X0306 4 2018-01-09 0 0000831547 SPECTRUM PHARMACEUTICALS INC SPPI 0001193918 SHROTRIYA RAJESH C MD 11500 S. EASTERN AVE. SUITE 240 HENDERSON NV 89052 1 0 0 0 Common Stock, $0.001 par value 2018-01-09 4 M 0 8818 11.34 A 1797865 D Common Stock, $0.001 par value 2018-01-09 4 M 0 27624 7.24 A 1825489 D Common Stock, $0.001 par value 2018-01-09 4 M 0 478495 4.65 A 2303984 D Common Stock, $0.001 par value 2018-01-09 4 M 0 500000 3.92 A 2803984 D Common Stock, $0.001 par value 2018-01-09 4 M 0 985444 6.87 A 3789428 D Common Stock, $0.001 par value 2018-01-09 4 M 0 500000 8.27 A 4289428 D Common Stock, $0.001 par value 2018-01-09 4 M 0 955847 11.34 A 5245275 D Common Stock, $0.001 par value 2018-01-09 4 M 0 650000 9.18 A 5895275 D Common Stock, $0.001 par value 2018-01-09 4 M 0 622376 7.24 A 6517651 D Common Stock, $0.001 par value 2018-01-09 4 M 0 412500 5.86 A 6930151 D Common Stock, $0.001 par value 2018-01-09 4 M 0 58480 6.69 A 6988631 D Common Stock, $0.001 par value 2018-01-09 4 F 0 3500294 18.03 D 3488337 D Common Stock, $0.001 par value 3477422 I By RS Irrevocable Trust Common Stock, $0.001 par value 498894 I By CS Family Trust Common Stock, $0.001 par value 28907 I By 401(k) Common Stock, $0.001 par value 40000 I By ROTH IRA Common Stock, $0.001 par value 9523 I By Spouse Common Stock, $0.001 par value 170473 I By Shrotriya Gift Trust Common Stock, $0.001 par value 67144 I By Shrotriya Family Foundation Stock Option Exercise (Right to Buy) 11.34 2018-01-09 4 M 0 8818 0.00 D 2015-12-19 2020-12-17 Common Stock 8818 0 D Stock Option Exercise (Right to Buy) 7.24 2018-01-09 4 M 0 27624 0.00 D 2017-12-19 2020-12-17 Common Stock 27624 0 D Stock Option Exercise (Right to Buy) 4.65 2018-01-09 4 M 0 478495 0.00 D 2013-01-08 2020-01-08 Common Stock 478495 0 D Stock Option Exercise (Right to Buy) 3.92 2018-01-09 4 M 0 500000 0.00 D 2013-07-01 2020-07-01 Common Stock 500000 0 D Stock Option Exercise (Right to Buy) 6.87 2018-01-09 4 M 0 985444 0.00 D 2014-01-03 2020-12-17 Common Stock 985444 0 D Stock Option Exercise (Right to Buy) 8.27 2018-01-09 4 M 0 500000 0.00 D 2014-06-12 2020-12-17 Common Stock 500000 0 D Stock Option Exercise (Right to Buy) 11.34 2018-01-09 4 M 0 955847 0.00 D 2015-12-19 2020-12-17 Common Stock 955847 0 D Stock Option Exercise (Right to Buy) 9.18 2018-01-09 4 M 0 650000 0.00 D 2016-12-13 2020-12-17 Common Stock 650000 0 D Stock Option Exercise (Right to Buy) 7.24 2018-01-09 4 M 0 622376 0.00 D 2017-12-19 2020-12-17 Common Stock 622376 0 D Stock Option Exercise (Right to Buy) 5.86 2018-01-09 4 M 0 412500 0.00 D 2017-12-17 2020-12-17 Common Stock 412500 0 D Stock Option Exercise (Right to Buy) 6.69 2018-01-09 4 M 0 58480 0.00 D 2017-12-17 2020-12-17 Common Stock 58480 0 D Represents shares withheld by Spectrum to satisfy the Reporting Person's payment of the exercise price and tax withholding obligations. The shares have not been sold by the Reporting Person or by Spectrum. The shares have been cancelled by the transfer agent. Upon completion of the proposed contribution of shares to the RS Irrevocable Trust referenced in footnote 3 below, the shares included in this Form 4 shall all be held indirectly by the Reporting Person. Includes 1,627,888 shares previously owned directly which the reporting person contributed to the RS Irrevocable Trust on December 29, 2017 and 1,762,320 shares exercised by the reporting person on January 9, 2018 and reported on this Form 4. Includes 40,000 shares previously owned directly which the reporting person contributed to a ROTH IRA. /s/ Kurt A. Gustafson, attorney-in-fact for Rajesh C. Shrotriya 2018-01-11