21.0	%		21.0	%
State income tax (benefit)		4.0			4.0
Permanent differences		(0.0	)		(0.0	)
NOL carryforward expiration		(2.5	)		(4.1	)
R&D tax credits, net of expiration		5.7			6.5
Change in valuation allowance and other adjustments		(28.2	)		(27.4	)
Effective tax rate		0.0	%		0.0	%