Note 10 - Stock-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2012

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	Three Months Ended June 30,				Six months Ended June 30,
	2012		2011		2012			2011
Risk-free interest rate		—		2.14%	0.87%	–	1.14%	2.14%	–	2.17%
Expected dividend yield		—		0		0			0
Expected terms in years		—		6.0	5.0	–	6.0	5.5	–	6.0
Expected volatility		—		112%	147%	–	157%	112%	–	118%

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

	Three Months Ended June 30,				Six Months Ended June 30,
	2012		2011		2012		2011
Research and development	$	4,123	$	382	$	8,247	$	38,484
Marketing and business development		7,003		4,380		58,629		8,769
General and administrative		22,207		63,059		85,062		71,696
Total stock-based compensation	$	33,333	$	67,821	$	151,938	$	118,949

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

	Shares Subject to Options			Weighted Average Exercise Price per Share		Weighted Average Remaining Contractual Life (Years)		Aggregate Intrinsic Value
Outstanding, December 31, 2011		3,264,207		$	0.65
Granted		1,200,000		$	0.25
Exercised		—			—
Forfeited		—			—
Expired		(395,000	)	$	0.87
Outstanding, June 30, 2012		4,069,207		$	0.51		5.91	$	274,644
Exercisable, June 30, 2012		3,009,677		$	0.60		4.68	$	128,033

Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]

			Options Outstanding						Options Exercisable
Range of Exercise Prices			Shares		Weighted Average Remaining Contractual Life (Years)		Weighted Average Exercise Price		Shares		Weighted Average Exercise Price
$0.15	–	$0.37		2,223,957		8.24	$	0.28		1,164,427	$	0.29
$0.40	–	$0.57		795,000		4.29	$	0.49		795,000	$	0.49
$0.70	–	$1.00		869,000		2.18	$	0.90		869,000	$	0.90
$1.20	–	$1.80		181,250		2.28	$	1.56		181,250	$	1.56
$0.15	–	$1.80		4,069,207		5.91	$	0.51		3,009,677	$	0.60