Note 8 - Income Taxes

12 Months Ended

Dec. 31, 2025

Notes to Financial Statements

Income Tax Disclosure [Text Block]

8.         Income Taxes

At December 31, 2025, we have a consolidated federal net operating loss (“NOL”) carryforward of approximately $135.4 million available to offset against future taxable income of which approximately $25.7 million expires in varying amounts in 2026 through 2037. Additionally, we have approximately $6.7 million in research and development (“R&D”) tax credits that expire in 2026 through 2045 unless utilized earlier. No income taxes have been paid to date. Section 382 of the Internal Revenue Code contains provisions that may limit our utilization of our NOL and R&D tax credit carryforwards in any given year as a result of significant changes in ownership interests that have occurred in past periods or may occur in future periods.

Deferred income taxes reflect the net effect of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. We have established a full valuation allowance equal to the amount of our net deferred tax assets due to uncertainties with respect to our ability to generate sufficient taxable income to realize these assets in the future. The table below presents significant components of our deferred tax assets and liabilities at December 31, 2025 and 2024.

	2025			2024
Deferred tax assets:
Net operating loss carryforward	$	35,197,253		$	30,374,640
Research and development tax credit carryforward		6,709,611			5,506,154
Stock-based compensation expense		965,107			676,250
Accrued expenses		47,212			256,540
Total deferred tax assets		42,919,183			36,813,584
Deferred tax liabilities
Depreciation		18,298			29,812
Net deferred tax assets		42,900,885			36,783,772
Valuation allowance		(42,900,885	)		(36,783,772	)
Net deferred tax asset after reduction for valuation allowance	$	0		$	0

A reconciliation of the U.S. federal income tax rate to the Company’s effective tax rate is as follows:

	2025			2024
U.S. federal statutory rate applied to pretax loss		21.0	%		21.0	%
State income tax (benefit)		4.0			4.0
Permanent differences		(0.0	)		(0.0	)
NOL carryforward expiration		(2.5	)		(4.1	)
R&D tax credits, net of expiration		5.7			6.5
Change in valuation allowance and other adjustments		(28.2	)		(27.4	)
Effective tax rate		0.0	%		0.0	%