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Note 5 - Property and Equipment - Schedule of Property and Equipment (Details) - USD ($)
Jun. 30, 2018
Dec. 31, 2017
Property and equipment, gross $ 674,596 $ 674,596
Accumulated depreciation and amortization (653,375) (643,445)
Property and equipment, net 21,221 31,151
Laboratory Equipment [Member]    
Property and equipment, gross 530,306 530,306
Leasehold Improvements [Member]    
Property and equipment, gross 115,605 115,605
Other Furniture Fixtures And Equipment [Member]    
Property and equipment, gross $ 28,685 $ 28,685