X0306 4 2022-06-21 0 0000831547 SPECTRUM PHARMACEUTICALS INC SPPI 0001743778 McGahan Keith M 11500 S. EASTERN AVE. SUITE 220 HENDERSON NV 89052 0 1 0 0 Chief Legal Officer Common Stock, $0.001 par value 2022-06-21 4 A 0 246085 0.00 A 491025 D Common Stock, $0.001 par value 6250 I By 401(k) Plan Stock Option (Right to Buy) 0.63 2022-06-21 4 A 0 904077 0.00 A 2032-01-27 Common Stock 904077 904077 D The restricted stock unit grant was approved by Spectrum Pharmaceuticals, Inc.'s ("Spectrum") board of directors on January 27, 2022, subject to stockholder approval of the Amended and Restated 2018 Long-Term Incentive Plan (the "Plan") under which the restricted stock unit was granted. Spectrum's stockholders approved the Plan on June 21, 2022. The option grant was approved by Spectrum's board of directors on January 27, 2022, subject to stockholder approval of the Plan under which the option was granted. Spectrum's stockholders approved the Plan on June 21, 2022. One third of the aggregate amount of option shares shall vest on each of January 27, 2023, 2024 and 2025, respectively. /s/ Keith M. McGahan 2022-06-23