Note 10 - Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2012

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	Three Months Ended September 30,						Nine Months Ended September 30,
	2012		2011				2012				2011
Risk-free interest rate		—		0.90%	–	1.17%		0.87%	–	1.14%		0.90%	–	2.17%
Expected dividend yield		—			0				0				0
Expected terms in years		—		5.0	–	6.0		5.0	–	6.0		5.0	–	6.0
Expected volatility		—			116%			147%	–	157%		112%	–	118%

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

	Three Months Ended September 30,				Nine Months Ended September 30,
	2012		2011		2012		2011
Research and development	$	4,169	$	607	$	12,416	$	39,091
Marketing and business development		6,551		4,150		65,180		12,919
General and administrative		22,451		9,258		107,513		80,954
Total stock-based compensation expense	$	33,171	$	14,015	$	185,109	$	132,964

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

	Shares Subject to Options			Weighted Average Exercise Price per Share		Weighted Average Remaining Contractual Life (Years)		Aggregate Intrinsic Value
Outstanding, December 31, 2011		3,264,207		$	0.65
Granted		1,200,000		$	0.25
Exercised		—			—
Forfeited		—			—
Expired		(540,000	)	$	0.91
Outstanding, September 30, 2012		3,924,207		$	0.49		5.87	$	7,960
Exercisable, September 30, 2012		2,955,982		$	0.57		4.78	$	4,391

Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]

			Options Outstanding						Options Exercisable
Range of Exercise Prices			Shares		Weighted Average Remaining Contractual Life (Years)		Weighted Average Exercise Price		Shares		Weighted Average Exercise Price
$0.15	–	$0.37		2,223,957		7.99	$	0.28		1,255,732	$	0.28
$0.40	–	$0.57		795,000		4.04	$	0.49		795,000	$	0.49
$0.70	–	$1.00		724,000		2.35	$	0.88		724,000	$	0.88
$1.20	–	$1.80		181,250		2.03	$	1.56		181,250	$	1.56
$0.15	–	$1.80		3,924,207		5.87	$	0.49		2,955,982	$	0.57